检索结果-南通市图书馆

不同剂量替格瑞洛治疗ST段抬高型心肌梗死患者的有效性和安全性:基于倾向性评分匹配

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2025年第3期28卷 372-378页

作者：汪雁博苏利芳刘畅畅周庆田佳支伟傅阳谷新顺河北医科大学第二医院心血管内五科河北省石家庄市050000

背景双联抗血小板治疗是接受直接经皮冠状动脉介入治疗(PPCI)的ST段抬高型心肌梗死(STEMI)患者治疗的基础。阿司匹林联合替格瑞洛是STEMI患者抗血小板治疗的首选方案,与氯吡格雷相比,其能够更快、更有效地抑制血小板,并改善预后。但是... 详细信息

背景双联抗血小板治疗是接受直接经皮冠状动脉介入治疗(PPCI)的ST段抬高型心肌梗死(STEMI)患者治疗的基础。阿司匹林联合替格瑞洛是STEMI患者抗血小板治疗的首选方案,与氯吡格雷相比,其能够更快、更有效地抑制血小板,并改善预后。但是尚缺乏在接受PPCI治疗的STEMI患者中应用减量替格瑞洛的研究。目的基于倾向性评分匹配(PSM)的方法,对比分析不同剂量替格瑞洛治疗STEMI患者的有效性和安全性。方法连续选取2019年6月—2021年5月在河北医科大学第二医院心血管内五科行PPCI并接受替格瑞洛治疗的STEMI患者为研究对象。根据应用替格瑞洛的维持剂量将患者分为减量组(60例:替格瑞洛60 mg/次,2次/d)和标准组(180例:替格瑞洛90 mg/次,2次/d)。采用PSM法对两组患者进行1∶1匹配,匹配变量包括性别、年龄、既往病史、入院时Killip分级和介入治疗相关参数等,最终减量组和标准组各纳入54例患者。分别于出院1、3、6个月时,对两组患者进行随访,记录和比较两组患者血小板功能相关参数和临床事件的发生情况。结果PSM后两组患者基线资料、介入治疗参数和住院期间主要不良心血管事件发生率比较,差异均无统计学意义(P>0.05)。基线时,两组患者血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)比较,差异均无统计学意义(P>0.05);减量组患者血小板聚集率(PAR)低于标准组(P0.05)。出院3个月时,减量组患者PDW高于标准组(P0.05)。减量组、标准组患者出院时MPV高于基线,减量组患者出院时PDW低于基线,标准组患者出院时PAR低于基线(P0.05)。结论在接受PPCI的STEMI患者中替格瑞洛60 mg治疗是安全有效的。

关键词： ST段抬高型心肌梗死经皮冠状动脉介入治疗替格瑞洛血小板主要不良心血管事件倾向性评分匹配

维普期刊数据库博看期刊

Hollow glass microspheres/silicone rubber composite materials toward materials for high performance deep in-situ temperaturepreserved coring

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2022年第1期19卷 309-320页

作者： Jian-Ping yang Ling Chen Xiao-Bin gu zhi-Yu Zhao Cheng-Hang fu Dong-Sheng yang Dong-Zhuang tian zhi-Sheng Chen He-Ping Xie College of Polymer Science and Engineering Sichuan UniversityChengdu610065China guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China School of Mechanical Engineering Sichuan UniversityChengdu610065China Jinshi Drilltech Company Limited Tangshan063004Hebei Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu610065China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'an710077China

Deep petroleum resources are stored under high temperature and pressure conditions,with the temperature having a significant influence on the properties of *** in-situ temperature-preserved coring(ITP-coring)devices were developed to assess deep petroleum reserves ***,hollow glass microspheres(HGMs)/silicone rubber(SR)composites that exhibit excellent thermal insulation properties were prepared as thermal insulation materials for deep ITP-coring *** mechanism and process of heat transfer in the composites were explored,as well as their other *** results show that the HGMs exhibit good compatibility with the SR *** the volume fraction of the HGMs is increased to 50%,the density of the HGMs/SR composites is reduced from 0.97 to 0.56 g/cm^(3).The HGMs filler introduces large voids into the composites,reducing their thermal conductivity to 0.11 W/m·*** addition of HGMs into the composites further enhances the thermal stability of the SR,wherein the higher the HGMs filler content,the better the thermal stability of the *** significantly enhance the mechanical strength of the *** increase the compressive strength of the composites by 828%and the tensile strength by 164%.Overall,HGMs improve the thermal insulation,pressure resistance,and thermal stability of HGMs/SR composites.

关键词： In-situ temperature-preserved coring(ITP-coring) Deep in-situ conditions Thermal insulation materials HGMs/SR composites

[Solid-phase extraction coupled with high performance liquid chromatography-triple quadrupole mass spectrometry for simultaneous determination of seven coumarins in water samples from drinking water treatment plants]

在线全文

学校读者我要写书评

暂无评论

Se pu = Chinese journal of chromatography 2025年第1期43卷 78-86页

作者： Wen-Mei Jiao Jing-Ming yang Ce Xu fu-Kang Gao Lu-Yao Shen Yu-Bo Yuan zhi-Fen guo guang Huang School of Life Sciences and Chemical Engineering Jiangsu Second Normal University Nanjing 211200 China. School of Stomatology Nanjing Medical University Nanjing 210029 China. School of Public Health Nanjing Medical University Nanjing 211166 China. Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University Nanjing 211166 China.

