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Oncology Research 2024年第6期32卷 1031-1036页

作者： CONSTANTINE N.LOGOTHETIS NATHAN P.HORVAT TONY KURIAN CELESTE BELLO JULIO CHAVEZ leidy isenalumhe BIJAL SHAH LUBOMIR SOKOL HAYDER SAEED JAVIER PINILLA SAMEH GABALLA Department of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone *** bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline BR prospectively in *** retrospective study reports outcomes among EMZL patients receiving frontline ***-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not *** estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

关键词： Extranodal marginal zone lymphoma Bendamustine Rituximab Front-line therapy

Engineering T cells for immunotherapy of primary human hepatocellular carcinoma

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Journal of Genetics and Genomics 2020年第1期47卷 1-15页

作者： leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He Georgia Cancer Center.Medical College of Georgia Augusta University.AugustaGA.30912USA Department of Medicine.Medical College of Georgia Augusta UniversityAugustaGA30912USA

Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects.

关键词： Immunotherapy Hepatocellular carcinoma T cell receptor Chimeric antigen receptor T cell engineering Gene transfer

Successful Factor Analysis for Innovation Projects in the Colombian Cocoa Industry

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Successful Factor Analysis for Innovation Projects in the Co...

作者： leidy Johanna Olarte Silva 山东大学

学位级别：硕士

哥伦比亚可可部（?）在哥伦比亚经济中因其在加工食品到生产、与当地合作伙伴结盟以及进入国际市场方面的投资机会而得到承认。这项研究旨在找出哥伦比亚可可行业创新项目的最重要因素。利用2017-2018年制造业发展和技术创新调查（EDIT... 详细信息

哥伦比亚可可部（?）在哥伦比亚经济中因其在加工食品到生产、与当地合作伙伴结盟以及进入国际市场方面的投资机会而得到承认。这项研究旨在找出哥伦比亚可可行业创新项目的最重要因素。利用2017-2018年制造业发展和技术创新调查（EDIT）的二次数据,对相关性质进行了定量研究,调查涵盖了 47家与可可豆生产相关的制造企业。对数据进行描述性分析和降维分析,并对数据进行压缩。最后进行回归分析,发现影响创新项目的因素是企业公司的特点、研发和制造能力、与合作伙伴的整合以及投资意愿。

关键词：哥伦比亚可可产业创新项目因素维度

Bats and their vital ecosystem services:a global review

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Integrative Zoology 2022年第1期17卷 2-23页

作者： leidy Azucena RAMÍREZ-FRÁNCEL leidy Viviana GARCÍA-HERRERA Sergio LOSADA-PRADO Gladys REINOSO-FLÓREZ Alfonso SÁNCHEZ-HERNÁNDEZ Sergio ESTRADA-VILLEGAS Burton KLIM Giovany GUEVARA Programa de Doctorado en Ciencias Biológicas&Grupo de Investigación en Zoología(GIZ) Facultad de CienciasUniversidad del TolimaIbaguéColombia Programa para la Conservación de los Murciélagos de Colombia BogotáD.C.Colombia Departamento de Biología&Grupo de Investigación en Zoología(GIZ) Facultad de CienciasUniversidad del TolimaIbaguéColombia Departamento de Matemáticas y Estadística Facultad de CienciasUniversidad del TolimaIbaguéColombia Yale School of the Environment Yale UniversityNew HavenConnecticutUSA Smithsonian Tropical Research Institute BalboaRepublic of Panama Department of Natural History Royal Ontario MuseumTorontoOntarioCanada

