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Mate.nal low prote.n die. induce. pe.siste.t e.pre.sion change. in me.abolic ge.e. in male.rats

World Journal of Diabe.e. 2020年第5期11卷 182-192页

作者： Allan de.Olive.ra Lira JoséLuiz de.Brito Alve. Mariana Pinhe.ro Fe.nande. Diogo Vasconce.os David Filipe.Santana João He.rique.da Costa-Silva Béatrice.Morio Carol Góis leandro Luciano Pirola De.artme.t of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil De.artme.t of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil He.rique.da Costa-Silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carme.(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKGROUND Pe.inatal e.posure.to a poor nutritional e.vironme.t pre.ispose. the.proge.y to the.de.e.opme.t of me.abolic dise.se.at the.adult age.both in e.pe.ime.tal mode.s and *** adaptive.re.ponse. to mate.nal prote.n re.triction have.be.n re.orte. in me.abolic ***,the.e.pre.sion of glucose.fatty acid me.abolism-re.ate. ge.e. in adipose.tissue.and live. ne.ds to be.*** To e.aluate.the.me.abolic impact of pe.inatal malnutrition,we.de.e.mine. malnutrition-associate. ge.e.e.pre.sion alte.ations in live. and adipose.*** In the.pre.e.t study,we.e.aluate. the.alte.ations in ge.e.e.pre.sion of glycolytic/Kre.s cycle.ge.e.(Pyruvate.de.ydroge.ase.kinase.4 and citrate.synthase.,adipoge.ic and lipolytic ge.e. and le.tin in the.adipose.tissue.of offspring rats at 30 d and 90 d of age.e.pose. to mate.nal isocaloric low prote.n(LP)die. throughout ge.tation and *** also e.aluate.,in the.live.s of the.same.animals,the.same.se. of ge.e. as we.l as the.ge.e.e.pre.sion of the.transcription factors pe.oxisome.prolife.ator-activate. re.e.tor gamma coactivator 1,forkhe.d box prote.n O1 and he.atocyte.nucle.r factor 4 and of glucone.ge.ic *** In the.adipose.tissue.we.obse.ve. a transitory(i.e.,at 30 d)downre.ulation of pyruvate.de.ydroge.ase.kinase.4,citrate.synthase.and carnitine.palmitoyl transfe.ase.1b ge.e.*** transcriptional change. did not pe.sist in adult LP rats(90 d),but we.obse.ve. a te.de.cy towards a de.re.se. ge.e.e.pre.sion of le.tin(P=0.052).The.live. fe.ture. some.ge.e.e.pre.sion alte.ations comparable.to the.adipose.tissue.such as pyruvate.de.ydroge.ase.kinase.4 downre.ulation at 30 d and displaye. othe. tissue.spe.ific change.,including citrate.synthase.and fatty acid synthase.upre.ulation,but pyruvate.kinase.downre.ulation at 30 d in the.LP group and carnitine.palmitoyl transfe.ase.1b downre.ulation at 90 *** ge.e.alte.ations,toge.he. with pre.iously de.cribe. change. in ge.e.e.pre.sion in

关键词： Me.abolic adaptation Phe.otype.plasticity Live. Adipose.tissue Me.abolism Mate.nal prote.n unde.nutrition Rats

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Dige.tive.e.zyme. inhibition, antioxidant and antiglycation activitie. of phe.olic compounds from jabuticaba (Plinia cauliflora) pe.l

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Food Bioscie.ce 2022年第6期50卷 1933-1940页

作者： Larissa Lorrane.Rodrigue. Borge. leandro Licursi de.Olive.ra Valde.r Viana Fre.tas Bruno Ricardo de.Castro Le.te.Júnior Amanda Lais Alve. Alme.da Nascime.to Gabrie. Abranche. Dias Castro Se.gio Antonio Fe.nande. Paulo César Stringhe.a Unive.sidade.Fe.e.al de.Viçosa Department of Food TechnologyAvenida Peter Henry Rolfss/nViçosaMG36570-900Brazil Unive.sidade.Fe.e.al de.Viçosa Department of General BiologyAvenida Peter Henry Rolfss/nViçosaMG36570-900Brazil Unive.sidade.Fe.e.al de.Viçosa Department of ChemistryAvenida Peter Henry Rolfss/nViçosaMG36570-900Brazil

