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Praseodymium metal nanorods as a 5-fluorouracil carrier

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Journal of rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： varnitha manikantan Govindaraj Sri varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma Alexander Anushka Lucas bose Allben Akash Israel v.m.v.Enoch centre for Nanoscience and Genomics Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia Department of Applied chemistry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide metal nanoparticles are particularly ***,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting *** material was made as a composite with the supramolecular host polymer,poly-β-*** praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron *** nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in *** material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polymer-containing praseodymium nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on mcF-7 and vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** Ic_(50)values on the cell lines are reported.

关键词： metal nanoparticles Praseodymium Poly-cyclodextrin Drug delivery Anticancer activity rare earths

An improved pulse coupled neural networks model for semantic IoT

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Digital communications and Networks 2024年第3期10卷 557-567页

作者： Rong ma Zhen Zhang Yide ma Xiping Hu Edith c.H.Ngai victor c.m.Leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China college of computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse coupled Neural Network(PcNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PcNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse coupled Neural Networks(IPcNN)model is proposed in this *** IPcNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPcNN on the gray images and natural images from the matlab and berkeley Segmentation *** IPcNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

Astrophysical S-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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chinese Physics c 2024年第4期48卷 130-145页

作者： S.b.Dubovichenko A.S.Tkachenko R.Ya.Kezerashvili N.A.burkova b.m.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York city college of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate School and University center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(mPcm)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)S_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)m1 *** calculated the astrophysical low-energy S-factor,and the extrapolated S(0)turned out to be within 34.7−40.4 kev·*** important role of the asymptotic constant(Ac)for the ^(15)N(p,γ0)16O process with interfering ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances is elucidated.A comparison of our calculation for the S-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of Ac but shows a strong impact of the interference of ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances in reference to the cNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.c.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the mPcm and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model cNO-cycle

Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane mazzarella Karina canon‑beltran Yulia N.cajas meriem Hamdi Encina m.Gonzalez Juliano c.da Silveira claudia L.v.leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of biochemistry and molecular biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de ciencias biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of veterinary medicine FZEA-USPPirassunungaBrazil

background Extracellular vesicles(Evs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(LmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. bioactive molecules within Evs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-Evs from the early luteal phase and UF-Evs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LmGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-Evs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-Evs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-Evs from the early luteal phase and UF-Evs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes mammalian Preimplantation Reproductive fluids

Freeze-thaw cycles and associated geomorphology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,mexico

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Journal of mountain Science 2024年第6期21卷 1954-1977页

作者： víctor SOTO carlos m.WELSH R. Kenji YOSHIKAWA Hugo DELGADO GraNADOS centro de ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental Research center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m *** retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction *** geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction mountain mechanical erosion Periglacial geomorphology Postglacial scenarios

A combined tectono-climatic control on Holocene sedimentation in Ladakh Himalaya,India: clues from Anisotropy of magnetic Susceptibility(AmS) of lake sediments

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Journal of Palaeogeography 2024年第4期13卷 738-753页

作者： b.v.Lakshmi K.Deenadayalan md.mujahed baba Saumitra misra Indian Institute of Geomagnetism Discipline of Geological Sciences SAEESUniversity of Kwa Zulu-Natal