Chlorinated coumarins, which are as cytotoxic as highly toxic halobenzoquinones toward CHO-K1 cells, have recently been identified as disinfection byproducts in drinking water disinfection processes. Therefore, detecting coumarins in water samples collected at various stages from drinking water treatment plants helps assess the formation of chlorinated coumarins in drinking water. Hence, a simple, rapid, accurate, and sensitive method for quantifying coumarins in water samples is required. In this study, a method was developed based on solid-phase extraction coupled with high performance liquid chromatography-triple-quadrupole mass spectrometry for analyzing seven coumarins in water samples from drinking water treatment plants, including 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, 8-chloro-7-hydroxycoumarin, coumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin. Sample pretreatment involved solid-phase extraction using HLB columns, followed by elution with water and methanol, each containing 0.25% formic acid. The extracted solution was separated via gradient elution using a Phenomenex Luna C18 column (100 mm×2.0 mm, 3 mm) with 0.1% formic acid aqueous solution and methanol as the mobile phases, with analytes detected by triple-quadrupole mass spectrometry equipped with electrospray ionization source in multiple reaction monitoring mode. The matrix effect, precision, and accuracy of the developed method were investigated using raw and treated water as matrices. Matrix effects of 0.84-1.12 were recorded for the detection of 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, and coumarin in raw water, while values of 0.67-0.70 were recorded for 8-chloro-7-hydroxycoumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin in finished water. The three chlorinated coumarins exhibited matrix effects above 0.80 after the finished water matrix had been diluted four times. These re

关键词： coumarins disinfection byproducts drinking water high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) solid-phase extraction (SPE)

An Innovative Approach to Separate Iron Oxide Concentrate from High-sulfur and Low-grade Pyrite Cinders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2016年第8期23卷 756-764页

作者： Yong LI fu-chun ZHOU Zhao-xin ZHOU zhi-han tian Chao yang Xi-ke tian Faculty of Materials Science and Chemistry China University of Geosciences

High-sulfur and low-grade pyrite cinders are the waste products of sulfuric acid manufacturing *** valuable components,such as iron oxide,are contained in pyrite cinders and difficult to be separated and purified just via the high temperature roasting *** this,an innovative method including water-washing,aqua regia leaching,hydrothermal alkali activation and acid-washing was *** the effects of different parameters on recovery efficiency of iron oxide were systematically *** optimum parameters were proposed as follows：water rinse-leaching at room temperature for 5-20 min,and melting at 160 ℃ for 2.0h with NaOH（concentration of 30mass%）,followed by leaching with aqua regia solution（3.0vol.%）for *** the treatment,the content of iron oxides increased from 54.3to 96.0mass% with the recovery rate exceeding 85%.Meanwhile,calcium sulphate was recovered as the high value-added products by alkali extraction ***,the phase transformation and microstructure of the samples in the process were studied by physicochemical methods to reveal the separation mechanisms of different components in the pyrite cinders.

关键词： sulfur leaching contained alkali regia pyrite recovered hydrothermal systematically leached

An improved deep forest model for forecast the outdoor atmospheric corrosion rate of low-alloy steels

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第14期47卷 202-210页

作者： Yuanjie zhi Tao yang Dongmei fu School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Beijing Engineering Research Center of Industrial Spectrum Imaging University of Science and Technology BeijingBeijing 100083China

The paper proposes a new deep structure model,called Densely Connected Cascade Forest-Weighted K Nearest Neighbors(DCCF-WKNNs),to implement the corrosion data modelling and corrosion ***,we collect 409 outdoor atmospheric corrosion samples of low-alloy steels as experiment ***,we give the proposed methods process,including random forests-K nearest neighbors(RF-WKNNs)and ***,we use the collected datasets to verify the performance of the proposed *** results show that compared with commonly used and advanced machine-learning algorithms such as artificial neural network(ANN),support vector regression(SVR),random forests(RF),and cascade forests(cForest),the proposed method can obtain the best prediction *** addition,the method can predict the corrosion rates with variations of any one single environmental variable,like pH,temperature,relative humidity,SO2,rainfall or Cl-.By this way,the threshold of each variable,upon which the corrosion rate may have a large change,can be further obtained.