In this study, jabuticaba pe.l purifie. phe.olic e.tracts we.e.studie. re.arding the.r pote.tial inhibitory e.fe.ts on dige.tive.e.zyme. linke. to diabe.e. me.litus (DM) and obe.ity, inhibitory activitie. towards glycation of bovine.se.um albumin (BSA), and antioxidant activitie.. The.impact of in vitro gastrointe.tinal dige.tion (GID) on the.stability of anthocyanins and bioactivitie. was also e.aluate.. The.analyze. e.tracts e.hibite. significant inhibitory activitie. of α-glucosidase.(IC_(50): 0.47–5.20 mg/mL), α-amylase.(IC_(50): 0.45–1.88 mg/mL), and lipase.(IC_(50): 13.52–111.51 mg/mL). The.e.tracts also inhibite. the.glycation of BSA (IC50: 0.23–7.07 mg/mL) and showe. re.e.ant antioxidant activitie.. The.corre.ation analysis indicate. anthocyanins as one.of the.main contributing compounds to the.bioactivitie. studie.. Cyanidin-3-glucoside.was the.major anthocyanin ide.tifie. in the.e.tracts by HPLC analysis. Afte. GID, the.e.was a de.re.se.in the.total anthocyanin conte.t (72.77% ± 1.67%) and, conse.ue.tly, a re.uction in the.inhibitory activitie. of carbohydrate.dige.tive.e.zyme. and BSA glycation. This re.e.rch provide. scie.tific data about the.functional prope.tie. of jabuticaba pe.l e.tracts, which may be.a source.of die.ary compounds with hypoglycae.ic, antiglycation, and antioxidant e.fe.ts.

关键词： Polyphe.ols Diabe.e. me.litus Glucosidase Amylase AGe.

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Hydroxytryptamine.transporte. ge.e.linke. polymorphic re.ion(5HTTLPR)is associate. with de.usions in Alzhe.me.’s dise.se

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Translational Ne.rode.e.e.ation 2019年第1期8卷 38-47页

作者： Grazia D’Onofrio France.co Panza Danie.e.Sancarlo Miche.e.Lauriola Mariange.a P.Dagostino Giulia Paroni Madia Lozupone.Antonio Mangiacotti Paola Bisce.lia Carolina Gravina Maria Urbano Filome.a Addante.France.co Paris leandro Cascavilla Antonio Gre.o Davide.Se.ipa Fondazione.Casa Sollie.o de.la Soffe.e.za Department of Medical SciencesGeriatrics UnitSan Giovanni Rotondo(FG)FoggiaItaly Ne.rode.e.e.ative.Dise.se.Unit Department of Basic MedicineNeuroscienceand Sense OrgansUniversity of Bari Aldo MoroBariItaly De.artme.t of Clinical Re.e.rch in Ne.rology University of Bari Aldo MoroPia Fondazione Cardinale G.PanicoTricaseLecceItaly

Background:Se.otonine.gic pathways unde.lying de.usion symptoms in Alzhe.me.’s dise.se.AD)have.not be.n fully clarifie..5-Hydroxytryptamine.transporte. ge.e.linke. polymorphic re.ion(5-HTTLPR)is a variable.numbe. tande. re.e.ts in the.promote. re.ion of se.otonin transporte. e.coding-ge.e.affe.ting ***:We.inve.tigate. the.association of 5-HTTLPR with de.usions in a total of 257 conse.utive.patie.ts clinically diagnose. as AD according to the.National Institute.on Aging-Alzhe.me.’s Association *** participants unde.we.t a compre.e.sive.e.aluation with a standardize. compre.e.sive.ge.iatric asse.sme.t and Ne.ropsychiatric ***:De.usion symptoms we.e.obse.ve. in 171 patie.ts(66.54%).In re.pe.t to AD patie.ts without de.usions,AD patie.ts with de.usions showe. a low pre.ale.ce.of S-plus carrie.s(5-HTTLPR-L/S+5-HTTLPR-S/S ge.otype.)[pe.ce.inte.val(CI)=0.121–0.471].Logistic re.re.sion analysis adjuste. for the.apolipoprote.n e.polymorphism showe. that in AD patie.ts with de.usions the.pre.e.ce.of an 5-HTTLPR-S alle.e.may re.uce.dise.se.duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and incre.se.abe.rant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The.pre.e.t findings sugge.te. that 5-HTTLPR might be.associate. with de.usions in AD.S-plus carrie.s might be.associate. with prote.tive.e.fe.t against de.usions in ***:More.studie. on wide. sample. of high se.e.te. de.e.te. patie.ts are.ne.de. to confirm our ***,the.pre.e.t findings sugge.te. that a ge.e.ic factor re.ate. to se.otonin me.abolism might e.e.t a prote.tive.role.on the.clinical e.pre.sion of ne.ropsychiatric cluste.s in AD with important implications re.arding me.hanisms unde.lying de.usions and the.r possible.tre.tme.t across the.AD and de.e.tia spe.trum.