Bats play crucial ecosystem services as seed dispersers,pollinators,controllers of insects,and nutrient ***,there has not been a thorough global review evaluating these roles in bats across all biogeographical regions of the *** reviewed the literature published during the last two decades and identified 283 relevant studies:78 dealt with the control of potential insect pests by bats,80 related to the suppression of other arthropods,60 on the dispersal of native or endemic seeds,11 dealt with the dispersal of seeds of introduced plants,29 on the pollination of native or endemic plants,1 study on pollination of introduced plants,and 24 on the use of guano as *** literature search showed that queries combining the terms“seed dispersal,”“insectivorous bats,”“nectarivorous bats,”“use of guano,”and“ecosystem services”returned 577 studies,but half were experimental in *** found that the evaluation of ecosystem services by bats has been mostly conducted in the Neotropical and Palearctic *** detect differences across relevant studies,and to explain trends in the study of ecosystem services provided by bats,we performed generalized linear mixed models(GLMM)fitted with a Poisson distribution to analyze potential differences among sampling *** identified 409 bat species that provide ecosystem services,752 insect species consumed by bats and 549 plant species either dispersed or pollinated by *** review summarizes the importance of conserving bat populations and the ecological services they provide,which is especially important during the current pandemic.

关键词： chiroptera ecosystem services frugivory,guano,insectivory nectarivory pest control pollination seed dispersal

Use of fly and bottom ashes from a thermoelectrical plant in the synthesis of geopolymers:Evaluation of reaction efficiency

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Energy Geoscience 2021年第2期2卷 167-173页

作者： leidy J.Jaramillo Nieves Fabio Elyseu Silviany Goulart Mariana de Souza Pereira Erick Zabot Valvassori Adriano Michael Bernardin Ceramic Materials Group Universidade do Extremo Sul CatarinenseAv.Universitaria 110588806-000CriciumaSanta CatarinaBrazil

The use of by-products as raw materials in the manufacturing of industrial products has risen in the last years because of environmental *** example is the use of coal ashes from thermalelectrical plants in the production of geopolymer–a green cement made by mixing aluminosilicate with alkaline *** this study,fly and bottom ashes from a thermal-electrical unit were used as sources of aluminosilicate in the synthesis of geopolymers.A mixture of sodium hydroxide(10 mol/L)and sodium silicate(SiO_(2)/Na_(2)O ratio of 2.2)was used as the alkaline *** type(fly or bottom ash)and content of the ash were the variables in the *** ashes were characterized by X-ray fluorescence(XRF),X-ray diffraction(DRX),particle size distribution(PSD),specific surface area(BET),and thermal analysis(DTA/TGA).The ash-based geopolymer samples were measured to obtain their compressive strength after *** evolution of the geopolymerization process was also assessed based on final alkali concentration *** results show that it is possible to obtain geopolymers using coal ashes as raw materials with high solid *** compressive strength for the bottom ash geopolymer after 90 days of curing is 35 *** low concentration of unreacted alkalis after curing(1.5×10^(-3)e 3.5×10^(-3)M)corresponds to high efficiency of the geopolymerization reaction.

关键词： Coal ash Geopolymer Industrial by-product Geopolymerization reaction

In-vitro assessment for the control of Fusarium species using a lactic acid bacterium isolated from yellow pitahaya(Selenicereus megalanthus(K. Schum. Ex Vaupel Moran))

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Journal of Integrative Agriculture 2021年第1期20卷 159-167页

作者： leidy J.VALENCIA-HERNANDEZ Karina LÓOPEZ-LÓPEZ Eyder D.GÓMEZ-LÓPEZ Liliana SERNACOCK Cristobal N.AGUILAR Universidad Nacional de Colombia Palmira CampusValle 763533Colombia Food Research Department School of ChemistryAutonomous University of CoahuilaSaltillo CampusCoahuila 25280Mexico

The fungistatic activity of a lactic acid bacterium, which had been isolated from yellow pitahaya cultures, against fungi associated with basal rot(Fusarium oxysporum and Fusarium fujikuroi) was measured in the present study. Its activity was assessed in three fractions: fermented(S1), metabolic products(S2), and biomass(S3), using two fermentation substrates: Man Rogosa Sharpe agar(MRS) and potato dextrose agar(PDA). The bacterium was molecularly identified as Lactobacillus plantarum. S3 reduced F. fujikuroi growth by 100% over 48 h of fermentation, which occurred during the stationary phase of bacterial growth. The three fractions' fungistatic activity against F. fujikuroi depended on the substrate employed. The fermentation kinetic parameters for L. plantarum indicated that its specific growth rate was 0.46 h^–1, with 93.63% substrate consumption, 0.045 kg kg^–1 cell yield, and 0.54 kg kg^–1 product yield. The kinetic parameters calculated will allow for bacteria production scaling. These in-vitro trials reveal L. plantarum's possible application as a biocontrol agent for diseases associated with Fusarium. However, further ex-vivo and in-vivo researches are required to demonstrate its behavior in crops.

