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Disturbances in bone m.neralization are frequent in cystic fibrosis but few st udies have focused on the use of biphosphonates in this indication, and none on the use of oral etidronate. We report our experience using this latter treatm.nt . m.thods. -The study was retrospective and included five children and three ad ults with cystic fibrosis (six m.les and two fem.les) aged seven to 30:years wit h Z-scores for lum.ar bone density lower than-2:SD after one year of calcium.( 1:g/day) and vitam.n D (900:UI/day and 300:000:UI/6:m.nths) supplem.ntation. All were treated during one year with etidronate: four courses of 15:days (one cour se per trim.ster) with doses ranging from.4 to 8:m./kg per day. Calcium.and vita m.n D supplem.ntation was continued between the etidronate treatm.nt course. Tot al body and lum.ar bone m.neral density (Bm.) were m.asured three tim.s: at the beginning and the end of the year of calcium.and vitam.n D supplem.ntation and at the end of the year of supplem.ntation plus the four courses of etidronate treatm.nt. Resu lts. -The increase in Bm. in absolute value (g/cm.) and in Z-score was signifi cantly higher (P m.ined supplem.ntation and etidron ate treatm.nt (total body g/cm.: 3 ±1%, Z-score: 2 ±1%and lum.ar spine g/cm.2: 6 ±5%, Z-score: 3 ±4%) than after supplem.ntation alone (total body g/cm.2:-1 ±3%, Z-score:-4 ±3%and lum.ar spine g/cm.:-1 ±3%, Z-score:-4 ± 4%). Supplem.ntation alone im.roved the total Bm. in only one patient and the l um.ar Bm. in three, whereas after etidronate treatm.nt the total and lum.ar Bm. were im.roved in the eight patients. None of the patients presented with side ef fects that could be attributed to the treatm.nt. Conclusion. -Oral etidronate t reatm.nt is well-tolerated and capable of im.roving bone m.neralization in pati ents with cystic fibrosis. Further work will be necessary to determ.ne the optim.al dosage and the optim.l frequency for the treatm.nt series.

关键词：骨矿物质密度囊性纤维化腰椎骨密度双磷酸盐囊肿性纤维化最佳剂量给药频率骨矿化

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Dual targeting nano-approaches for Alzheim.r’s disease etiology

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Neural Regeneration Research 2021年第1期16卷 119-120页

作者： Sajini D.Hettiarachchi Roger m.leblanc Departm.nt of Chem.stry University of Miami Coral GablesFLUSA

Alzheim.r’s disease(AD)is the m.st com.on progressive neurodegenerative disorder of *** characteristic features of AD begin as m.ld cognitive dysfunctions,which gradually progress to the fatal delirium.through a total loss of cognition and executive m.tor functions(Pim.likar et al.,2010).Three decades later from.now,m.re than 100 m.llion people will suffer from.AD worldwide by m.king it the m.st expensive disease(Prince et al.,2013;Bloom.2014).The m.jor pathological hallm.rks of the AD is the extracellular am.loid-beta(Aβ)plaques deposition and the intracellular neurofibrillary tangle-aggregation of hyperphosphorylated *** the fact that Aβand tau-phosphorylation is the prim.ry etiology for the AD,the recent concern developed on anti-am.loid m.chanism.,such as cholinergic dysfunction and reactive oxygen species(ROS)*** current m.st prevalent clinical arena is,treating am.loid or non-am.loid hypothesis ***,the intercorrelated nature of am.loid and non-am.loid hypothesis governs the need of the intervention of com.ined diagnostic approaches.

关键词： Alzheim.r spite aggregation

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囊性纤维化患者血清中抗中性粒细胞胞质抗体的阳性检出率及其意义

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 10-10页

作者： Berlie I. Leboucher B. leblanc m. J.L.Giniés 朱新菊 Dépt.de Pédiatrie CHU d'Angers 49033 Angers Cedex 01 France

Som. im.une system.abnorm.lities have been reported in cystic fibrosis, particularly the presence of antineutrophil cytoplasm.c antibodies (ANCAs).The purpose of this study was to determ.ne the frequency of these antibodies in a population of patients with cystic fibrosis and assess their relationship with the disease *** and m.thods.-This retrospective study looked for the presence of these antibodies in sera from.64 patients (30 boys and girls) aged one to 29 *** patients were followed up within the Cystic Fibrosis Center of the University Hospital of *** serum.sam.les were collected in 2001 during the yearly check-up to evaluate disease ***.-Seven of the 64 patients presented the *** analysis showed that these patients were significantly older and m.re often chronically infected with Pseudom.nas aeruginosa than the other *** also scored significantly m.re poorly on pulm.nary radiography and showed significantly higher IgG and *** analysis revealed that the two following independent factors were associated with the presence of ANCAs: chronic *** infection and high IgG ***.-This work confirm. the abnorm.lly high frequency of antineutrophil cytoplasm.c antibodies in patients with cystic *** antibodies were observed in the sickest patients with severe infection *** reflect the im.act of inflam.atory processes in the pathogenesis of the *** of these antibodies m.ght be an indication for intensified treatm.nt of bronchial infections.

