检索结果-南通市图书馆

Chinese Chemical letters 2016年第4期27卷 511-517页

作者： le-chen chen Shan lei Mo-Zhen Wang Jun Yang Xue-Wu Ge The USTC-Anhui Tobacco Joint Laboratory of Tobacco Chemistry CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China The USTC-Anhui Tobacco Joint Laboratory of Tobacco Chemistry Research Center of Tobacco and Health University of Science and Technology of China

Macroporous polystyrene microsphere/graphene oxide（PS/GO） composite monolith was first prepared using Pickering emulsion droplets as the soft template. The Pickering emulsion was stabilized by PS/GO composite particles in-situ formed in an acidic water phase. With the evaporation of water and the oil phase（octane）, the Pickering emulsion droplets agglomerated and combined with each other, forming a three-dimensional macroporous PS/GO composite matrix with excellent mechanical strength. The size of the macrospores ranged from 4 mm to 20 mm. The macroporous PS/GO composite monolith exhibited high adsorption capacity for tetracycline（TC） in an aqueous solution at p H 4–6. The maximum adsorption capacity reached 197.9 mg g 1at p H 6. The adsorption behaviour of TC fitted well with the Langmuir model and pseudo-second-order kinetic model. This work offers a simple and efficient approach to fabricate macroporous GO-based monolith with high strength and adsorption ability for organic pollutants.

关键词： Graphene oxide Polystyrene microsphere Macroporousm Adsorption Tetracycline

In-situ Enhanced Toughening of Poly（ethylene terephthalate）/elastomer Blends via Gamma-Ray Radiation at Presence of Trimethylolpropane Triacrylate

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2016年第6期29卷 703-709,I0001,I0002页

作者： Li-zhao Xie le-chen chen Mo-zhen Wang Qi-chao Wu Xiao Zhou Xue-wu Ge CASKeyLaboratoryofSoftMatterChemistry DepartmentofPolymerScienceandEngineeringUniversityofScienceandTechnologyofChinaHefei230026China GuangdongTiananNewMaterialCo. Ltd.Foshan528000China

Gamma-ray radiation has always been a convenient and effective way to modify the inter- facial properties in polymer blends. In this work, a small amount of trimethylolpropane triacrylate （TMPTA） was incorporated into poly（ethylene terephthalate）（PET）/random terpolymer elastomer （ST2000） blends by melt-blending. The existence of TMPTA would induce the crosslinking of PET and ST2000 molecular chains at high temperatures of blend- ing, resulting in the improvement in the impact strength but the loss in the tensile strength. When the PET/ST2000 blends were irradiated by gamma-ray radiation, the integrated me- chanical properties could be enhanced significantly at a high absorbed dose. The irradiated sample at a dose of 100 kGy even couldn＇t be broken under the impact test load, and at the same time, has nearly no loss of tensile strength. Based on the analysis of the impact- fractured surface morphologies of the blends, it can be concluded that gamma-ray radiation at high absorbed dose can further in situ enhance the interfacial adhesion by promoting the crosslinking reactions of TMPTA and polymer chains. As a result, the toughness and strength of PET/ST2000 blend could be dramatically improved. This work provides a facial and practical way to the fabrication of polymer blends with high toughness and strength.

关键词： Toughened PET blend Interracial interaction Gamma-ray radiation Radia- tion crosslink Trimethylolpropane triacrylate

Rock mass quality prediction on tunnel faces with incomplete multi-source dataset via tree-augmented naive Bayesian network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第3期34卷 323-337页

作者： Hongwei Huang chen Wu Mingliang Zhou Jiayao chen Tianze Han le Zhang Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Qingdao Guoxin Second Jiaozhou Bay Subsea Tunnel Co. Ltd.Qingdao 266071China

