检索结果-南通市图书馆

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3875-3886页

作者： Lu Zhang Yan-Ping Chen Min Ji le-qian ying Chun-Chun Huang Jing-Yi Zhou Lin Liu Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI)and prognostic nutritional index(PNI)could reflect tumor immune microenvironment and predict prognosis of ***,it had not been explored in alpha-fetoprotein(AFP)producing gastric cancer(GC).AIM To determine the predictive value of inflammation-related peripheral blood markers including as NLR,PLR,MLR,SII,SIRI and PNI in the prognosis of AFPproducing GC(AFPGC).Besides,this study would also compare the differences in tumor immune microenvironment,clinical characteristics and prognosis between AFPGC and AFP-GC patients to improve the understanding of this *** 573 patients enrolled were retrospectively *** were divided into AFP+group(AFP≥20 ng/mL)and AFP-group(AFPlevels of NLR/PLR/MLR/SII/SIRI/PNI and *** AFP+group,the impact of NLR/PLR/MLR/SII/SIRI/PNI and their dynamic changes on prognosis were further *** Compared with AFP-patients,AFP+patients had higher NLR/PLR/MLR/SII/-SIRI and lower PNI levels and poorer overall survival(OS).In the AFP+group,mortality was significantly lower in the lower NLR/PLR/MLR/SII/SIRI group and higher PNI ***,the dynamic increase(NLR/PLR/MLR/SII/-SIRI)or decrease(PNI)was associated with the rise of mortality within 1 year of *** Compared with AFP-patients,the level of inflammation-related peripheral blood markers significantly increased in AFP+patients,which was correlated with OS of AFP+***,the gradual increase of SII and SIRI was associated with the risk of death within one year in AFP+*** should be considered as a separate type and distinguished from AFP-GC because of the difference in tumor immune *** requires basic experiments and large clinical samples in the f

关键词： Alpha-fetoprotein producing gastric cancer Inflammatory indicator Prognosis Dynamic changes Tumor immune microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma:A case report and review of literature

引用

World Journal of Gastrointestinal Surgery 2023年第11期15卷 2627-2638页

作者： Chun-Chun Huang le-qian ying Yan-Ping Chen Min Ji Lu Zhang Lin Liu Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsu Province210009China

BACKGROUND The prevalence of multiple primary malignant neoplasms(MPMNs)is increasing in parallel with the incidence of malignancies,the continual improvement of diagnostic models,and the extended life of patients with tumors,especially those of the digestive ***,the co-existence of MPMNs and duodenal adenocarcinoma(DA)is rarely *** addition,there is a lack of compre-hensive analysis of MPMNs regarding multi-omics and the tumor microenvir-onment(TME).CASE SUMMARY In this article,we report the case of a 56-year-old man who presented with a complaint of chest discomfort and abdominal *** patient was diagnosed with metachronous esophageal squamous cell carcinoma and DA in the Department of *** underwent radical resection and chemotherapy for the esophageal tumor,as well as chemotherapy combined with a programmed death-1 inhibitor for the duodenal *** overall survival was 16.6 *** evaluation of the multi-omics and microenvironment features of primary and metastatic tumors was conducted to:(1)Identify the reasons responsible for the poor prognosis and treatment resistance in this case;and(2)Offer novel diagnostic and therapeutic approaches for *** case demonstrated that the development of a second malignancy may be independent of the location of the first ***,tumor recurrence(including metastases)should be distinguished from the second primary for an accurate diagnosis of *** Multi-omics characteristics and the TME may facilitate treatment selection,improve efficacy,and assist in the prediction of *** Tip:Multiple primary malignant neoplasms(MPMNs)are increasingly prevalent in clinical practice,most frequently in the digestive *** report a rare case of MPMN with a combination of esophageal squamous cell carcinoma and duodenal *** to PubMed-indexed literature,there are no standard guidelines or expert consensus on the etiology and comprehensive treatment.W

关键词： Multiple primary malignancies Esophageal tumor Duodenal adenocarcinoma Multi-omics Tumor microenvironment Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hierarchical vectorization for facial images

引用

Computational Visual Media 2024年第1期10卷 97-118页

作者： qian Fu Linlin Liu Fei Hou ying He School of Computer Science and Engineering Nanyang Technological University639798SingaporeSingapore Data61 Commonwealth Scientific and Industrial Research OrganisationSydney2015Australia Interdisciplinary Graduate School Nanyang Technological University and Alibaba Group639798SingaporeSingapore State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

The explosive growth of social media means portrait editing and retouching are in high *** portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the user to be highly *** at developing intuitive and easy-to-use portrait editing tools,we propose a novel vectorization method that can automatically convert raster images into a 3-tier hierarchical *** base layer consists of a set of sparse diffusion curves(DCs)which characterize salient geometric features and low-frequency colors,providing a means for semantic color transfer and facial expression *** middle level encodes specular highlights and shadows as large,editable Poisson regions(PRs)and allows the user to directly adjust illumination by tuning the strength and changing the shapes of *** top level contains two types of pixel-sized PRs for high-frequency residuals and fine details such as pimples and *** train a deep generative model that can produce high-frequency residuals *** to the inherent meaning in vector primitives,editing portraits becomes easy and *** particular,our method supports color transfer,facial expression editing,highlight and shadow editing,and automatic *** quantitatively evaluate the results,we extend the commonly used FLIP metric(which measures color and feature differences between two images)to consider *** new metric,illumination-sensitive FLIP,can effectively capture salient changes in color transfer results,and is more consistent with human perception than FLIP and other quality measures for portrait *** evaluate our method on the FFHQR dataset and show it to be effective for common portrait editing tasks,such as retouching,light editing,color transfer,and expression editing.