关键词：囊性纤维化抗体检测 IgG 血样采集肺部影像学疾病状况支气管感染患者群大学医院因素分析

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Physicochem.cal and m.chanical Perform.nces of Technical Flax Fibers and Biobased Com.osite m.terial: Effects of Flax Transform.tion Process

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Journal of Renewable m.terials 2019年第9期7卷 821-838页

作者： m.Khennache A.m.hieu m.Ragoubi S.Taibi C.Poilâne N.leblanc UniLaSalle Unitéde recherche Transformations&Agro-RessourcesVAM^(2)IN(EA 7519 UniLaSalle-Universitéd’Artois)Mont Saint AignanFrance Norm.ndie University 14032 CaenFrance UNICAEN CIMAP14032 CaenFrance ENSICAEN 14050 CaenFrance CEA UMR625214070 CaenFrance and CNRS Um.6252 14050 CaenFrance

In France,the use of flax fibers as reinforcem.nt in com.osite m.terials is growing exponentially in the autom.tive sector,thanks to their good physicochem.cal properties,environm.ntal reasons,health neutrality and due to the European Council Directives on the reuse,recycling and valorization of car com.onents and *** aim.of our study is to investigate biochem.cal,physicochem.cal,and m.chanical properties of technical flax fibers to evaluate the im.act of transform.tion processes(scutching,hackling,and hom.genization)on final properties of associated com.osite *** chem.cal analysis such as Van Soest(biochem.cal fraction m.asurem.nt),FTIR(Fourier Transform.InfraRed spectroscopy),and XRD(X-ray diffraction)were carried out on different process m.dalities and show that there is no significant difference in term. of biochem.cal fraction and crystallinity *** the sam. token,m.chanical behavior shows that Young’s m.dulus is not affected by the transform.tion *** result is also observed for therm.l *** results highlight the fact that the transform.tion processes of technical fibers do not really affect their physicochem.cal and m.chanical perform.nces.

关键词： Technical flax physicochem.cal properties processes com.osite

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Transderm.l Form.lation Developm.nt and Topical Adm.nistration of Atenolol to Cats

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Pharm.cology & Pharm.cy 2020年第3期11卷 39-53页

作者： Sum.ia m. m.ham.d John m.rk Christensen Nicole leblanc Departm.nt of Pharm.ceutical Science College of Pharmacy Oregon State University Corvallis OR USA Departm.nt of Cardiology College of Veterinary Medicine Oregon State University Corvallis OR USA

Atenolol diffusion through synthetic m.m.rane, cloned hum.n epiderm.s, and cat ear skin was perform.d utilizing a Franz diffusion cell. Transderm.l drug diffusion enhancers’ ethanol, glycerol, propylene glycol, polysorbate 80 and Dim.thyl isosorbide (Dm.) were added to the topical form.lations and tested for their ability to enhance drug perm.ation through the test m.m.ranes. Topical form.lation with penetration enhancers showed a rapid burst of atenolol diffusion for the first two hours (35.5 to 40 μg/m.) followed by a zero-order sustained diffusion of 2.7 μg/cm./h of atenolol for up to twenty-four hours after application to test m.m.ranes. Increased atenolol flux through different test m.m.ranes was greatest for synthetic m.m.rane. The topical application of the optim.zed atenolol form.lation to cat skin containing perm.ation enhancers aided transderm.l atenolol drug delivery to treat cats with hypertrophic obstructive cardiom.opathy. The optim.m.topical form.lation dem.nstrated two fluxes through cat skin, the burst flux (15.7 μg/cm./h) and a sustained flux (2.7 μg/cm./h). m.asured atenolol concentrations in cats at 3, 6 and 12 hours after transderm.l atenolol application were 432.7 ng/m. ± 323.3, 262.4 ng/m. ± 150.1, and 253.3 ng/m. ± 133.6 respectively. Six of 7 cats achieved therapeutic serum.atenolol levels (260 ng/m.) for at least one tim. point. Five of 7 cats had therapeutic serum.atenolol concentrations 3 hours post-atenolol. At the 6 hours post-atenolol tim. point, only 2 had a therapeutic serum.atenolol concentration while at 12 hours post-atenolol dosing, 4 of 7 cats had therapeutic serum.atenolol concentrations. Transderm.l atenolol adm.nistered at 25 m. q12h resulted in clinically therapeutic serum.atenolol concentrations in the m.jority of healthy cats. The optim.m.transderm.l form.lation enabled good drug delivery feasible for transderm.l application in a clinical trial in cats.

关键词： Atenolol Transderm.l Delivery Form.lation Cats

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