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Preparation and evaluation of a novel antibacterial glass-ionomer cement

Journal of Biomedical Science and Engineering 2013年第12期6卷 1117-1128页

作者： leah howard Yiming Weng Ruijie Huang Yuan Zhou Dong Xie Department of Biomedical Engineering Purdue School of Engineering and Technology Indiana University-Purdue University at Indianapolis Indianapolis USA

A novel antibacterial glass-ionomer cement has been developed. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the formed cement. Compressive yield strength (YS), modulus (M), diametral tensile strength (DTS) and flexural strength (FS) were also determined. All the formulated antibacterial cements showed a significant antibacterial activity, accompanying with an initial CS reduction. The effect of the synthesized antibacterial polymer loading was significant. Increasing loading from 1% to 20% significantly decreased the S. mutans viability from 3% to 50% and also reduced the initial CS (325 MPa) of the formed cements from 19% to 75%. The cement with 5% antibacterial polymer loading showed 142 MPa, 6.9 GPa, 224 MPa, 52 MPa, and 62 MPa in YS, M, CS, DTS and FS, respectively, as compared to 170, 7.1, 325, 60 and 87 for the experimental cement without antibacterial polymer addition and 141, 6.9, 236, 42 and 53 for Fuji II LC. It was also found that the chlorine-containing antibacterial cement showed better CS values than the bromine-containing cement, with no significant difference in antibacterial activity. The antibacterial cement also showed a similar antibacterial activity to Streptococcus mutans, lactobacillus, Staphylococcus aureus and Staphylococcus epidermidis. The human saliva did not affect the antibacterial activity of the cement. The thirty-day aging study indicates that the cements may have a long-lasting antibacterial function.

关键词： Dihalomalealdehydic Acid Derivative Antibacterial Polymer S. mutans Viability Glass-Ionomer Cement CS

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Synthesis and evaluation of a novel antibacterial dental resin composite with quaternary ammonium salts

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Journal of Biomedical Science and Engineering 2011年第3期4卷 147-157页

作者： Yiming Weng Xia Guo Voon Joe Chong leah howard Richard L. Gregory Dong Xie 不详

The novel quaternary ammonium bromide (QAB)-containing oligomers were synthesized and applied for developing an antibacterial resin composite. Compressive strength (CS) and S. mutans (an oral bacteria strain) viability were used to evaluate the mechanical strength and antibacterial activity of the formed composites. All the QAB-modified resin composites showed significant antibacterial activity and mechanical strength reduction. Increasing chain length and loading significantly enhanced the antibacterial activity but dramatically reduced the CS as well. The 30-day aging study showed that the incorporation of the QAB accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled, unlike its use in dental glass-ionomer cements. The work in this study is beneficial and valuable to those who are interested in studying antibacterial dental resin composites.

关键词： QAB substitute chain length antibacterial S. mutans viability CS dental resin composites

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A Novel Antibacterial Dental Resin Composite

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 130-135页

作者： Yiming Weng Voon J. Chong leah howard Ruijie Huang Richard L. Gregory Dong Xie Department of Biomedical Engineering Purdue School of Engineering and Technology Indiana University-Purdue University at Indianapolis Indianapolis USA Department of Oral Biology School of Dentistry Indiana University Indianapolis USA

This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.

关键词： Furanone Derivative Antibacterial Resin Composite CS S. mutans Viability

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谷歌遭遇最大反断挫败面临拆分风险

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商业周刊（中文版） 2024年第13期 16-18页

作者： leah Nylen 程玺(译) 不详

这是20余年来首宗由美国联邦政府起诉科技公司的反垄断案件.8月5日,美国法官裁定Alphabet Inc.旗下的谷歌公司在搜索市场构成非法垄断,这是谷歌遭遇的最大反垄断挫败。这标志着美国司法部和州检察长的重大胜利,而成立25载的谷歌也将因... 详细信息

这是20余年来首宗由美国联邦政府起诉科技公司的反垄断案件.8月5日,美国法官裁定Alphabet Inc.旗下的谷歌公司在搜索市场构成非法垄断,这是谷歌遭遇的最大反垄断挫败。这标志着美国司法部和州检察长的重大胜利,而成立25载的谷歌也将因此面临拆分风险。

关键词：美国司法部反垄断谷歌公司美国联邦政府拆分检察长美国法官挫败

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沙漠彩虹丝兰谷住宅

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室内设计与装修 2024年第1期 18-23页

作者： [美国]leah Ring 秋落(编译) 无不详 Another Human

经过对丝兰谷多年的考察,室内设计公司Another Human的创始人leah Ring决定在此购买一处房产,用来实践她设计敏感性的极端版本。这处房产由4栋年久失修的小屋组成,为Ring提供了一块空白的创作空间。Ring只保留了建筑的外壳,发挥她的想... 详细信息

经过对丝兰谷多年的考察,室内设计公司Another Human的创始人leah Ring决定在此购买一处房产,用来实践她设计敏感性的极端版本。这处房产由4栋年久失修的小屋组成,为Ring提供了一块空白的创作空间。Ring只保留了建筑的外壳,发挥她的想象力和创造力,将大胆的色彩、活泼的造型与复古的产品相结合,体现一种趣味性。这处房产既是她的第二个家,也是她室内设计和家具设计的展示场所。

