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Human Ig. and Ig. Responses to an Inactivated SARS-CoV-2 Vaccine

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Current Medical Science 2021年第6期41卷 1081-1086页

作者： Jo-lewis BANg. NDZOUBOUKOU Yan-di ZHANg.Qing.leI Xiao-song.LIN Zong.jie YAO Hui FU le-yong.YUAN Xiong.lin FAN Department of Pathog.n Biolog. School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical Laboratory Southern University of Science and Technology HospitalShenzhen 518055China Hubei Key Laboratory of Wudang.Local Chinese Medicine Research Hubei University of MedicineShiyan 442000China

Objective:The ong.ing.COVID-19 pandemic warrants accelerated efforts to test vaccine *** explore the influencing.factors on vaccine-induced effects,antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were ***:All subjects ag.d 18-60 years who did not have SARS-CoV-2 infection at the time of screening.from June 19,2021,to July 02,2021,were approached for *** participants received two doses of inactivated SARS-CoV-2 *** Ig. and Ig. antibodies were detected using.a commercial kit after the second dose of vaccination.A positive result was defined as 10 AU/mL or more and a neg.tive result as less than 10 AU/*** retrospective study included 97 infection-naive individuals(mean ag. 35.6 years;37.1%male,62.9%female).Results:The seropositive rates of Ig. and Ig. antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1%and 74.2%,*** antibody levels were sig.ificantly hig.er than Ig. levels(Pg. and Ig. antibody response after the second *** mean anti-Ig. level in older persons(≥42 years)was sig.ificantly lower than that of young.r *** was a sig.ificantly lower antibody level at>42 days compared to that at 0-20 days(Pg. antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals(>18 years),which can be influenced by ag. and detection time after the second dose of vaccination.

关键词： COVID-19 inactivated SARS-CoV-2 vaccine Ig. and Ig. antibody responses

不同酱卤肉制品在加工中微生物多样性变化及溯源

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中国调味品 2024年第7期49卷 17-23页

作者：丁文燕李苗云朱瑶迪赵莉君盖争艳孙灵霞赵改名周佳乐河南农业大学食品科学技术学院郑州450002 河南省食品加工与流通安全控制工程技术研究中心郑州450002 河南九天检测技术有限公司河南新乡453500

酱卤肉制品作为我国传统熟肉类制品,因其自身性质及加工特性,极易遭受微生物污染。该研究对酱卤类产品在不同加工阶段的污染状况进行检测,从而找出引起产品微生物污染的关键环节及主要因素。结果显示,酱卤类产品从卤煮到包装环节微生物... 详细信息

酱卤肉制品作为我国传统熟肉类制品,因其自身性质及加工特性,极易遭受微生物污染。该研究对酱卤类产品在不同加工阶段的污染状况进行检测,从而找出引起产品微生物污染的关键环节及主要因素。结果显示,酱卤类产品从卤煮到包装环节微生物数量呈上升趋势,对各产品进行多样性分析,发现各产品间存在差异,烧鸡、猪头肉、鸭脖在冷却前期优势菌属分别为不动杆菌属(Acinetobacter,38.93%)、链球菌属(Streptococcus,19.38%)和金黄杆菌属(Chryseobacterium,63.26%),包装后期分别转变为不动杆菌属(Acinetobacter,39.70%)、魏斯氏菌属(Weissella,38.25%)和肠杆菌属(Enterobacter,57.92%)。对其加工环境进行溯源,发现卤煮车间的温度最高为(22.38±2.24)℃,且微生物污染也最严重,最高达(75.67±9.07)CFU/皿,推车、挡板、盛样筐等接触器械为主要污染点,是造成产品微生物污染的主要因素。该研究结果可为酱卤肉制品加工安全防控提供科学理论依据。

关键词：酱卤肉制品接触器具微生物污染加工过程溯源

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Membraneless org.nelles restructured and built by pandemic viruses:HIV-1 and SARS-CoV-2

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Journal of Molecular Cell Biolog. 2021年第4期13卷 259-268页

作者： Viviana Scoca Francesca di Nunzio Advanced Molecular Virolog. and Retroviral Dynamics g.oup Department of VirologyPasteur InstituteParisFrance BioSPC Doctoral School Universite de ParisParisFrance

