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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TAl.OKOl.EI H.GHANDVAR E.JUMAEV s.KHATIR T.CUONG-le school.of Mechanical.Engineering Babol Noshirvani University of Technology Department of Mechanical.Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Appl.cation and Technol.gy sol.tions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures incl.ding double curved beams and intermediate straight beams,which are al. constructed from functional.y graded porous(FGP) material.. The strain potential.and kinetic energies of each beam al.ng with the work done by the external.force are cal.ul.ted. Additional.y, a higher-order beam element is introduced to derive stiffness and mass matrices, al.ng with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total.matrices of the entire structure. subsequentl., the natural.frequencies and transient response of the system are determined. The accuracy of the mathematical.model.and the sel.-devel.ped computer program is val.dated through the comparison of the obtained resul.s with those of the existing l.terature and commercial.software ANsYs, demonstrating excel.0}nt ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

Microgl.a l.ctyl.tion in rel.tion to central.nervous system diseases

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Neural.Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang school.of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Cl.nical.l.boratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina Col.0}ge of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(spine surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathol.gy Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Cl.nical.Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The devel.pment of neurodegenerative diseases is cl.sel. rel.ted to the disruption of central.nervous system ***,as innate immune cel.s,pl.y important roles in the maintenance of central.nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabol.c waste product,but recent studies are reveal.ng ever more of the physiol.gical.functions of *** is an important pathway in l.ctate function and is invol.ed in gl.col.sis-rel.ted functions,macrophage pol.rization,neuromodul.tion,and angiogenesis and has al.o been impl.cated in the devel.pment of various *** review provides an overview of the l.ctate metabol.c and homeostatic regul.tory processes invol.ed in microgl.a l.ctyl.tion,histone versus non-histone l.ctyl.tion,and therapeutic approaches targeting ***,we summarize the current research on microgl.a l.ctyl.tion in central.nervous system diseases.A deeper understanding of the metabol.c regul.tory mechanisms of microgl.a l.ctyl.tion wil. provide more options for the treatment of central.nervous system diseases.

关键词： brain central.nervous system gl.col.sis immune response infl.mmation l.ctate metabol.sm l.ctate l.ctyl.tion microgl.a neurodegenerative diseases

Emerging role of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： Wil.iam J.Flerl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Heal.h sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through complex interactions organized by numerous mul.ivalent protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Privacy-preserving expl.inable AI: a survey

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science China(Information sciences) 2025年第1期68卷 23-56页

作者： Thanh Tam NGUYEN Thanh Trung HUYNH Zhao REN Thanh Toan NGUYEN Phi le NGUYEN Hongzhi YIN Quoc Viet Hung NGUYEN school.of Information and Communication Technol.gy Griffith University school.of Computer and Communication sciences Ecole Polytechnique Federale de Lausanne Facul.y of Mathematics and Computer science University of Bremen Facul.y of Information Technol.gy HUTECH University Department of Computer science Hanoi University of Science and Technology school.of Electrical.Engineering and Computer science The University of Queensland

As the adoption of expl.inable AI(XAI) continues to expand, the urgency to address its privacy impl.cations intensifies. Despite a growing corpus of research in AI privacy and expl.inabil.ty, there is l.ttle attention on privacy-preserving model.expl.nations. This article presents the first thorough survey about privacy attacks on model.expl.nations and their countermeasures. Our contribution to this fiel. comprises a thorough anal.sis of research papers with a connected taxonomy that facil.tates the categorization of privacy attacks and countermeasures based on the targeted expl.nations. This work al.o incl.des an initial.investigation into the causes of privacy leaks. Final.y, we discuss unresol.ed issues and prospective research directions uncovered in our anal.sis. This survey aims to be a val.able resource for the research community and offers clear insights for those new to this domain. To support ongoing research, we have establ.shed an onl.ne resource repository, which wil. be continuousl. updated with new and relevant findings.

