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Negative impact of hepatitis B surface seroclearance on prognosis of hepatitis B-related primary liver cancer

World Journal of Clinical Cases 2018年第8期6卷 192-199页

作者： Cheng Lou Tong Bai le-wei bi Ying-Tang Gao Zhi Du Department of Hepatobiliary Surgery Third Central Hospital of Tianjin Tianjin Institute of Hepatobiliary Disease Tianjin Key Laboratory of Artificial Cell Artificial Cell Engineering Technology Research Center of Public Health Ministry the Graduate School of Tianjin Medical University

AIM To assess the impact of hepatitis B surface(HBs Ag) seroclearance on survival outcomes in hepatitis B-related primary liver *** Information from patients with hepatitis B-related liver cancer admitted in our hospital from 2008-2017 was retrieved. Cases diagnosed with HBs Ag(-) and HBc Ab(+) liver cancer were included in the HBs Ag seroclearance(SC) group. HBs Ag(+) liver cancer patients strictly matched for liver cancer stage(AJCC staging system, 8 th edition), Child-Pugh score, and first diagnosis/treatment method(surgery, ablation and TACE) were assigned to the HBsA g non-seroclearance(NSC) group. Then, clinical, pathological and survival data in both groups were *** The SC and NSC groups comprised of 72 and 216 patients, respectively. Patient age(P let count(P = 0.001) in the SC group were significantly higher than those of the NSC group. SC group patients who underwent surgery had more intrahepatic cholangiocarcinoma(ICC) and combined HCC-CC(CHC) cases than the NSC group, but no significant differences in tumor cell differentiation and history of liver cirrhosis were found between the two groups. The numbers of interventional treatments were similar in both groups(4.57 vs 5.07, P > 0.05). Overall survival was lower in the SC group than the NSC group(P = 0.019), with 1-,3-, and 5-year survival rates of 82.1% vs 85.1%, 43.2%vs 56.8%, and 27.0% vs 45.2%, respectively. Survival of patients with AJCC stage Ⅰ disease in the SC group was lower than that of the NSC group(P = 0.029).CONCLUSION Seroclearance in patients with hepatitis B-related primary liver cancer has protective effects with respect to tumorigenesis, cirrhosis, and portal hypertension but confers worse prognosis, which may be due to the frequent occurrence of highly malignant ICC and CHC.

关键词： Primary liver cancer Hepatitis B surface Hepatitis B surface seroclearance Prognosis Chronic hepatitis B

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Performance enhancement of perovskite solar cells with Cs2PtI6-xBrx absorber layer based on numerical simulation

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Optoelectronics letters 2025年

作者： Du Zuyan Yuan Yujie Hou Guofu Xin Yupeng bi Jinlian Li wei Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology Institute of Photoelectronic Thin Film Devices and Technology， Nankai University

Cs2TiBr6， characterized as a lead-free vacancy-ordered double perovskite material， demonstrates notable stability and photoelectric performance， rendering it suitable for application in perovskite solar cells. However， the experimental efficiency of this material is currently limited， achieving only 3.12%. This efficiency limitation primarily stems from the material’s wide bandgap， which results in insufficient light absorption. To address this issue， this study utilized Cs2PtI6-xBrxfor band structure fine-tuning. By adjusting the bandgap of Cs2PtI6-xBrxthrough Br-doping， not only was the alignment of the energy bandgap in the absorption layer effectively adjusted， but the cutoff range of light absorption was also significantly expanded. Setting the Cs2PtI6-xBrxbandgap to 1.4 eV resulted in optimal device performance. Additionally， comparative analyses aimed at boosting solar cell efficiency were performed on both hole transport and electron transport layer materials. Subsequently， the structure of the perovskite solar cell was optimized using an FTO/TiO2/Cs2TiBr6/Cs2PtI6-xBrx/Cu2O/Au configuration. Furthermore， the influence of the absorber layer thickness and defect density on device performance was studied. Ultimately， this configuration enabled the Cs2TiBr6/Cs2PtI6-xBrxsolar cell to achieve a peak conversion efficiency of 29.69%.

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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Photosynthetic reaction pathways of natural and artificial systems

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Science China Chemistry 2025年

作者： Shixing lei Liting bi Lingxuan Chen Zhanting Li Jia Tian State Key Laboratory of Organometallic Chemistry and Shanghai Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences

Photosynthesis converts solar energy into chemical energy through highly coordinated photosynthetic *** by natural systems,artificial photosynthesis aims to develop an efficient,sustainable,and cost-effective pathway for solar-tochemical *** review examines natural photosynthetic pathways,including retinal/rhodopsin-,bacteriochlorophyll-,and chlorophyll-based systems,highlighting their key components and ***,we outline reaction pathways in artificial photosynthetic systems constructed via heterogeneous,homogeneous,self-assembly,and semi-artificial strategies,focusing on water splitting,carbon fixation,and nitrogen ***,we offer insights into future directions for artificial photosynthesis,emphasizing the importance of using self-assembly strategies and the potential of using primitive phototrophic microorganisms as models.