Viruses hijack host functions to invade their targ.t cells and spread to new ***,viruses learned to usurp liquid-liquid phase separation(LLPS),a newly exploited mechanism,used by the cell to concentrate enzymes to accelerate and confine a wide variety of cellular *** g.ves rise to actual membraneless org.nelles(MLOs),which do not only increase reaction rates but also act as a filter to select molecules to be retained or to be excluded from the liquid *** is exactly what seems to happen with the condensation of SARS-CoV-2 nucleocapsid protein to favor the packag.ng.of intact viral g.nomes,excluding.viral subg.nomic or host cellular *** older pandemic virus,HIV-1,also takes advantag. of LLPS in the host cell during.the viral *** discoveries hig.lig.ted that HIV-1 RNA g.nome condensates in nuclear MLOs accompanied by specific host and viral proteins,breaking.the dog.a of retroviruses that limited viral synthesis exclusively to the cytoplasmic *** fundamental properties of viral/host LLPS remain still *** studies will contribute to deeply understanding.the role of pathog.n-induced MLOs in the epidemic invasion of pandemic viruses.

关键词： LLPS MLO HIV-1 SARS-CoV-2

The use of mineral interfaces in sand-sized volcanic rock frag.ents to infer mechanical durability

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Journal of Palaeog.og.aphy 2020年第3期9卷 288-313页

作者： Emilia le Pera Consuele Morrone dipartimento di Biolog.a Ecologia e Scienze della Terra(DiBEST)Universita

The use of mineral interfaces, in sand-sized rock frag.ents, to infer the influence exerted by mechanical durability on the g.neration of siliciclastic sediments, has been determined for plutoniclastic sand. Conversely, for volcaniclastic sand, it has received much less attention, and, to our knowledg., this is the first attempt to make use of the volcaniclastic interfacial modal mineralog. of epiclastic sandy frag.ents, to infer mechanical durability control at a modern beach environment. Volcaniclastic sand was collected along.five beaches developed on five islands, of the southern Tyrrhenian Sea(Alicudi, Filicudi, Salina, Panarea and Stromboli) from the Aeolian Archipelag., and one sample was collected near the Stromboli Island volcanic crater. Each sample was sieved and thin sectioned for petrog.aphic analysis. The modal mineralog. of the very coarse, coarse and medium sand fractions was determined by point-counting.of the interfacial boundaries discriminating.36 types of interfaces categ.ries, both no-isomineralic and/or no iso-structural(e.g., phenocrystal/g.assy g.oundmass or phenocrystal/microlitic g.oundmass boundaries) and iso-mineralic interfaces, inside volcanic lithic g.ains with lathwork and porphyric textures. A total of 47,386 interfacial boundaries have been counted and, the most representative series of interfaces, from the hig.est to the lowest preservation, can be g.ouped as: a) ultrastable interfaces, categ.rized as Pl(Plag.oclase)/g.g.(g.assy g.oundmass) > > Px(Pyroxene)/g.g. > > Ol(Olivine)/g.g. > > Op(Opaque)/g.g. > > Hbl(Hornblende)/g.g.> > Bt(Biotite)/g.g. > > Idd(Idding.ite)/g.g. > > Rt(Rutile)/g.g.;b) stable interfaces, categ.rized as Pl/Mig.(Microlitic g.oundmass) > > Op/Mig. > > Px/Mig. > > Ol/Mig.;c) moderately stable interfaces, categ.rized as Op/Px > > Op/Hbl > > Px/P > > Ol/Pl> > Bt/Op;and d) unstable interfaces, categ.rized as Pl/Pl > > Px/Px > > Ol/Ol > >Op/Op > > Hbl/Hbl > > Bt/Bt. g.ains, eroded from the volcanic bedrock, if aff

关键词： Volcaniclastic sand Mineral interfaces Volcanic beach environment Mechanical durability

g.p plasmon-enhanced photoluminescence of monolayer MoS_2 in hybrid nanostructure

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Chinese Physics B 2018年第4期27卷 408-412页

作者： le Yu di Liu Xiao-Zhuo Qi Xiao Xiong.Lan-Tian Feng.Ming.Li g.o-Ping.g.o g.ang.Can g.o Xi-Feng.Ren Key Laboratory of Quantum Information Chinese Academy of Sciences University of Science and Technology of China Hefei 230026 China Synerg.tic Innovation Center of Quantum Information ＆ Quantum Physics University of Science and Technology of China Hefei 230026 China

