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An effective strategy to inhibit grain coarsening:Construction of multi-element co-segregated grain boundary complexion

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Journal of Advanced Ceramics 2024年第7期13卷 1060-1071页

作者： le Fu Gabriel Arcuri Wenjun Yu Bohan Wang Zihua lei ying Deng Kathryn Grandfield School of Material Science and Engineering Central South UniversityChangsha 410083China Canadian Centre for Electron Microscopy McMaster UniversityHamilton L8S 4L8Canada State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Materials Science and Engineering McMaster UniversityHamilton L8S 4L8Canada

When exposed to moderate to high temperatures,nanomaterials typically suffer from severe grain coarsening,which has long been a major concern that prevents their wider ***,we proposed an effective strategy to inhibit grain coarsening by constructing grain boundary(GB)complexions with multiple codoped dopants,which hindered coarsening from both energetic and kinetic *** demonstrate the feasibility of this strategy,multiple selected dopants were doped into a ZrO_(2)-SiO_(2)nanocrystalline glass ceramic(NCGC)to form GB *** results showed that NCGC was predominantly composed of ZrO_(2)nanocrystallites(NCs)distributed in an amorphous SiO_(2)*** layers of GB complexions(~2.5 nm)were formed between adjacent ZrO_(2)NCs,and they were crystalline superstructures with co-segregated *** addition,a small amount of quartz solid solution was formed,and it adhered to the periphery of ZrO_(2)NCs and bridged the adjacent NCs,acting as a“bridging phase”.The GB complexions and the“bridging phase”synergistically enhanced the coarsening resistance of ZrO_(2)NCs up to 1000°*** findings are important for understanding GB complexions and are expected to provide new insights into the design of nanomaterials with excellent thermodynamic stability.

关键词： Zr_(2)-Si_(2) multi-element co-segregation grain boundary(GB)complexion grain coarsening atom probe tomography(APT)

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Identification of Bovine Casein Phosphorylation Using Titanium Dioxide Enrichment in Combination with Nano Electrospray Ionization Tandem Mass Spectrometry

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Journal of Integrative Agriculture 2012年第3期11卷 439-445页

作者： LI Shan-shan WANG Jia-qi WEI Hong-yang YANG Yong-xin BU Deng-pan ZHANG le-ying ZHOU Ling-yun State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Protein phosphorylation is an important post-translational modification that regulates milk protein structure and *** objective of this study was to analyze the presence of phosphorylated *** milk proteins were first separated by SDS polyacrylamide gel *** in gels digestion and extraction,phosphorylated peptides were enriched by titanium dioxide and identified by ultra performance liquid chromatography coupled with nano electrospray ionization tandem mass *** method ensured the identification of 20 phosphorylated peptides,including 7 phosphorylated forms of α_s1-casein,8 α_s2-casein,and 5 β-*** phosphorylated sites derived from 3 α_s1-caseins,3 α_s2-caseins,and 2 β-caseins were also identified,and localized on residues Ser^61,Ser^63 and Ser^130 in α_s1-casein;Thr^145,Ser^146 and Ser^158 in α_s2-casein;and Ser^50 and Thr^56 in β-*** findings provide valuable information for investigating casein phosphorylation of the bovine milk.

关键词： bovine milk casein phosphorylation mass spectrometry titanium dioxide enrichment

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Experimental study on the CO_(2) concentration and age of air distribution inside tiny sleeping spaces

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Building Simulation 2024年第4期17卷 591-605页

作者： Jingying Zhang Yanyan Li Haiguo Yin Linfeng Liang Songmei Zu le Gao ying Zhang Angui Li School of Building Services Science and Engineering Xi’an University of Architecture and TechnologyXi’anShaanxi710055China

