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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan ying-Shi Zou ying-Lin Yu le-yi hu Ting Zhang hui Chen Ling Jin Duo-Ru Lin yi-Zhi Liu Hao-Tian Lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[le the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022:a scientometric analysis

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国际眼科杂志:英文版 2023年第10期16卷 1682-1691页

作者： Yuan Tan Wei Jiang le-yi hu Yan-Yu Shen hui Chen ying-Shi Zou Li-Xia Luo Guang-Ming Jin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Zhongshan Medical School Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the hotspots and frontiers of genetic research on pediatric ***:Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection,and were analyzed in terms of the publication counts,countries,journals,authors,keywords,cited references,subject categories,and the underlying hotspots and ***:Totally 699 publications were included in the final *** predominant actors were identified,with China(n=240)and PLoS One(n=33)being the most productive country and journal *** research hotspots extracted from keywords were crystallin gene mutations,pathogenicity evaluation,phenotypes of ocular and neurodevelopmental abnormalities,genes encoding membrane proteins,and diagnosis of multisystemic *** co-cited articles formed 10 clusters of research topics,including FYCO1(56 items),mutation screening(43 items),gap junction(29 items),the Warburg Micro syndrome(29 items),ephrin-A5(28 items),novel mutation(24 items),eye development and function(22 items),cholestanol(7 items),OCRL(6 items),and pathogenicity prediction(3 items).The research frontiers were FYCO1,ephrin-A5,and *** biology showed the strongest bridging effects among different disciplines in the field(betweenness centrality=0.44).CONCLUSION:With the progress in next-generation sequencing and multidisciplinary collaboration,genetic research on pediatric cataracts broadens the knowledge scope of the crystalline lens,as well as other organs and systems,shedding light on the molecular mechanisms of systemic *** biology may integrate multidisciplinary content to address cutting-edge issues in the field.

关键词： gene pediatric cataract next generation sequencing genotype phenotype association

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Outlier-resistant distributed fusion filtering for nonlinear discrete-time singular systems under a dynamic event-triggered scheme

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 237-249页

作者： Zhibin hu Jun hu Cai CHEN Hongjian LIU Xiaojian yi Department of Applied Mathematics Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and TechnologyHarbin150080China School of Automation Harbin University of Science and TechnologyHarbin150080China School of Mathematics and Physics Anhui Polytechnic UniversityWuhu241000China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing314003China Tangshan Research Institute Beijing Institute of TechnologyTangshan063099China

This paper investigates the problem of outlier-resistant distributed fusion filtering(DFF)for a class of multi-sensor nonlinear singular systems(MSNSSs)under a dynamic event-triggered scheme(DETS).To relieve the effect of measurement outliers in data transmission,a self-adaptive saturation function is ***,to further reduce the energy consumption of each sensor node and improve the efficiency of resource utilization,a DETS is adopted to regulate the frequency of data *** the addressed MSNSSs,our purpose is to construct the local outlier-resistant filter under the effects of the measurement outliers and the DETS;the local upper bound(UB)on the filtering error covariance(FEC)is derived by solving the difference equations and minimized by designing proper filter ***,according to the local filters and their UBs,a DFF algorithm is presented in terms of the inverse covariance intersection fusion *** such,the proposed DFF algorithm has the advantages of reducing the frequency of data transmission and the impact of measurement outliers,thereby improving the estimation ***,the uniform boundedness of the filtering error is discussed and a corresponding sufficient condition is ***,the validity of the developed algorithm is checked using a simulation example.

关键词： Distributed fusion filtering Multi-sensor nonlinear singular systems Dynamic event-triggered scheme Outlier-resistant filter Uniform boundedness

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Land use effects on the dynamics of soil C,N and microbes in the water-wind erosion crisscross region of the northern Loess Plateau,China

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Pedosphere 2024年第1期34卷 181-190页

作者： yi WANG Chunyue LI Shunjin hu State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationNorthwest A&F UniversityYangling 712100China School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China Department of Entomology&Plant Pathology North Carolina State UniversityRaleigh 27695USA

