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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： yang le Mei ZHENG Qi LIU Xiao Jia LI xian xian Veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Polyoxometalates-derived ternary metal oxides electrocatalyst for N_(2) reduction under ambient conditions

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Tungsten 2024年第2期6卷 428-437页

作者： Meng-le yang Zhong-Xin Jin Xi-xian Cao Xin-Ming Wang Hui-Yuan Ma Hai-Jun Pang Gui-Xin yang The School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China

Accelerating the breaking of the nitrogen nonpolar bond(N≡N)is an important factor to improve the effi ciency of the electro-catalytic nitrogen reduction reaction(e-NRR).In this work,polyoxometalates-derived FeMo-based ternary oxide materials MoO_(2)-Mo_(4)O_(11)-FeMoO_(4)@X(abbreviated as MoFeO@X,X represents the synthesis temperature of 650,750 and 850℃)were designed and synthesized for e-NRR under ambient *** scanning electron microscopy images of MoFeO@750 show an ellipsoidal-like structure(0.86×0.6μm).The relatively large specifi c surface area,formation of multiple interfaces,together with the synergistic eff ect of iron and molybdenum bimetals,would make MoFeO@X catalyst more easily absorb and activate N_(2)in the ***,the synthesized MoFeO@750 shows an optimal NH_(3)production rate of 16.57μg·h^(−1)·mg cat.^(−1)and Faradaic effi ciency of 12.33%at−0.3 V versus reversible hydrogen electrode(ν***),with outstanding electrochemical and structural stability.

关键词： Polyoxometalates Electrocatalytic nitrogen reduction reaction Ternary oxide Electrocatalyst

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Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

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World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： le-yang Li Song-Mei Li Bo-xian Pang Jun-Ping Wei Qiu-Hong Wang Department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The PubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,P=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,Pleukin-6(IL-6)(SMD:-1.31;95%CI:-2.07 to-0.55,P=0.0007),C-reactive protein(CRP)(SMD:-0.64;95%CI:-1.21 to-0.08,P=0.03),and leptin(SMD:-3.43;95%CI:-5.82 to-1.05,P=0.005)in overweight and obese *** training increased adiponectin levels(SMD:1.24;95%CI:0.30 to 2.18,P=0.01)but did not improve tumor necrosis factor-alpha(TNF-α)levels(SMD:-0.80;95%CI:-1.77 to 0.18,P=0.11).CONCLUSION In summary,exercise therapy improves glucose metabolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRP,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

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Measurement of Superconductivity and Edge States in Topological Superconductor Candidate TaSe_(3)

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Chinese Physics letters 2021年第7期38卷 110-115页

作者： Shuai Liu Si-Min Nie Yan-Peng Qi Yan-Feng Guo Hong-Tao Yuan le-xian yang Yu-Lin Chen Mei-Xiao Wang Zhong-Kai Liu School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Beijing 100084China Department of Physics University of OxfordOxfordOX13PUUK ShanghaiTech Laboratory for Topological Physics Shanghai 201210China

Topological superconductors(TSCs)have been widely investigated in recent years due to their novel physics and ability to host Majorana fermions(MFs)which are key to topological quantum *** the great interest,only a few compounds have been proposed as candidates of intrinsic TSCs,such as iron-based superconductor FeSe_(0.55)Te_(0.45) and 2M-WS_(2).Among them,quasi-one-dimensional superconductor TaSe_(3) possesses fascinating properties such as its simple stoichiometry,layered nature and chemical ***,using scanning tunneling microscope/spectroscopy(STM/STS),we systematically investigate the topography and electronic structure of TaSe_(3).Our STM/STS measurement reveals large atomically flat,defect-free surfaces suitable for the search of MF;electronic density of states consistent with our angle-resolved photoemission result and band-structure calculations,and a uniform superconducting gap with a typical size of∼0.25 ***,additional edge states are observed in the vicinity of the terrace edge,suggesting they may have a topological *** result proves the coexistence of superconductivity and topological electronic structure in TaSe_(3),making it an intriguing platform to investigate topological superconductivity.

