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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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A Novel Recognition Method for Low SNR DSSS Signals Based on Four-Order Cumulant and Eigenvalue Analysis

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Chinese Journal of Electronics 2015年第3期24卷 648-653页

作者： GUAN Mingxiang wang le School of Electronic and Communication Shenzhen Institute of Information Technology

At present it is very difficult to estimate the carrier frequency, spread spectrum code period and spread spectrum code pattern of Direct sequence spread spectrum(DSSS) signals with low Signal-to-noise ratio(SNR) accurately and simultaneously in the condition of Gaussian white noise. A novel method of estimation for carrier frequency and spread spectrum code period of DSSS signals based on four-order cumulant and eigenvalue analysis is presented. Compared with the correlative detection in time domain, square filtering detection and Hebbian rule, the proposal method in this study can realize the estimation for the carrier frequency and period of spread spectrum code of low SNR DSSS signals with a high accuracy simultaneously. In a priori condition of the spread spectrum code period the proposal method can calculate synchronization loss time between spread spectrum code and information symbol. The proposal method this paper has a strong ability to suppress Gaussian noise.

关键词： DSSS Low signal to noise ratio Recognition Four-order cumulant Eigenvalue analysis

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Adaptive Optimization with Periodic Dither Signals

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Journal of Systems Science & Complexity 2021年第5期34卷 1766-1781页

作者： XIE Siyu wang le Yi Department of Electrical and Computer Engineering Wayne State UniversityDetroitMichigan 48202USA

Optimization methods in cyber-physical systems do not involve parameter uncertainties in most existing *** paper considers adaptive optimization problems in which searching for optimal solutions and identifying unknown parameters must be performed *** to the dual roles of the input signals on achieving optimization and providing persistent excitation for identification,a fundamental conflict *** this paper,a method of adding a small deterministic periodic dither signal to the input is deployed to resolve this conflict and provide sufficient excitation for estimating the unknown *** designing principle of the dither is *** dithered inputs,the authors show that simultaneous convergence of parameter estimation and optimization can be *** properties and convergence rates of parameter estimation and optimization variable updates are presented under the scenarios of uncertainty-free observations and systems with noisy observation and unmodeled *** fundamental relationships and tradeoff among updating step sizes,dither magnitudes,parameter estimation errors,optimization accuracy,and convergence rates are further investigated.

关键词： Adaptive optimization cyber-physical system identification optimization parameter uncertainty periodic dither signal

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Effect of nano-oxide layers on the magnetoresistance of ultrathin permalloy films

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Rare Metals 2009年第6期28卷 624-628页

作者： wang le ZHANG Jinzhong wang Lijin Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China

Ta/NiFe/Ta ultrathin films with and without nano-oxide layers （NOLs） were prepared by magnetron sputtering followed by a vacuum annealing process. The influence of NOLs on the magnetoresistance （MR） ratio of ultrathin permalloy films was studied. The results show that the influence of grain size and textures on the MR ratio becomes weak when the thickness of the NiFe layer is below 15 nm. A higher MR ratio was observed for the thinner （〈 15 nm） NiFe film with NOLs. The MR ratio of a 10 nm NiFe film can be remarkably enhanced by NOLs. The enhanced MR ratio for these ultrathin films can be attributed to the enhanced specular reflection of conduction electrons.

关键词： material surface and interface anisotropic magnetoresistance magnetron sputtering nano oxide layer NiFe

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Adaptive fault-tolerant control for non-minimum phase hypersonic vehicles based on adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第3期37卷 290-311页

作者： le wang Ruiyun QI Bin JIANG State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

In this paper,a novel adaptive Fault-Tolerant Control(FTC)strategy is proposed for non-minimum phase Hypersonic Vehicles(HSVs)that are affected by actuator faults and parameter *** strategy is based on the output redefinition method and Adaptive Dynamic Programming(ADP).The intelligent FTC scheme consists of two main parts:a basic fault-tolerant and stable controller and an ADP-based supplementary *** the basic FTC part,an output redefinition approach is designed to make zero-dynamics stable with respect to the new ***,Ideal Internal Dynamic(IID)is obtained using an optimal bounded inversion approach,and a tracking controller is designed for the new output to realize output tracking of the nonminimum phase HSV *** the ADP-based compensation control part,an ActionDependent Heuristic Dynamic Programming(ADHDP)adopting an actor-critic learning structure is utilized to further optimize the tracking performance of the HSV control ***,simulation results are provided to verify the effectiveness and efficiency of the proposed FTC algorithm.

