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Importance of complementary data to histopathological image analysis of oral leukoplakia and carcinoma using deep neural networks

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Intelligent Medicine 2023年第4期3卷 258-266页

作者： leandro muniz de lima Maria Clara Falcão Ribeiro de Assis Júlia Pessini Soares Tânia Regina Grão-Velloso Liliana Aparecida Pimenta de Barros Danielle Resende Camisasca Renato Antonio Krohling Nature-inspired Computing Lab Federal University of Espirito SantoVitoriaBrazil Graduate Program in Computer Science Federal University of Espirito SantoVitoriaBrazil School of dentistry Departamento de Clinica OdontologicaFederal University of Espirito SantoVitoriaBrazil Graduate Program in Clinical dentistry Federal University of Espirito SantoVitoriaBrazil

Background Oral cancer is one of the most common types of cancer in men causing mortality if not *** recent years,computer-aided diagnosis(CAD)using artificial intelligence techniques,in particular,deepneural networks have been investigated and several approaches have been proposed to deal with the automateddetection of various pathologies using digital *** studies indicate that the fusion of images with thepatient’s clinical information is important for the final clinical *** such dataset does not yet exist fororal cancer,as far as the authors are aware,a new dataset was collected consisting of histopathological images,demographic and clinical *** study evaluated the importance of complementary data to histopathologicalimage analysis of oral leukoplakia and carcinoma for *** A new dataset(NDB-UFES)was collected from 2011 to 2021 consisting of histopathological imagesand *** 237 samples were curated and analyzed by oral pathologists generating the gold standardfor ***-of-the-art image fusion architectures and complementary data(Concatenation,MutualAttention,MetaBlock and MetaNet)using the latest deep learning backbones were investigated for 4 distincttasks to identify oral squamous cell carcinoma,leukoplakia with dysplasia and leukoplakia without *** evaluate them using balanced accuracy,precision,recall and area under the ROC curve *** Experimental results indicate that the best models present balanced accuracy of 83.24%using images,demographic and clinical information with MetaBlock fusion and ResNetV2 *** represents an improvement in performance of 30.68%(19.54 pp)in the task to differentiate samples diagnosed with oral squamous cellcarcinoma and leukoplakia with or without *** This study indicates that cured demographic and clinical data may positively influence the performance of artificial intelligence models in automated classification of

关键词： Leukoplakia Squamous carcinoma Pathology deep learning Transfer learning

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Pseudo-discontinuum model to simulate hard-rock mine pillars

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Underground Space 2023年第4期11卷 81-95页

作者： Erick Ro genes Alessandra dos Santos Gomes Marcio muniz de Farias leandro lima Rasmussen Faculty of Technology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the pseudo-discontinuum modeling technique,called continuum Voronoi block model(CVBM),was applied to repre-sent the behavior of hard-rock pillars from underground mines subjected to high field *** CVBM’s ability to produce numerical results consistent with the observed behavior of pillars is demonstrated through the numerical analysis of a hypothetical case and a back analysis of the Creighton mine *** results show that the model can capture convergence displacements and explicitly show the formation of macro-fractures parallel to excavation walls,intact rock slabs,and V-shaped *** components are characteristics of brittle failure induced by highly stressed ground *** studies presented in this work confirm the CVBM as a convenient tool for the numerical modeling of intact rock pillars excavated in deep underground mines.

关键词： Brittle failure Spalling Bulking Voronoi tessellation

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Soot combustion; Ceria; Ternary mixed oxide; Cordierite coating; Diesel particulate filter

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Journal of Environmental Sciences 2018年第11期30卷 58-68页

作者： leandro Fontanetti Nascimento Juliana Fonseca lima Paulo Cesar de Sousa Filho Osvaldo Antonio Serra department of Chemistry FFCLRP University of Sao Paulo 14040-901 Ribeirao Preto Sao Paulo Brazil Institute of Chemistry Rio de Janeiro State University 20550-900 Rio de Janeiro Rio de Janeiro Brazil Institute of Chemistry Uniuersity of Campinas 13083-970 Campinas Silo Paulo Brazil Center of-Natural and Human Sciences Federal Uniuerty of ABC 09210-580 Santo Andre Sao Paulo Brazil