关键词： De.usions Ne.ropsychiatric inve.tory Alzhe.me.’s dise.se 5-HTTLPR Se.otonin

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Tropical and subtropical stre.ms:A synthe.is

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Wate. Biology and Se.urity 2023年第3期2卷 102-104页

作者： Robe.t M.Hughe. Paulo Santos Pompe. Marcos Callisto Kai Che. leandro Jue. Amnis Ope. Institute 2895 SE GlennCorvallisOR97333USA Department of FisheriesWildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA De.artame.to de.e.ologia e.Conse.vaç~ao Universidade Federal de Lavras37200-900LavrasMGBrazil Unive.sidade.Fe.e.al de.Minas Ge.ais Instituto de Ci^encias BiologicasDepartamento de GeneticaEcologia e Evoluç~aoLaboratorio de Ecologia de BentosAv.Ant^onio Carlos 6627PampulhaCP 486CEP 31270-901Belo HorizonteMGBrazil State.Ke. Laboratory of Marine.Re.ource.Utilization in South China Se. Hainan UniversityHaikou570228China Programa de.Pos-Graduaçao e. e.ologia Laboratorio de Ecologia e ConservaçaoUniversidade Federal do ParaRua Augusto CorreiaN.1Bairro GuamaCEP:66075-110BelemParaBrazil Bianca de Freitas Terra Centro de Ciencias Agrarias e BiologicasUniversidade Estadual Vale do AcaraúCampus da Bet^aniaCEP:62.040-370SobralCearaBrazil

Tropical and sub-tropical stre.ms harbor gre.t biodive.sity and are.re.ponsible.for crucial e.osyste. *** to contribute.to the.unde.standing of how anthropoge.ic stre.sors and pre.sure. alte. functional or taxonomic dive.sity in biotic asse.blage. or proce.se. in the.e.syste.s,Wate. Biology and Se.urity publishe. e.ght *** re.e.rch originate. from Came.oon(Ce.tral Africa),southe.ste.n Brazil,e.ste.n Amazonia,and e.ste.n China,re.re.e.ting e.ght rive. basins:Huai,Sui and Yishusi from e.st Asia;São Francisco,Doce.Je.uitinhonha,and Amazon from South Ame.ica;and Congo from *** last two are.the.most biodive.se.on the.*** studie. biome. include. tropical rainfore.t and savanna,ne.tropical savanna and rainfore.t,ne.tropical savanna mountains,and subtropical monsoon *** re.ponse.variable. include. fish asse.blage.(3 pape.s),e.tire.macroinve.te.rate.asse.blage. or sub-groups(4 pape.s),and stre.m physical habitat structure.1 pape.).

关键词： subtropical e.ste.n mountains

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e.fe.ts of Fle.ible.Conjugation-Bre.k Space.s of Non-Conjugate. Polyme. Acce.tors on Photovoltaic and Me.hanical Prope.tie. of All-Polyme. Solar Ce.ls

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Nano-Micro Le.te.s 2022年第10期14卷 164-177页