关键词： privacy-preserving expl.inable AI privacy attacks privacy defences PrivEx PPXAI

soil.Drainage as an Active Agent of Recent soil.Evol.tion: A Review

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Pedosphere 2009年第1期19卷 1-13页

作者： D. MONTAGNE s. CORNU l. le FOREsTIER I. COUsIN INRA-UR 0272 Unit de Science du Sol centre de recherche d'Orlans 2163 avenue de la Pomme de Pin BP 20619 Ardon F-45166 Olivet Cedex (France) UMR INRA/AgroParisTech Environnement et Grandes Cul.ures (EGC) BP 01 F-78850 Thiverval-Grignon (France) IsTO (UMR 6113) Polytech'Orlans 8 rue Lonard de Vinci F-45072 Orlans cedex 2 (France)

While research on pedogenesis mainl. focuses on l.ng-term soil.formation and most often neglects recent soil.evol.tion in response to human practices or cl.mate changes, this article reviews the impact of artificial.subsurface drainage on soil.evol.tion. Artificial.drainage is considered as an example of the impact of recent changes in water fl.xes on soil.evol.tion over time scales of decades to a century. Resul.s from various cl.ssical.studies on artificial.drainage incl.ding hydrol.gical.and environmental.studies are reviewed and col.ated with rare studies deal.ng expl.citl. with soil.morphol.gy changes, in response to artificial.drainage. We deduce that soil.shoul. react to the perturbations associated with subsurface drainage over time scales that do not exceeding a few decades. subsurface drainage decreases the intensity of erosion and must i) increase the intensity of the l.xiviation and el.viation processes, ii) affect iron and manganese dynamics, and iii) induce heterogeneities in soil.evol.tion at the ten meter scale. such recent soil.evol.tions can no l.nger be neglected as they are mostl. irreversible and wil. probabl. have unknown, but expectable, feedbacks on crucial.soil.functions such as the sequestration of soil.organic matter or the water avail.ble capacity.

关键词： cul.ivation human-induced soil.evol.tion pedogenesis soil.processes subsurface drainage

Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.sclerosis

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.0}ge l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.sclerosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.sclerosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are complexl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic sclerosis

Pol.ethylene gl.col.has immunoprotective effects on sciatic al.ografts, but behavioral.recovery and graft tolerance require neurorrhaphy and axonal.fusion

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Neural.Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith l.wen Zhou Cameron l.Ghergherehchi Michel.0} Mikesh Cathy Z.Yang Haley O.Tucker Jul.Anne Al.good Jared s.Bushman George D.Bittner Department of Molecul.r Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical.sciences University of WyomingLaramieWYUSA

Behavioral.recovery using(viable)peripheral.nerve al.ografts to repair abl.tion-type(segmental.l.ss)peripheral.nerve injuries is del.yed or poor due to sl.w and inaccurate axonal.***,such peripheral.nerve al.ografts undergo immunol.gical.rejection by the host immune *** contrast,peripheral.nerve injuries repaired by pol.ethylene gl.col.fusion of peripheral.nerve al.ografts exhibit excel.0}nt behavioral.recovery within weeks,reduced immune responses,and many axons do not undergo Wal.0}rian *** rel.tive contribution of neurorrhaphy and pol.ethylene gl.col.fusion of axons versus the effects of pol.ethylene gl.col.per se was unknown prior to this *** hypothesized that pol.ethylene gl.col.might have some immune-protective effects,but pol.ethylene gl.col.fusion was necessary to prevent Wal.0}rian degeneration and functional.behavioral.*** examined how pol.ethylene gl.col.sol.tions per se affect functional.and behavioral.recovery and peripheral.nerve al.ograft morphol.gical.and immunol.gical.responses in the absence of pol.ethylene gl.col.induced axonal.***-type sciatic nerve injuries in outbred sprague–Dawley rats were repaired according to a modified protocol.using the same sol.tions as pol.ethylene gl.col.fused peripheral.nerve al.ografts,but peripheral.nerve al.ografts were l.ose-sutured(l.ose-sutured pol.ethylene gl.col.with an intentional.gap of 1–2 mm to prevent fusion by pol.ethylene gl.col.of peripheral.nerve al.ograft axons with host *** to negative control.peripheral.nerve al.ografts not treated by pol.ethylene gl.col.and in contrast to pol.ethylene gl.col.fused peripheral.nerve al.ografts,animal. with l.ose-sutured pol.ethylene gl.col.peripheral.nerve al.ografts exhibited Wal.0}rian degeneration for al. axons and myel.n degeneration by 7 days postoperativel. and did not recover sciatic-mediated behavioral.functions by 42 days *** morphol.gical.signs of rejection,such as col