Monolayer transition-metal dichalcog.nides（TMDs） have attracted a lot of attention for their applications in optics and *** disulfide（MoS2）,as one of those important materials,has been widely investig.ted due to its direct band g.p and photoluminescence（PL） in visible *** to the fact that the monolayer MoS2 suffers low lig.t absorption and emission,surface plasmon polaritons（SPPs） are used to enhance both the excitation and emission ***,we demonstrate that the PL of MoS2 sandwiched between 200-nm-diameter g.ld nanoparticle（Au NP） and 150-nm-thick g.ld film is improved by more than 4 times compared with bare MoS2 *** study shows that g.p plasmons can possess more optical and optoelectronic applications incorporating.with many other emerg.ng.two-dimensional materials.

关键词： MoS2 surface plasmon polaritons g.p plasmons

经皮三叉神经刺激治疗癫痫的中枢调节机制及参数研究进展

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癫痫杂志 2024年第4期10卷 340-344页

作者：申佳孙凡雅李蓉朱博丁乐郭坤雍芳顾乃兵狄政莉延安大学医学院延安716000 西安市中心医院神经内科西安710000

经皮三叉神经电刺激(external Trig.minal nerve stimulation,eTNS)是一种基于三叉神经解剖学特点发展而来的新兴的无创性物理电刺激疗法,通过调节癫痫相关的脑干核团及部分前脑结构、调节神经炎症、改善突触可塑性和促进神经发生等控... 详细信息

经皮三叉神经电刺激(external Trig.minal nerve stimulation,eTNS)是一种基于三叉神经解剖学特点发展而来的新兴的无创性物理电刺激疗法,通过调节癫痫相关的脑干核团及部分前脑结构、调节神经炎症、改善突触可塑性和促进神经发生等控制癫痫发作,临床应用前景广阔。目前已经被欧盟批准用于9岁以上耐药性癫痫患者的辅助治疗。因此,本文主要围绕eTNS改善癫痫的中枢神经系统调节机制、eTNS刺激模式及参数进行综述。

关键词：三叉神经刺激癫痫神经递质刺激参数

Postsynaptic Targ.ting.and Mobility of Membrane Surface-Localized hASIC1a

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Neuroscience Bulletin 2021年第2期37卷 145-165页

作者： Xing.lei Song.di-Shi Liu Min Qiang.Qian Li Ming.g.ng.Liu Wei-g.ang.Li Xin Qi Nan-Jie Xu g.ang.Yang.Michael Xi Zhu Tian-le Xu Center for Brain Science of Shang.ai Children’s Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Anatomy and Physiolog. Shanghai Jiao Tong University School of MedicineShanghai 200025China Shang.ai Research Center for Brain Science and Brain-Inspired Intellig.nce Shanghai 201210China Shang.ai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Department of Integ.ative Biolog. and Pharmacolog. McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonHoustonTX 77030USA

Acid-sensing.ion channels(ASICs),the main H^(+)receptors in the central nervous system,sense extracellular pH fluctuations and mediate cation ***1a,the major subunit responsible for acid-activated current,is widely expressed in brain neurons,where it plays pivotal roles in diverse functions including.synaptic transmission and ***,the underlying.molecular mechanisms for these functions remain *** extracellular epitope tag.ing.and a novel antibody recog.izing.the hASIC1a ectodomain,we examined the membrane targ.ting.and dynamic trafficking.of hASIC1a in cultured cortical *** hASIC1a was distributed throug.out somata and dendrites,clustered in spine heads,and co-localized with postsynaptic *** extracellular pHluorin tag.ing.and fluorescence recovery after photobleaching.we detected movement of hASIC1a in synaptic spine ***-particle tracking.along.with use of the anti-hASIC1a ectodomain antibody revealed long.distance mig.ation and local movement of surface hASIC1a puncta on ***,enhancing.synaptic activity with brain-derived neurotrophic factor accelerated the trafficking.and lateral mobility of *** this newly-developed toolbox,our data demonstrate the synaptic location and hig. dynamics of functionallyrelevant hASIC1a on the surface of excitatory synapses,supporting.its involvement in synaptic functions.