Rock mass quality serves as a vital index for predicting the stability and safety status of rock tunnel *** tunneling practice,the rock mass quality is often assessed via a combination of qualitative and quantitative ***,due to the harsh on-site construction conditions,it is rather difficult to obtain some of the evaluation parameters which are essential for the rock mass quality *** this study,a novel improved Swin Transformer is proposed to detect,segment,and quantify rock mass characteristic parameters such as water leakage,fractures,weak *** site experiment results demonstrate that the improved Swin Transformer achieves optimal segmentation results and achieving accuracies of 92%,81%,and 86%for water leakage,fractures,and weak interlayers,respectively.A multisource rock tunnel face characteristic(RTFC)dataset includes 11 parameters for predicting rock mass quality is *** the limitations in predictive performance of incomplete evaluation parameters exist in this dataset,a novel tree-augmented naive Bayesian network(BN)is proposed to address the challenge of the incomplete dataset and achieved a prediction accuracy of 88%.In comparison with other commonly used Machine learning models the proposed BN-based approach proved an improved performance on predicting the rock mass quality with the incomplete *** utilizing the established BN,a further sensitivity analysis is conducted to quantitatively evaluate the importance of the various parameters,results indicate that the rock strength and fractures parameter exert the most significant influence on rock mass quality.

关键词： Rock mass quality Tunnel faces Incomplete multi-source dataset Improved Swin Transformer Bayesian networks

在线全文

学校读者我要写书评

暂无评论

Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 437-454页

作者： Jiamei le Yilong chen Wei Yang Ligong chen Jianping Ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter *** transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and *** actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUT4), glucose reabsorption(e.g., SLC5A2/SGLT2), thermogenesis(e.g., SLC25A7/UCP-1), and ATP production(e.g., SLC25A4/ANT1 and SLC25A5/ANT2). The activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(T2DM). Notably, SLC5A2 has emerged as a valid drug target for T2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for T2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1B1/OATP1B1) and metformin(SLC22A1-3/OCT1-3 and SLC47A1, 2/MATE1, 2). By consolidating insights into the biological activities and clinical relevance of SLC transporters in T2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) Energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis Polymorphisms

Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第4期76卷 167-175页

作者： Xingyu Qi Zilong Guo Shimin le Hu chen Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

Force spectrum measurements with constant loading rates are widely used in single-molecule manipulation experiments to study the mechanical stability and force response of ***-dependent transition rates can be obtained from the transition force distribution,but it is limited to the force range with non-zero force *** constant loading rate control can be realized with magnetic tweezers,the loading rate range is limited due to the slow movement of permanent ***-linear exponential and exponential squared force loading functions are more feasible in magnetic tweezers,while there is no theoretical result available for these two kinds of non-linear force loading *** this study,we solved the unfolding process of a protein following Bell's model under nonlinear exponential and exponential squared force loading functions,which offer a broader range of unfolding force distribution compared to the traditional constant loading rate ***,we derived two force loading functions,which can produce uniform unfolding force *** research contributes fundamental equations for the analysis of experimental data obtained through single-molecule manipulation under nonlinear force loading controls,paving the way for the use of nonlinear force control in magnetic tweezer experiments.

关键词： single-molecule manipulation magnetic tweezers force loading transition rates force distribution

Retrospective Study Immune function status of postoperative patients with colon cancer for predicting liver metastasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第2期16卷 463-470页

作者： le Xiong Fang-chen Liu Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Blood Transfusion Xiangyang No.1 People’s HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina

BACKGROUND Colon cancer(CC)has a high incidence *** resection is the main treatment method for CC;however,liver metastasis(LM)often occurs *** liver contains both innate and adaptive immune cells that monitor and remove abnormal cells and *** LM,tumor cells secrete cytokines and exosomes to adjust the immune microenvironment of the liver,thus forming an inhibitory immune microenvironment for colonization by circulating tumor *** indicates that the immune state of patients with CC plays a crucial role in the occurrence and progression of *** To observe and analyze the relationship between immune status and expression of tumor factors in patients with LM of CC,and to provide a scientific interven-tion method for promoting the patient *** A retrospective analysis was *** baseline data of 100 patients with CC and 100 patients with CC who suffered from postoperative LM and were admitted to our hospital from May 2021 to May 2023 were included in the non-occurrence and occurrence groups,*** immune status of the pa-tients and the expression of tumor factor-related indicators in the two groups were compared,and the predictive value of the indicators for postoperative LM in patients with CC was *** Compared with the non-occurrence group,the expression of serum carcinoem-bryonic antigen(CEA),CA19-9,CA242,CA72-4 and CA50 in patients in the occurrence group were significantly higher,while the expression of CD3+,CD4+,CD8+,natural killer(NK)and CD4+/CD25 in patients in the occurrence group were significantly lower(P0.05).Multivariate logistic regression model analysis revealed that the expressions of CEA,CA19-9,CA242,CA72-4,CA50,CD3+,CD4+,CD8+,NK,and CD4+/CD25 were associated with the LM in patients with *** expressions of serum CEA,CA19-9,CA242,CA72-4 and CA50,and low expressions of CD3+,CD4+,CD8+,