关键词： stability topological superconductor

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Hybrid electromechanical properties of hetero-doped and homogeneously bonded dual-mode pressure sensor for indoor body area network node

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Science China(Information Sciences) 2024年第1期67卷 240-253页

作者： Junbin YU Shuai xian Jinbiao MU Min WANG Yin WANG Xiaojuan HOU le ZHANG Jian HE Jiliang MU Xiujian CHOU Science and Technology on Electronic Test and Measurement Laboratory North University of China Sichuan Aerospace Fenghuo Servo Control Technology Corporation

Pressure sensors are considerably important for continuous monitoring of human movement and the surrounding environment to construct a caregiving system for the elderly living *** challenge for pressure sensors that still remains is combining self-driven,comfort,and ***,an all-in-one conformal pressure sensor(ACPS) based on a homogeneous integrated triboelectric-piezoelectric hybrid sensor is *** ACPS has dual-mode sensing properties due to coupling triboelectrification and piezoelectric effect ensuring a stable response to various external ***-coated glass microspheres and polyacrylonitrile were uniformly filleted into the silicone rubber substrate using a hetero-doping method to create a stretchable electrode layer with flexible conformal characteristics and a piezoelectric layer with excellent piezoelectric properties,***,the triboelectric layer was fabricated using the same silicone rubber,allowing ACPS to be homogeneously bonded into an all-in-one structure with reliable *** allowed various functional layers to have outstanding interface characteristics and thus improve the electrical transmission *** developed ACPS had outstanding sensitivity(1.04 V/104Pa),high linearity(about 0.984),a wide measurement range(10–700 k Pa),and can accurately and continuously distinguish multiple ***,using a homemade signal processing circuit,ACPSs can be deployed in the human body and the room as indoor body area network *** successfully applied to the remote tracking of daily dynamic home life and the remote operation of small electrical equipment,these ACPSs can achieve real-time caregiving for the elderly living *** an application area desperately needed by society,this study envisions a caregiving system for the elderly living alone without violating personal privacy.

关键词： dual-mode pressure sensor homogeneous bonding all-in-onestructure indoor body area network node elderly caregiving microsystem

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An Analysis of the Fragmentation of Observing Time At the Muztagh-Ata Site

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Research in Astronomy and Astrophysics 2024年第3期24卷 29-33页

作者： Wen-Bo Gu Jing Xu Guo-Jie Feng Xuan Zhang le-Tian Wang Xin-Liang Wang Ali Esamdin Li-xian Shen Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 83001lChina School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Cloud cover plays a pivotal role in assessing observational conditions for astronomical *** for the fraction of observing time,its fragmentation also wields a significant influence on the quality of nighttime sky *** this article,we introduce the functionΓ∈[0,1],designed to comprehensively capture both the fraction of available observing time and its *** in situ measurement data gathered at the Muztagh-Ata site between 2017 and 2021,we showcase the effectiveness of our *** statistical result illustrates that the Muztagh-Ata site affords approximately 122 nights that were absolutely clear and 205 very good nights annually,corresponding toΓ≥0.9 andΓ≥0.36 respectively.

关键词： site testing-atmospheric effects-methods statistical

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Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin Shen Jie-Hui Kuang Si-Kai Zhan Bang Liu Jia-le Cai Sheng-Wang Liang Ming-Hua xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

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基于遗传算法的嵌入式仿真的系统辨识与控制优化

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系统仿真学报 2009年第21期21卷 6945-6949页

作者：赵文龙颜乐先代冀阳曹博南昌航空大学无损检测技术教育部重点实验室南昌330063

数字随动(伺服)系统因具有非线性、不确定性和时变性,难以精确地建立系统的数学模型,由此对设计高性能的控制器造成困难。遗传算法因其隐含并行性、全局搜索等优点,在优化问题领域得到了很好的应用,但遗传算法简单应用于如数字随动系统... 详细信息

