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Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival

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World Journal of Gastroenterology 2016年第39期22卷 8798-8805页

作者： Hao-Jie Yang Jing-Hang Jiang Yu-ting Yang Xiang-Di Yang Zhe Guo Ya-Peng Qi Feng-Hua Zeng Ke-Lan Zhang Neng-Zhi Chen Bang-De Xiang le-qun li Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Department of General Surgery The First People’s Hospital of Changde Department of General Surgery Second People’s Hospital of Jing Men Department of Chemotherapy Affiliated Tumor Hospital of Guangxi Medical University Department of Oncology Chenzhou No.1 People’s Hospital Department of Thyroid and Breast Surgery Central Hospital of Wuhan

AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict *** We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were *** Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.

关键词： Cyclooxygenase-2 Hepatocellular carcinoma liver resection Prognosis Prostaglandin E1 receptor

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Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein

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World Journal of Gastroenterology 2016年第13期22卷 3632-3643页

作者： Hai-Hong Ye Jia-Zhou Ye Zhi-Bo Xie Yu-Chong Peng Jie Chen liang Ma Tao Bai Jun-Ze Chen Zhan Lu Hong-Gui Qin Bang-De Xiang le-qun li Department of Hepatobiliary Surgery Affiliated Minzu Hospital of Guangxi Medical University Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Department of Pancreatic Surgery Pancreatic Disease Institute Huashan Hospital Shanghai Medical College Fudan University

AIM: To evaluate the efficacy of transcatheter arterial chemoembolisation (TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma (HCC) in patients with tumor thrombus extending to the main portal ***: From 2009 to 2013, a total of 418 HCC patients with tumor thrombus extending to the main portal vein were enrolled in this study and divided into four groups. These groups underwent different treatments as follows: TACE (n = 307), surgical intervention (n = 54), sorafenib (n = 15) and palliative treatment (n = 42). Overall survival rates were determined by Kaplan-Meier method, and differences between the groups were identified through log-rank analysis. Cox’s proportional hazard model was used to identify the risk factors for ***: The mean survival periods for patients in the TACE, surgical intervention, sorafenib and palliative treatment groups were 10.39, 4.13, 5.54 and 2.82 mo, respectively. For the TACE group, the 3-, 6-, 12- and 24-mo survival rates were 94.1%, 85.9%, 51.5% and 0.0%, respectively. The corresponding rates were 60.3%, 22.2%, 0.0% and 0.0% for the surgical intervention group and 50.9%, 29.5%, 0.0% and 0.0% for the sorafenib group. Evidently, the results in the TACE group were significantly higher than those in the other groups (P liative treatment groups (P > 0.05). These values significantly increased after TACE with/without sorafenib compared with other treatments (P < 0.05).CONCLUSION: For HCC patients with tumor thrombus extending to the main portal vein, TACE can yield a higher survival rate than surgical intervention or sorafenib treatment.

关键词： Hepatocellular carcinoma Portal vein Tumor thrombus Sorafenib Transcatheter arterial chemoembolisation Surgery

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Adjuvant sorafenib in hepatocellular carcinoma: A cautionary comment of STORM trial

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World Journal of Hepatology 2016年第23期8卷 957-960页

作者： Jian-Hong Zhong Xue-Ke Du Bang-De Xiang le-qun li Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Department of Anesthesia Affiliated Tumor Hospital of Guangxi Medical University

Recurrence rate of hepatocellular carcinoma(HCC) is very high even after curative surgery, and no postoperative therapies have been definitively shown to prevent HCC recurrence. Sorafenib is proved to be effective for advanced HCC by two large randomized controlled trials in 2008 and 2009. Therefore it stands to reason to expect that adjuvant sorafenib may improve post-surgery outcomes of patients with HCC. However, many questions still exist about the value of sorafenib for patients with HCC after surgery or transarterial chemoembolization. In this editorial, we complehensively reviewed the safety and efficacy of adjuvant sorafenib for patients with hepatocellar carcinoma after surgery or transarterial chemoembolization. We emphasized the positive and negative role of sorafenib.

关键词： Adjuvant Hepatocellular carcinoma Tumor recurrence Sorafenib

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A new staging system for hepatocellular carcinoma associated with portal vein tumor thrombus

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 782-795,I0003-I0005页

作者： Wan Yee Lau Kang Wang Xiu-Ping Zhang le-qun li Tian-Fu Wen Min-Shan Chen Wei-Dong Jia li Xu Jie Shi Wei-Xing Guo Ju-Xian Sun Zhen-Hua Chen lei Guo Xu-Biao Wei Chong-De Lu Jie Xue li-Ping Zhou Ya-Xing Zheng Meng Wang Meng-Chao Wu Shu-qun Cheng Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghaiChina Faculty of Medicine The Chinese University of Hong KongHong KongChina Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningChina Department of liver Surgery&Transplantation Center West China Hospital of Sichuan UniversityChengduChina Department of Hepatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhouChina Department of General Surgery Affiliated Provincial HospitalAnhui Medical UniversityHefeiChina Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery HefeiChina