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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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Effect of bi/Si Ratio of biBSi Glass on Its Structure, Properties and Laser Sealing Shear Strength for Vacuum Glazing

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 13-24页

作者： LIU wei JIAO Jinxu LUO Dusha ZHOU Junjie SHI Lifen WANG weiwei LI Changqing WANG Peng XIONG Dehua LI Hong State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Silica-Based Materials Laboratory of Anhui Province CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China State Key Laboratory of Advanced Technology for Float Glass CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China

The low-melting glass of bi2O_(3)-B2O_(3)-SiO_(2)(biBSi)system was used for the first time for laser sealing of vacuum *** the condition of constant boron content,how the structure and properties vary with bi/Si ratio in low-melting glass was *** addition,the relationships between laser power,low-melting glass solder with different bi/Si ratios and laser sealing shear strength were *** results show that a decrease in the bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal *** laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the bi/Si ratio will affect the valence state transition of the copper ions in the low-melting *** absorbance of the low-melting glass does not follow the expected correlation with the bi/Si ratio,but shows a linear correlation with the content of divalent copper *** greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser *** shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.

关键词： bi2O_(3)-B2O_(3)-SiO_(2)(biBSi) bi/Si ratio low-melting glass laser sealing vacuum glazing

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A TCP Performance Enhancement Scheme in Infrastructure based Vehicular Networks

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China Communications 2015年第6期12卷 73-84页

作者： HA le FANG Lijin bi Yuanguo LIU wei Northeastern University Shenyang Ligong University

Transmission Control Protocol （TCP） in infrastructure based vehicular net- works is dedicated to support reliable Intemet services for mobile users. However, an end-to- end TCP flow not only experiences some com- mon challenges in wireless mobile networks, such as high packet loss rate, medium access competition, unstable wireless bandwidth, and dynamic topology, etc., but also suffers from performance degradation due to traffic congestion at the Road-Side Units （RSUs） that connect the wireline and wireless networks. In order to address the challenging issues related to reliable TCP transmissions in infrastruc- ture based vehicular networks, we propose an RSU based TCP （R-TCP） scheme. For wireline source nodes, R-TCP adopts a novel flow control mechanism to adjust transmission rates according to the status of bottleneck link. Specifically, during the short wireless connec- tion time in Infrastructure based vehicular net- works, R-TCP quickly chooses an ideal trans- mission rate for data transmissions instead of activating the slow start algorithm after the connection is established, and successfully avoids the oscillation of the transmission rate. Simulation results show that R-TCP achieves great advantages than some relate proposals in terms of throughput, end-to-end delay, and packet loss rate.

关键词： rate control bottleneck node packet loss infrastructure based vehicular net-works

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A fast streptomycin sulfate sensing based on Nb2CTX functionalized titled fiber Bragg grating

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Optoelectronics letters 2025年

作者： bi Mingpan LIU Jie ZHANG Yuchen LI Xiaolan MIAO Yinping Tianjin Key Laboratory of Film Electronic & Communicate Devices，School of Integrated Circuit Science and Engineering，Tianjin University of Technology Key Laboratory of Quantum Optics and Intelligent Photonics， School of Science， Tianjin University of Technology

We proposed a fast and temperature self-compensation method to detect streptomycin sulfate aqueous solution concentration based on a 2D Nb2CTXMXene nanosheets functionalized tilted Bragg grating（N-TFBG）. The introduction of 2D Nb2CTXMXene nanosheets brought more than 100% increase in sensitivity and exhibited a high sensitivity of 253.8 pm/mg/mL and detection limit 80 μg/mL in range of 0.2-0.8 mg/mL. Due to high sensitivity and compact structure， N-TFBG sensor has a faster measure time than previous method; additionally， the sensor has simultaneous temperature measurement by detecting the cladding mode and the core mode resonance peak simultaneously. Our research will hopefully open a new research platform for online detection of streptomycin sulfate concentration.

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定向电场下W_(6)C_(6)团簇的超卤素调制及非线性光学特性

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原子与分子物理学报 2025年第3期42卷 72-76页

作者：蔡璧钧段宇静魏强重庆理工大学理学院重庆400050

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且... 详细信息

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且在特定强度下,OEEF可以将W_(6)C_(6)团簇转变为超卤素.通过对EA值的非线性拟合可以实现对W_(6)C_(6)团簇的连续调制.进一步对不同外电场下W_(6)C_(6)团簇的最高占据分子轨道(HOMO)和最低未占据分子轨道(LUMO)能级进行分析,发现OEEF降低了W_(6)C_(6)团簇LUMO能级是其EA值增大的主因.此外,OEEF可以显著增大W_(6)C_(6)团簇的平均极化率和第一超极化率,尤其是第一超极化率,改变其非线性光学性质.

关键词：定向外电场超原子密度泛函理论 NLO W_(6)C_(6)团簇

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美国在线高等教育动态及启示:基于《美国在线教育发展全景报告》(第8版)的分析

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黑龙江高教研究 2025年第1期43卷 80-90页

作者：王继翔姜珠璧刘薇四川农业大学四川成都610000

由美国著名在线教育质量保证机构Quality Matters(QM)和高等教育研究咨询公司Eduventures Research联合发布的《美国在线教育发展全景报告》,从美国高等教育管理视角全景式地调查了不同层次高等教育机构在线教育的现状、影响和发展趋势... 详细信息

由美国著名在线教育质量保证机构Quality Matters(QM)和高等教育研究咨询公司Eduventures Research联合发布的《美国在线教育发展全景报告》,从美国高等教育管理视角全景式地调查了不同层次高等教育机构在线教育的现状、影响和发展趋势。报告数据源于各样本高校首席信息官,其视角可以为人们了解美国在线教育的发展与趋势提供直观的认识。以2023年推出的《美国在线教育发展全景报告》(第8版)(CHLOE8)为基础,分析并梳理了美国近年来在线教育的发展动态及走向,有助于对世界在线高等教育的主要趋势和关键挑战作出预判,为中国在线高等教育的创新变革提供参考和启示。

关键词：美国在线教育发展动态趋势 CHLOE

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