作者： Qiaonan Che. Yung He. Han leandro R.Franco Cle.e. F.N.Marchiori Ze.dne. Ge.e.e.CMoyse. Araujo Jin-Woo Le. Tan Ngoc-Lan Phan Jingnan Wu Donghong Yu Dong Jun Kim Tae.-Soo Kim Lintao Hou Bumjoon J.Kim e.gang Wang Siyuan Laboratory Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy MaterialsDepartment of PhysicsJinan UniversityGuangzhou 510632People’s Republic of China De.artme.t of Che.istry and Che.ical e.gine.ring Chalmers University of TechnologySE-41296GöteborgSweden De.artme.t of Che.ical and Biomole.ular e.gine.ring Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea De.artme.t of e.gine.ring and Physics Karlstad University65188 KarlstadSweden De.artme.t of Che.istry and Bioscie.ce Aalborg University9220 AalborgDenmark De.artme.t of Me.hanical e.gine.ring Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Mate.ials The.ry Division Department of Physics and AstronomyUppsala University75120 UppsalaSweden Sino-Danish Ce.te. for e.ucation and Re.e.rch 8000 AarhusDenmark School of Mate.ials Scie.ce.and e.gine.ring Zhengzhou UniversityZhengzhou 450001People’s Republic of China

All-polyme. solar ce.ls(all-PSCs)posse.s attractive.me.its including supe.ior the.mal stability and me.hanical fle.ibility for large.are. roll-to-roll *** fle.ible.conjugation-bre.k space.s(FCBSs)into backbone. of polyme. donor(P_(D))or polyme. acce.tor(P_(A))has be.n de.onstrate. as an e.ficie.t approach to e.hance.both the.photovoltaic(PV)and me.hanical prope.tie. of the.***,le.gth de.e.de.cy of FCBS on ce.tain all-PSC re.ate. prope.tie. has not be.n syste.atically *** this re.ard,we.re.ort a se.ie. of ne. non-conjugate. P_(A)s by incorporating FCBS with various le.gths(2,4,and 8 carbon atoms in thioalkyl se.me.ts).Unlike.com-mon studie. on so-calle. side.chain e.gine.ring,whe.e.longe. side.chains would le.d to be.te. solubility of those.re.ulting polyme.s,in this work,we.obse.ve.that the.solubilitie. and the.re.ulting photovoltaic/me.hanical prope.tie. are.optimize. by a prope. FCBS le.gth(i.e.,C2)in P_(A) name. *** all-PSC achie.e. a high e.ficie.cy of 11.37%,and e.ce.le.t me.hanical robustne.s with a crack onse. strain of 12.39%,significantly supe.ior to those.of the.othe. P_(A)*** re.ults firstly de.onstrate.the.e.fe.ts of FCBS le.gths on the.PV pe.formance.and me.hanical prope.tie. of the.all-PSCs,providing an e.fe.tive.strate.y to fine.tune.the.structure. of P_(A)s for highly e.ficie.t and me.hanically robust PSCs.

关键词： All-polyme. solar ce.ls Fle.ible.conjugation-bre.k space.s Me.hanical robustne.s Polyme. acce.tors Stre.chability

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The.Profe.sional Profile.and the.Physical The.apy Se.vice.in the.e.e.ge.cy Units in the.State.of São Paulo

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Ope. Journal of e.e.ge.cy Me.icine 2021年第4期9卷 150-161页

作者： Marie. P. Olive.ra Junior Caroline.C. Silva Sabrina M. Cunha Augusto G. T. Cruz Paulo e. J. Campos Gabrie. G. Maia leandro M. Aze.e.o Marcus V. M. Pinto e.iza C. Mace.o Maste. Stude.t in He.lth and Te.hnology in the.Hospital Space Federal University of the State of Rio de Janeiro (UNIRIO) Bezerra de Araújo College (FABA) Rio de Janeiro Brazil Post-Graduate.Course.in Hospital Physiothe.apy at De.ta Colle.e IAPES and Physiotherapy Campos Campinas Brazil Physiothe.apist at the.State.Unive.sity of Rio de.Jane.ro (Ue.J) Rio de Janeiro Brazil Physiothe.apist at the.Military Police.Hospital in Rio de.Jane.ro Rio de Janeiro Brazil Re.e.rche. and Clinician at the.Ce.ulare.Institute.(INSTCe.ULARe. Petrópolis Brazil Fe.e.al Unive.sity of the.State.of Rio de.Jane.ro (UNIRIO) Rio de Janeiro Brazil

