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Diabe.e. and inflammatory dise.se.:An ove.vie. from the.pe.spe.tive.of Ca^(2+)/3'-5'-cyclic ade.osine.monophosphate.signaling

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World Journal of Diabe.e. 2021年第6期12卷 767-779页

作者： leandro Bue.o Be.gantin De.artme.t of Pharmacology Universidade Federal de São PauloSão Paulo 04039-032Brazil

A large.amount of e.ide.ce.has supporte. a clinical link be.we.n diabe.e. and inflammatory dise.se.,e.g.,cance.,de.e.tia,and *** addition,it is also sugge.te. that dysre.ulations re.ate. to Ca^(2+)signaling could link the.e.dise.se.,in addition to 3'-5'-cyclic ade.osine.monophosphate.cAMP)signaling ***,re.e.ling this inte.play be.we.n diabe.e. and inflammatory dise.se. may provide.nove. insights into the.pathoge.e.is of the.e.*** involving signaling pathways re.ate. to Ca^(2+)and cAMP,inflammation,diabe.e.,de.e.tia,cance.,and hype.te.sion(alone.or combine.)we.e.colle.te. by se.rching PubMe. and *** signaling pathways,Ca^(2+)and cAMP signaling,control the.re.e.se.of ne.rotransmitte.s and hormone.,in addition to ne.rode.e.e.ation,and tumor ***,the.e.is a cle.r re.ationship be.we.n Ca^(2+)signaling,e.g.,incre.se. Ca^(2+)signals,and inflammatory *** also re.ulate. pro-and anti-inflammatory *** to the.e.pe.ie.ce.of our group in this fie.d,this article.discusse. the.role.of Ca^(2+)and cAMP signaling in the.corre.ation be.we.n diabe.e. and inflammatory dise.se.,including its pharmacological *** a nove.ty,this article.also include.:(1)A time.ine.of the.major e.e.ts in Ca^(2+)/cAMP signaling;and(2)As coronavirus dise.se.2019(COVID-19)is an e.e.ging and rapidly e.olving situation,this article.also discusse. re.e.t re.orts on the.role.of Ca^(2+)channe. blocke.s for pre.e.ting Ca^(2+)signaling disruption due.to COVID-19,including the.corre.ation be.we.n COVID-19 and diabe.e..

关键词： Diabe.e. Cance. Hype.te.sion De.e.tia Ca^(2+)/3'-5'-cyclic ade.osine.monophosphate.signaling Ca^(2+)channe. blocke.s Pharmacothe.apy Ne.rode.e.e.ation COVID-19

Strong optical nonline.ritie. of se.f-asse.ble. polymorphic microstructure. of phe.yle.hynyl functionalize. fluore.one.

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Chine.e.Che.ical Le.te.s 2018年第2期29卷 297-300页

作者： Xinyue.Li Se.ge. Se.in leandro A. e.trada Chunqing Yuan Yulong Duan Jonathan Cre.e.s Paul Tinne.ans Paul Kouwe. Alan e. Rowan The. Rasing Jialiang Xu School of Che.ical and e.gine.ring Te.hnology Tianjin University Tianjin 300350 China Institute.for Mole.ule. and Mate.ials (IMM) Radboud University 6525 A J Nijrnegen The Netherlands Ce.te. for Photoche.ical Scie.ce. Bowling Green State University Bowling Green OH 43403 USA Solvay Spe.ialty Polyme.s Alpharetta CA 30005 USA Australian Institute.for Bioe.gine.ring and Nanote.hnology (AIBN) The University of Queensland Brisbane OLD 4072 Australia

Highly e.ficie.t nonline.r optical（NLO） mate.ials with we.l-de.ine. archite.ture. in the.wave.e.gth and subwave.e.gth le.gth scale. are.of particular importance.for ne.t ge.e.ation of inte.rate. photonic circuits. Fluore.one.analogue. have.be.n de.onstrate. to be.promising candidate. as building blocks for asse.bly of organic NLO mate.ials thanks to the.r syne.gistic supramole.ular inte.actions and brilliant optical prope.tie.. He.e.we.have.studie. the.polymorphs of a phe.yle.hynyl functionalize. fluore.one.de.ivative. and the.r controlle. se.f-asse.bly for microstructure. with diffe.e.t morphologie.. The.e.polymorphic microcrystals e.hibit ve.y distinctive.NLO prope.tie., highly re.ate. to the.r supramole.ular and e.e.tronic structure..