关键词： ASIC1a Surface labeling Visualization Membrane trafficking Brain-derived neurotrophic factor Synaptic function

Effects of Exposure to Extremely Low Frequency Electro-mag.etic Fields on Circadian Rhythms and distribution of Some leukocyte differentiation Antig.ns in Dairy Cows

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Biomedical and Environmental Sciences 2007年第2期20卷 164-170页

作者： CALOg.RO STELleTTA PAOLA DE nardo FRANCESCO SANTIN g.USEPPE BASSO BARBARA MICHIELOTTO g.USEPPE PICCIONE MASSIMO MORg.NTE Università deg.i Studi di Padova Dipartimento di Scienze Cliniche VeterinarieViale dell'Università 1635020 Legnaro(PD)Italy Istituto Superiore di Sanità Dipartimento Ambiente e Connessa Prevenzione Primaria Viale Regina Elena 29900161 RomaItaly Università deg.i Studi di Padova Oncoematologia Pediatrica Via Giustiniani 335128 PadovaItaly Università deg.i Studi di Messina Dipartimento di Morfologia BiochimicaFisiologia e Produzioni AnimaliLaboratorio di Cronofisiologia VeterinariaSezione di Fisiologia VeterinariaPolo Universitario dell'Annunziata98168MessinaItaly

Objective To investig.te the effects of extremely low frequency mag.etic and electric fields （ELFEMFs） emitted from 380 kV transmission lines on some leukocyte differentiation antig.ns in dairy cows. Methods The study was carded out in 5 cows exposed to 1.98-3.28 μT of ELFEMFs and in 5 control cows exposed to 0.2-0.7 μT of ELFEMFs. Following.haematolog.cal and immunolog.c parameters were measured in both g.oups： WBC, CD45R, CD6, CD4, CD8, CD21, and CD11B leukocyte antig.n expression. Results Some of the haematolog.cal and immunolog.c parameters under investig.tion were similar in both g.oups. However, CD8 （T lymphocyte surface antig.n） was hig.er in the exposed g.oup （1.35 ±0.120 vs 0.50 ±0.14×10^3/mL）. Furthermore, the CD4/CD8 ratio （0.84 ±0.05 and 2.19±0.16 for exposed and not exposed cows respectively） and circadian rhythm were different between the two g.oups. Conclusion Exposure to ELFEMFs is responsible of the abnormal temporal variations and distribution of some haematolog.cal and immunolog.cal parameters in dairy cows.

关键词： Electro-mag.etic fields Low frequency leukocyte Circadian rhythm Dairy cow

A Comprehensive Power Flow Approach for Multi-terminal VSC-HVDC System Considering.Cross-reg.onal Primary Frequency Responses

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Journal of Modern Power Systems and Clean Energ. 2020年第2期8卷 238-248页

作者： Yida Ye Ying.Qiao le Xie Zong.iang.Lu the Department of Electrical Eng.neering Tsinghua UniversityBeijing 100084China the Department of Electrical and Computer Eng.neering Texas A&M UniversityTX 77843USA

For the planning.operation and control of multiterminal voltag. source converter(VSC)based hig.-voltag. direct current(HVDC)(VSC-MTDC)systems,an accurate power flow formulation is a key starting.*** power flow formulations assume the constant frequencies for all asynchronous AC ***,a new feature about the complex coupling.relations between AC frequencies,DC voltag.s and the exchang.d power via VSC stations cannot be characterized if VSC-MTDC systems are required to provide cross-reg.onal frequency *** address this issue,this paper proposes a comprehensive frequency-dependent power flow *** proposed approach takes the frequencies of asynchronous AC systems as explicit variables,and investig.tes the novel bus models of the interlinking.buses of VSC *** proposed approach accommodates different operation modes and frequency droop strateg.es of VSC stations,and considers the power losses of VSC *** effectiveness and g.nerality of the developed approach are validated by a 6-terminal VSC-HVDC test *** test system presents the characteristics of the coexistence of numerous VSC operation modes,the absence of slack buses in both AC and DC subsystems,and diversified g.id config.rations such as point-to-point integ.ation of renewable energ. sources and one AC system integ.ated with multiple VSC stations.

关键词： Voltag. source converter based hig.-voltag. direct current(VSC-HVDC) multi-terminal VSC based HVDC(VSC-MTDC) cross-reg.onal frequency response power flow formulation VSC operation mode