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Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities

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World Journal of Clinical Cases 2020年第15期8卷 3218-3229页

作者： Alexis Mae Bayudan chien-Huan Chen Department of Medicine Washington University School of MedicineSt.LouisMO 63108United States Division of Gastroenterology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110United States

BACKGROUND Refractory gastrointestinal bleeding(GIB)secondary to gastrointestinal vascular malformations(GIVM)such as gastrointestinal angiodysplasia(GIAD)and gastric antral vascular ectasia(GAVE)remains challenging to treat when endoscopic therapy *** thalidomide has been suggested as a treatment option for refractory *** To determine the outcome of patients treated with thalidomide for refractory GIB due to *** IRB approved,single center,retrospective review of electronic medical records from January 2012 to November *** age>18 years old,who had>3 episodes of GIB refractory to medical or endoscopic therapy,and who had been treated with thalidomide for at least 3 mo were *** primary endpoint was recurrence of GIB 6 mo after initiation of *** Fifteen patients were included in the study,all with significant cardiac,hepatic,or renal *** cause of GIB was GIAD in 10 patients and GAVE in 5 *** patients were lost to follow *** the 13 patients followed,38.5%(n=5)had no recurrent GIB or transfusion requirement after treatment with ***,84.6%(n=11)of patients had a reduction in transfusion requirements and hospitalizations for *** was discontinued in 2 patients due to cost(n=1)and medication interaction(n=1).Reported adverse reactions included fatigue(n=3),neuropathy(n=2),dizziness(n=1),and constipation(n=1).Six patients died during follow up due to unknown cause(n=4)and sepsis(n=2).CONCLUSION Thalidomide appears to be an effective treatment for refractory GIB due to GIAD or GAVE in a Western population with significant comorbidities.

关键词： Vascular malformation Thalidomide Refractory gastrointestinal bleeding Gastric antral vascular ectasia Angiodysplasia

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Asymptotic limit of the Gross-Pitaevskii equation with general initial data

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Science China Mathematics 2016年第6期59卷 1113-1126页

作者： LI FuCai LIN Chi-Kun WU Kung-chien Department of Mathematics Nanjing UniversityNanjing 210093 Department of Applied Mathematics and Center of Mathematical Modeling and Scientific Computing Chiao Tung UniversityHsinchu 30010 Department of Mathematics Cheng Kung UniversityTainan 70101

This paper mainly concerns the mathematical justification of the asymptotic limit of the GrossPitaevskii equation with general initial data in the natural energy space over the whole space. We give a rigorous proof of the convergence of the velocity fields defined through the solutions of the Gross-Pitaevskii equation to the strong solution of the incompressible Euler equations. Furthermore, we also obtain the rates of the convergence.

关键词： Gross-Pitaevskii equation asymptotic limit incompressible Euler equation general initial data

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Decomposition of formaldehyde by EPD photocatalyst filters in HVAC

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Particuology 2011年第5期9卷 497-501页

作者： chien-Chih Chen Ching-Song Jwo Tun-Ping Teng Graduate Institute of Mechanical and Electrical Engineering National Taipei University of Technology Taipei. Taiwan China Department of Energy and Refrigerating Air Conditioning Engineering. National Taipei University of Technology Taipei Taiwan China Department of Industrial Education. National Taiwan Normal University Taipei Taiwan China

This study used electrophoretic deposition （EPD） to apply titanium oxide （TiO2） coating on stainless steel filters and investigated the effectiveness of photocatalytic oxidation of formaldehyde by TiO2 under various conditions of heating ventilation air conditioning （HVAC）. The results showed photocatalytic efficiency could reach 35,59% at 21 ℃ and 36.39% at 26℃ with 7 photocatalyst filters and 5 UVC lamps, the overall efficiency of formaldehyde removal of 52.37% at 21 ℃, and 56.8% at 26 ℃, By all experimental data can be found that the temperature for the photocatalytic performance is not obvious in the range of this study.

关键词： Electrophoretic deposition (EPD) TiO2 Filter HVAC

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A Model for Analyzing the Transshipment Competition Relationship Between the Port of Hong Kong and the Port of Kaohsiung

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Journal of Ocean University of China 2009年第4期8卷 377-384页

作者： CHOU chien Chang Department of Shipping Technology Kaohsiung Marine University Kaohsiung 805 Taiwan China

The transshipment is an important issue in the current marine transportation. This paper constructed a mathematical programming model to elaborate the transshipment port selection for the shipping company. This model is tested by the data collected from the ports of Hong Kong and Kaohsiung. The results show that this model can be used to explain the transshipment competition relationship between the ports of Hong Kong and Kaohsiung well. A sensitivity analysis was also executed. The sensitivity analysis results showed that both the port of Hong Kong and Kaohsiung should decrease the charges of port and increase the effi- ciency of loading and discharging. Based on the sensitivity analysis results, some interesting conclusions and helpful suggestions were obtained for the managers of the ports of Hong Kong and Kaohsiung to improve their port management.