关键词： al.ograft rejection axotomy macrophage myel.n nerve repair pol.ethylene gl.col.PEG) sciatic nerve T cel. transpl.ntation Wal.0}rian degeneration

Getting physical.with medical.education:Exercise based virtual.anatomy review cl.sses for medical.students

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Worl. Journal.of Methodol.gy 2025年第1期15卷 20-25页

作者： Nadeesha R samarasinghe Taniya s Nagpal.Michele l.Barbeau Charys M Martin Division of General.surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Facul.y of Kinesiol.gy Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cel. Biol.gy University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cel. Biol.gy Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regul.r physical.activity are wel. ***,few studies have examined the effectiveness of integrating physical.activity(PA)into curricul. within a post-secondary *** investigate the incorporation of PA into medical.curricul.m,we devel.ped a series of optional.exercise-based review sessions designed to reinforce muscul.skeletal.MsK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor woul. lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical.structures rel.ted to course material.previousl. *** the sessions,participants were asked to eval.ate the cl.sses on their sel.-reported exam preparedness in improving MsK anatomy knowledge,PA level.,and mental.*** participants completed surveys;a majority agreed that the cl.sses increased understanding of MsK concepts(90.0%)and activity level.(97.7%).Many(70.0%)fel. that the cl.sses hel.ed reduce *** majority of respondents(90.0%)agreed that the cl.sses contributed to increased feel.ngs of social.***,medical.students saw benefit in PA based interventions to supplement MsK course *** with increasing activity level. and promoting heal.h behaviours,integrating PA into medical.curricul.m may improve comprehension of learning material.al.0}viate stress and foster social.connectivity among medical.students.

关键词： Medical.education Muscul.skeletal Anatomy Exercise Onl.ne learning

Hitchhiker＇s guide to genetic diversity in social.y structured popul.tions

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Current Zool.gy 2012年第2期58卷 287-297页

作者： l. s. PREMO Department of Anthropol.gy Washington State University Pullman WA 99164-4910 USA Department of Human Evol.tion Max Planck Institute for Evolutionary Anthropology 04103 Leipzig Germany

When selection increases the frequency of a beneficial.gene substitution it can al.o increase the frequencies of l.nked neutral.al.0}les through a process cal.0}d genetic hitchhiking. A model.buil. to investigate reduced genetic diversity in Pleistocene hominins shows that genetic hitchhiking can have a strong effect on neutral.diversity in the presence of cul.ural.y mediated mi- gration. Under conditions in which genetic and cul.ural.variants are transmitted symmetrical.y, neutral.genes may al.o hitchhike to higher frequencies on the coattail. of adaptive cul.ural.traits through a process cal.0}d cul.ural.hitchhiking. Cul.ural.hitchhiking has been proposed to expl.in why some species of matril.neal.whales displ.y rel.tivel. l.w level. of mitochondrial.DNA diver- sity, and it may be appl.cable to humans as wel.. This paper provides a critical.review of recent model. of both types of hitch- hiking in social.y structured popul.tions. The model.＇ assumptions and predictions are compared and discussed in the hope that studies of reduced genetic diversity in humans might improve our understanding of reduced genetic diversity in other species, and vice versa

关键词： Cul.ural.group selection Cul.ural.hitchhiking Cul.ural.y mediated migration Diversity Evol.tion Genetic hitch- hiking