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现代电信科技 1991年第5期21卷 33-41页

作者： leak.,dm 朱军

A geocomputational analysis of Twitter activity around different world cities

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Geo-Spatial Information Science 2014年第3期17卷 145-152页

作者： Muhammad ADNAN Alistair leak.Paul LONGLEY Department of Geography University College LondonGower StreetLondon WC1E 6BTUK Department of Security and Crime Science University College London35 Tavistock SquareLondon WC1H 9EZUK

The penetration and use of social media services differs from city to *** paper is aimed to provide a comparison of the use of Twitter between different cities of the *** present a temporal analysis of activity on Twitter in 15 *** study consists of two parts:First,we created temporal graphs of the activity in the 15 cities,through which hours of high and low activity could be ***,we created heat map visualizations of the Twitter activities during the period of 19 September 2012–25 September *** heat map visualizations make the periods of intense and sparse activity apparent and provide a snapshot of the activity during the whole year.

关键词： Twitter temporal analysis heat map visualization activity patterns

Neurotransmitter receptors on microglia

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Stroke & Vascular Neurology 2016年第2期1卷 52-58页

作者： Huan Liu Rehana K leak.Xiaoming Hu Center of Cerebrovascular Disease Research University of Pittsburgh School of MedicinePittsburghPennsylvaniaUSA Division of Pharmaceutical Sciences Duquesne UniversityPittsburghPennsylvaniaUSA

As the resident immune cells in the central nervous system,microglia have long been hypothesised to promote neuroinflammation and exacerbate ***,this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status,polarisation phenotype and cellular context.A variety of neurotransmitter receptors are expressed on microglia and help mediate the bidirectional communication between neurons and *** we review data supporting the importance of neurotransmitter receptors on microglia,with a special emphasis on glutamate,γ-aminobutyric acid(GABA),norepinephrine,cannabinoid and acetylcholine *** summarise evidence favouring a significant role for neurotransmitter receptors in modulating microglial activation,phagocytic clearance and phenotypic *** the effects of neurotransmitter receptors on microglia and dissecting the underlying mechanisms may help accelerate the discovery of novel drugs that tap the therapeutic potential of microglia.

关键词： drugs inflammation supporting

The role of the T follicular helper cells in allergic disease

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Cellular & Molecular Immunology 2012年第5期9卷 386-389页

作者： dm Kemeny Department of Microbiology and Immunology Programme National University of Singapore Singapore

T follicular helper （Tfh） cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 （Th2） effector cells.

关键词： allergy asthma IgE follicular helper T cells

Eight decades of compositional change in a managed northern hardwood landscape

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Forest Ecosystems 2023年第3期10卷 398-410页

作者： Mark J.Ducey Olivia L.Fraser Mariko Yamasaki Ethan P.Belair William B.leak University of New Hampshire Department of Natural Resources and the Environment114 James HallDurhamNH03824USA U.S.D.A.Forest Service White Mountain National Forest71 White Mountain DriveCamptonNH03223USA U.S.D.A.Forest Service Northern Research Station271 Mast RoadDurhamNH03824USA The Nature Conservancy Natural Climate SolutionsAfrica Regional Portland Office45 Exchange StSuite 303PortlandME04101USA

We analyzed over 8 decades of change in forest composition(represented by species proportion of basal area)and size class from more than 400 permanent plots located on the Bartlett Experimental Forest in the White Mountains of New *** data represent one of the longest-term landscape-scale records of forest change based on permanent plots in North *** analyzed the plots based on elevation class,land type indicating assumed successional direction(grouped into coniferous and deciduous),and inventory period within managed and unmanaged portions of the *** ongoing shift from small-to large-diameter stems is clear across all species,in response to the overall aging of the forest following exploitative harvesting in the 19th *** compositional changes include a continuing decline in shade-intolerant species(paper birch and aspen),along with the mid-tolerant yellow *** increase in red maple abundance through the early 1990s has leveled off or *** shade-tolerant species,increases in beech and red spruce were largely consistent with assumed land type on unmanaged plots,but heavy marking against diseased beech on managed plots restricted increase of that *** maple declined in abundance except where silvicultural intervention helped maintain *** contrast,eastern hemlock showed a continuing expansion at all elevations below 600 *** data continue to show little or no evidence of upward migration of species,despite evidence of recent regional change in ***,the BEF is poised for substantial changes when emerald ash borer and hemlock woolly adelgid,both of which are known to infest nearby areas,do arrive.