关键词：创作空间丝兰住宅房产 Ring 趣味性敏感性

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Viability and hatchability of brine shrimp Artemia franciscana cysts after passing through the digestive system of eared grebes Podiceps nigricollis

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Journal of Oceanology and Limnology 2023年第4期41卷 1300-1306页

作者： Michael R.CONOVER Mark E.BELL leah M.DELAHOUSSAYE Department of Wildland Resources and Ecology Center LoganUT 84322-5230USA

Brine shrimp Artemia franciscana provide food for many migrating and staging birds that spend summer and fall on Great Salt Lake,Utah,*** produce live young and cysts(hard-walled eggs);these cysts are commercially harvested on Great Salt Lake and support a large industry in *** is unclear the impact that millions of hungry birds have on the Artemia population in the *** help assess that,this study evaluated cyst viability(percentage of cysts that contain an embryo)and hatchability(percent of cysts that hatch)from cysts that had passed through the digestive tract of eared grebes Podiceps nigricollis and cysts obtained directly from Great Salt Lake at the same site where each grebe was *** was significantly higher for cysts collected from the water column(19%)than from the stomach(0.3%)or intestines(3%)of eared *** also was significantly different for cysts collected from the water column(29%),stomach(0.7%),and intestines(5%).These results indicate that eared grebes nutritionally benefit from eating cysts and that they may be an important food source for grebes in late fall after the adult population of Artemia dies off due to the water becoming too ***,enough cysts survive their passage through the digestive system that grebes can vector hatchable cysts to other waterbodies.

关键词： Artemia dispersal eared grebes hatchability invasive species Great Salt Lake salty lakes viability

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Encapsulated peracetic acid as a valid broad‑spectrum antimicrobial alternative,leading to beneficial microbiota compositional changes and enhanced performance in broiler chickens

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2128-2142页

作者： Salvatore Galgano leah Conway Nikki Dalby Adrian Fellows Jos G.MHoudijk Monogastric Science Research Centre Scotland’s Rural CollegeWest Mains RoadEdinburgh EH93JGScotlandUK Aga2tech Ltd HalifaxUK Centre for Innovation Excellence in Livestock YorkUK

Background Antimicrobial alternatives are urgently needed,including for poultry production *** this study,we tested the potential broad-range antimicrobial alternative peracetic acid,delivered in feed via the hydrolysis of encapsulated precursors through a 28-day study using 375 Ross 308 broiler *** tested two peracetic acid concentrations,30 and 80 mg/kg on birds housed on re-used litter,and we evaluated the impact of both levels on gut microbial communities,bacterial concentration,antimicrobial resistance genes relative abundance and growth performance when compared to control birds housed on either clean or re-used *** Body weight gain and feed conversion ratio improved in peracetic acid fed *** d 28,birds given 30 mg/kg of peracetic acid had a decreased Firmicutes and an increased Proteobacteria abundance in the jejunum,accompanied by an increase in Bacillus,Flavonifractor and Rombustia in the caeca,and a decreased abundance of tetracycline resistance *** given 80 mg/kg of peracetic acid had greater caecal abundance of macrolides lincosamides and streptogramins resistance *** performance on clean litter was reduced compared to reused litter,which concurred with increased caecal abundance of Blautia,decreased caecal abundance of Escherichia/Shigella,Anaerostipes and Jeotgalicoccus,and greater gene abundance of vancomycin,tetracycline,and macrolides resistance *** Peracetic acid could be used as a safe broad-spectrum antimicrobial alternative in *** precursors were able to reduce the bacterial concentration in the jejunum whilst promoting the proliferation of probiotic genera in the caeca,especially at the low peracetic acid concentrations tested,and improve growth ***,our findings offer further insights on potential benefits of rearing birds on re-used litter,suggesting that the latter could be associated with better performance and reduced antimicrobial resistance

关键词： Antimicrobial alternative Antimicrobial resistance Broiler chicken Microbiota Peracetic acid Performance 16S rRNA gene

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Retinal regeneration requires dynamic Notch signaling

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Neural Regeneration Research 2022年第6期17卷 1199-1209页

作者： leah J.Campbell Jaclyn L.Levendusky Shannon A.Steines David R.Hyde Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre DameNotre DameINUSA

Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal *** signaling,which is a fundamental mechanism known to drive cell-cell communication,is required to maintain Müller glia in a quiescent state in the undamaged retina,and repression of Notch signaling is necessary for Müller glia to reenter the cell *** dynamic regulation of Notch signaling following retinal damage also directs proliferation and neurogenesis of the Müller glia-derived progenitor cells in a robust regeneration *** contrast,mammalian Müller glia respond to retinal damage by entering a prolonged gliotic state that leads to additional neuronal death and permanent vision *** the dynamic regulation of Notch signaling in the zebrafish retina may aid efforts to stimulate Müller glia reprogramming for regeneration of the diseased human *** findings identified DeltaB and Notch3 as the ligand-receptor pair that serves as the principal regulators of zebrafish Müller glia *** addition,multi-omics datasets and functional studies indicate that additional Notch receptors,ligands,and target genes regulate cell proliferation and neurogenesis during the regeneration time ***,our understanding of Notch signaling during retinal regeneration is *** fully appreciate the complex regulation of Notch signaling that is required for successful retinal regeneration,investigation of additional aspects of the pathway,such as post-translational modification of the receptors,ligand endocytosis,and interactions with other fundamental pathways is *** we review various modes of Notch signaling regulation in the context of the vertebrate retina to put recent research in perspective and to identify open areas of inquiry.