In recent years,rapid urban development has led to capsule hotels,sleep pods,and other tiny sleeping spaces that adapt to people’s fast-paced lives,achieving maximum functionality with a very small ***,due to the small space,human metabolic pollutant(such as CO_(2))is more likely to accumulate,and the air is not easily *** this paper,a full-size experimental platform is set up with three types of ventilation modes to explore the exclusion efficiency of metabolic pollutants and the overall distribution of age of air under these ventilation *** conclusions showed that the mean values of metabolic pollutant exclusion rates for the different ventilation modalities varied very little across the spatial dimensions of the confined space but varied considerably in the area around the *** double-side attached ventilation method was the most effective in removing human metabolic pollutants,especially in the head region(CN≥0.92),while the single-wall attached ventilation method had the best air exchange efficiency(η≥0.85).This suggests an inconsistent distribution of CO_(2) and age of air,which is contrary to general common *** conclusions of this paper can guide the design of ventilation for tiny sleeping spaces.

关键词： attached ventilation mode human metabolic pollutant indoor air quality air exchange efficiency tiny sleeping spaces

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电磁各向异性介质球的散射研究

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电波科学学报 2010年第4期25卷 646-650页

作者：李应乐黄际英咸阳师范学院电波传播与散射研究所陕西咸阳712000 西安电子科技大学理学院陕西西安710071

基于电磁场的多尺度理论,研究了各向异性介质球内部电场的表达式,得到了各向异性介质球形目标散射振幅、散射截面等的解析表达式,并对其正确性进行了检验;仿真结果表明:在瑞利散射条件下各向异性介质球的散射具有偶极辐射的特点,介电常... 详细信息

基于电磁场的多尺度理论,研究了各向异性介质球内部电场的表达式,得到了各向异性介质球形目标散射振幅、散射截面等的解析表达式,并对其正确性进行了检验;仿真结果表明:在瑞利散射条件下各向异性介质球的散射具有偶极辐射的特点,介电常数越大,产生的偶极矩也愈大,散射也越强;磁各向异性对微分散射有一定的影响。结果可为各向异性目标监测、电磁兼容等提供理论支持。

关键词：各向异性球 Rayleigh散射电磁散射

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Molecular and therapeutic landscape of ferroptosis in skin diseases

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中华医学杂志(英文版) 2024年第15期137卷 1777-1789页

作者： le Jiayuan Meng Yu Wang ying Li Daishi Zeng Furong Xiong Yixiao Chen Xiang Deng Guangtong Department of Dermatology Xiangya Hospital Central South University Changsha Hunan China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha Hunan China Furong Laboratory Changsha Hunan China Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital Central South University Changsha Hunan China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha Hunan China Department of Oncology Xiangya Hospital Central South University Changsha Hunan China Department of Dermatology Tongji Hospital Huazhong University of Science and Technology Wuhan Hubei China

Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (Sle), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.

关键词： Ferroptosis Skin diseases Regulated cell death Homeostasis Melanoma Psoriasis Systemic lupus erythematosus Vitiligo

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Treatment patterns and survival outcomes in patients with nonmetastatic early-onset pancreatic cancer

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World Journal of Gastroenterology 2024年第12期30卷 1739-1750页

作者： le-Tian Zhang ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Graduate School Chinese PLA Medical SchoolBeijing 100853China Department of Radiation Oncology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Internal Medicine Hospital of University of Science and Technology BeijingBeijing 100083China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The incidence of patients with early-onset pancreatic cancer(EOPC;age≤50 years at diagnosis)is on the rise,placing a heavy burden on individuals,families,and *** role of combination therapy including surgery,radiotherapy,and chemotherapy in non-metastatic EOPC is not *** To investigate the treatment patterns and survival outcomes in patients with non-metastatic *** A total of 277 patients with non-metastatic EOPC who were treated at our institution between 2017 and 2021 were investigated *** survival(OS),disease-free survival,and progression-free survival were estimated using the Kaplan-Meier *** and multivariate analyses with the Cox proportional hazards model were used to identify prognostic *** With a median follow-up time of 34.6 months,the 1-year,2-year,and 3-year OS rates for the entire cohort were 84.3%,51.5%,and 27.6%,*** median OS of patients with localized disease who received surgery alone and adjuvant therapy(AT)were 21.2 months and 28.8 months,respectively(P=0.007).The median OS of patients with locally advanced disease who received radiotherapy-based combination therapy(RCT),surgery after neoadjuvant therapy(NAT),and chemotherapy were 28.5 months,25.6 months,and 14.0 months,respectively(P=0.002).The median OS after regional recurrence were 16.0 months,13.4 months,and 8.9 months in the RCT,chemotherapy,and supportive therapy groups,respectively(P=0.035).Multivariate analysis demonstrated that carbohydrate antigen 19-9 level,pathological grade,T-stage,N-stage,and resection were independent prognostic factors for non-metastatic *** AT improves postoperative survival in localized *** after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.