关键词： Colon cancer Liver metastases Immune status Tumor factors Predicted value

A modified back analysis method for deep excavation with multi-objective optimization procedure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1373-1387页

作者： chenyang Zhao le chen Pengpeng Ni Wenjun Xia Bin Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Guangdong Research Center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai519000China Jiangsu Provincial Transportation Engineering Construction Bureau Nanjing210004China

Real-time prediction of excavation-induced displacement of retaining pile during the deep excavation process is crucial for construction *** paper proposes a modified back analysis method with multi-objective optimization procedure,which enables a real-time prediction of horizontal displacement of retaining pile during *** opposed to the traditional stage-by-stage back analysis,time series monitoring data till the current excavation stage are utilized to form a multi-objective ***,the multi-objective particle swarm optimization (MOPSO) algorithm is applied for parameter *** optimized model parameters are immediately adopted to predict the excavation-induced pile deformation in the continuous construction *** achieve efficient parameter optimization and real-time prediction of system behavior,the back propagation neural network (BPNN) is established to substitute the finite element model,which is further implemented together with MOPSO for automatic *** proposed approach is applied in the Taihu tunnel excavation project,where the effectiveness of the method is demonstrated via the comparisons with the site monitoring *** method is reliable with a prediction accuracy of more than 90%.Moreover,different optimization algorithms,including non-dominated sorting genetic algorithm (NSGA-II),Pareto Envelope-based Selection Algorithm II (PESA-II) and MOPSO,are compared,and their influences on the prediction accuracy at different excavation stages are *** results show that MOPSO has the best performance for high dimensional optimization task.

关键词： Multi-objective optimization Back analysis Surrogate model Multi-objective particle swarm optimization(MOPSO) Deep excavation

Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

Treatment patterns and survival outcomes in patients with nonmetastatic early-onset pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第12期30卷 1739-1750页

作者： le-Tian Zhang Ying Zhang Bi-Yang Cao chen-chen Wu Jing Wang Graduate School Chinese PLA Medical SchoolBeijing 100853China Department of Radiation Oncology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Internal Medicine Hospital of University of Science and Technology BeijingBeijing 100083China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The incidence of patients with early-onset pancreatic cancer(EOPC;age≤50 years at diagnosis)is on the rise,placing a heavy burden on individuals,families,and *** role of combination therapy including surgery,radiotherapy,and chemotherapy in non-metastatic EOPC is not *** To investigate the treatment patterns and survival outcomes in patients with non-metastatic *** A total of 277 patients with non-metastatic EOPC who were treated at our institution between 2017 and 2021 were investigated *** survival(OS),disease-free survival,and progression-free survival were estimated using the Kaplan-Meier *** and multivariate analyses with the Cox proportional hazards model were used to identify prognostic *** With a median follow-up time of 34.6 months,the 1-year,2-year,and 3-year OS rates for the entire cohort were 84.3%,51.5%,and 27.6%,*** median OS of patients with localized disease who received surgery alone and adjuvant therapy(AT)were 21.2 months and 28.8 months,respectively(P=0.007).The median OS of patients with locally advanced disease who received radiotherapy-based combination therapy(RCT),surgery after neoadjuvant therapy(NAT),and chemotherapy were 28.5 months,25.6 months,and 14.0 months,respectively(P=0.002).The median OS after regional recurrence were 16.0 months,13.4 months,and 8.9 months in the RCT,chemotherapy,and supportive therapy groups,respectively(P=0.035).Multivariate analysis demonstrated that carbohydrate antigen 19-9 level,pathological grade,T-stage,N-stage,and resection were independent prognostic factors for non-metastatic *** AT improves postoperative survival in localized *** after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.

关键词： Pancreatic cancer Early-onset Non-metastatic Multimodal treatment Radiotherapy Overall survival