The water-wind erosion crisscross region of the northern Loess Plateau in China is under constant pressure from severe erosion due to its windy and dry climate and intensive human activities. Identifying sustainable land use patterns is key to maintaining ecosystem sustainability in the area. Our aim was to appraise the impacts of different land use regimes on the dynamics of soil total organic C(TOC), total N(TN), and microbes in a typical watershed in the northern Loess Plateau to identify suitable land use types that can maintain soil fertility and sustainability. A field experiment was performed in Liudaogou watershed in Shenmu City, Shaanxi Province, China, where the dynamics of soil TOC and TN, microbial biomass C and N, microbial respiration, and net N mineralization in six typical land use types, dam land, rainfed slope land, deciduous broadleaf forest, evergreen coniferous forest, shrubland, and grassland,were measured in three different growing seasons. Land use type and season significantly affected TOC, TN, and the dynamics of microbial biomass and activity. As the most anthropogenically disturbed land use pattern, dam land was an optimal land use pattern for TOC sequestration due to its higher TOC and TN, but lower microbial activity. Soil TOC, TN, and microbial properties demonstrated a decreasing trend after natural grassland was converted to shrubland,forest, and rainfed slope land. Shrubland with exotic N-fixing Korshinsk peashrub(Caragana korshinskii Kom.) can maintain TOC, TN, and microbial properties similar to those in grassland. Soil TOC, NH_(4+)^(-)N, TN, moisture, and extractable C were the principal indexes for soil microbial biomass and activity and explained 88.90% of the total variance. Thus, grassland was the optimal land use pattern in the water-wind erosion crisscross region of the northern Loess Plateau to maintain ecosystem stability and sustainability.

关键词： grassland microbial activity microbial biomass total organic C total N watershed

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Effects of the urban landscape on heatwave-mortality associations in Hong Kong: comparison of different heatwave definitions

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 145-156页

作者： Jinglu Song yi Lu Thomas Fischer Kejia hu Department of Urban Planning and Design Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Architecture and Civil Engineering City University of Hong KongKowloon TongHong Kong 999077China Environmental Assessment and Management Research Centre School of Environmental SciencesUniversity of LiverpoolLiverpool L35TRUK Research Unit for Environmental Sciences and Management Faculty of Natural and Agricultural SciencesNorth West UniversityPotchefstroom 31750South Africa Institute of Big Data in Health Science School of Public HealthZhejiang UniversityZijingang CampusHangzhou 310058China

Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.

关键词： Urban landscape Heatwave Mortality Effect modification Intra-urban differences Health risk reduction

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Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

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Communications in Theoretical Physics 2024年第4期76卷 167-175页

作者： Xingyu Qi Zilong Guo Shimin le hu Chen Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

Force spectrum measurements with constant loading rates are widely used in single-molecule manipulation experiments to study the mechanical stability and force response of ***-dependent transition rates can be obtained from the transition force distribution,but it is limited to the force range with non-zero force *** constant loading rate control can be realized with magnetic tweezers,the loading rate range is limited due to the slow movement of permanent ***-linear exponential and exponential squared force loading functions are more feasible in magnetic tweezers,while there is no theoretical result available for these two kinds of non-linear force loading *** this study,we solved the unfolding process of a protein following Bell's model under nonlinear exponential and exponential squared force loading functions,which offer a broader range of unfolding force distribution compared to the traditional constant loading rate ***,we derived two force loading functions,which can produce uniform unfolding force *** research contributes fundamental equations for the analysis of experimental data obtained through single-molecule manipulation under nonlinear force loading controls,paving the way for the use of nonlinear force control in magnetic tweezer experiments.

关键词： single-molecule manipulation magnetic tweezers force loading transition rates force distribution

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High-order time-reversal symmetry breaking normal state