关键词： Pancreatic cancer Early-onset Non-metastatic Multimodal treatment Radiotherapy Overall survival

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轻型急性缺血性脑卒中静脉阿替普酶溶栓治疗效果分析

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农垦医学 2024年第3期46卷 193-197页

作者：郑清柳乐灵颖徐志鸿刘雄蔺际龑刘昌云厦门大学附属第一医院急诊科福建厦门361000 四川大学华西医院厦门医院神经内科福建厦门361000 福建医科大学附属协和医院神经内科福州350000

目的:探讨轻型缺血性脑卒中在溶栓时间窗内进行静脉阿替普酶溶栓治疗的有效性、安全性及溶栓后远期预后的影响因素。方法:采用回顾性研究,选取2019年09月至2022年09月就诊于厦门大学附属第一医院的MIS患者,并符合静脉rt-PA溶栓治疗的适... 详细信息

目的:探讨轻型缺血性脑卒中在溶栓时间窗内进行静脉阿替普酶溶栓治疗的有效性、安全性及溶栓后远期预后的影响因素。方法:采用回顾性研究,选取2019年09月至2022年09月就诊于厦门大学附属第一医院的MIS患者,并符合静脉rt-PA溶栓治疗的适应症及排除禁忌症,观察每位患者静脉溶栓治疗前、给药结束后、24h、7d和14d的NIHSS变化及入院时和90d的mRS评分,同时观察记录神经功能缺损恶化、溶栓后全身出血等并发症发生率,并探讨MIS患者溶栓远期预后的影响因素。结果:静脉溶栓治疗前、后NIHSS得分比较差异有统计学意义(P<0.05),溶栓后出血并发症发生率为6.32%;到观察终点,共有166例患者具有良好的远期预后(mRS 0-1分),与发病前相比,其差异有统计学意义(P<0.05);二元Logistic回归发现,影响MIS静脉rt-PA溶栓治疗远期预后主要与发病前NIHSS评分及发病类型为心源性栓塞相关(P<0.05),而与发病前是否致残无明显相关。结论:MIS患者4.5h内实施静脉rt-PA溶栓治疗可能改善远期预后;就诊时NIHSS评分越高,其溶栓后远期预后可能越差;心源性栓塞可能是影响MIS患者溶栓远期预后的独立危险因素。

关键词：轻型缺血性脑卒中溶栓时间窗阿替普酶

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Identification of Dual Receptor-binding Specific Strains of Human H5N1 Viruses in China

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Biomedical and Environmental Sciences 2012年第1期25卷 104-108页

作者： ZHOU Jian Fang ZOU Shu Mei LI Zi WANG Min DONG Jie GUO Jun Feng WEI He Jiang WEN le ying XU Hong SHU Yue Long State Key Laboratory for Molecular Virology and Genetic Engineering National Institute for Viral Disease Control and Prevention China CDC Beijing 102206 China