We report the application of a solid lanthanum-ceria-zinc catalyst in the catalytic regeneration of diesel particulate filters （DPF） in diesel engines. We synthesized a CeO2- ZnO-La2O3 （Ce-Zn-La） mixed oxide by a lactic acid-mediated sol-gel method, which efficiently coated cordierite substrates for soot capture and combustion. We studied the effects of La loading on the physicochemical and catalytic properties of Ce-Zn mixed oxide during lowtemperature soot combustion processes. We characterized the synthesized catalysts by X-ray diffraction （XRD）, Fourier-transform infrared spectroscopy （FTIR）, N2 adsorption, Raman spectroscopy, oxygen storage capacity （OSG）, and scanning and transmission electron microscopy （SEM and TEM）. Thermogravimetric and differential thermal analysis （TGA/DTA） confirmed that the catalysts effectively reduced the soot oxidation temperature. The ternary Ce-Zn-La mixed oxide catalyst with Ce/Zn/La atomic ratio of 2：1：0.5 had the highest catalytic activity and promoted soot oxidation at temperatures below 390℃. This indicated that the large number of oxygen vacancies in the catalyst structure generated oxygen species at low temperatures. Raman spectroscopy measurements revealed the presence of oxygen vacancies and lattice defects in Ce-Zn-La samples, which were key parameters concerning the stability and redox properties of the prepared catalysts.

关键词： Soot combustion Ceria Ternary mixed oxide Cordierite coating Diesel particulate filter

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Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： Ana Carolina Marinho Monteiro lima Greice Carolina Santos da Silva Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego Luana leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgraduate Program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

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Assessing physical habitat structure and biological condition in eastern Amazonia stream sites

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Water Biology and Security 2023年第2期2卷 23-31页

作者： Jady Vivia Almeida da Silva Santos Myllena lima Josinete Sampaio Monteles Daiany Larissa Ribeiro Carrera Ana Paula Justino de Faria leandro Schlemmer Brasil leandro Juen Faculdades de Ciencias Biologicas Instituto de Ciencias BiologicasUniversidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Laboratorio de Ecologia e Conservacao Universidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduacao em Zoologia Universidade Federal do Para/Museu Paraense Emílio GoeldiRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduacao em Ecologia Universidade Federal do Para e Embrapa Amazonia OrientalRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-Graduacao em Agricultura e Ambiente Laboratorio de Ciencias Ambientais e BiodiversidadeUniversidade Estadual do MaranhaoSao LuísBrazil Instituto de Ciencias Biologicas e Saúde Universidade Federal do Mato GrossoCampus AraguaiaPontal do AraguaiaMato GrossoBrazil

The advance of agricultural frontiers and industrialization in Amazonia has increased natural resource deterioration,resulting in degraded physical habitat structure and reduced local aquatic *** evaluated the relative sensitivities of the Biological Monitoring Working Party(BMWP)and Average Score Per Taxon(ASPT)biotic indexes based on EPT(Ephemeroptera,Plecoptera,Trichoptera)versus EPT taxa richness,EPT abundance,and Shannon-Wiener EPT diversity for evaluating anthropogenic impacts on Amazonian *** expected that EPT-BMWP and EPT-ASPT would be more sensitive in detecting environmental changes on stream biota than the other *** sampled 32 stream sites in eastern Amazonia distributed along an environmental gradient resulting from different land use *** the biological metrics except EPT-ASPT were significantly responsive to anthropogenic pressures;however,EPT taxa richness was slightly more responsive.

