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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang Zhong Li Shuang Lin Xiao-le.Chen Nan-Wen Zhang Qin Ye xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical Colle.e Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American Colle.e of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labele. ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was imple.ented to estimate the interaction between EphA2 and other le.s membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause le.s opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile.alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other le.s membrane *** mutant notably enhanced human le.s epithelial cell migration,and induced a central cloudy region and roughness in zebrafish le.ses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

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Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1259-1270页

作者： Gan-Bin Li Chen-Tong Wang Xiao Zhang Xiao-Yuan Qiu Wei-Jie Chen Jun-Yang Lu Lai xu Bin Wu YiXiao Guo-le.Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Intestinal flora disorder(IFD)poses a significant challe.ge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and *** To analyze the clinical features and risk factors of *** Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)*** on the occurrence of IFD,patients were categorized into IFD and non-IFD *** clinical characteristics and treatment approaches for patients with IFD were *** regression analysis was performed to identify the risk factors of *** The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,*** most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and *** patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ile.s tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective *** A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for *** attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics.

关键词： Colon cancer,Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors

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Anisotropic Plasmon Resonance Enable. Spatially Controlle. Photothermal and Photochemical Effects in Hot Carrier-Driven Catalysis

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Chinese Journal of Chemistry 2024年第16期42卷 1877-1885页

作者： Jiaqi Wang Zhijie Zhu Kai Feng Shuang Liu Yuxuan Zhou Ifra Urooj Jiari He Zhiyi Wu Jiahui Shen xu Hu Zhijie Chen xudong Dong Manzar Sohail Yanyun Ma Jinxing Chen Chaoran Li Xingda An le.He Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhouJiangsu 215123China Jiangsu Key Laboratory ofAdvanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsu 215123China Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Soochow UniversitySuzhouJiangsu 215123China Department of Chemistry School of Natural SciencesNational University of Sciences and TechnologyIslamabad 44000Pakistan

Localized surface plasmon resonance has been demonstrated to provide effective photophysical enhancement mechanisms in plasmonic ***,it remains highly challe.ging for distinct mechanisms to function in synergy for a colle.tive gain in catalysis due to the lack of spatiotemporal control of their ***,the anisotropic plasmon resonance nature of Au nanorods was exploited to achieve distinct functionality towards synergistic *** and photochemical effects were enable. by the longitudinal and transverse plasmon resonance modes,respectively,and were enhanced by partial coating of silica nanoshells and epitaxial growth of a reactor *** excitation le.ds to a synergistic gain in photothermal-mediated hot carrier-driven hydrogen evolution *** approach provides important design principle. for plasmonic photocatalysts in achieving spatiotemporal modulation of distinct photophysical enhancement *** also effectively broadens the sunlight response range and increases the efficacy of distinct plasmonic enhancement pathways towards solar energy harvesting and conversion.

关键词： Plasmon resonance Photothermal effect Photochemistry Photocatalysis Metal nanoparticle. Charge carrier injection Heterogeneous catalysis Photoele.trochemistry

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Aerodynamic characteristics of a pitching airfoil with le.ding-edge morphing

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Chinese Journal of Aeronautics 2024年第7期37卷 81-92页

作者： Chaoyuan WEN Yuting DAI Yuntao xu Chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Tianmushan Laboratory Hangzhou 311115China

This paper focuses on the effect of the phase offset of le.ding-Edge(le.morphing on the aerodynamic characteristics of a pitching NACA0012 *** an unstretched camber and using polynomial interpolation,an explicit expression for le.nonlinear morphing is proposed and imple.ented for the large pitching motion of the *** field results and aerodynamic forces are obtained by solving the unsteady Reynolds-averaged Navier-Stokes equations for both the airfoil’s pitching motion and le.***,the index of instantaneous aerodynamic power is used to quantify the work done by the airflow in a dynamic *** to the instantaneous aerodynamic power and energy map,which denotes the energy transfer between the airfoil’s oscillation and flow field,the airfoil is subject to stall *** results show that le.morphing with an optimal phase offset of 315°reduces the energy extraction from the flow field,suppressing the stall flutter *** optimal phase offset is effective at different pitching axis positions of the *** results signify that le.morphing can suppress stall flutter by advancing the occurrence of the first le.vortex and increasing the nose-down moment during the upstroke period.