关键词： face editing vectorization Poisson editing color transfer illumination editing expression editing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys

引用

Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： Chee ying Tan Cuie Wen Hua qian Ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability Corrosion Implant applications Laser surface modification Magnesium alloys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic advances in atrial fibrillation based on animal models

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 135-152页

作者： qian GONG Xuan le Pengcheng YU lenan ZHUANG Institute of Genetics and Reproduction College of Animal SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with *** the high frequency of AF in clinical practice,its etiology and management remain *** develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its *** spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic *** review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and *** data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词： Atrial fibrillation Animal model Therapeutic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DDI-Transform:A neural network for predicting drug-drug interaction events

引用

Quantitative Biology 2024年第2期12卷 155-163页

作者： Jiaming Su ying qian School of Computer Science and Technology Shanghai Frontiers Science Center of Molecule Intelligent SynthesesEast China Normal UniversityShanghaiChina

Drug-drug interaction(DDI)event prediction is a challenging problem,and accurate prediction of DDI events is critical to patient health and new drug ***,many machine learning-based techniques have been proposed for predicting DDI ***,most of the existing methods do not effectively integrate the multidimensional features of drugs and provide poor mitigation of noise to get effective feature *** address these limitations,we propose a DDI-Transform neural network framework for DDI event *** DDI-Transform,we design a drug structure information feature extraction module and a drug bind-protein feature extraction module to obtain multidimensional feature information.A stack of DDI-Transform layers in the DDI-Transform network module are then used for adaptive learning,thus adaptively selecting the effective feature information for *** results show that DDI-Transform can accurately predict DDI events and outperform the state-of-the-art *** on different scale datasets confirm the robustness of the method.

关键词： adaptive learning graph convolutional networks interaction prediction meta-path

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

leader-follower Optimal Selection Method for Distributed Control System in Active Distribution Networks

引用

CSEE Journal of Power and Energy Systems 2024年第1期10卷 314-323页

作者： Jian le Liangang Zhao Cao Wang qian Zhou Yang Wang School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China

Aiming at the shortcomings of a traditional centralized control in an active distribution network(AND),this paper proposes a leader-follower distributed group cooperative control strategy to realize multiple operation and control tasks for an *** distributed information exchange protocols of the distributed generation(DG)group devoted to node voltage regulation or exchange power control are developed using a DG power utilization ratio as the consensus *** these bases,this study further investigates the leader optimal selection method for a DG group to improve the response speed of the distributed control ***,a single or multiple leader selection model is established to minimize the constraints of the one-step convergence factor and the number of leaders to improve the response speed of the distributed control *** simulation results of the IEEE 33 bus standard test system show the effectiveness of the proposed distributed control *** addition,the response speed of a DG control group can be improved effectively when the single or multiple leaders are selected optimally.

关键词： Active distribution1network consensus algorithm leader-follower system mixed-integer semidefinite programming optimal distributed control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rethinking multi-spatial information for transferable adversarial attacks on speaker recognition systems

引用

CAAI Transactions on Intelligence Technology 2024年第3期9卷 620-631页

作者： Junjian Zhang Hao Tan le Wang Yaguan qian Zhaoquan Gu Guangzhou University GuangzhouChina Department of New Networks Peng Cheng LaboratoryShenzhenChina Harbin Institute of Technology(Shenzhen) ShenzhenChina Zhejiang University of Science and Technology HangzhouChina

Adversarial attacks have been posing significant security concerns to intelligent systems,such as speaker recognition systems(SRSs).Most attacks assume the neural networks in the systems are known beforehand,while black-box attacks are proposed without such information to meet practical *** black-box attacks improve trans-ferability by integrating multiple models or training on multiple datasets,but these methods are *** by the optimisation strategy with spatial information on the perturbed paths and samples,we propose a Dual Spatial Momentum Iterative Fast Gradient Sign Method(DS-MI-FGSM)to improve the transferability of black-box at-tacks against ***,DS-MI-FGSM only needs a single data and one model as the input;by extending to the data and model neighbouring spaces,it generates adver-sarial examples against the integrating *** reduce the risk of overfitting,DS-MI-FGSM also introduces gradient masking to improve *** authors conduct extensive experiments regarding the speaker recognition task,and the results demonstrate the effectiveness of their method,which can achieve up to 92%attack success rate on the victim model in black-box scenarios with only one known model.

关键词： speaker recognition spoofing attacks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

引用

Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： Xiuxiu Liu ying Zhang Yanming Zhao qian Zhang Feng Han Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An investigation on topologies of hybrid manifold,impinging-jet nozzle and micro-pin-fin heat sinks

引用

Science China(Technological Sciences) 2024年第4期67卷 1061-1076页

作者： SHI qianlei YAO Xiaole LIU qian QIN le JU Xing XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of MOE North China Electric Power UniversityBeijing 102206China

The hybrid manifold micro-pin-fin(MMPF)heat sink combined nozzle jets is an option for large-scale integrated circuits(LSI).The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately *** work aims to solve the problem of fluid *** proposed basic tiling topologies,including square,regular hexagon,30°rhombus,and 60°rhombus topologies,provide different organized fluid flows and heat transfer *** present study focuses on comparing these topologies according to independent porous medium parameters,such as nozzle pore size D_(Z),flow pore size D_(X,Y),and porosityε.The results show that the square topology achieves the smallest total thermal resistance R_(tot)value of0.0975×10^(-4)K m^2/W,while the hexagon topology achieved the highest value of COP/?T,which was 2033.9 K^(-1).According to the sensitivity analysis results,the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size,flow pore size,and *** optimal pressure drop can be obtained by maximizing the porosity.

关键词： heat sink ultra-high heat flux manifold micro-pin-fin impinging-jet topology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：