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Stability and transepithelial transport of oligopeptide(KRQKYD)with hepatocyte-protective activity from Jinhua ham in human intestinal Caco-2 monolayer cells

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Food Science and Human Wellness 2024年第3期13卷 1503-1512页

作者： Wen nie Feiran Xu Kai Zhou Jieying deng Ying Wang Baocai Xu Engineering Research Center of Bio-process Ministry of EducationSchool of Food and Biological EngineeringHefei University of TechnologyHefei 230601China School of Biological and Food Engineering Chuzhou UniversityChuzhou 239001China

The study evaluated the stability of an oligopeptide(Lys-Arg-Gln-Lys-Tyr-Asp,KRQKYD)and its transport mechanism by simulating gastrointestinal digestion and a model of human intestinal Caco-2 monolayer cells in *** this study,the effects of environmental factors(temperature,pH and NaCl concentration)and simulated gastrointestinal digestion on the stability of KRQKYD were evaluated by indicators of the levels of alanine transaminase(ALT),aspartate transaminase(AST)and malondialdehyde(MDA)in an alcoholinduced hepatocyte injury *** results showed that KRQKYD still maintained satisfactory hepatocyteprotective activity after treatment with different temperatures(20-80℃),pH(3.0-9.0),NaCl concentration(1%-7%)and simulated gastrointestinal digestion,which indicated that KRQKYD showed good stability to environmental factors and simulated gastrointestinal ***,the intact KRQKYD could be absorbed in a model of Caco-2 monolayer cells with a P_(app)value of(9.70±0.53)×10^(-7)cm/*** with an energy inhibitor(sodium azide),a competitive peptide transporter inhibitor(Gly-Pro)and a transcytosis inhibitor wortmannin did not decrease the level of transepithelial KRQKYD transport,indicating that the transport mechanism of KRQKYD was not associated with energy dependent,vector mediated and *** tight junction disruptor cytochalasin D significantly increased the level of transepithelial KRQKYD transport(P<0.05),suggesting that intact KRQKYD was absorbed by paracellular transport.

关键词： Jinhua ham KRQKYD(Lys-Arg-Gln-Lys-Tyr-Asp) Environmental stability Gastrointestinal digestive Transport mechanism

Toward a learnable Climate Model in the Artificial Intelligence Era

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Advances in Atmospheric Sciences 2024年第7期41卷 1281-1288页

作者： Gang HUANG Ya WANG Yoo-Geun ham Bin MU Weichen TAO Chaoyang XIE State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China department of Environmental Planning Graduate School of Environmental StudiesSeoul National UniversitySeoul 08826South Korea School of Software Engineering Tongji UniversityShanghai 200092China

Artificial intelligence(AI)models have significantly impacted various areas of the atmospheric sciences,reshaping our approach to climate-related *** this AI-driven transformation,the foundational role of physics in climate science has occasionally been *** perspective suggests that the future of climate modeling involves a synergistic partnership between AI and physics,rather than an“either/or”*** controversies around current physical inconsistencies in large AI models,we stress the critical need for detailed dynamic diagnostics and physical ***,we provide illustrative examples to guide future assessments and constraints for AI *** AI integration with numerical models,we argue that offline AI parameterization schemes may fall short of achieving global optimality,emphasizing the importance of constructing online ***,we highlight the significance of fostering a community culture and propose the OCR(Open,Comparable,Reproducible)*** a better community culture and a deep integration of physics and AI,we contend that developing a learnable climate model,balancing AI and physics,is an achievable goal.

关键词： artificial intelligence deep learning learnable climate model

Strong coupling and catenary field enhancement in the hybrid plasmonic metamaterial cavity and TMDC monolayers

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Opto-Electronic Advances 2024年第5期7卷 20-32页

作者： Andergachew Mekonnen Berhe Khalil As’ham Ibrahim Al-Ani Haroldo T.Hattori Andrey E.Miroshnichenko School of Engineering and Technology University of New South Wales at CanberraNorthcott DriveCanberra ACT 2610Australia

Strong coupling between resonantly matched surface plasmons of metals and excitons of quantum emitters results in the formation of new plasmon-exciton hybridized energy *** plasmon-exciton strong coupling,plasmonic nanocavities play a significant role due to their ability to confine light in an ultrasmall ***,two-dimensional transition metal dichalcogenides(TMDCs) have a significant exciton binding energy and remain stable at ambient conditions,making them an excellent alternative for investigating light-matter *** a result,strong plasmon-exciton coupling has been reported by introducing a single metallic ***,single nanoparticles have lower spatial confinement of electromagnetic fields and limited tunability to match the excitonic ***,we introduce the concept of catenary-shaped optical fields induced by plasmonic metamaterial cavities to scale the strength of plasmon-exciton *** demonstrated plasmon modes of metallic metamaterial cavities offer high confinement and tunability and can match with the excitons of TMDCs to exhibit a strong coupling regime by tuning either the size of the cavity gap or *** calculated Rabi splitting of Au-MoSe_2 and Au-WSe_2 heterostructures strongly depends on the catenary-like field enhancement induced by the Au cavity,resulting in room-temperature Rabi splitting ranging between 77.86 and 320 me *** plasmonic metamaterial cavities can pave the way for manipulating excitons in TMDCs and operating active nanophotonic devices at ambient temperature.