Background:A new staging system for patients with hepatocellular carcinoma(HCC)associated with portal vein tumor thrombus(PVTT)was developed by incorporating the good points of the BCLC classification of HCC,and by improving on the currently existing classifications of HCC associated with ***:Univariate and multivariate analysis with Waldχ2 test were used to determinate the clinical prognostic factors for overall survival(OS)in patients with HCC and PVTT in the training *** the conditional inference trees analysis was applied to establish a new staging ***:A training cohort of 2,179 patients from the Eastern Hepatobiliary Surgery Hospital and a validation cohort of 1,550 patients from four major liver centers in China were enrolled into establishing and validating a new staging *** system was established by incorporating liver function,general health status,tumor resectability,extrahepatic metastasis and extent of *** staging system had a good discriminatory ability to separate patients into different stages and *** median OS for the two cohorts were 57.1(37.2-76.9),12.1(11.0-13.2),5.7(5.1-6.2),4.0(3.3-4.6)and 2.5(1.7-3.3)months for the stages 0 to IV,respectively(Plidation cohort were 6.4(4.9-7.9),2.8(1.3-4.4),10.8(9.3-12.4),and 1.5(1.3-1.7)months for the stages II to IV,respectively(Plished which provided a good discriminatory ability to separate patients into different stages and substages after *** can be used to supplement the other HCC staging systems.

关键词： Hepatocellular carcinoma(HCC) portal vein tumor thrombus(PVTT) staging system overall survival(OS)

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Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after surgery: A comment for moving forward

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World Journal of Hepatology 2016年第13期8卷 605-606页

作者： Jian-Hong Zhong Tian Yang Bang-De Xiang le-qun li liang Ma Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Department of Hepatobiliary Surgery Eastern Hepato-biliary Surgery Hospital Second Military Medical University

Recurrence rate of hepatocellular carcinoma remains quite high even after surgery,and no postoperative therapies have been definitively shown to prevent hepatocellular carcinoma recurrence.A previous study showed that therapy with nucleos(t)ide analogues given to such patients after surgery significantly improved ***,many questions still exist about the usage of nucleos(t)ide analogues for patients with hepatocellular carcinoma after surgery.

关键词： Antiviral therapy Hepatocellular carcinoma Hepatitis B virus Unanswered question

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Genes expression induced by restraint stress in mouse lymphocyte studied by SSH technique

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Acta Pharmacologica Sinica 1999年第5期 84-85页

作者： li le-qun, li Yi-Fan, HAN Wen-lin, MA Da-Long, DING Gui-Feng, FAN Shao-Guang ( Department of Physiology, Department of Immunology, Beijing Medical University, Beijing 100083, China)

To research the special expressed genes in lymphocytes induced by restraint stress.A new gene screening technique for differential expression of genes, suppression subtractive hybridization (SSH), was *** mRNA was isolated from lymph node of restraint-stressed mice (Tester) or normal mice (Driver) and reverse transcript into cDNA. Then the cDNA was cut with Rsa 1 into suitable *** the Tester cDNA fragments were linked with a specially designed oligonucleotide *** Tester cDNA and Driver cDNA were combined for hybridization at 68 ℃ for 10 *** the product of hybridization as template, the suppression PCR was performed. Since the primer was designed to selectively anneal to the adapter,

关键词： SSH Genes expression induced by restraint stress in mouse lymphocyte studied by SSH technique cDNA

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Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after radical hepatectomy

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Cancer Biology & Medicine 2013年第3期10卷 158-164页

作者： Yang Ke liang Ma Xue-Mei You Sheng-Xin Huang Yong-Rong liang Bang-De Xiang le-qun li Jian-Hong Zhong Hepatobiliary Surgery Department Tumor Hospital of Guangxi Medical University

Objective： To assess the effect of antiviral therapy for hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC） after radical hepatectomy. Methods： A total of 478 HBV-related HCC patients treated by radical hepatectomy were retrospectively collected. Patients in the treatment group （n=141） received postoperative lamivudine treatment （100 rag/d）, whereas patients in the control group （n=337） did not. Recurrence-free survival （RFS） rates, overall survival （OS） rates, treatments for recurrent HCC and cause of death were compared between the two groups. Propensity score matching （PSM） analysis was also conducted to reduce confounding bias between the two groups. Results： The 1-, 3-, and 5-year RFS rates didn＇t significantly differ between the two groups （P=0.778）; however, the 1-, 3-, and 5-year OS rates in the treatment group were significantly higher than those in the control group （P=0.002）. Similar results were observed in the matched data. Subgroup analysis showed that antiviral treatment conferred a significant survival benefit for Barcelona Clinical liver Cancer stage A/B patients. Following HCC recurrence, more people in the treatment group were able to choose curative treatments than those in the control group （P=0.031）. For cause of death, fewer people in the treatment group died of liver failure than those in the control group （P=0.041）. Conclusion： Postoperative antiviral therapy increases chances of receiving curative treatments for recurrent HCC and prevents death because of liver failure, thereby significantly prolonging OS, especially in early- or intermedian-stage tumors.

