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revealing the regulation effect of Surface Charge at Aromatic Interface to Dynamic Conformational Changes of α-Synuclein at early Aggregation Stage

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Chinese Journal of Chemistry 2024年第16期42卷 1867-1876页

作者： Yuqi Zhang lie Wu Xiue Jiang State Key Laboratoryof electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun Jilin 130022China Schoolof Applied Chemistry and engineering University of Science and Technology of ChinaHefei Anhui 230026China research Center for Analytical Science College of ChemistryNankai UniversityTianjin 300071China

The aggregation ofα-synuclein(α-syn)is strongly influenced by membrane interfaces,but the mechanism of transition from monomers to oligomers at early aggregation stage is not ***,we investigate the adsorption and structure changes ofα-syn on oppositely charged aromatic interfaces through in-situ surface-enhanced infrared absorption(SeIrA)spectroscopy and nano-Ir *** results show that the synergy of electrostatic and hydrophobic interactions leads to a“fast-slow”two-step aggregation pathway on negatively charged *** adsorption induces the formation of an extended helix structure and subsequently partial helix unwinding in NAC region,which enables the hydrophobic stacking between nearby NAC *** antiparallel β-sheet rich aggregates are gradually emerging as further interactions of monomers with the fast formed“first layer”.Monomers electrostatically adsorb on positively charged interface by C-terminus with NAC region and N-terminus stretched in solvent,which serve as an aggregation core and induce further adsorption and gradual formation of aggregates with C-terminus *** results demonstrate the modulation of surface charge and synergy of electrostatic and hydrophobic interactions on the interaction modes and aggregation pathways,which provide insights into dynamic conformation changes ofα-syn at early aggregation stage and imply the important role of spatial-temporal heterogeneity of membranes inα-synucleinopathies.

关键词： α-Synuclein Interface early aggregation Ir spectroscopy Surface analysis Analytical methods Proteins Dynamic monitoring

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Storylines of family medicine Ⅷ:clinical approaches

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Family Medicine and Community Health 2024年第S3期12卷 70-78页

作者： William B Ventres le.lie.a stone.laure. e.gibson-oliv.r elizabeth Kyle Meehan Mari A ricker David Loxterkamp Stacy A Ogbeide Frank V deGruy Megan r Mahoney Steven Lin Clare Macrae Stewart W Mercer Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Medicine The University of Arizona College of Medicine-TucsonTucsonArizonaUSA Bucksport regional Health Center BucksportMaineUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA eugene S.Farley Jr.Health Policy CenterUniversity of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Division of Primary Care and Population Health Stanford MedicinePalo AltoCaliforniaUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅷ:clinical approaches’,authors address the following themes:‘evaluation,diagnosis and managementⅠ—toward a working diagnosis’,‘evaluation,diagnosis and managementⅡ—process steps’,‘Interweaving integrative medicine and family medicine’,‘Halfway—the art of clinical judgment’,‘Seamless integration in family medicine—team-based care’,‘Technology—uncovering stories from noise’and‘Caring for patients with multiple long-term conditions’.May readers recognise in these essays the uniqueness of a family medicine approach to care.

关键词： uniqueness dimensions illustration

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Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding rNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

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Journal of Integrative Medicine 2024年第2期22卷 188-198页

作者： Meng Li Yang Zhou Hui Zhu lie-ming Xu Jian Ping Institute of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Preventive Treatment Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437 China Department of Gastroenterology Suzhou Traditional Chinese Medicine HospitalSuzhou 215000Jiangsu ProvinceChina Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China Key Laboratory of Liver and Kidney Diseases(Ministry of education) Shanghai 201203China

Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver ***:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver *** was administered orally for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-related ***-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding rNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphorylation in the liver tissue of Mdr2-/-*** addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 *** overexpressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell *** intervention effect of DHQ on these processes was also *** overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of ***:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19expression,STAT3 expression and STAT3 *** formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in *** overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphorylation and HSC activation,and DHQ was able to successfully inhibit these ***:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Md

关键词： Liver cirrhosis biliary Long non-coding rNA H19 Danhongqing formula Cholangiocyte Hepatic stellate cells STAT3 transcription factor

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Investigating the impact of the universal function of the nuclear proximity potential in heavy-ion fusion cross sections

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Communications in Theoretical Physics 2024年第5期76卷 86-93页

作者： r Gharaei e Sarvari Department of Physics Sciences FacultyHakim Sabzevari UniversityPO Box 397SabzevarIran Department of Physics Faculty of ScienceFerdowsi University of MashhadPO Box 91775-1436MashhadIran Science Faculty Department of PhysicsTarbiat Modares UniversityTehranIran