关键词： lactic acid bacteria Fusarium fungistatic activity biomass yellow pitahaya

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在哥伦比亚创建一个惊奇旅行经营者

在哥伦比亚创建一个惊奇旅行经营者

作者： leidy Vivian Duque Gil 上海外国语大学

学位级别：硕士

商业计划的主要目的是评估在哥伦比亚创建一家提供惊喜旅行套餐的旅游公司的可行性。目前,来哥伦比亚的国内和国际旅行者不断增加,旅游业的创新却不足,互联网的发展提供接入,我们看到了一个独特的机会,在哥伦比亚市场上提供一种创新的... 详细信息

商业计划的主要目的是评估在哥伦比亚创建一家提供惊喜旅行套餐的旅游公司的可行性。目前,来哥伦比亚的国内和国际旅行者不断增加,旅游业的创新却不足,互联网的发展提供接入,我们看到了一个独特的机会,在哥伦比亚市场上提供一种创新的旅游业发展理念。我们主要提供一个惊喜旅行套餐,由3至4星级酒店的2晚住宿和包含多次的往返机票组成。提供的前提需要保证:价格低廉,并在出发前2天确定目的地。此优惠允许我们实施这样一种商业模式,即首先考虑航班和住宿的价格,而不是特定的目的地。通过这种方式,我们根据空座位和不同可能目的地中存在的空房间选择最终目的地(最初始为6个目的地),从而在不同选项中选择与客户先前支付的价格一致的最佳报价,以及能够保证运营的利润率。为了评估项目的可行性,我们对市场、行业和不同的金融服务场景等多方面进行了深入分析。基于不断增长的市场、旅游业的新增长趋势,以及过去几年行业缺乏创新等特点,我们进行了不同场景下的盈利性财务预测,该分析得到了积极的结果。此外,这项研究也表明客户对我们这类有特色的惊喜旅行产品很感兴趣。因此,该研究表明在哥伦比亚实行惊喜旅行是一个可行的项目,从长远来看可以盈利和可持续发展。

关键词：惊喜旅游旅游运营商惊喜套餐商业模式

Acid-Functionalized Nanoparticles for Pretreatment of Wheat Straw

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Journal of Biomaterials and Nanobiotechnology 2012年第3期3卷 342-352页

作者： leidy Pena Myles Ikenberry Keith L.Hohn Donghai Wang Department of Biological and Agricultural Engineering Kansas State UniversityManhattanUSA Department of Chemical Engi-neering Kansas State UniversityManhattanUSA

Perfluoroalkylsufonic (PFS) and alkylsufonic (AS) acid-functionalized magnetic nanoparticles were synthesized and characterized, then evaluated for their ability to hydrolyze hemicelluloses. The magnetic core was made of cobalt spinel ferrite and was coated with silica to protect it from oxidation. The silanol groups allowed surface chemical modification of the nanoparticles with the PFS and AS acid functionalities. Thermogravimetric analysis gave a total organic load of 12.6% and 32.5% (w/w) for AS and PFS nanoparticles, respectively. The surface sulfur content was calculated from XPS analysis as 1.37% and 1.93% for PFS and AS nanoparticles, respectively. Wheat straw samples were treated with the acid-functionalized nanoparticles at two different conditions: 80℃ for 24 h and 160℃ for 2 h. These experiments aimed to hydrolyze wheat straw hemicelluloses to soluble oligosaccharides. PFS nanoparticles solubilized significantly higher amounts of hemicelluloses (24.0% ± 1.1%) than their alkyl-sulfonic counterparts (9.1% ± 1.7%) at 80℃, whereas the hydrothermolysis control solubilized 7.7% ± 0.8% of the original hemicelluloses in the sample. At 160℃, PFS and AS nanoparticles gave significantly higher amounts of oligosaccharides (46.3% ± 0.4% and 45 ± 1.2%, respectively) than the control (35.0% ± 1.8%). The hemicelluloses conversion at 160?C reached 66.3% ± 0.9% using PFS nanoparticles and 61.0% ± 1.2% using AS nanoparticles compared with the control experiment, which solubilized 50.9% ± 1.7% of hemicelluloses in the biomass.

