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Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients

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World Journal of Gastroenterology 2006年第44期12卷 7161-7164页

作者： Leonardo A Sechi Maria Gazouli lee e sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti Dipartimento di Scienze Biomediche Sezionedi Microbiologia Sperimentale e Clinica Università degli studi diSassari Viale S. Pietro 43/B Sassari 07100 Italy Stefania Zanetti Daniela Paccagnini ISOGEM International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial disease. Sassari Italy Department of Biology School of Medicine University of Athens Athens Greece Thunder Bay District Health Unit 999 Balmoral Street Thunder Bay Ontario Canada Dipartimento di Scienze Biomediche Sezionedi Microbiologia Sperimentale e Clinica Università degli studi diSassari Viale S. Pietro 43/B Sassari 07100 Italy Stefania Zanetti Daniela Paccagnini ISOGEM International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial disease. Sassari Italy Pathogen Evolution Group Centre for DNAFingerprinting and Diagnostics Hyderabad India Agricultural University of Athens Department of Anatomy-Physiology Faculty of Animal ScienceAthens Greece Clinica Chirurgica Università degli studi diSassari Viale S. Pietro 07100 Sassari Italy

AIM： To study the association between Crohn＇s disease （CD）, Mycobacterium avium subspecies paratubercuolsis （MAP）, and genetic factors by examining the role of natural resistance-associated macrophage protein 1 （NRAMP1） gene polymorphisms （now SLCllA1） in Sardinian patients with CD and controls. MeTHODS： Thirty-seven CD patients and 34 controls with no inflammatory bowel disease （IBD） were recruited at the University of Sassari after giving written consent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M, pafatubefculosis was identified by IS900 PCR and sequencing. Logistic regression was used to calculate odds ratios （OR） for the associations among CD, presence of MAP, and 6 loci described above.＇ ReSULTS： For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION： Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of genetic, infectious, and immunologic factors in the etiology of CD is complex.

关键词： Mycobacterium avium subspecies paratuber- culosis Crohn's disease SCLllA1 polymorphisms

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