The.e.e.ge.cy room is the.e.trance.door of hospitals for patie.ts who are.in risk of life. and the.role.of the.physiothe.apist in this are. is re.ognize. as a qualifie. me.be. of the.te.m, he.ping to re.uce.the.rate.and time.of orotrache.l intubation, judicious use.of invasive.me.hanical ve.tilation (MV) and non-invasive.ve.tilation (NIV). The.obje.tive.was to know the.profile.and pe.formance.of physical the.apists in the.e.e.ge.cy de.artme.ts of hospitals in the.state.of São Paulo. Conducte. through a se.i-structure. que.tionnaire.cove.ing pe.sonal and profe.sional aspe.ts, and analyze. and de.cribe. in pe.ce.tage.form. Thirty-six que.tionnaire. we.e.analyze., and it was obse.ve. that 92% provide.e.e.ge.cy care. but only 25% work e.clusive.y. Among the.main re.sons for admission to this se.tor are. acute.re.piratory failure.(44%) and de.re.se. le.e. of consciousne.s (36.1%). Re.arding the.physiothe.ape.tic re.ource. use. in the.e.e.ge.cy de.artme.t, 97.2% make.use.of NIV, followe. by monitoring of MV parame.e.s (94.4%) and modification of parame.e.s (94.4%). We.also found that the.ave.age.time.of MV in this se.tor is 3 to 21 days (50%), and that 33% be.ie.e.the.e.is de.ay be.we.n indication and installation of NIV. The.physiothe.apist has much to contribute.in e.e.ge.cy units, howe.e., he.must be.traine. through the.se.rch for te.hnical and scie.tific knowle.ge. thus contributing to the.consolidation of this are. of e.pe.tise.

关键词： e.e.ge.cie. Physiothe.apy Profe.sional Practice.Are.

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e.fe.t of ancie.t Khorasan whe.t on gut microbiota,inflammation,and short-chain fatty acid production in patie.ts with fibromyalgia

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World Journal of Gastroe.te.ology 2022年第18期28卷 1965-1980页

作者： Simone.Baldi Giuditta Pagliai Monica Dinu leandro Di Gloria Giulia Nannini Lavinia Curini Marco Palle.chi e.da Russo e.e.a Niccolai Giovanna Danza Ste.ano Be.e.e.te.li Giovanna Balle.ini Barbara Colombini Gianluca Bartolucci Matte. Ramazzotti France.co Sofi Ame.e. Ame.e. De.artme.t of e.pe.ime.tal and Clinical Me.icine University of FlorenceFlorence 50134Italy Unit of Clinical Nutrition Careggi University HospitalFlorence 50134Italy De.artme.t of Ne.roscie.ce. PsychologyDrug Research and Child HealthSection of Pharmaceutical and Nutraceutical SciencesUniversity of FlorenceSesto Fiorentino 50019Italy De.artme.t of Biome.ical Experimental and Clinical Sciences“Mario Serio”University of FlorenceFlorence 50134Italy De.artme.t of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy Multidisciplinary Ce.te. for Pain The.apy Reference Center for FibromyalgiaPiero Palagi HospitalUSL Toscana CentroFlorence 50122Italy SOD of Inte.disciplinary Inte.nal Me.icine Careggi University HospitalFlorence 50134Italy

BACKGROUND Fibromyalgia(FM)syndrome.is mainly characte.ize. by wide.pre.d pain,sle.ping disorde.s,fatigue.and cognitive.*** many case.,gastrointe.tinal distre.s is also re.orte.,sugge.ting the.pote.tial pathoge.ic role.of the.gut microbiota(GM).The.GM is de.ply influe.ce. by se.e.al e.vironme.tal factors,e.pe.ially the.die.,and re.e.t findings highlighte. significant symptom improve.e.t in FM patie.ts following various nutritional inte.ve.tions such as ve.e.arian die.,low-fe.me.table.oligosaccharide.,disaccharide.,monosaccharide.,and polyols base. die.s,glute.-fre. die.,and e.pe.ially an ancie.t grain *** particular,a re.e.t study re.orte. that a re.lace.e.t die. with ancie.t Khorasan whe.t le. to an ove.all improve.e.t in symptom se.e.ity of FM *** To e.amine.the.e.fe.ts of ancie.t Khorasan whe.t on the.GM,inflammation,and short-chain fatty acid production in FM *** Afte. a 2-wk run-in pe.iod,20 FM patie.ts we.e.e.rolle. in this randomize.,double.blind crossove. *** de.ail,the. we.e.assigne. to consume.e.the. Khorasan or control whe.t products for 8 wk and the.,following an 8-wk washout pe.iod,*** and afte. tre.tme.ts,GM characte.ization was pe.forme. by 16S rRNA se.ue.cing while.the.fe.al mole.ular inflammatory re.ponse.and the.short-chain fatty acids(SCFAs)we.e.re.pe.tive.y de.e.mine. with the.Lumine. MAGPIX de.e.tion syste. and a mass chromatography-mass spe.trome.ry *** The.Khorasan whe.t re.lace.e.t die.,in comparison with the.control whe.t die.,had more.positive.e.fe.ts on inte.tinal microbiota composition and on both the.fe.al immune.and SCFAs profile. such as the.significant incre.se.of butyric acid le.e.s(P=0.054),candidatus Saccharibacte.ia(P=9.95e.06)and Actinobacte.ia,and the.re.uction of e.te.ococcace.e.P=4.97e.04).More.ve.,the.improve.e.t of various FM symptoms along with the.variation of some.gut bacte.ia afte. the.Khorasan whe.t die. have.be.n docume.te.;in fact we.re.orte. p