Anisotropy of magnetic Susceptibility(AmS) data from a ～27.8 m thick soft sedimentary mud sequence(～10.5-3.25 k yrs) from the Spituk Palaeolake Sequence(SPSS) of Holocene age, located in the northern bank of the Indus River in the Leh-Ladakh Himalaya, show effects of tectonic versus climate dynamics responsible for the Himalayan sedimentation. The sedimentary sequence, consisting of alternating of aeolian sand and glacio-fluvial mud flow deposits, has been subdivided into an older Last Glacier Phase I(LGP 1) and a younger Last Glacier Phase II(LGP 2), where the termination of each phase is marked by the occurrence of gravel beds of thickness ≤1 m, which were deposited due to glacial melting. The present AmS data along with previously published information on sedimentology confirm that the mudflow deposits of the LGP 1 and LGP 2phases were deposited in a lacustrine environment under glacio-fluvial conditions. However, a weak fluvial flow towards NW and NE could have existed for the LGP 1 and LGP 2, respectively. The glacial beds terminating LGP 1 and LGP 2 appear to have formed by climatic warming and tectonic activity, respectively. Hence, the Holocene Himalayan sedimentation was influenced by both climatic and tectonic activities. However, the thickness of the gravel bed(～0.8 m) terminating LGP 2 occupies only ～ 2.8 vol % of the total studied thickness～28 m, of the SPSS in the present study, which indicated a lesser control of tectonism in the growth of the Himalaya in and around the study area.

关键词： Holocene palaeolake sequence AmS studies Gravel beds Deglaciation Tectonic instability

comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and biotechnology 2024年第2期15卷 535-545页

作者： melissa A.Stephen chris R.burke Jennie E.Pryce Nicole m.Steele Peter R.Amer Susanne meier claire v.c.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL rae centre for Genetics and breeding-massey University RuakuraHamilton 3214New Zealand Agriculture victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems biology La Trobe UniversityBundooraVictoria 3083Australia Abacusbio DunedinNew Zealand

background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(Ebvs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： cattle Gibbs sampler markov-chain monte carlo(mcmc) Puberty

carbon monoxide as c1 building block in Fine chemical Synthesis

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chinese Journal of chemistry 2024年第2期42卷 199-221页

作者： Rui m.b.carrilho mario J.F.calvete Gabor mikle Laszlo Kollar mariette m.Pereira University of coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic chemistry and ELKH-PTE Research Groupfor Selective chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

carbon monoxide(cO)has become one of the most relevant and versatile renewable c1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of cO as a renewable feedstock for fine chemicals *** review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and c-H *** examples of the synthesis of relevant building blocks and/or known pharmaceuticals are *** is placed on examples of utilizing cO as the c1 building block in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： carbon monoxide Fine chemicals carbonylation Hydroformylation c-H functionalization

Effect of proton irradiation on the optical properties of thermal control coating based on polystyrene with silica filler

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Propulsion and Power Research 2024年第1期13卷 1-11页

作者： N.I.cherkashina v.I.Pavlenko m.m.mikhailov A.N.Lapin S.A.Yuriev R.v.Sidelnikov D.S.Romanyuk belgorod State Technological University named after v.G.Shoukhov Kostyukov Str.46Belgorod 308012Russia Tomsk State University of control Systems and radioelectronics 40Prospect LeninaTomsk 634050Russia

This paper presents the results of studying the surface properties changes of a ther-moregulating coating based on polystyrene and silicaﬁller after proton irradiation with an en-ergy of 50 kev at afluence of 3�1015 cm�*** proton irradiation,the values of the contact angle of wetting with water increase by 3.5%and 14.9%for polystyrene and the coating,*** free surface energy(energy of the surface layer)of polystyrene and the coat-ings before and after proton irradiation was calculated using the Owens-Wendt-rabel-Kaelble *** was a signiﬁcant increase in the polarity of the polystyrene surface(gp increased by a factor of 2.2)after proton *** the coating,an increase in gp by a factor of 3.89 was observed after proton *** changes in the coating were presented by IR Fourier spectroscopy.A slight decrease in the absorption intensity of all characteristic bands compared to the unirradiated sample was *** was found that the irradiation of the coating with protons led to the formation of macromolecules with hydroxyl,carbonyl,and carboxyl bonds,as well as the formation of dimeric and oligomeric siloxane *** was also found that after irradiation of a pure polystyrene sample with protons,the value of the solar absorption as increased by only 4.2%;whereas for the coating with silicaﬁller,the value of as increased by 28.6%.

关键词： Thermal control coating Proton irradiation Hydrophobicity Free surface energy radiation crosslinking