关键词： Nonline.r optics Se.ond harmonic ge.e.ation Two-photon e.cite. fluore.ce.ce.Transition dipole.Fluore.one

Validity of continuous-failure.state.unloading triaxial te.ts as a me.ns to e.timate.the.re.idual stre.gth of rocks

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Journal of Rock Me.hanics and Ge.te.hnical e.gine.ring 2021年第4期13卷 717-726页

作者： Gabrie. Walton Ste.e. Gaine. leandro R.Ale.ano De.artme.t of Ge.logy and e.gine.ring Ge.logy Colorado School of MinesGoldenCO80401USA Natural Re.ource. Canada CanmetMININGOttawaOntarioK1A 1M1Canada De.artme.t of Natural Re.ource. and e.vironme.tal e.gine.ring Universidad de VigoVigo36310Spain

The.re.idual stre.gth of rocks and rock masse. is an important parame.e. to be.constraine. for analysis and de.ign purpose. in many rock e.gine.ring applications.A re.idual stre.gth e.ve.ope.in principal stre.s space.is typically de.e.ope. using re.idual stre.gth data obtaine. from compre.sion te.ts on many diffe.e.t spe.ime.s of the.same.rock *** this study,we.e.amine. the.pote.tial for use.of the.continuous-failure.state.te.ting conce.t as a me.ns to constrain the.re.idual stre.gth e.ve.ope.using a limite. numbe. of ***,cylindrical spe.ime.s of thre. rock type.(granodiorite.diabase.and Stanste.d granite.we.e.unloade. at the.re.idual state.such that a full re.idual stre.gth e.ve.ope.for e.ch individual spe.ime. was *** a re.idual stre.gth mode. that introduce. a single.ne. stre.gth parame.e.(the.re.idual stre.gth inde.,or RSI),the.re.ults of the.continuous-failure.tate.unloading te.ts we.e.compare. to conve.tionally obtaine. re.idual stre.gth ***,the.continuous-failure.state.re.idual stre.gth data we.e.found to be.consiste.t with the.conve.tional re.idual stre.gth ***,it was ide.tifie. that the.primary factor limiting an accurate.characte.ization of the.re.idual stre.gth for a give. rock type.is not the.amount of data for a give. spe.ime.,but the.varie.y of spe.ime.s available.to characte.ize.the.inhe.e.t variability of the.rock unit of ***,the.use.of continuous-failure.state.te.ting for e.timation of the.re.idual stre.gth of a rock unit is only re.omme.de. whe. the.numbe. of spe.ime.s available.for te.ting is ve.y limite.(i.e.<5).

关键词： Re.idual stre.gth Continuous-failure.state.te.ting Compre.sion te.ting Brittle.rock me.hanics

Proce.sing of me.astable.be.a titanium alloy:Compre.e.sive.study on de.ormation be.aviour and e.ce.tional microstructure.variation me.hanisms

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Journal of Mate.ials Scie.ce.& Te.hnology 2022年第31期126卷 22-43页

作者： Qinyang Zhao leandro Bolzoni Yongnan Che. Yiku Xu Rob Torre.s Fe. Yang School of Mate.ials Scie.ce.and e.gine.ring Chang’an UniversityXi’an 710064China Waikato Ce.tre.for Advance. Mate.ials and Manufacturing School of EngineeringThe University of WaikatoHamilton 3240New Zealand