关键词： Aerodynamics Computational fluid dynamics le.ding-edge morphing OpenFOAM Dynamic stall Dynamic mesh

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NiAl和Cu在40CrNi3MoV钢中的析出行为及其对力学性能的影响

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金属学报 2024年第2期60卷 201-210页

作者：梁恩溥徐乐王毛球时捷钢铁研究总院有限公司特殊钢研究院北京100081

为提高40CrNi3MoV钢的力学性能,在40CrNi3MoV钢中添加Al、Cu元素,研究了调质处理后实验用钢中的NiAl、Cu析出行为及其对力学性能的影响。利用SEM、TEM和EDS等手段表征了NiAl和Cu析出相的成分、结构、尺寸和形貌,通过三维原子探针(3DAP)... 详细信息

为提高40CrNi3MoV钢的力学性能,在40CrNi3MoV钢中添加Al、Cu元素,研究了调质处理后实验用钢中的NiAl、Cu析出行为及其对力学性能的影响。利用SEM、TEM和EDS等手段表征了NiAl和Cu析出相的成分、结构、尺寸和形貌,通过三维原子探针(3DAP)对析出相形成元素的分布特征进行表征,对比研究了实验用钢的力学性能。结果表明,只添加Al元素后实验用钢中形成与基体共格的B2-NiAl析出相,这些NiAl相主要在晶界处析出且尺寸较大;进一步添加Cu元素后,析出了与基体共格的bcc结构富Cu相,添加Cu后减少了大尺寸NiAl相在晶界处的析出,促进了晶内纳米级NiAl析出。实验用钢中的NiAl析出相和基体点阵错配度小,对抗拉强度提供了200 MPa强化增量;添加Cu后,均匀分布的细小富Cu相和被细化的NiAl相增加了对位错的阻碍作用,屈服强度进一步提高了200 MPa,然而大量细小高密度的NiAl和Cu析出相降低了拉伸过程中产生裂纹的临界应变,因此与只添加Al元素的实验用钢相比,抗拉强度并未提高。

关键词： 40CrNi3MoV钢 NiAl和Cu析出 3DAP 拉伸强度

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循证教育的哲学批判与建构

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大学教育科学 2024年第1期 50-57页

作者：徐乐乐何美姣广西师范大学教育学部桂林541004

循证教育理念正在逐渐深入教育各处脉络,对我国教育领域产生了多方面的影响。然而,循证教育理念是不完善的,这主要来源于其实证主义哲学本质所固有的理论困境。从教育本体论、认识论、方法论及伦理观四个维度探讨循证教育的局限性可以发... 详细信息

循证教育理念正在逐渐深入教育各处脉络,对我国教育领域产生了多方面的影响。然而,循证教育理念是不完善的,这主要来源于其实证主义哲学本质所固有的理论困境。从教育本体论、认识论、方法论及伦理观四个维度探讨循证教育的局限性可以发现:在本体论维度,循证教育是一种还原性实践,忽视教育的生成性;在认识论维度,循证教育追求“研究—实践”的确定性,忽视教育中的不确定性;在方法论维度,循证教育的“方法—目的”是一种线性关联,忽视教育中的非线性关联;在伦理观维度,循证教育遵循实践的技术命令,忽视教育中的价值维度。从以上四个维度对循证教育进行的批判和厘清,为建构其实践原则提供了理论前提。因此,循证教育完善自身要基于以下原则:引入教育判断力,实现人的主体性回归;注重证据的价值判断,以达致教育问题的本质;厘清“目的—方法”的主客位置,重视“目的—方法”的内在关联性;构建复杂性和规范性相统一的方法论体系,对教育进行整体性把握。

关键词：循证教育实证主义技术理性价值理性实践原则

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农村电商发展有助于碳减排吗?——来自淘宝村建设的证据

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中国人口·资源与环境 2024年第8期34卷 36-46页

作者：刘洋邵帅徐乐山东大学经济学院山东济南250100 华东理工大学商学院上海200237 上海财经大学自由贸易区研究院上海200433

农村电商作为数字技术在农村地区的重要渗透形式,其对乡村振兴与城乡均衡发展的积极作用已得到充分认可,但对于其能否助推实现“双碳”目标尚未得到广泛关注。明晰农村电商发展对碳减排的影响及其作用机制对于回应“数字乡村”建设能否... 详细信息

农村电商作为数字技术在农村地区的重要渗透形式,其对乡村振兴与城乡均衡发展的积极作用已得到充分认可,但对于其能否助推实现“双碳”目标尚未得到广泛关注。明晰农村电商发展对碳减排的影响及其作用机制对于回应“数字乡村”建设能否兼顾乡村振兴与低碳发展战略这一现实问题具有重要意义。鉴于淘宝村建设已经成为中国农村电商发展的缩影,该研究通过2014—2021年淘宝村数据与282个地级及以上城市面板数据的匹配,并使用对数平均迪氏指数法,将碳排放分解为技术进步效应、经济发展效应与人口规模效应,进而综合运用双向固定效应模型、工具变量法和空间计量模型,从淘宝村建设的视角对农村电商发展的碳减排效应及其作用机制进行了考察。结果显示,农村电商发展对碳减排具有积极作用,即农村电商发展可以兼顾乡村振兴与低碳发展战略。然而,农业类农村电商发展与工业类农村电商发展的碳减排效应具有明显的异质性,其中,农业类农村电商的发展可以有效降低碳排放,而工业类农村电商发展则不利于碳减排。同时,农村电商发展通过降低碳排放强度而对碳排放产生的抑制效应比其通过规模效应产生的碳排放促增作用更强,而农村电商发展对经济发展效应的作用并不显著,因而在总体层面表现出碳减排效应。此外,农村电商发展能够推动城乡人口与产业的再平衡,通过缓解城市化压力和抑制资本深化而助力碳减排。据此,该研究提出应以“数字乡村”建设为契机,通过调节城乡人口迁徙路径和合理规划城乡产业分布,协同推进“十四五”规划中的城乡均衡发展与低碳发展战略目标。