关键词： transshipment mathematical programming port of Hong Kong port of Kaohsiung

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Numerical analysis of pile–slope stability and the soil arching around two adjacent piles

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Journal of Mountain Science 2022年第11期19卷 3270-3285页

作者： chien-Yuan CHEN Chun-Kai CHANG Yu-Shan LIN Department of Civil and Water Resources Engineering National Chiayi UniversityChiayi City 60004Chinese Taipei

Seismic pile–slope stability analysis and the formation mechanism of soil arching have not been well studied. This study used a threedimensional(3D) finite difference to determine soil and pile parameter changes in the static and seismic stability of the pile–slope caused by the interaction between stabilizing piles. Pile–slope stability analysis was performed to determine the optimal design of piles along a slope and the corresponding failure mode involving the formation of soil arching around two adjacent piles. The Factor of Safety(FS) of the slope was evaluated using the shear strength reduction method for static and seismic analyses. The results of the analysis show that suitable pile spacing(S) and a suitable pile diameter(D) in the middle of a slope result in the maximum FS for the pile–slope system and the formation of soil arching around two adjacent piles. FS of the pile–slope increased negligibly in the seismic analysis of piles located at the slope crest and toe. An optimized pile diameter and installation location afforded the maximum FS for the slope that corresponded to a specified slope failure mode for different pile locations. A pile spacing S ≤ 2.5D for piles installed in the middle of the slope is suggested for increasing the static and seismic pile–slope stability.

关键词： Numerical modeling Slope stability Stabilizing pile Arching effect Seismic analysis Failure mode

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Sawdust discharge rate from aerated hoppers

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Particuology 2011年第3期9卷 306-313页

作者： Pan Chen Zhulin Yuan chien-Song Chyang Fu-Xiong Zhuan School of Energy and Environment Southeast UniversityNanjing 210096JiangsuChina Department of Chemical Engineering Chung Yuan Christian UniversityChungli 32023TaiwanChina

This paper presents a numerical and experimental study of the discharge rate of sawdust from an aerated hopper as an important parameter in many industrial processes involving the handling of other granular materials. Numerical experiments are conducted by means of an Eulerian-Eulerian approach coupled with the kinetic theory of granular flow （KTGF）. Emphasis is given to the effects of particle size, hopper outlet width, hopper half angle, aeration height and air flow rate. The results show that the discharge rate is significantly affected by hopper outlet width, particle size and air flow rate, but is not sensitive to the hopper half angle and aeration height： increasing hopper outlet width or air flow rate increases discharge rate, while increasing particle size decreases discharge rate. Close agreement between numerical predictions and experimental results is obtained.

关键词： Granular flow Aeration Hopper Flow rate GranuLar kinetic theory Sawdust

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Coupling of zero valent iron and biobarriers for remediation of trichloroethylene in groundwater

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Journal of Environmental Sciences 2011年第4期23卷 560-567页

作者： Mullika Teerakun Alissara Reungsang chien-Jung Lin Chih-Hsiang Liao Department of Biotechnology Khon Kaen University Khon Kaen 000 Thailand. National Center of Excellence for Environmental and Hazardous Waste Management (EHWM) Bangkok 10330 Thailand Research Center for Environmental and Hazardous Substance Management Khon Kaen University A. Muang Khon Kaen 40002 Thailand Department of Environmental Engineering and Science Chia Nan University of Pharmacy and Science Tainan 71710 Taiwan China Department of Environmental Resources Management Chia Nan University of Pharmacy and Science Tainan 71710 Taiwan China

This study attempted to construct a three series barrier system to treat high concentrations of trichloroethylene （TCE; 500 mg/L） in synthetic groundwater. The system consisted of three reactive barriers using iron fillings as an iron-based barrier in the first column, sugarcane bagasse mixed with anaerobic sludge as an anaerobic barrier in the second column, and a biofilm coated on oxygen carbon inducer releasing material as an aerobic barrier in the third column. In order to evaluate the extent of removal of TCE and its metabolites in the aquifer down gradient of the barrier system, a fourth column filled with sand was applied. Residence time of the system was investigated by a bromide tracer test. The results showed that residence time in the column system of the control set and experimental set were 23.62 and 29.99 days, respectively. The efficiency of the three series barrier system in removing TCE was approximately 84% in which the removal efficiency of TCE by the iron filling barrier, anaerobic barrier and aerobic barrier were 42%, 16% and 25%, respectively. cis-Dichloroethylene （cis-DCE）, vinyl chloride （VC）, ethylene and chloride ions were observed as metabolites following TCE degradation. The presence of chloride ions in the effluent from the column system indicated the degradation of TCE. However, cis-DCE and VC were not fully degraded by the proposed barrier system which suggested that another remediation technology after the barrier treatment such as air sparging and adsorption by activated carbon should be conducted.