关键词： catenary-shaped field enhancement strong coupling plasmon exciton Rabi splitting

Enhancement of vertical phase separation in sequentially deposited organic photovoltaics through the independent processing of additives

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Journal of Energy Chemistry 2024年第7期94卷 768-777页

作者： Damin lee Changwoo Park Gayoung ham Young Yong Kim Sung-Nam Kwon Junyeong lee Sungjin Jo Seok-In Na Hyojung Cha department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea department of Flexible and Printable Electronics Jeonbuk National UniversityJeonju-siJeollabuk-do 54896Republic of Korea School of Energy Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

Herein,the impact of the independent control of processing additives on vertical phase separation in sequentially deposited (SD) organic photovoltaics (OPVs) and its subsequent effects on charge carrier kinetics at the electron donor-acceptor interface are *** film morphology exhibits notable variations,significantly depending on the layer to which 1,8-diiodooctane (DIO) was *** incidence wide-angle X-ray scattering analysis reveals distinctly separated donor/acceptor phases and vertical crystallinity details in SD ***-of-flight secondary ion mass spectrometry analysis is employed to obtain component distributions in diverse vertical phase structures of SD films depending on additive *** addition,nanosecond transient absorption spectroscopy shows that DIO control significantly affects the dynamics of separated charges in SD *** SD OPVs,DIO appears to act through distinct mechanisms with minimal restriction,depending on the applied *** study emphasizes the significance of morphological optimization in improving device performance and underscores the importance of independent additive control in the advancement of OPV technology.

关键词： Sequential deposition Vertical phase separation Charge dynamics Organic photovoltaics Nonfullerene acceptors

Identification and Molecular Docking Mechanism of Novel Anti-Inflammatory Peptides from Lactobacillus paraplantarum Fermented Cannabis sativa L. (hemp) Seeds

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Food Science and Human Wellness 2024年

作者： LingYue Shan Akanksha Tyagi HunJu ham deog Hwan Oh department of Food Science and Biotechnology， College of Agriculture and Life Sciences， Kangwon National University Future F Biotech Co.， Ltd department of Biological Environment， College of Agriculture and Life Sciences， Kangwon National University

The inflammatory response is a crucial physiological process that can lead to tissue damage and is considered a causative factor for various chronic diseases， such as rheumatoid arthritis. Recent research has focused on exploring valuable nutrients derived from Cannabis sativa L. (hemp) seeds， particularly hemp seed proteins. Therefore， this study aimed to investigate the release of anti-inflammatory peptides from Lactobacillus paraplantarum-fermented hemp seed proteins. To confirm the complete hydrolysis of hemp seed proteins during the fermentation process， SDS-PAGE was employed. Further， the isolation and purification of peptides were achieved through ultrafiltration. The identity of peptides was nextly established using ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). The results revealed a total of 39 identified peptides in fermented hemp seeds， with 9 peptides selected based on their relative quantity. Notably， AAELIGVP (P1)， AAVPYPQ (P2)， VFPEVAP (P4)， DVIGVPLG (P6)， and PVPKVL (P9) demonstrated strong anti-inflammatory abilities in LPS-induced Raw 264.7 macrophage cells. Molecular docking was used to understand the potential anti-inflammatory mechanism of these five peptides， and in silico results indicated that P1， P2， P4， P6， and P9 could bind to the active sites of TLR-4， NF-kB， and IKK with higher binding energies. Overall， these findings indicate that hemp seeds have potential to be a source of bioactive peptides for functional foods with anti-inflammatory properties.

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Interfacial engineering through lead binding using crown ethers in perovskite solar cells

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Journal of Energy Chemistry 2024年第5期92卷 263-270页

作者： Sun-Ju Kim YeonJu Kim Ramesh Kumar Chitumalla Gayoung ham Thanh-Danh Nguyen Joonkyung Jang Hyojung Cha Jovana Milić Jun-Ho Yum Kevin Sivula Ji-Youn Seo department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Adolphe Merkle Institute University of FribourgCH-1700 FribourgSwitzerland

In the domain of perovskite solar cells(PSCs),the imperative to reconcile impressive photovoltaic performance with lead-related issue and environmental stability has driven innovative *** study pioneers an approach that not only rectifies lead leakage but also places paramount importance on the attainment of rigorous interfacial *** ethers,notably benzo-18-crown-6-ether(B18C6),were strategically integrated at the perovskite-hole transport material *** ethers exhibit a dual role:efficiently sequestering and immobilizing Pb^(2+)ions through host-guest complexation and simultaneously establishing a robust interfacial passivation *** crown ether candidates,guided by density functional theory(DFT)calculations,demonstrated proficiency in binding Pb2+ions and optimizing interfacial *** devices incorporating these materials achieved exceptional power conversion efficiency(PCE),notably 21.7%for B18C6,underscoring their efficacy in lead binding and interfacial *** techniques,including time-of-flight secondary ion mass spectrometry(ToF-SIMS),ultraviolet photoelectron spectroscopy(UPS),time-resolved photoluminescence(TRPL),and transient absorption spectroscopy(TAS),unequivocally affirmed Pb^(2+)ion capture and suppression of non-radiative ***,these PSCs maintained efficiency even after enduring 300 h of exposure to 85%relative *** research underscores the transformative potential of crown ethers,simultaneously addressing lead binding and stringent interfacial passivation for sustainable PSCs poised to commercialize and advance renewable energy applications.