关键词：农村电商淘宝村建设碳减排数字乡村空间溢出效应

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Colle.tive decision-making and spatial patterns in orientation of an endemic ungulate on the Tibetan Plateau

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Current Zoology 2024年第1期70卷 45-58页

作者：严雪婷王旭赵雨梦祝芹杨乐李忠秋 Lab of Animal Behavior&Conservation School of Life SciencesNanjing UniversityNanjingJiangsu210023China Tibet Plateau Institute of Biology Lhasa850000China

Group living animals form striking aggregation patterns and display synchronization,polarization,and colle.tive *** many col-le.tive behavioral studies have been conducted on small animals like insects and fish,research on large animals is still rare due to the limited availability of field colle.tive *** used drones to record videos and analyzed the decision-making and behavioral spatial patterns in orienta-tion of Kiang(Tibetan wild ass,Equus kiang).le.dership is unevenly distributed among Kiang,with the minority initiating majority behavior-shift *** of individual to join are driven by imitation between group members,and are largely dependent on the number of members who have already *** respond to the behavior and position of neighbors through different *** strongly polarize when moving,therefore adopting a linear *** vigilant,orientation deviation increases as they form a tighter *** remain scattered while.feeding and,in that context,adopt a side-by-side *** study reveals partially-shared decision-making among Kiang,whereby copying neighbors provides the wisdom to thrive in harsh *** study also suggests that animals'spatial patterns in orientation depend largely ontheirbehavioral states inachieving synchronization.

关键词： decision-making imitation spatial position Tibetan wild ass

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建构印度教民族认同与他者——印度历史教科书中的涉华叙事解析

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南亚研究 2024年第1期 24-52,154,155页

作者：王旭乐石滢北京大学外国语学院南亚学系

印人党政府2014年执政以来在历史教科书中书写了一系列涉华叙事。本研究选取了印度五个邦的四语种历史教科书展开对比研究,基于民族认同、他者建构理论,解析印度教民族主义话语体系中的涉华叙事,发现教科书中存在涉藏、中印对抗、新中... 详细信息

印人党政府2014年执政以来在历史教科书中书写了一系列涉华叙事。本研究选取了印度五个邦的四语种历史教科书展开对比研究,基于民族认同、他者建构理论,解析印度教民族主义话语体系中的涉华叙事,发现教科书中存在涉藏、中印对抗、新中国政权三类叙事。涉藏叙事主要服务于民族认同建构,历经了古代印度教神话、近代印度教社会改革思想、“大印度”研究三个阶段的演变,最终参与民族诗意空间和黄金年代建构,实现大众动员。后两类叙事与三重他者建构相关,与印度教民族主义政治议程高度耦合:中印边界冲突导致中国被建构为印度教民族的主要他者;中巴关系走近催生中国的次要他者性;此外,中国也被建构为印度在东方的他者,印度从而与殖民主义建构的某些东方性特质划清界限,在现代化进程中确定自身在民族国家世界中的位置和目标,但这一做法却未能摆脱殖民主义的规训。涉华叙事推动印度对华认知更趋负面,为更强硬的对华政策提供理论基础,全面影响印度内政外交的涉华议题。

关键词：印度教民族主义历史教科书涉华叙事中印关系

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Research Progress of Zhuang Medicine Combined with Nanogels in Mastitis

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Agricultural Biotechnology 2024年第2期13卷 68-71页

作者： Liying xu Chunling YANG Yeting le.Lianzhi TAN Liying TAN Ting LIU Guangxi University of Chinese Medicine Nanning 530001China

Mastitis is a common and frequently-occurring disease among Chinese women, which seriously harms their mental and physical health. External application of Zhuang medicine has the effects of dredging collaterals, relieving pain, promoting blood circulation, removing blood stasis, and softening hardness to dissipate stagnation, and show definite curative effect in preventing and treating breast diseases. Nano-composite hydrogels have the advantages of small toxic and side effects, high bioavailability, high targeting and controllable.drug rele.se. Therefore, this paper summarized and analyzed rele.ant literature of Zhuang medicine in treating breast diseases and clinical research of nanogels, providing new ideas and scientific basis for the treatment of mastitis with Zhuang medicine combined with nanogels.

关键词： Mastitis Zhuang medicine Nanogel Overview

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