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玉米对大斑病菌3号小种表达的单基因抗性在不同光温条件下的变异

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园艺与种苗 1990年第6期 33-37页

作者： s.leath 高必达

玉米大斑病是由Exserohilum turcicum（Pass.）(其有性阶段为setosphaeria turcica)所引起的,可利用多基因和单基因的抗性有效地控制。对于大斑病的多基因抗性早在35年之前已经得到鉴定。后来育种的程序则发展用多基因抗性以改进玉米的... 详细信息

玉米大斑病是由Exserohilum turcicum（Pass.）(其有性阶段为setosphaeria turcica)所引起的,可利用多基因和单基因的抗性有效地控制。对于大斑病的多基因抗性早在35年之前已经得到鉴定。后来育种的程序则发展用多基因抗性以改进玉米的群体。玉米大斑病菌小种专化的抗性通常是由单一显性基因所控制,表现为褪绿斑和减少病原孢子的产生。由H t

关键词：大斑病菌病斑毒力毒性小种玉米

含和不含Ht1基因的玉米近等基因系对4种叶斑病菌抗性

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园艺与种苗 1988年第1期 39-43页

作者： s.leath W.L.Pedersen 刘维志

单基因抗性(小种专化性抗性)是控制植物病害的一种基本方法,而且通常对于一种病原物的某些小种有效,但对其它小种无效。Martin等(1976)证实,与含隐性等位基因Pr04的小麦近等基因系对同一分离菌比较时,小种专化性抗性基因Pm4能够降低带... 详细信息

单基因抗性(小种专化性抗性)是控制植物病害的一种基本方法,而且通常对于一种病原物的某些小种有效,但对其它小种无效。Martin等(1976)证实,与含隐性等位基因Pr04的小麦近等基因系对同一分离菌比较时,小种专化性抗性基因Pm4能够降低带有毒性基因Pm4的小麦白粉病菌(*** ***)同一分离菌的侵染频率。Nass等(1981)发现,

关键词：等基因系分离菌大斑病菌 Ht1 基因杂交种杂交品种生理小种玉米叶斑病蛇眼病

新型化疗药物KW-2170对复发卵巢上皮细胞癌的疗效和毒性

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 47-48页

作者： Estes J.M. leath C.A. Williams s. R.D. Alvarez 马超 Department of Obstetrics and Gynecology University of Alabama at Birmingham618 South 19th StreetBirminghamAL 35233United States

Objectives.:KW-2170 is a novel DNA intercalating agent whose mechanism of action is similar to doxorubicinHCl,yet is associated with less cardiac toxicity. The objective of this study was to evaluate the activity and toxicity of this novel chemotherapeutic agent in patients with recurrent ovarian carcinoma. Methods.:A prospective phase II trial was performed in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma and measurable disease. Patients could have platinum-sensitive or refractory disease and could have received any number of prior treatments. One treatment cycle consisted of KW-2170 administered at a dose of 18 mg/m2 weekly for 3 weeks followed by a 21-day rest period. Toxicity was assessed using the NCI Common Toxicity Criteria (Version 2.0),and dose reduction was allowed for significant toxicity. Response to therapy was assessed in patients who completed at least 2 cycles using RECIsT criteria. Results.:A total of 28 patients were enrolled in this phase II trial at 5 separate centers. Of the 28 patients evaluated,all had stage III/IV disease at initial diagnosis. The median number of prior therapeutic regimens in these patients was 4 (range 1-8). The median number of KW-2170 cycles administered was 2 (range 1-5). Treatment-related toxicity in this heavily pretreated population was acceptable as only 6 patients (21%) had grade 3-4 neutropenia. Dose reductions occurred in 6 patients (21%) for grades 1-4 neutropenia,and no patient had febrile neutropenia. Four patients completed less than 1 cycle; 3 secondary to progressive disease,and one due to Gram-positive sepsis. Of patients receiving at least 2 full cycles,10 patients (55%) had stable disease with a median of 4.5 months (range 3-10) to disease progression. All other patients were removed from the study after 1-2 cycles of therapy with no significant clinical effect noted. Conclusions.:Although associated with relatively little toxicity,KW-2170 at the dose and schedul

关键词：上皮细胞癌 KW-2170 化疗药物治疗周期腹膜癌嵌入剂休息期盐酸阿霉素发热性作用机制

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用筋膜修复术治疗继发于产科出血的腹腔隔室综合征

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 59-59页

作者： Kendrick IV J.E. leath III C.A. Melton s.M. straughn Jr. J.M. 柳蕴 Department of Obstetrics and Gynecology University of Alabama at Birmingham 618 South 19th Street OHB 340 Birmingham AL 35233 United States Dr.

BACKGROUND: Massive obstetric hemorrhage can be catastrophic, with considerable maternal morbidity and mortality. CAsE: A 41-year-old term gravida experienced massive postpartum hemorrhage attributed to an amniotic fluid embolism with rapid development of disseminated intravascular coagulation and resultant abdominal compartment syndrome. In this critically ill patient, a fascial prosthesis used for abdominal wall closure was placed to expedite multiple abdominal explorations and packing. Additionally, this device facilitated fascial closure once the abdominal compartment syndrome was resolved. CONCLUsION: Abdominal compartment syndrome resulting from overwhelming obstetric hemorrhagemay necessitate emergent decompressive laparotomy to alleviate increased intra-abdominal pressure and end-organ dysfunction. The fascial prosthesis allows a staged abdominal wall closure to be performed once the abdominal compartment syndrome is resolved.

关键词：隔室综合征产科出血修复术产科大出血羊水栓塞腹腔探查减压手术腹腔内压

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