关键词： Antiviral therapy hepatocellular carcinoma propensity score matching recurrence-free survival rate

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磷石膏对水泥稳定碎石基层性能影响研究

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合成材料老化与应用 2019年第5期48卷 91-95,106页

作者：乐群力驻马店市公路工程开发有限公司

为掌握磷石膏对水泥稳定碎石基层性能的影响,通过制备不同磷石膏用量的水泥磷石膏稳定碎石试件,并结合室内试验对其无侧限抗压强度、抗压回弹模量和抗裂性能进行研究。研究表明:随着水泥用量增加,水泥磷石膏稳定碎石7d无侧限抗压强度、... 详细信息

为掌握磷石膏对水泥稳定碎石基层性能的影响,通过制备不同磷石膏用量的水泥磷石膏稳定碎石试件,并结合室内试验对其无侧限抗压强度、抗压回弹模量和抗裂性能进行研究。研究表明:随着水泥用量增加,水泥磷石膏稳定碎石7d无侧限抗压强度、抗压回弹模量和干缩应变均逐渐增加;随着磷石膏用量增加,水泥磷石膏稳定碎石7d无侧限抗压强度和抗压回弹模量呈先增加后减小趋势,在用量为6%时性能最好,干缩应变则逐渐降低,抗裂性能变好;磷石膏水化过程随龄期增长逐渐深入,故龄期越长其对水泥磷石膏稳定碎石的强度指标提高作用越明显;采用6%磷石膏取代1%水泥制备的水泥磷石膏稳定碎石强度指标和抗裂性能较好。

关键词：水泥稳定碎石基层磷石膏性能

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富盐冻融条件下多级配沥青混凝土疲劳特性研究

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合成材料老化与应用 2019年第6期48卷 83-88页

作者：乐群力驻马店市公路工程开发有限公司

为探究富盐冻融条件下沥青混凝土路面疲劳特性下降机理。通过室内试验制备了AC-20、AC-16以及AC-13的沥青混凝土试件,并以清水和饱和NaCl溶液,分别模拟未撒布及撒布除冰条件下的路面积水特征;以-20℃~50℃恒温箱条件模拟沥青混凝土路面... 详细信息

为探究富盐冻融条件下沥青混凝土路面疲劳特性下降机理。通过室内试验制备了AC-20、AC-16以及AC-13的沥青混凝土试件,并以清水和饱和NaCl溶液,分别模拟未撒布及撒布除冰条件下的路面积水特征;以-20℃~50℃恒温箱条件模拟沥青混凝土路面使用过程中的外界温度变化情况;通过室内控制冻融循环次数,模拟实际路面服役过程的冻融作用条件;选取了3种应力比,针对沥青混合料试件进行拉伸疲劳试验,从而得出各条件对多级配沥青混凝土疲劳特性的影响规律。研究结果为指导路面设计施工及冬季除冰盐撒布提供了参考价值。

关键词：配合比设计病害沥青混凝土除冰盐

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融雪剂对再生沥青混合料路用性能影响研究

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当代化工 2020年第3期49卷 605-608页

作者：乐群力驻马店市公路工程开发有限公司河南驻马店463799

为研究融雪剂对再生沥青混合料路用性能的影响,选用CaCl2和NaCl两种常见的氯盐类融雪剂溶液对再生沥青混合料AC-13 C试件进行冻融循环,然后依次展开车辙试验、低温弯曲试验及冻融劈裂试验来探究其路用性能。研究结果表明:融雪剂对再生... 详细信息

为研究融雪剂对再生沥青混合料路用性能的影响,选用CaCl2和NaCl两种常见的氯盐类融雪剂溶液对再生沥青混合料AC-13 C试件进行冻融循环,然后依次展开车辙试验、低温弯曲试验及冻融劈裂试验来探究其路用性能。研究结果表明:融雪剂对再生沥青混合料进行冻融循环会造成其路用性能降低;随着冻融循环次数或融雪剂浓度的增加,再生沥青混合料的路用性能逐渐下降;CaCl2融雪剂造成再生沥青混合料路用性能降低程度小于NaCl融雪剂。研究结果对再生沥青路面养护具有意义。

关键词：融雪剂再生沥青混合料低温抗裂性高温稳定性水稳定性

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