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 136-148页

作者： Meng Zeng Lun-hui hu Hong-Ye hu yi-Zhuang You Congjun Wu Department of Physics University of CaliforniaSan DiegoCalifornia 92093USA Department of Physics Zhejiang UniversityHangzhou 310058China New Cornerstone Science Laboratory Department of PhysicsSchoolof ScienceWestlake UniversityHangzhou 30024China Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional *** two superconducting gap functions with different symmetries compete,the relative phase channel(θ_(-)≡θ_(1)-θ_(2))exhibits an Ising-type Z_(2) symmetry due to the second order Josephson coupling,where θ_(1,2) are the phases of two gap *** contrast,the U(1) symmetry in the channel of θ_(+)≡(θ_(1)+θ_(2))/2 is *** phase locking,i.e.,ordering of θ_(-),can take place in the phase fluctuation regime before the onset of superconductivity,i.e.,when θ_(+) is *** θ_(-) is pinned at ±π/2,then timereversal symmetry is broken in the normal state,otherwise,if θ_(-)=0,or,π,rotational symmetry is broken,leading to a nematic normal *** both cases,the order parameters possess a 4-fermion structure beyond the scope of mean-field theory,which can be viewed as a high order symmetry *** employ an effective two-component XY-model assisted by a renormalization group analysis to address this *** a natural by-product,we also find the other interesting intermediate phase corresponds to ordering of θ_+ but with θ_(-)*** is the quartetting,or,charge-4e,superconductivity,which occurs above the low temperature Z_(2)-breaking charge-2e superconducting *** results provide useful guidance for studying novel symmetry breaking phases in strongly correlated superconductors.

关键词： superconductivity strong correlation time-reversal breaking charge-4e

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Improved Reall-Santos method for AdS black holes in general 4-derivative gravities

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 74-86页

作者： Peng-Ju hu Liang Ma Hong Lu yi Pang Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Peng huanwu Center for Fundamental Theory Hefei 230026China

For asymptotically flat black holes,Reall-Santos method is a convenient tool to compute leading higher derivative corrections to the thermodynamic quantities without actually solving the modified field ***,there are subtleties in its generalization to asymptotically AdS black holes with general higher derivative *** of all,it is necessary to know all the higher derivative holographic counterterms and the surface terms implementing the variational principle and subtracting the *** then needs to solve for the modified AdS radius and rescale the time coordinate in an appropriate way such that the induced metric on the conformal boundary of AdS black hole is not *** observe that Reall-Santos method can be directly applied to a particular 4-derivative gravity model,known as the Einstein-Weyl gravity,which does not modify the AdS radius and requires only the Gibbons-Hawking-York term and holographic counterterms for the 2-derivative *** thus suggest that to compute the thermodynamic quantities of AdS black holes in general 4-derivative theories of gravity,one simply needs to transform it to a Einstein-Weyl gravity with identical thermodynamic variables by appropriate field *** explicitly verify this proposal with spherically-symmetric and static charged black holes in Einstein-Maxwell theory extended with generic 4-derivative interactions.

关键词： black holes thermodynamics higher-derivative corrections effective theories higher dimensional black holes quantum gravity

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Photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na

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Science China Chemistry 2024年第2期67卷 587-594页

作者： Fangming Chen Lvqi Jiang Chunyang hu Jie Liu Wenbin yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai200032China

Since the first report of sodium trifluoromethanesulfinate(CF_(3)SO_(2)Na) as an electrophilic trifluoromethylthiolation reagent in 2015,there has been no breakthrough in research in this ***,we disclose an unprecedented usage of CF_(3)SO_(2)Na as a radical trifluoromethylthiolation reagent.A photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na in the presence of PPh_(3) and catalytic copper has been ***,either Ir[(p-Fppy)_(2)(bpy)]PF_6 or Ir(ppy)_(3) could facilitate this *** studies indicate that initiation of the radical chain proceeded via two different photocatalytic quenching *** protocol provides a practical method for the construction of diverse vicinal ditrifluoromethylthiolated compounds.

关键词： trifluoromethylthiolation photocatalysis radical difunctionalization alkenes

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Advances and challenges in artificial intelligence text generation

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 64-83页

作者： Bing LI Peng YANG Yuankang SUN Zhongjian hu Meng yi School of Computer Science and Engineering Southeast UniversityNanjing 210000China Key Laboratory of Computer Network and Information Integration Ministry of EducationSoutheast UniversityNanjing 210000China

Text generation is an essential research area in artificial intelligence(AI)technology and natural language processing and provides key technical support for the rapid development of AI-generated content(AIGC).It is based on technologies such as natural language processing,machine learning,and deep learning,which enable learning language rules through training models to automatically generate text that meets grammatical and semantic *** this paper,we sort and systematically summarize the main research progress in text generation and review recent text generation papers,focusing on presenting a detailed understanding of the technical *** addition,several typical text generation application systems are ***,we address some challenges and future directions in AI text *** conclude that improving the quality,quantity,interactivity,and adaptability of generated text can help fundamentally advance AI text generation development.

关键词： AI text generation Natural language processing Machine learning Deep learning

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