Objective Both the 2, 6 linkage and its topology on target cells are critical for the recognition by human influenza virus. The binding preference of avian flu virus H5N1 HA to the 2, 3-1inked sialylated glycans is considered the major factor limiting its efficient infection and transmission in humans. To monitor potential adaptation of H5N1 virus in human population, the surveillance of receptor-binding specificity was undertaken in China. Methods The binding specificity of 32 human H5N1 virus strains isolated from 2003 to 2009 was tested by 2, 3-specific sialidase-treated chicken red blood cell （CRBC） agglutination assay and a solid-phase direct binding assay with synthetic sialylglycopolymers. Results Dual binding preference to 2, 3 and 2, 6-glycans were found in two strains： A/Guangdong/1/06 （A/GD/1/06） and A/Guangxi/1/08 （A/GX/1/08）. Though minor effect of short-2, 6-binding was detected in A/GX/1/08 at a low virus titer, both showed high affinity to the oligosaccharide at a high load. Notably both are of the long-2, 6-recognition, with the same topology as that of human H1N1 and H3N2 viruses. Conclusion The findings suggest that human H5N1 virus in China likely acquired the potential human-adaptation ability. Further research and surveillance on receptor-binding specificity of H5N1 viruses are required.

关键词： Receptor-binding specificity Human H5N2 virus China

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Inflammatory airway features and hypothalamic-pituitary- adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease

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Chinese Medical Journal 2010年第13期123卷 1720-1726页

作者： CAI Cui ZHANG Hong-ying le Jing-jing DONG Jing-cheng CUI Yan XU Chang-qing LIU Bao-jun WU Jin-feng DUAN Xiao-hong CAO Yu-xue Lab of Integrative Medicine for Lung Inflammation and Cancers Huashan Hospital Fudan University Shanghai 200040 China

Background Bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD） are both inflammatory airway diseases with different characteristics. However, there are many patients who suffer from both BA and COPD. This study was to evaluate changes of inflammatory airway features and hypothalamic-pituitary-adrenal （HPA） axis function in asthmatic rats combined with COPD. Methods Brown Norway （BN） rats were used to model These three models were compared and evaluated with the inflammatory airway diseases of BA, COPD and COPD＋BA. respect to clinical symptoms, pulmonary histopathology, airway hyperresponsiveness （AHR）, inflammatory cytokines and HPA axis function. Results The inflammatory airway features and HPA axis function in rats in the COPD＋BA model group were greatly influenced. Rats in this model group showed features of the inflammatory diseases BA and COPD. The expression of inflammatory cytokines in this model group might be up or downregulated when both disease processes are present. The levels of corticotrophin releasing hormone mRNA and corticosterone in this model group were both significantly decreased than those in the control group （P 〈0.05）. Conclusions BN rat can be used as an animal model of COPD＋BA. By evaluating this animal model we found that the features of inflammation in rats in this model group seem to be exaggerated. The HPA axis functions in rats in this model group have been disturbed or impaired, which is prominent at the hypothalamic level.

关键词： chronic obstructive pulmonary disease bronchial asthma inflammatory airway disease hypothalamic-pituitary-adrenal axis

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脉冲波在随机雨介质中的传输特性

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西安电子科技大学学报 2007年第4期34卷 583-586,680页

作者：黄际英李应乐弓树宏西安电子科技大学理学院陕西西安710071

在用随机系统法得到随机雨介质中电磁波传输函数的基础上,导出了雨介质中的脉冲波的双频相关函数和强度解析表达式.研究了脉冲波的起伏特性.分析了脉冲波展宽效应机理,得到脉冲波群速度与电波频率、降雨率的函数关系.在毫米波段仿真计... 详细信息

在用随机系统法得到随机雨介质中电磁波传输函数的基础上,导出了雨介质中的脉冲波的双频相关函数和强度解析表达式.研究了脉冲波的起伏特性.分析了脉冲波展宽效应机理,得到脉冲波群速度与电波频率、降雨率的函数关系.在毫米波段仿真计算了频率与带宽对脉冲波展宽速率的影响.通过计算得出了以下结果:水平极化脉冲波的展宽速率大于垂直极化的脉冲波;脉冲波展宽速率随带宽和降雨率增加而增加.

关键词：雨介质脉冲波双频相关函数展宽

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