关键词： Hypersonic vehicle Fault-tolerant control Non-minimum phase system Adaptive control Nonlinear control Adaptive dynamic programming

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Adaptive Asymptotic Tracking Control for Stochastic Nonlinear Systems with Unknown Backlash-Like Hysteresis

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Journal of Systems Science & Complexity 2022年第5期35卷 1824-1838页

作者： wang le SUN Wei WU Yuqiang School of Mathematics Science Liaocheng UniversityLiaocheng 252000China School of Engineering Qufu Normal UniversityRizhao 276826China

In this study,an adaptive asymptotic tracking control problem is considered for stochastic nonlinear systems with unknown backlash-like *** utilizing backstepping technology and bound estimation approach,an adaptive asymptotic tracking control scheme is designed,where fuzzy systems are applied to approximate unknown function terms,the effect of hysteresis and stochastic disturbances is compensated *** proposed scheme ensures that the tracking error can asymptotically converge to zero in probability and all signals of the closed-loop system are bounded almost ***,the effectiveness of the control scheme is verified by giving a simulation example.

关键词： Adaptive fuzzy control asymptotic tracking stochastic nonlinear systems unknown backlash-like hysteresis

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Hot deformation behavior of EA4T steel

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Acta Metallurgica Sinica(English letters) 2012年第5期25卷 374-382页

作者： Gang XU Lina wang Shiqi LI le wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing100083 China

The compressive deformation behavior of EA4T steel was investigated at tempera- tures ranging from 950 to 1150℃ and strain rates from 0.1 to 20 s-1 on Gleeble-1500 thermo-simulation machine. The work hardening rate versus stress curves were used to determine the characteristic points of flow curves. The application of constitutive equations to determine the hot working constants of this material was discussed. Fur- thermore, the effect of Zener-Hollomon parameter （Z） on the characteristic points of flow curves was studied using the power law relation. The deformation activation energy of this steel was determined as 309.5 kJ/mol. Some behaviors were compared to other steels.

关键词： EA4T steel Constitutive equations Activation energy Workhardening rate

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Compressed ghost imaging based on differential speckle patterns

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Chinese Physics B 2020年第2期29卷 294-300页

作者： le wang Shengmei Zhao Institute of Signal Processing and Transmission Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210003China Key Laboratory of Broadband Wireless Communication and Sensor Network Technology(NUPT) Ministry of EducationNanjing 210003China

We propose a compressed ghost imaging scheme based on differential speckle patterns,named *** the scheme,a series of bucket detector signals are acquired when a series of random speckle patterns are employed to illuminate an unknown *** the differential speckle patterns(differential bucket detector signals)are obtained by taking the difference between present random speckle patterns(present bucket detector signals)and previous random speckle patterns(previous bucket detector signals).Finally,the image of object can be obtained directly by performing the compressed sensing algorithm on the differential speckle patterns and differential bucket detector *** experimental and simulated results reveal that CGI-DSP can improve the imaging quality and reduce the number of measurements comparing with the traditional compressed ghost imaging schemes because our scheme can remove the environmental illuminations efficiently.

关键词： ghost imaging compressed sensing differential speckle patterns differential bucket detector signals

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Settlement Mode Analysis for An Immersed Tube Tunnel Considering A Nonuniform Foundation Under Tidal Load

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China Ocean Engineering 2022年第3期36卷 427-438页

作者： wang Yan-ning ZHOU Huan-zhu wang le-chen Department of Civil and Environmental Engineering Shantou UniversityShantou 515063China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221000China

Immersed tube tunnels are usually placed on soft soil layers in cross-sea tunnelling *** to the influence of stratum conditions and slope design,the longitudinal distribution of substratum layers is generally ***,the inhomogeneous deformation of the element-joint becomes the key factor in the failure of the immersed tube ***,a corresponding calculation method for joint deformation is needed to explore the deformation law of immersed tube *** constructing a three-section immersed tube tunnel analysis model(TTM),the relationship between the two types of deformation of the immersed tube tunnel structure in a longitudinal nonuniform soft soil foundation is described,and the deformation characteristics of the immersed structure under different boundaries are *** on the mechanical behaviour of the joint and foundation,according to the Timoshenko beam on the Vlasov two-parameter foundation(VTM),considering the tidal cyclic load during the operation and maintenance period,an example analysis is ***,the deformation characteristics and development trend of the immersed tube tunnel under the influence of different soil layers are *** obtained results have a certain guiding significance for the deformation calculation of immersed tube tunnels.

关键词： geotechnical engineering immersed tube tunnel theoretical analysis soft soil foundation element-soil interaction

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In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie Hu Hong-Xin Lao Xiu-Wu Xu Wei-Kang wang le-le wang Qin-Qin Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into Hf-BPDC MOF by forming coordinating bonds with Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

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