The fusion barriers and cross sections of 15 colliding systems with 320≤Z_(1)Z_(2)≤1512 are investigated in detail to understand the influence of the universal function of proximity potential formalism in the heavy-ion fusion *** realize this goal,we select three versions of the phenomenological proximity potentials,including Prox.77,Zhang 2013,and Guo 2013,to calculate the nucleus-nucleus *** experimental fusion cross sections for the selected reactions are analyzed using the standard coupled-channel calculations,including couplings to the low-lying 2^(+)and 3^(-)states in the target and *** calculated results show that the universal functions of the Guo 2013 and Prox.77 models provide the lowest and highest fusion barriers,*** addition,it is found that the height of the fusion barriers is enhanced by increasing the mass number of the projectile from light to heavy *** highest sensitivity to the mass number of the projectile belongs to the results of Prox.77.A discussion is also presented on the influence of the universal function on the radial behavior of the interaction potential in the allowed region for overlapping *** results reveal that the best fit to the experimental data of the fusion cross sections for the reactions involving light and medium nuclei is obtained using the universal function of the Zhang 2013 *** the heavier systems,the results of the Guo 2013 model at sub-barrier energies provide a good description of the available data.

关键词： fusion reactions proximity-type potentials universal function coupled-channel calculations

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Synthesis of hierarchically porous carbon materials by zinc salts-assisted carbonization of biomass and organic solid wastes

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Particuology 2024年第1期84卷 45-52页

作者： le-le Zhang lei Tong Yanwei Ding Wanqun Zhang Hai-Wei Liang Hefei National research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei230026China

Hierarchically porous carbons(HPCs)with multimodal pores have attracted considerable attention due to their unique physical and chemical properties and various application potentials in heterogeneous catalysis,environmental treatment,and energy storage and ***,we report a general and simple zinc salts-assisted method for the synthesis of HPCs with varied porosity and chemical func-tionalities by the direct carbonization of diverse biomass and *** the carbonization,zinc salts are thermally decomposed into nanoparticles that serve as in-situ templates to introduce nanopores in *** prepared HPCs exhibit high specific surface areas(up to 2432 m2 g-1),large pore volumes(up to 4.30 cm^(3)g^(-1)),and broad pore size ***,the zinc salts can be recovered and recycled,supporting the sustainable production of HPCs on large *** prepared HPCs-supported catalysts with atomically dispersed metal sites exhibit promising electrocatalytic performance for the oxygen reduction reaction.

关键词： Hierarchical porous carbon Zinc salts Biomass Wastes electrocatalysis

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Contrasting physical mechanisms of yellowfin tuna fluctuations between the western and eastern Indian Ocean

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Journal of Oceanology and Limnology 2024年第3期42卷 960-971页

作者： Peng LIAN le GAO Key Laboratory of Ocean Observation and Forecasting and Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Laboratory for Ocean Dynamics and Climate Laoshan LaboratoryQingdao 266061China

As an economically critical pelagic migratory species,yellowfin tuna(Thunnus albacores,YFT)is very sensible to physical and environmental conditions,such as sea surface temperature(SST),ocean heat content(OHC),and the mixed layer depth(MLD).We investigated the impact of SST,OHC,and MLD on fluctuations of YFT catch in the western/eastern Indian Ocean using the long time series of 63-year environmental and YFT *** found that the impact of SST on YFT was heavily overestimated in the past,and MLD plays a more critical role in the YFT catch *** the MLD deepens(>34.8 m),SST was more influential in predicting the catches of YFT than OHC in the western Indian Ocean,and OHC was more critical to YFT than SST in the eastern Indian ***,when the MLD shallows(re vital to predict the catch per unit effort(CPUe)of YFT than SST/OHC in the *** 2000,there was an asynchronous pattern of YFT CPUe induced by higher frequency variations and ocean hiatus of SST/OHC signals in the western and eastern Indian Oceans *** impact of the subsurface hiatus may induce the decrease of YFT in the eastern Indian *** above findings clarified a non-stationary relationship between the environmental factors and catches of YFT and provided new insights into variations in YFT abundance.