关键词： Northern hardwoods Succession Stand dynamics Silviculture

Protective effects of prostaglandin E1 on hepatocytes

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World Journal of Gastroenterology 2000年第3期6卷 326-329页

作者： Liu XL Fan dm Fourth Mil Med Univ Xijing Hosp Inst Digest Dis Xian 710032 Peoples R China

INTRODUCTION E Numerous studies have demonstrated the protective action of prostaglandin E1(PGE1) on experimental animal models of liver injury and on patients with

关键词： prostaglandin El hepatitis liver injury hepatic cytoprotective effects lipid microspheres

Modified Dye for Water-Fast Ink-Jet Printing

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Journal of Donghua University(English Edition) 2001年第4期18卷 49-53页

作者：郑庆康朱谱新吴大诚 Lewis dm Textile College Sichuan University Chengdu 610065 China Depanment of Color Chemistry The University of Leeds LS2 9 JT UK

A quaternary ammonium compound containing amino acid residue was synthesized by Converting 3-chloro-2-hydroxy- propyalkyldimethylammonium chlorides into its epoxide derivatives, then attaching an amino acid to the epoxide derivatives synthesized a quaternary ammonium compound containing amino acid residue. Modified dyes were prepared by the ionotropy of anionic dyes with the quaternary ammonium compound containing amino acid residue. It was discovered that the modified dyes exhibited an excellent pH controllable solubility. These modified dyes have good water solubility at pH> 8.0, but they were water insoluble at pH < 6.5. On the printing paper, modified dyes in water-based ink-jet print ink could convert to water insoluble form and give prints excellent water fastness.

关键词： Modification, Dye, Printing

A case of cerebral malaria and dengue concurrent infection

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 416-417页

作者： Anwar Alam Md dm Department of Neurology Ruban Emergency Hospital

Cerebral malaria and dengue are the common infections which cause higher mortality and morbidities in every part of the world especially in *** infection of cerebral malaria and dengue is rare entity due to different habitat of vectors and it was reported rarely from Southeast *** this case report,the authors reported a case of concurrent cerebral malaria and dengue which was recovered after eight days of admission with increase in morbidity.

关键词： Cerebral malaria Dengue Concurrent infection

Solid state reaction of aromatic ketones with heteroaromatics

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Chinese Journal of Chemistry 1995年第6期13卷 520-524页

作者： Du, dm Meng, SM Wang, YM Meng, JB Zhou, XZ NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA YANBEI TEACHERS COLL DATONG 037000JILINPEOPLES R CHINA

The solid state reactions of p-nitroacetophenone, acetyl-ferrocene with indole were catalyzed by anhydrous zinc chloride or aluminum chloride, and gave exclusively the 1:2 condensation products. The solid state condensation of aromatic ketones with 1-phenyl-3-methyl-5-pyrazolone was also investigated, and the 1:1 and 2:1 condensation products were obtained. The structures of eleven new products were determined by IR, MS, H-1 NMR and elemental analysis.

关键词： solid state reaction aromatic ketone indole 1-phenyl-3-methyl-5-pyrazolone

Pharmacological effects of aqueous-ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 883-888页

作者： Rajesh J Mandade SA Sreenivas dm Sakarkar Avijit Choudhury Pharmacology Department S.N.Institute of PharmacyPusadIndia Guru Nanak Institute of Pharmacy IbrahimpattnamHyderabad.(A.P.) India S.N.Institute of Pharmacy PusadIndia Pharmacology Department Shree Dhanvantary college pharmacyKimIndia

Objective:To explore the effects of extract of Hibiscus rosasinensis(***) on the volume,free and total acidity of gastric secretion induced by ***:Animals were kept on fasting for 48 *** the pylorus of each animal was *** were randomly divided into 5 groups and treated by carbachol at 600μg/*** animals in groupⅡ-Ⅴwere treated by *** extract at 250 and 500 mg/kg body weight,cimetidine at 2.5 mg/ kg and verapamil at 10 mg/kg body weight intraperitoneally,*** volume,free and total acidity of gastric secretion were observed and ***:It was found that the extract significantly reduced the volume,free and total acidity of gastric secretion(P<0.01). These reductions were comparable to cimetidine and *** the reduction in the volume and free acidity were more significant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more ***:The extract of *** can reduced the volume,free and total acidity of gastric secretion,and can be used effectively in the treatment of peptic ulcer.

关键词： Verapamil Cimetidine Carbachol Hibiscus rosasinensis Rats