数字随动(伺服)系统因具有非线性、不确定性和时变性,难以精确地建立系统的数学模型,由此对设计高性能的控制器造成困难。遗传算法因其隐含并行性、全局搜索等优点,在优化问题领域得到了很好的应用,但遗传算法简单应用于如数字随动系统这样的控制系统在线闭环辨识或参数优化时,会面临大量重复实验成本高、实验时间过长引起系统不稳定等实际问题。针对以上困难,提出一种基于嵌入式仿真的系统辨识方法,采用遗传算法进行数字随动系统同步在线闭环模型参数辨识与控制参数寻优.经过在数字随动系统实物环境下实验,证明了该方法的有效性.

关键词：数字随动系统遗传算法嵌入式仿真在线闭环辫识参数寻优

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朝鲜半岛农乐舞巫戏构造与演绎程式

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北京舞蹈学院学报 2024年第1期 100-109页

作者：韩贤杰郭罗乐北京舞蹈学院北京100081 南京艺术学院南京210013

农乐舞是朝鲜半岛古老的舞蹈形态,是农耕文化的产物。文章列举农耕仪礼中的祝愿仪礼、播种仪礼、成长仪礼、收获,分析农乐舞巫戏演绎程式与角色构造,阐述其蕴含的审美特征,体现执器而舞的审美传统,阐释朝鲜半岛传统舞蹈的文化价值。

关键词：传统农乐巫戏构造演绎程式

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基于XGBoost算法的鱼粉中微塑料的红外光谱识别研究

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光谱学与光谱分析 2024年第7期44卷 1835-1842页

作者：许晓栋张慧敏刘佳乐韩鲁佳杨增玲刘贤中国农业大学工学院农业工程系北京100083

作为四大新兴污染物之一的“微塑料”带来的危害日益凸显,微塑料的检测识别是其污染评估和风险管理防控的关键。以鱼粉饲料中的微塑料(包括PA、PE、PET、PP、PS、PVC)作为研究对象,运用XGBoost算法分别研究构建了近红外光谱和红外光谱... 详细信息

作为四大新兴污染物之一的“微塑料”带来的危害日益凸显,微塑料的检测识别是其污染评估和风险管理防控的关键。以鱼粉饲料中的微塑料(包括PA、PE、PET、PP、PS、PVC)作为研究对象,运用XGBoost算法分别研究构建了近红外光谱和红外光谱定性识别模型。采用GridSearchCV工具包研究优化XGBoost模型的主要超参数,近红外光谱模型的超参数优化结果为n_estimators:300,learning_rate:0.08,gamma:0,max_depth:4,min_child_weight:1;红外光谱的超参数优化结果为n_estimators:100,learning_rate:0.02,gamma:0.20,max_depth:4,min_child_weight:1。基于优化后的超参数构建的近红外定性识别模型平均精确率(Precision)为0.985,平均召回率(Recall)为0.977,平均F1值(F1 score)为0.978,相比于优化前模型效果分别提升了40.17%,51.00%,50.00%;红外定性识别模型平均精确率(Precision)、平均召回率(Recall)和平均F1值(F1 score)均为1.000,优化后的模型效果分别提升了20.67%,27.50%,26.33%。进一步与PLS-DA模型对比分析发现,红外光谱的XGBoost模型与PLS-DA模型效果基本一致,近红外光谱的XGBoost模型各参数(Accuracy,Precision,Recall,F1 score)效果均不同程度地优于PLS-DA模型。综上所述,运用XGBoost算法可以有效识别鱼粉中不同种类的微塑料,该研究为鱼粉饲料中微塑料的快速检测识别方法提供理论支持和技术支撑。

关键词：微塑料红外光谱 XGBoost PLS-DA

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