关键词： Land use Aquatic insects Biotic index Environmental monitoring

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Use of Logistic Regression Model for Prediction of Non-Timber Forest Products

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American Journal of Plant Sciences 2017年第11期8卷 2847-2859页

作者： Alexandre leandro Santos de Abreu Ricardo de Oliveira Gaspar Mirella Basileu de Oliveira lima Mauro Eloi Nappo Eraldo Aparecido Trondoli department of Forest Science University of Brasilia Brasília Brazil

The use of non-timber is a valuable alternative for the conservation of tropical forests. Juçara (Euterpe edulis Mart.) is considered one of the main alternatives in the Atlantic Forest for the production of açaí pulp. However, there are few studies that aim to evaluate their production. The present study aimed to construct a probabilistic model to predict the production of Euterpe edulis bunches, using dendrometric variables and competition index. Twenty plots of 10 × 50 m were sampled in an area with said specie, showing the arboreal entities with diameter at breast height > 4.8 cm, and recording the Euterpe edulis phenomena. The main variables influencing the production of bunches were assessed using logistic regression model. The logistic regression showed the variables diameter breast height (DBH) and total height (h) as significant to explain the variation between productive and non-productive entities. The competition index tested was not significant (p-value = 0.221). The model of prediction of curl production in Juçara can be written as: Zi = -6.878594 + 0.2522454 × DBH + 0.1951574 × h. The use of a logistic regression model showed potential for prediction of non-timber forest products.

关键词： Forest Management Regression Model Logit Euterpe edulis Mart

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Evaluation of the Genotoxicity of Polymeric Microparticles Containing Ametryn Herbicide

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 553-565页

作者： Renata de lima leandro O. Feitosa Renato Grillo Anderson E.S. Pereira Leonardo FernandesFraceto department of Biotechnology University of Sorocaba Sorocaba 18023-000 Brazil Federal University of Sao Carlos Sorocaba 18052-780 Brazil department of Environmental Engineering UNESP-Univ. Estadual Paulista Sorocaba 18087-180 Brazil department of Biochemistry Institute of Biology UNICAMP Campinas 18083-862 Brazil

Agrochemicals have been used throughout the ages to eradicate weeds and pests. Use of agrochemicals is now commonplace, serving as an aid in farming procedures and contributing to greater agricultural production. However, the indiscriminate use of agrochemicals is a cause for concern because they can exert toxic effects on the environment and hence on living beings. This work involved a genotoxic analysis of controlled release formulations of the herbicide ametryn encapsulated in microspheres of poly（hydroxybutyrate） and poly（hydroxybutyrate-co^valerate）. Genotoxicity was analyzed using cytogenetic, micronucleus, comet and Allium cepa assays, as well as molecular analysis. The results showed that the rate of chromosome breakdown caused by unencapsulated ametryn was much higher than that caused by ametryn encapsulated in the polymer microspheres （p 〈 0.05）. This indicates that controlled release delivery systems employing the polymer formulations should be significantly safer for the environment and for living beings.

关键词： Ametryn controlled release environmental chemistry genotoxicity.

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Dual-delay-Path Ring Oscillator with Self-Biased delay Cells for Clock Generation

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Circuits and Systems 2023年第6期14卷 19-28页

作者： Agord de Matos Pinto Jr Raphael Ronald Noal Souza Mateus Biancarde Castro Eduardo Rodrigues de lima leandro Tiago Manêra School of Electrical and Computer Engineering (FEEC) University of Campinas Campinas Brazil Eldorado Research Institute Campinas Brazil

This work summarizes the structure and operating features of a high-performance 3-stage dual-delay-path (DDP) voltage-controlled ring oscillator (VCRO) with self-biased delay cells for Phase-Locked Loop (PLL) structurebased clock generation and digital system driving. For a voltage supply VDD = 1.8 V, the resulting set of performance parameters include power consumption PDC = 4.68 mW and phase noise PN@1MHz = -107.8 dBc/Hz. From the trade-off involving PDC and PN, a system level high performance is obtained considering a reference figure-of-merit ( FoM = -224 dBc/Hz ). Implemented at schematic level by applying CMOS-based technology (UMC L180), the proposed VCRO was designed at Cadence environment and optimized at MunEDA WiCkeD tool.