关键词： iron filling biobarrier remediation permeable reactive barriers trichloroethylene

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Effects of solution treatment and cold rolling on structure and tensile properties of hot-rolled Ti-7.5Mo alloy

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Journal of Iron and Steel Research International 2019年第12期26卷 1366-1375页

作者： Yen-chun Chen chien-ping Ju Jiin-huey Chern Lin Department of Materials Science and Engineering ChengKung UniversityTaiwan 70101China

The effects of solution treatment(ST)and cold rolling(CR)on structure and tensile properties of a heavily hot-rolled(HR)Ti–7.5Mo alloy were *** results indicated that,after HR with a one-pass 65%reduction in thickness,the pores in as-received samples substantially disappeared,the misorientation angle distribution became broader,and grain texture shifted toward.Post-HR ST produced an orthorhombicα''-phase with fine needle-type morphology and caused misorientation to narrow down to 55°–65°with substantially random texture;post-ST CR caused misorientation shift toward high-angle side and texture towardand.With an increase in reduction in thickness,α'(102)intensity increased at the expense of two adjacent(112)/(022)α''-*** X-ray diffraction,metallography and electron backscattered diffraction on scanning electron microscope results indicated that pre-ST HR did not affect the formation of the desired low-modulusα''-phase when the alloy was subsequently *** a practical point of view,the most optimal tensile properties may be found in the sample solution-treated at 900°C for 30 min and cold-rolled by a 20%reduction in thickness,which demonstrated a yield strength of 924 MPa,an ultimate tensile strength of 933 MPa,a tensile modulus of 73 GPa,and an elongation of 26%.

关键词： Titanium alloy Ti–Mo alloy Electron backscattered diffraction Microstructure Mechanical property

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Stochastic seismic slope stability assessment using polynomial chaos expansions combined with relevance vector machine

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Geoscience Frontiers 2021年第1期12卷 405-414页

作者： Qiu-Jing Pan Yat-Fai leung Shu-chien Hsu School of Civil Engineering Central South UniversityNo.22Shaoshan South RoadChangsha410075China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina

This paper presents probabilistic assessment of seismically-induced slope displacements considering uncertainties of seismic ground motions and soil properties.A stochastic ground motion model representing both the temporal and spectral non-stationarity of earthquake shakings and a three-dimensional rotational failure mechanism are integrated to assess Newmark-type slope displacements.A new probabilistic approach that incorporates machine learning in metamodeling technique is proposed,by combining relevance vector machine with polynomial chaos expansions(RVM-PCE).Compared with other PCE methods,the proposed RVM-PCE is shown to be more effective in estimating failure *** sensitivity and relative influence of each random input parameter to the slope displacements are ***,the fragility curves for slope displacements are established for sitespecific soil conditions and earthquake hazard *** results indicate that the slope displacement is more sensitive to the intensities and strong shaking durations of seismic ground motions than the frequency contents,and a critical Arias intensity that leads to the maximum annual failure probabilities can be identified by the proposed approach.

关键词： Earthquake 3D slope stability Failure probability Seismic displacements Seismic hazard analysis

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A Review of Predictive and Contrastive Self-supervised learning for Medical Images

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Machine Intelligence Research 2023年第4期20卷 483-513页

作者： Wei-chien Wang Euijoon Ahn Dagan Feng Jinman Kim Biomedical and Multimedia Information Technology(BMIT)Research Group School of Computer ScienceThe University of SydneySydneyNSW2006Australia College of Science and Engineering James Cook UniversityCairnsQLD4811Australia

Over the last decade, supervised deep learning on manually annotated big data has been progressing significantly on computer vision tasks. But, the application of deep learning in medical image analysis is limited by the scarcity of high-quality annotated medical imaging data. An emerging solution is self-supervised learning (SSL), among which contrastive SSL is the most successful approach to rivalling or outperforming supervised learning. This review investigates several state-of-the-art contrastive SSL algorithms originally on natural images as well as their adaptations for medical images, and concludes by discussing recent advances, current limitations, and future directions in applying contrastive SSL in the medical domain.

关键词： Self-supervised learning(SSL) contrastive learning deep learning medical image analysis computer vision

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