关键词： Perovskite solar cells Interfacial passivation Crown ether materials Stability

Emerging probing perspective of two-dimensional materials physics:terahertz emission spectroscopy

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Light(Science & Applications) 2024年第7期13卷 1278-1298页

作者： Yifei Wu Yuqi Wang Di Bao Xiaonan deng Simian Zhang Lin Yu-chun Shengxian Ke Jianing Liu Yingjie Liu Zeli Wang Pingren ham Andrew Hanna Jiaming Pan Xinyue Hu Zhengcao Li Ji Zhou Chen Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua University100084 BeijingChina Beijing Advanced Innovation Center for Integrated Circuits 100084 BeijingChina

Terahertz(THz)emission spectroscopy(TES)has emerged as a highly effective and versatile technique for investigating the photoelectric properties of diverse materials and nonlinear physical processes in the past few ***,research on two-dimensional(2D)materials has experienced substantial growth due to their atomically thin structures,exceptional mechanical and optoelectronic properties,and the potential for applications in flexible electronics,sensing,and ***,these materials offer advantages such as tunable bandgap,high carrier mobility,wideband optical absorption,and relatively short carrier *** applying TES to investigate the 2D materials,their interfaces and heterostructures,rich information about the interplay among photons,charges,phonons and spins can be unfolded,which provides fundamental understanding for future *** it is timely to review the nonlinear processes underlying THz emission in 2D materials including optical rectification,photon-drag,high-order harmonic generation and spin-to-charge conversion,showcasing the rich diversity of the TES employed to unravel the complex nature of these *** applications based on THz emissions,such as THz lasers,ultrafast imaging and biosensors,are also *** further,we analyzed the unique advantages of spintronic terahertz emitters and the future technological advancements in the development of new THz generation mechanisms leading to advanced THz sources characterized by wide bandwidth,high power and integration,suitable for industrial and commercial *** continuous advancement and integration of TES with the study of 2D materials and heterostructures promise to revolutionize research in different areas,including basic materials physics,novel optoelectronic devices,and chips for post-Moore’s era.

关键词： optoelectronic versatile exceptional

A Fast Algorithm for Mining Top-Rank-k Erasable Closed Patterns

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Computers, Materials & Continua 2022年第8期72卷 3571-3583页

作者： ham Nguyen Tuong le Faculty of Information Technology HUTECH UniversityHo Chi Minh CityVietnam Informetrics Research Group Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Information Technology Ton Duc Thang UniversityHo Chi Minh CityVietnam

The task of mining erasable patterns(EPs)is a data mining problem that can help factory managers come up with the best product plans for the *** problem has been studied by many scientists in recent times,and many approaches for mining EPs have been *** closed patterns(ECPs)are an abbreviated representation of EPs and can be con-sidered condensed representations of EPs without information *** methods of mining ECPs identify huge numbers of such patterns,whereas intelligent systems only need a small number.A ranking process therefore needs to be applied prior to use,which causes a reduction in *** overcome this limitation,this study presents a robust method for mining top-rank-k ECPs in which the mining and ranking phases are combined into a single ***,we propose a virtual-threshold-based pruning strategy to improve the mining *** on this strategy and dPidset structure,we then develop a fast algorithm for mining top-rank-k ECPs,which we call ***,we carry out experiments to compare the runtime of our TRK-ECP algorithm with two algorithms modified from dVM and TEPUS(Top-rank-k Erasable Pattern mining Using the Subsume concept),which are state-of-the-art algorithms for mining top-rank-k *** results for the running time confirm that TRK-ECP outperforms the other experimental approaches in terms of mining the top-rank-k ECPs.

关键词： Pattern mining erasable closed pattern mining top-rank-k pattern mining

Role of E3 ubiquitin ligases in lung cancer

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World Journal of Clinical Oncology 2013年第3期4卷 58-69页

作者： Barbara C Snoek le.nie.ham de.wilt Gerrit Jansen Godefridus J Peters department of Medical Oncology VU University Medical Center1081 HV AmsterdamThe Netherlands department of Rheumatology VU University Medical Center1081 HV AmsterdamThe Netherlands

E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S ***,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer ***,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical *** this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung ***,we discuss the processes in which they are involved and evaluate them as potential anti-cancer *** better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients.

关键词： E3 ubiquitin ligases Lung cancer Ubiquitinproteasome system Proteasome inhibitors Bortezomib Apoptosis Gene regulation DNA repair