关键词： Phase Locked Loop (PLL) Voltage-Controlled Ring Oscillators (VCRO) Dual-delay-Path DDP delay Cells

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Sward Structural Characteristics and Performance of Beef Heifers Reared under Rotational Grazing Management on Campos Grassland

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American Journal of Plant Sciences 2014年第7期5卷 1020-1029页

作者： Cezar Wancura Barbieri Fernando Luiz F. de Quadros Felipe Jochims émerson Mendes Soares leandro Bittencourt de Oliveira Régis Maximiliano R. Carvalho Gabriela Machado Dutra Felipe Xavier de lima Franciele Gusatto Natural Grassland Ecology Research Group (LEPAN-UFSM) Universidade Federal de Santa Maria Animal Science Department Santa Maria Brazil

This study aimed to evaluate the effect of two rest intervals on structural sward characteristics and productive performance of beef heifers reared on Campos grassland managed on rotational grazing. The treatments were two intervals between grazing of 375 and 750 DD (degree days), based on thermal cumulative sum for leaf expansion of native grasses belonging to two functional groups. The experimental design was a randomized complete block design with two treatments and three replications. The tested animals were beef heifers with initial age of 12 months and average weight of 185.2 ± 17.4 kg. Measures in the pasture were: herbage mass, mass of green leaf blades, stem mass, dead material mass and green leaf allowance. The 750 DD rest interval presented higher herbage mass (24%), higher green herbage mass and 19% more leaves in the canopy. This rest interval also presents a high proportion of dead material and stems in the sward structure. In the other way, the 375 DD rest interval presents better chemical characteristics, with 20% more crude protein in the hand plucking samples. Heifers’ dry matter intake was similar between the rest intervals (2.04% of live weight) and the bite mass was also similar (0.22 g DM per bite) but the animal performance was higher in the 375 DD rest interval. The stocking density showed similarity between treatments with an average of 875 kg/LW/ha. The live weight gain per area was higher in 40 kg/LW/ha (P = 0.117) for 375 DD rest interval, reaching 251 kg/LW/ha produced over the 149 experimental days. Based on these results, we can conclude that the treatment of shortest interval between defoliation gave the highest gain individual animals in warm seasons.

关键词： Average Daily Gain Duration of Leaf Expansion Herbage Mass Rotational Grazing Stocking Rate

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Possibilities of using silicate rock powder:An overview

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Geoscience Frontiers 2022年第1期13卷 446-456页

作者： Claudete Gindri Ramos James C.Hower Erika Blanco Marcos leandro Silva Oliveira Suzi Huff Theodoro department of Civil and Environmental Engineering Universidad de la CostaCalle 58#55-66BarranquillaColombia departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru Center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA department of Earth&Environmental Sciences University of KentuckyLexingtonKY 40511USA Postgraduate Program of Environment and Rural development(PPG-MAdeR) Área Universitária01Vila Nossa Senhora de Fátima–Campus UnBPlanaltinaDFBrazil

This study evaluates the on use of crushed rocks(remineralizers)to increase soil fertility levels and which contributed to increase agricultural productivity,recovery of degraded areas,decontamination of water,and carbon *** use of these geological materials is part of the assumptions of rock technology and,indirectly,facilitates the achievement of sustainable development goals related to soil management,climate change,and the preservation of water *** over the past 50 years on silicate rocks focused on soil fertility management and agricultural *** recently,the combined use with microorganisms and organic correctives have shown positive results to mitigate soil degradation;to expand carbon sequestration and storage;and to contribute to the adsorption of contaminants from water and *** this article we show results obtained in several countries and we show that this technology can contribute to the sustainability of agriculture,as well as to reverse global *** mineral nutrients are released more slowly from these types of inputs,they remain in the soil for a longer time,stimulating the soil *** addition,they are a technology to soluble synthetic fertilizers replace,since the few nutrients derived from such inputs not consumed by plants are lost by leaching,contaminating groundwater and water *** addition,conventional methods rely heavily on chemical pesticides which cause damage to soil’s microfauna(responsible for the decomposition of organic matter and nutrient cycling)and the loss of organic carbon(in the form of dioxide),which is quickly dispersed in the *** rock powders are applied in natura,have long-lasting residual effects and reduce greenhouse gas emissions.

关键词： Rock powder Soil management Carbon storage Water contaminant adsorption

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