关键词： differentiation gliosis Müller glia neuronal progenitor cell Notch signaling proliferation quiescence retinal development retinal regeneration zebrafish

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Lipidomic insights into the response of Arabidopsis sepals to mild heat

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aBIOTECH 2023年第3期4卷 224-237页

作者： Zican Chen Weronika Jasinska Muhammad Ashraf leah Rosental Jung Hong Dabing Zhang Yariv Brotman Jianxin Shi Joint International Research Laboratory of Metabolic and Developmental Sciences State Key Laboratory of Hybrid RiceSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Life Sciences Ben Gurion University of the NegevBeersheva 84105Israel School of Agriculture Food and WineUniversity of AdelaideUrrbraeSA 5064Australia Yazhou Bay Institute of Deepsea Sci-Tech Shanghai Jiao Tong UniversityShanghai 200240China

Arabidopsis sepals coordinate flower opening in the morning as ambient temperature rises;however,the underlying molecular mechanisms are poorly understood. Mutation of one heat shock proteinencoding gene, HSP70-16, impaired sepal heat stress responses (HSR), disrupting lipid metabolism,especially sepal cuticular lipids, leading to abnormal flower opening. To further explore, to what extent,lipids play roles in this process, in this study, we compared lipidomic changes in sepals of hsp70-16 andvdac3 (mutant of a voltage-dependent anion channel, VDAC3, an HSP70-16 interactor) grown underboth normal (22 C) and mild heat stress (27 C, mild HS) temperatures. Under normal temperature,neither hsp70-16 nor vdac3 sepals showed significant changes in total lipids;however, vdac3 but nothsp70-16 sepals exhibited significant reductions in the ratios of all detected 11 lipid classes, except themonogalactosyldiacylglycerols (MGDGs). Under mild HS temperature, hsp70-16 but not vdac3 sepalsshowed dramatic reduction in total lipids. In addition, vdac3 sepals exhibited a significant accumulationof plastidic lipids, especially sulfoquinovosyldiacylglycerols (SQDGs) and phosphatidylglycerols (PGs),whereas hsp70-16 sepals had a significant accumulation of triacylglycerols (TAGs) and simultaneousdramatic reductions in SQDGs and phospholipids (PLs), such as phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), and phosphatidylserines (PSs). These findings revealed that the impact ofmild HS on sepal lipidome is influenced by genetic factors, and further, that HSP70-16 and VDAC3differently affect sepal lipidomic responses to mild HS. Our studies provide a lipidomic insight intofunctions of HSP and VDAC proteins in the plant’s HSR, in the context of floral development.

关键词： Floral development Heat shock protein Lipidomic profiling Stress response Voltage-dependent anion channel protein

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A GPU-Accelerated Mixed-Precision WENO Method for Extremal Black Hole and Gravitational Wave Physics Computations

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Communications on Applied Mathematics and Computation 2023年第1期5卷 97-115页

作者： Scott E.Field Sigal Gottlieb Zachary J.Grant leah F.Isherwood Gaurav Khanna University of Massachusetts Dartmouth North DartmouthMA 02747USA Department of Computational and Applied Mathematics Oak Ridge National LaboratoryOak RidgeTN 37830USA University of Rhode Island KingstonRI 02881USA

We develop and use a novel mixed-precision weighted essentially non-oscillatory(WENO)method for solving the Teukolsky equation,which arises when modeling perturbations of Kerr black *** show that WENO methods outperform higher-order finite-difference methods,standard in the discretization of the Teukolsky equation,due to the need to add dissipation for stability purposes in the *** particular,as the WENO scheme uses no additional dissipation,it is well suited for scenarios requiring long-time evolution such as the study of price tails and gravitational wave emission from extreme mass ratio *** the mixed-precision approach,the expensive computation of the WENO weights is performed in reduced floating-point precision that results in a significant speedup factor of≈*** addition,we use state-of-the-art Nvidia general-purpose graphics processing units and cluster parallelism to further accelerate the WENO *** optimized WENO solver can be used to quickly generate accurate results of significance in the field of black hole and gravitational wave *** apply our solver to study the behavior of the Aretakis charge—a conserved quantity,that if detected by a gravitational wave observatory like LIGO/Virgo would prove the existence of extremal black holes.

关键词： Numerical methods-Finite differencing Hyperbolic Partial differential equations Black holesblack holes WENO

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