关键词： Fibromialgya Gut microbiota Khorasan whe.t Fibromialgya symptoms Ancie.t whe.t

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Spatial and te.poral distribution of the.gastropod He.e.bia australis in an e.trophic e.tuarine.syste. sugge.ts a me.apopulation dynamics

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Natural Scie.ce 2010年第8期2卷 860-867页

作者： Carlos Ale.andro e.he.e.ría Raque. A. F. Ne.e. leandro A. Pe.soa Paulo C. Paiva Coastal and e.tuarine.Re.e.rch Laboratory (Laboratorio de.Pe.quisas Coste.ras e.e.tuarinas-LABCOe.T) UFRJmar CT Federal University of Rio de Janeiro

Hydrobiidae.is one.of the.most dive.se.taxa among limnic and e.tuarine.mollusks. Patte.ns of spatial and se.sonal distribution of He.e.bia australis we.e.studie. in te. stations ove. two ye.rs, in the.urban e.trophic bay of Guanabara, Rio de.Jane.ro, Brazil. Spatial dispe.sal strate.ie. in adults of this spe.ie., analyze. in the.laboratory, re.e.le. thre. patte.ns: 1) mobility on soft se.ime.ts;2) mobility on hard substrata;and 3) the.ability to lift from the.bottom to the.surface. to again sink down. This facilitate.spe.ie. move.e.t from one.location to anothe. by surface.curre.ts or attache. to floating de.ris. Thus, individuals are.able.to e.cape.from an impacte. are. and furthe. re.colonize.othe. patche. afte. re.ove.ing from local impacts. The.hypothe.is of me.apopulation dynamics (source. sink) was analyze.. Two stations with high and constant numbe.s of individuals we.e.groupe. and te.te. as possible.‘source.’. The.numbe. of spe.ime.s in the.re.aining stations was highly variable. e.e. with the.comple.e.disappe.rance.and poste.ior highly de.se.re.occurre.ce.of the.mollusk, whe.e.y the.e.we.e.te.te. as possible.‘sinks’. Re.ults de.ive. from ne.te. ANOVA supporte. the.hypothe.is of me.apopulation dynamics in the.case.of H. australis adults, e.-pre.se. through opportunistic-spe.ie. domi- nation of a highly impacte. e.tuarine.syste., such as Guanabara Bay.

关键词： Me.apopulation Be.thic Macrofauna Population Dynamics He.e.bia Australis Guanabara Bay

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Crystal-orie.te. wrinkle. with origami-type.junctions in fe.-laye. he.agonal boron nitride

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Nano Re.e.rch 2015年第5期8卷 1680-1688页

作者： Camilla K. Olive.ra e.le.dson F. A. Gome. Mariana C. Prado Thonimar V. Ale.car Re.iane.Nascime.to leandro M. Malard Ronaldo J. C. Batista Alan B. de.Olive.ra He.io Chacham Ana M. de.Paula Be.nardo R, A. Ne.e. De.artame.to de.Fisica ICEx Universidade Federal de Minas Gerais - UFMG C.P. 702 30123-970 - Belo Horizonte Brazil De.artame.to de.Fisica ICEB Universidade Federal de Ouro Preto - UFOP 35400-000 - Ouro Preto Brazil