The.mome.hanical proce.sing(TMP)is e.pe.ially crucial for me.astable.titanium alloys,which has re.e.ve. significant atte.tion in the.community for a long *** this contribution,the.proce.sing-re.ponding be.aviour including microstructure.e.olution proce.s,te.ture.variation me.hanism,and un-de.lying de.ormation proce.s of powde. me.allurgy Ti-5553 alloy in a wide.proce.sing parame.e. range.was compre.e.sive.y *** physical simulation was pe.forme. on the.alloy at te.pe.-ature. ranging from 800℃ to 1100℃,and strain rate. be.we.n 0.001 s^(−1) and 10 s^(−1),to varie. de.or-mation de.re.s of 20%-80%he.ght *** was found that the.proce.sing parame.e.s(***-ature.strain rate.and de.ormation de.re.)are.influe.tial on the.de.ormation proce.s and re.ultant *** microstructural e.olution proce.se. forβphase.including flow localization,dynamic re.ove.y,dynamic re.rystallization,and grain coarse.ing are.activate. in diffe.e.t proce.sing domains,while.diffe.e.t e.olution me.hanisms forαphase.including dynamic pre.ipitation,phase.se.aration,dy-namic coarse.ing,and me.hanical she.ring also play the.r role. unde. diffe.e.t proce.sing *** particular,four e.ce.tional e.olution me.hanisms ofαpre.ipitation which have.not be.n pre.iously re.orte. in titanium alloys we.e.discove.e. and cle.rly de.onstrate.,more.spe.ifically,the. are.multi-inte.ior twinning,inte.nal compositing,laye.e. coarse.ing and se.e.tive.diffusion-actuate. *** the.e.tablishme.t of compre.e.sive.microstructural e.olution me.hanism maps,the.guidance.for pre.ise.proce.sing and the.knowle.ge.re.e.ve.e.te.sion for de.ormation proce.s of me.astable.tita-nium alloys can be.e.fe.tive.y achie.e..

关键词： Me.astable.titanium alloy Powde. me.allurgy TMP Microstructure.e.olution Te.ture.variation

Spatial and te.poral patte.ns of fore.t fire. in the.Ce.tral Monte.re.ationships with re.ional climate

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e.ological Proce.se. 2024年第1期13卷 66-79页

作者： Pablo e.ge.io Villagra e.ica Ce.ca leandro Manue. Alvare. Silvia De.gado Ricardo Villalba Instituto Arge.tino de.Nivología Glaciología y Cie.cias Ambie.tale.–CONICe.-CCT Me.doza Facultad de.Cie.cias Agrarias Unive.sidad Nacional de.Cuyo

Background Natural and anthropoge.ic wildfire. burn large.are.s of arid and se.i-arid fore.ts with significant socio-e.onomic and e.vironme.tal impacts. Fire.re.ime. are.controlle. by climate. ve.e.ation type. and anthropoge.ic factors such as ignition source. and human-induce. disturbance.. Proje.tions of climate.and land-use.change.sugge.t that the.e.controlling factors will change. alte.ing fire.re.ime. in the.ne.r future. In the.southe.n Ce.tral Monte. Me.doza, Arge.tina, the.factors that modulate.the.fire.te.poral and spatial variability are.poorly unde.stood. We.re.onstructe. the.fire.history of southe.st of Me.doza from 1984 to 2023 and inve.tigate. the.re.ationships be.we.n fire.e.te.t and climate.variability at se.sonal and inte.annual scale.. Burne. are.s we.e.de.e.mine. using Google.e.rth e.gine.by proce.sing Landsat 5-TM, Landsat 7-e.M+, and Landsat 8-OLI-TIRS se.sor *** The.re.ion e.hibite. high spatial and te.poral variability in fire.occurre.ce. be.ng a mosaic of are.s with diffe.e.t fire.historie. and re.ove.y time.. Be.we.n 1985 and 2023, fire.re.urre.ce.range. from site. unburne. to site. with up to 14 fire.. The.occurre.ce.of large.fire. was strongly favore. by a combination of a ye.r with abundant spring–e.rly summe. pre.ipitation, which favors fue. accumulation, followe. by a ye.r of low spring–e.rly summe. pre.ipitation. Pre.ipitation and burnt are. showe. a ve.y pronounce. 6–7 ye.r cycle. sugge.ting a dominant climatic control on fire.*** Fire.distribution in southe.ste.n Me.doza fore.ts is not homoge.e.us, re.ulting in a mosaic of patche. with diffe.e.t fire.historie.. This he.e.oge.e.ty may be.re.ate. to ve.e.ation patte.ns and land use. The.te.poral variability of fire. is strongly influe.ce. by climate.variability, which would promote.fue. production and subse.ue.t drying. Large.fire. are.conce.trate. in pe.iods of high inte.annual pre.ipitation variability. Climate.change.sce.arios pre.ict an incre.se.in te.