关键词： yellowfin tuna Indian Ocean sea surface temperature(SST) ocean heat content(OHC) mixed layer depth(MLD) hiatus

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Impacts of central-Pacific el Niño and physical drivers on eastern Pacific bigeye tuna

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Journal of Oceanology and Limnology 2024年第3期42卷 972-987页

Bigeye tuna Thunnus obesus is an important migratory species that forages deeply,and el Niño events highly influence its distribution in the eastern Pacific *** sea surface temperature is widely recognized as the main factor affecting bigeye tuna(BeT)distribution during el Niño events,the roles of different types of el Niño and subsurface oceanic signals,such as ocean heat content and mixed layer depth,remain *** conducted A spatial-temporal analysis to investigate the relationship among BeT distribution,el Niño events,and the underlying oceanic signals to address this knowledge *** used monthly purse seine fisheries data of BeT in the eastern tropical Pacific Ocean(eTPO)from 1994 to 2012 and extracted the central-Pacific el Niño(CPeN)indices based on Niño 3 and Niño ***,we employed explainable Artificial Intelligence(XAI)models to identify the main patterns and feature importance of the six environmental variables and used information flow analysis to determine the causality between the selected factors and BeT ***,we analyzed Argo datasets to calculate the vertical,horizontal,and zonal mean temperature differences during CPeN and normal years to clarify the oceanic thermodynamic structure differences between the two types of *** findings reveal that BeT distribution during the CPeN years is mainly driven by advection feedback of subsurface warmer thermal signals and vertically warmer habitats in the CPeN domain area,especially in high-yield fishing *** high frequency of CPeN events will likely lead to the westward shift of fisheries centers.

关键词： bigeye tuna central-Pacific el Niño(CPeN) ocean heat content Argo explainable artificial intelligence(XAI) information flow

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regulation of insect behavior by non-coding rNAs

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Science China(Life Sciences) 2024年第6期67卷 1106-1118页

作者： Jing He le Kang State Key Laboratory of Integrated Management of Pest Insects and rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Sciences Chinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071002China

The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological *** the past several decades,accumulating studies have unveiled the roles of non-coding rNAs(nc rNAs)in regulating insect *** rNAs assume particularly pivotal roles in the behavioral plasticity of insects by rapidly responding to environmental *** rNAs also contribute to the maintenance of homeostasis of insects by fine-tuning the expression of target ***,a comprehensive review of nc rNAs'roles in regulating insect behaviors has yet to be ***,we present the recent progress in our understanding of how nc rNAs regulate various insect behaviors,including flight and movement,social behavior,reproduction,learning and memory,and *** refine the intricate mechanisms by which nc rNAs modulate the function of neural,motor,reproductive,and other physiological systems,as well as gene expression in insects like fruit flies,social insects,locusts,and ***,we discuss potential avenues for future studies in nc rNA-mediated insect behaviors.

关键词： ncrNAs insect behavior plasticity fine-tuning environmental adaptation

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A Comprehensive Survey of recent Transformers in Image,Video and Diffusion Models

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Computers, Materials & Continua 2024年第7期80卷 37-60页

作者： Dinh Phu Cuong le Dong Wang Viet-Tuan le College of Computer Science and electronic engineering Hunan UniversityChangsha410082China Faculty of Information Technology Yersin University of Da LatDa Lat66100Vietnam Faculty of Information Technology Ho Chi Minh City Open UniversityHo Chi Minh City722000Vietnam

Transformer models have emerged as dominant networks for various tasks in computer vision compared to Convolutional Neural Networks(CNNs).The transformers demonstrate the ability to model long-range dependencies by utilizing a self-attention *** study aims to provide a comprehensive survey of recent transformerbased approaches in image and video applications,as well as diffusion *** begin by discussing existing surveys of vision transformers and comparing them to this ***,we review the main components of a vanilla transformer network,including the self-attention mechanism,feed-forward network,position encoding,*** the main part of this survey,we review recent transformer-based models in three categories:Transformer for downstream tasks,Vision Transformer for Generation,and Vision Transformer for *** also provide a comprehensive overview of recent transformer models for video tasks and diffusion *** compare the performance of various hierarchical transformer networks for multiple tasks on popular benchmark ***,we explore some future research directions to further improve the field.

关键词： Transformer vision transformer self-attention hierarchical transformer diffusion models

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Boundless love:a German Professor Uli Schwarz in China

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Protein & Cell 2024年第8期15卷 553-558页

作者： le Kang State Key Laboratory of Integrated Management of Pest Insects and rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China

More than 20 years ago,an old German man embarked on a quest to explore the suburbs of Shanghai and the villages of jiangsu Province in search of antique Chinese *** was not a mere antique collector or aficionado of ancient furmiture,but a German scientist motivated by his profound love of Chinese *** name was Uli Schwarz(Fig.1),a distinguished German scientist who had dedicated the majority of his life to promoting cross-cultural scientific exchanges,an effort that left an indelible mark on the landscape of research collaborations between China and Germany.

关键词： Schwarz German landscape

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