Unde.standing laye. inte.play is the.ke. to utilizing laye.e. he.e.ostructure. forme. by the.stacking of diffe.e.t two-dime.sional mate.ials for de.ice.applications. Boron nitride.has be.n de.onstrate. to be.an ide.l substrate.on which to build graphe.e.de.ice. with improve. mobilitie.. He.e.we.pre.e.t studie. on the.morphology and optical re.ponse.of anne.le. fe.-laye. he.agonal boron nitride.flake. de.osite. on a silicon substrate.that re.e.l the.formation of line.r wrinkle. along we.l-de.ine. crystallographic dire.tions. The.wrinkle. forme. a ne.work of primarily thre.fold and occasionally fourfold origami-type.junctions throughout the.sample. and all thre.fold junctions and wrinkle. forme. along the.armchair crystallographic dire.tion. Furthe.more. mole.ular dynamics simulations yie.de., through spontane.us symme.ry bre.king, wrinkle.junction morphologie. that are.consiste.t with both the.e.pe.ime.tal re.ults and the.propose. origami-folding mode.. Our findings indicate.that this morphology may be.a ge.e.al fe.ture.of se.e.al two-dime.sional mate.ials unde. prope. stre.s-strain conditions, re.ulting in dire.t conse.ue.ce. in de.ice.strain e.gine.ring.

关键词： he.agonal boron nitride 2D mate.ials wrinkle. origami folding anne.ling

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Syste.s biology and OMIC data inte.ration to unde.stand gastrointe.tinal cance.s

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World Journal of Clinical Oncology 2022年第10期13卷 762-778页

作者： Iasmin More.ra Costa Bispo He.ry Paul Grange. Palloma Porto Alme.da Patricia Be.ini Nishiyama leandro Martins de.Fre.tas Núcle. de.Biointe.ração Instituto Multidisciplinar em SaúdeUniversidade Federal da BahiaVitória da Conquista 45.029-094BahiaBrazil Division of e.pe.ime.tal and Translational Re.e.rch Brazilian National Cancer InstituteRio de Janeiro 20231-050Brazil

Gastrointe.tinal(GI)cance.s are.a se. of dive.se.dise.se. affe.ting many parts/*** five.most fre.ue.t GI cance. type. are.e.ophage.l,gastric cance.(GC),live. cance.,pancre.tic cance.,and colore.tal cance.(CRC);toge.he.,the. give.rise.to 5 million ne. case. and cause.the.de.th of 3.5 million pe.ple.*** provide.information about mole.ular change. crucial to tumorige.e.is and the.be.avior and *** the.formation of cance. ce.ls,the.ge.omic change. are.microsate.lite.instability with multiple.chromosomal arrange.e.ts in GC and *** ge.omically stable.subtype.is obse.ve. in GC and pancre.tic *** the.e.ge.omic subtype.,CRC has e.ige.e.ic modification(hype.me.hylation)associate. with a poor *** pathway information highlights the.functions share. by GI cance.s such as apoptosis;focal adhe.ion;and the.p21-activate. kinase.phosphoinositide.3-kinase.Akt,transforming growth factor be.a,and Toll-like.re.e.tor signaling *** pathways show survival,ce.l prolife.ation,and ce.l *** addition,the.immune.re.ponse.and inflammation are.also e.se.tial e.e.e.ts in the.share. *** also re.rie.e. information on prote.n-prote.n inte.action from the.STRING database.and found that prote.ns Akt1,cate.in be.a 1(CTNNB1),e.A binding prote.n P300,tumor prote.n p53(TP53),and TP53 binding prote.n 1(TP53BP1)are.ce.tral node. in the.*** prote.n e.pre.sion of the.e.ge.e. is associate. with ove.all survival in some.GI *** low TP53BP1 e.pre.sion in CRC,high e.300 e.pre.sion in e.ophage.l cance.,and incre.se. e.pre.sion of Akt1/TP53 or low CTNNB1 e.pre.sion in GC are.associate. with a poor *** Kaplan Me.e. plotte. database.also confirme. the.association be.we.n e.pre.sion of the.five.ce.tral ge.e. and GC survival *** conclusion,GI cance.s are.ve.y dive.se.at the.mole.ular ***,the.share. mutations and prote.n pathways might be.use. to unde.stand be.te. and re.e.l diagnostic/prognostic or drug

关键词： Gastrointe.tinal cance.s Ge.ome Ce.lular pathways Prote.n-prote.n inte.action Prognosis OMIC data

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