关键词： Fire.re.urre.ce Fire.mapping Re.ove.y time Climate Dry fore.t Wildfire

Antibacte.ial Ti-Mn-Cu alloys for biome.ical applications

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Re.e.e.ative.Biomate.ials 2021年第1期8卷 26-33页

作者： Mohammad Alqattan Linda Pe.e.s Youse. Alshammari Fe. Yang leandro Bolzoni The.Unive.sity of Waikato HamiltonNew Zealand

Titanium alloys are.common biome.ical mate.ials due.to the.r biocompatibility and me.hanical ***,titanium alloys are.e.pe.sive.and,unle.s surface.tre.te.,ge.e.ally cannot pre.e.t surgical infe.tions re.ate. to bacte.ia which can damage.the.inte.rity of the.*** this study,ne. titanium alloys we.e.de.e.ope. via powde. me.allurgy and the.addition of mangane.e.and coppe.,re.pe.tive.y,aiming to limit the.manufacturing costs and induce.ne. functionality on the.mate.ials including antibacte.ial *** addition of mangane.e.and coppe. to titanium significantly change. the.be.aviour of the.Ti-Mn-Cu alloys le.ding to the.succe.sful stabilization of the.be.a titanium phase.gre.t re.ine.e.t of the.typical lame.lar structure.and achie.e.e.t of mate.ials with low le.e. of ***,it is found that the.me.hanical pe.formance.and the.antibacte.ial e.ficacy are.e.hance. by the.addition of a highe. amount of alloying *** manufacture. Ti-Mn-Cu alloys fulfil the.re.uire.e.ts for structural biome.ical implants and have.antibacte.ial re.ponse.making the. pote.tial candidate. for pe.mane.t me.ical implants.

关键词： titanium aloys powde. me.tllurgy homoge.e.us microstu cture me.ha nical prope.tie. antibacte.ial activity e.coli(e.che.ichia col)

Inte.lige.t spe.d adaptation for visibility te.hnology affe.ts drive.s’spe.d se.e.tion along curve. with sight limitations

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Journal of Traffic and Transportation e.gine.ring(e.glish e.ition) 2024年第1期11卷 16-27页

作者： Abrar Hazoor Albe.to Te.rafino leandro L.Di Stasi Marco Bassani De.artme.t of e.vironme.t Landand Infrastructure EngineeringPolitecnico di TorinoTorino 10129Italy Road Traffic Division Nord UniversityStjørdal 7502Norway Mind Brainand Behavior Research Centre(CIMCYC)University of GranadaGranada 18071Spain

Sight obstructions along road curve. can le.d to a crash if the.drive. is not able.to stop the.ve.icle.in *** is a particular issue.along curve. with limite. available.sight,whe.e.spe.d manage.e.t is ne.e.sary to avoid unsafe.situations(e.g.,driving off the.road or invading the.othe. traffic lane..To solve.this issue.we.propose. a nove. inte.lige.t spe.d adaptation(ISA)syste. for visibility,calle. V-ISA(inte.lige.t spe.d adaptation for visibility).It e.timate. the.re.l-time.safe.spe.d limits base. on the.pre.ailing sight conditions.V-ISA come. with thre. variants with spe.ific fe.dback modalitie.(1)visual and(2)auditory information,and(3)dire.t inte.ve.tion to assume.control ove. the.ve.icle.***,we.inve.tigate. the.e.ficie.cy of e.ch of the.thre. V-ISA variants on driving spe.d choice.and late.al be.avioural re.ponse.along road curve. with limite. and unsafe.available.sight distance.,using a driving *** also conside.e. curve.road ge.me.ry(curve.dire.tion:rightward ***).Sixty active.drive.s we.e.re.ruite. for the.*** half of the.(e.pe.ime.tal group)te.te. the.thre. V-ISA variants(and a V-ISA off condition),the.othe. half always drove.with the.V-ISA off(validation group).We.use. a line.r mixe.-e.fe.t mode. to e.aluate.the.influe.ce.of V-ISA on drive. *** V-ISA variants we.e.e.ficie.t at re.ucing spe.ds at e.trance.points,with no disce.nible.ne.ative.impact on drive. late.al *** rightward curve.,the.V-ISA inte.ve.ing variant appe.re. to be.the.most e.fe.tive.at adapting to sight *** of the.curre.t study implie. that V-ISA might assist drive.s to adjust the.r ope.ating spe.d as pe. pre.ailing sight conditions and,conse.ue.tly,e.tablishe. safe. driving conditions.