关键词： Random forests Deep forest model Low-alloy steels Outdoor atmospheric corrosion Prediction and data-mining

Faceted interfaces: a key feature to quantitative understanding of transformation morphology

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2016年第1期2卷 44-57页

作者： Wen-Zheng Zhang Xin-fu gu fu-zhi Dai School of Materials Science and Engineering Tsinghua UniversityBeijingChina Institute for Materials Research Tohoku UniversitySendaiJapan Science and Technology on Advanced functional Composite Laboratory Aerospace Research Institute of Materials and Processing TechnologyBeijingChina

Faceted interfaces are a typical key feature of the morphology of many microstructures generated from solid-state phase ***,prediction and simulation of this faceted morphology remain a challenge,especially for systems where irrational orientation relationships(ORs)between two phases and irrational interface orientations(IOs)are *** terms of structural singularities,this work suggests an integrated framework,which possibly encompasses all candidates of faceted *** structural singularities are identified from a matching pattern,a dislocation structure and/or a ledge *** resultant singular interfaces have discrete IOs,described with low-index g’s(rational orientations)and/orΔg’s(either rational or irrational orientations).Various existing models are grouped according to their determined results regarding the OR and IO,and the links between the models are clarified in the integrated *** of defect types as far as possible in a dominant singular interface often exerts a central restriction on the *** irrational IO is usually due to the elimination of dislocations in one direction,i.e.,an O-line *** methods using both three-dimensional and two-dimensional models for quantitative determinations of O-line interfaces are reviewed,and a detailed example showing the calculation for an irrational interface is *** association between structural singularities and local energy minima is verified by atomistic calculations of interfacial energies in fcc/bcc alloys where it is found that the calculated equilibrium cross-sections are in a good agreement with observations from selected alloys.

关键词： transformation rational interface

Arc Behavior and Droplet Transfer of CWW CO_2 Welding

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2016年第8期23卷 808-814页

作者： zhi-dong yang Chen-fu FANG Yong CHEN guo-xiang XU Qing-xian HU Xiao-yan gu School of Materials Science and Engineering Jiangsu University of Science and Technology

Cable-type welding wire（CWW）CO2 welding is an innovative process arc welding with high quality,high efficiency and energy saving,in which CWW is used as consumable *** CWW is composed of seven wires with a diameter of *** is in the center,while others uniformly distribute around *** diameter of twisted wire is up to 3.6mm,which can increase the deposition rate *** continual wire-feeding and melting of CWW,the formed rotating arc improved welding quality *** arc behavior and droplet transfer were observed by the electrical signal waveforms and corresponding synchronous images,based on the high speed digital camera and electrical signal *** results showed that the shape of welding arc changed from bell arc to beam arc with the increase of welding *** droplet transfer mode changed from repelled transfer,globular transfer to projected transfer in *** transfer frequency increased from 18.17 Hz to 119.05 Hz,while the droplet diameter decreased from 1.5times to 0.3times of the CWW diameter.

关键词： welding Welding droplet camera rotating projected melting distribute innovative frames

Influence of carbon addition on mechanical properties of Fe-Mn-C twinning-induced plasticity steels

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第9期29卷 1446-1454页

作者： Peng fu zhi-bing Zheng Wei-ping yang Hao-kun yang School of Engineering Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Institute of New Materials GuangdongAcademy of SciencesGuangdong Provincial iron Matrix Composite Engineering Research CenterGuangzhou 510650GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077.China

Mechanical properties and microstructural evolution of Fe-22Mn-0.6C and Fe-22Mn-1.0C(wt.%)twinning-induced plasticity(TwIP)steels were investigated by monotonic,stress-relaxation and unloading-reloading tensile *** dynamic strain aging(DSA)effect,resulting from pinning of dislocations,effectively improved the dislocation activation volume of the two TWIP *** the meanwhile,DSA-facilitated twinning nucleation mechanism kept similar twinning capabilities of the two TWIP *** strain increasing,the formation of high-density deformation twins restricted the dislocation motion and reduced the activation volume with increasing ***,C addition simultaneously improved the ultimate tensile strength and uniform elongation,and significantly enhanced the friction stress,rather than back *** stronger short-range order effect,brought by friction stress,promotes the planar dislocation slipping,thus improving the work-hardening *** a result,the additional work-hardening capacity can be achieved in Fe-Mn-C with higher C addition.

关键词： Twinning induced plasticity steel Work-hardening rate Dynamic strain aging Short-range order Deformation twin

In situ observation of the effect of Al N particles on bainitic transformation in a carbide-free medium carbon steel

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 620-629页

作者： Xiao-jie Zhao zhi-nan yang fu-cheng Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004China

The bainitic transformation of the steels with different mass fractions of N, ~0.002% and 0.021%, was observed in situ by using high-temperature metalloscope. Micrometer-and nanometer-sized aluminum nitride(AlN) particles were found in the steel with 0.021% *** boundaries, the interior of the grains, and Al N particles were used as initial nucleation sites of bainitic ferrite, and bainitic ferrite subunits served as new nucleation sites to induce secondary nucleation. The lengthening rate of bainitic ferrite varied at different nucleation sites, which was controlled by the repeated nucleation and growth of bainitic subunits. The Al N particles not only provided several nucleation sites, but also increased the autocatalytic effect on the transformation, further shortening the incubation period, promoting the bainitic transformation, and refining the bainitic microstructure.

关键词： bainitic steel In situ observation phase transformation aluminum nitride