关键词： Acid-Functionalized Magnetic Nanoparticles Biomass Hemicelluloses Hydrolysis

Meeting Engineering Program Objectives through Service Learning Opportunities in Developing Countries

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Journal of Civil Engineering and Architecture 2011年第2期5卷 97-103页

作者： Jeffery M. Plumblee Lansford Bell leidy ]E. Klotz Department of Civil Engineering Clemson University Clemson SC 29634 USA

The civil engineering profession, in an adaptive reaction to emerging roles for civil engineers, is recognizing the need for new engineers to possess a more robust skill set than just the typical design background. This paper describes the efforts of Clemson Engineers for Developing Countries （CEDC） to fulfill the more nontraditional and often unaddressed ＂learning outcomes＂ noted by ASCE＇s Civil Engineering Body of Knowledge lbr the 21st Century as important prerequisites for licensure. The learning outcomes are addressed through ongoing international service learning projects in Cange, Haiti. The paper focuses on the following four outcomes and their fulfillment methods： leadership, globalization, teamwork, and communications. The student led organization has allowed students to set up their own fundraising mechanisms, to seek out members to join design review boards, and to develop their own project objectives. This level of student autonomy is n,3ted as key to ensuring that students achieve competency in these four areas.

关键词： ASCE BOK2 leadership service learning communication teamwork.

Propyl-Sulfonic Acid Functionalized Nanoparticles as Catalyst for Pretreatment of Corn Stover

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Journal of Biomaterials and Nanobiotechnology 2014年第1期5卷 8-16页

作者： leidy Pena Feng Xu Keith L.Hohn Jun Li Donghai Wang Department of Biological and Agricultural Engineering Kansas State UniversityManhattanUSA Department of Chemical Engineering Kansas State UniversityManhattanUSA Department of Chemistry Kansas State UniversityManhattanUSA

Propyl-sulfonic (PS) acid-functionalized nanoparticles were synthesized, characterized and evaluated as catalysts for pretreatment of corn stover. Silica coated nanoparticles were functionalized with 0.5% mercaptopropyltrimethoxysilane (MPTMS) at neutral pH in a mixture of water and ethanol. Sulfur contents of the acid functionalized nanoparticles, measured in a CHNS analyzer, varied from 6%-10%, and the acid load ranged from 0.040 to 0.066 mmol H+/g. A Box-Behnken design was employed to calculate the minimum number experiments required to obtain an estimate of the surface response for temperature, catalyst load, and %S content of the catalyst. Pretreatment of corn stover was carried out at three temperature levels 160, 180, and 200°C for 1 h. Three levels of catalyst load were used 0.1, 0.2, and 0.3 g of catalyst per gram of biomass. Hydro-thermolysis controls were carried at each temperature level. The catalyst load did not have an effect on the glucose yield at 160°C, and the average glucose yield obtained at this temperature was 59.0%. The glucose yield was linearly correlated to the catalyst load during pretreatment at 180°C, and a maximum glucose yield of 90% was reached when using 0.2 g of PS nanoparticles that had a total sulfur content of 6.1%. Complete hydrolysis of glucose was reached at 200°C but the average xylose yield was 4.6%, and about 20.2% of the combined glucose and xylose were lost as hydroxymethylfurfural and furfural. Results showed that acid-functionalized nanoparticles can be potential catalysts for the pretreatment of biomass for its later conversion to ethanol.

关键词： Acid Functionalized Nanoparticles Catalyst Biomass Pretreatment Hydrolysis