关键词： Sight distance Inte.lige.t spe.d adaptation Drive. be.aviour Road safe.y Driving simulation Advance. drive. assistance.syste.s

Ultra-thin chips for high-pe.formance.fle.ible.e.e.tronics

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npj Fle.ible.e.e.tronics 2018年第1期2卷 50-66页

作者： Shoubhik Gupta William Taube.Navaraj leandro Lore.ze.li Ravinde. Dahiya Be.dable.e.e.tronics and Se.sing Te.hnologie.(Be.T)Group University of GlasgowGlasgow G128QQUK Micro-Syste.s Te.hnology Group Fondazione Bruno KesslerTrento 38123Italy

Fle.ible.e.e.tronics has significantly advance. ove. the.last fe. ye.rs,as de.ice. and circuits from nanoscale.structure. to printe. thin films have.starte. to ***,the.de.and for high-pe.formance.e.e.tronics has also incre.se. be.ause.fle.ible.and compact inte.rate. circuits are.ne.de. to obtain fully fle.ible.e.e.tronic *** is challe.ging to obtain fle.ible.and compact inte.rate. circuits as the.silicon base. CMOS e.e.tronics,which is curre.tly the.industry standard for high-pe.formance.is planar and the.brittle.nature.of silicon make. be.dability *** this re.son,the.ultra-thin chips from silicon is gaining *** re.ie. provide. an in-de.th analysis of various approache. for obtaining ultra-thin chips from rigid silicon *** compre.e.sive.study pre.e.te. he.e.include. analysis of ultra-thin chips prope.tie. such as the.e.e.trical,the.mal,optical and me.hanical prope.tie.,stre.s mode.ling,and packaging *** unde.pinning advance. in are.s such as se.sing,computing,data storage.and e.e.gy have.be.n discusse. along with se.e.al e.e.ging applications(e.g.,we.rable.syste.s,m-He.lth,smart citie. and Inte.ne. of Things e.c.)the. will *** pape. is targe.e. to the.re.de.s working in the.fie.d of inte.rate. circuits on thin and be.dable.silicon;but it can be.of broad inte.e.t to e.e.yone.working in the.fie.d of fle.ible.e.e.tronics.

关键词： pe.formance e.e.tronics e.e.yone

Pse.do-discontinuum mode. to simulate.hard-rock mine.pillars

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Unde.ground Space 2023年第4期11卷 81-95页

作者： e.ick Ro ge.e. Ale.sandra dos Santos Gome. Marcio Muniz de.Farias leandro Lima Rasmusse. Faculty of Te.hnology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the.pse.do-discontinuum mode.ing te.hnique.calle. continuum Voronoi block mode.(CVBM),was applie. to re.re.se.t the.be.avior of hard-rock pillars from unde.ground mine. subje.te. to high fie.d *** CVBM’s ability to produce.nume.ical re.ults consiste.t with the.obse.ve. be.avior of pillars is de.onstrate. through the.nume.ical analysis of a hypothe.ical case.and a back analysis of the.Cre.ghton mine.*** re.ults show that the.mode. can capture.conve.ge.ce.displace.e.ts and e.plicitly show the.formation of macro-fracture. paralle. to e.cavation walls,intact rock slabs,and V-shape. *** compone.ts are.characte.istics of brittle.failure.induce. by highly stre.se. ground *** studie. pre.e.te. in this work confirm the.CVBM as a conve.ie.t tool for the.nume.ical mode.ing of intact rock pillars e.cavate. in de.p unde.ground mine..

关键词： Brittle.failure Spalling Bulking Voronoi te.se.lation