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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo le tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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On Bidding Strategies for Competitive Generators Based on PSO Method under Incomplete Information 36

On Bidding Strategies for Competitive Generators Based on PS...

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第36届中国控制会议

作者： tong le School of Automation Beijing Institute of Technology

ISBN: (纸本)9781538629185

In power market, it is rather important for Gencos to choose their bids wisely. This paper conducts a research on bidding strategies for Gencos under incomplete information and proposes a bidding strategy model with elimination mechanism. By narrowing the searching space of bids to simplify the model, it avoids the algorithm trapped into a local optimum to some extent. Meanwhile, the elimination mechanism also optimizes the bids in a way which provides a Genco with more assurance under the prerequisite of pursuing maximum profits. The experimental results verify the validity of the proposed model.

关键词： Bidding strategy Particle swarm Profit optimization

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Improved lazy theta algorithm based on octree map for path planning of UAV

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Defence Technology（防务技术） 2023年第5期23卷 8-18页

作者： Meng-shun Yuan tong-le Zhou Mou Chen College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing211106China

This paper investigates the path planning method of unmanned aerial vehicle(UAV)in threedimensional ***,in order to keep a safe distance between UAV and obstacles,the obstacle grid in the map is *** using the data structure of octree,the octree map is constructed,and the search nodes is significantly ***,the lazy theta*algorithm,including neighbor node search,line-of-sight algorithm and heuristics weight adjustment is *** the process of node search,UAV constraint conditions are considered to ensure the planned path is actually *** redundant nodes are reduced by the line-of-sight algorithm through judging whether visible between two *** weight adjustment strategy is employed to control the precision and speed of ***,the simulation results show that the improved lazy theta*algorithm is suitable for path planning of UAV in complex environment with *** effectiveness and flight ability of the algorithm are verified by comparing experiments and real flight.

关键词： Unmanned aerial vehicle Path planning Lazy theta*algorithm Octree map Line-of-sight algorithm

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Numerical study of the cyclic load behavior of AISI 316L stainless steel shear links for seismic fuse device

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Frontiers of Structural and Civil Engineering 2014年第4期8卷 414-426页

作者： Ruipeng LI Yunfeng ZHANG le-Wei tong Department of Civil & Environmental Engineering University of Maryland College Park Maryland 21042 USA State key laboratory for Disaster Reduction in Civil Engineering College of Civil Engineering Tongji University Shanghai 200092China

This paper presents the results of nonlinear finite element analyses conducted on stainless steel shear links. Stainless steels are attractive materials for seismic fuse device especially for corrosion-aware environment such as coastal regions because they are highly corrosion resistant, have good ductility and toughness properties in combination with low maintenance requirements. This paper discusses the promising use ofAISI 316L stainless steel for shear links as seismic fuse devices. Hysteresis behaviors of four stainless steel shear link specimens under reversed cyclic loading were examined to assess their ultimate strength, plastic rotation and failure modes. The nonlinear finite element analysis results show that shear links made of AISI 316L stainless steel exhibit a high level of ductility. However, it is also found that because of large over-strength ratio associated with its strain hardening process, mixed shear and flexural failure modes were observed in stainless steel shear links compared with conventional steel shear links with the same length ratio. This raises the issue that proper design requirements such as length ratio, element compactness and stiffener spacing need to be determined to ensure the full development of the overall plastic rotation of the stainless steel shear links.

关键词： hysteretic damper eccentrically braced frame energy dissipation seismic stainless steel shear link

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Comparison of drug concentrations in blood and gastric lavage fluid before and after gastric lavage:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7680-7683页

作者： Yue Zhou Jia-le tong Ai-Hua Peng Shu-Yun Xu Department of Emergency Medicine and West China School of Nursing Laboratory of Emergency MedicineWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Disaster Medical Center Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastric lavage(GL)is one of the most important early therapies to remove unabsorbed toxins from the gastrointestinal ***,the details of performing gastric lavage remain to be *** is controversy in clinical practice regarding individual choice of the timing of GL and its *** SUMMARY We report the case of a young woman who presented to the Emergency Department with drug intoxication for four *** used the latest toxicological screening techniques to compare drug concentrations in the patient's blood and gastric lavage fluid before and after gastric *** results confirmed that gastric lavage was effective in reducing drug concentrations in the stomach;a small amount of drug remained in the stomach at the end of gastric *** Gastric lavage is effective in reducing drug concentrations in the stomach,with a small amount of drug remaining in the stomach at the end of gastric lavage.

关键词： Gastric lavage Drug concentrations Oral poisoning Case report

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循环荷载作用下钢梁临界侧向长细比研究

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振动与冲击 2015年第2期34卷 30-37,54页

作者：刘洋童乐为同济大学土木工程学院建筑工程系土木工程防灾国家重点实验室上海200092

针对我国《建筑抗震设计规范》推荐的临界侧向长细比计算公式来源于单调荷载研究结果,并未反映不同抗震等级影响问题,基于抗震等级应与适宜的转动能力相匹配准则,对循环荷载作用下钢梁进行非线性有限元分析。所建模型考虑初始几何缺陷... 详细信息

针对我国《建筑抗震设计规范》推荐的临界侧向长细比计算公式来源于单调荷载研究结果,并未反映不同抗震等级影响问题,基于抗震等级应与适宜的转动能力相匹配准则,对循环荷载作用下钢梁进行非线性有限元分析。所建模型考虑初始几何缺陷、残余应力影响,并得到试验验证。通过对钢梁端部弯矩比、腹板高厚比、翼缘宽厚比、残余应力分布图式及平面外边界约束条件等5类影响因素数值分析,提出循环荷载作用下钢梁临界侧向长细比计算公式。该公式具有计算精度高、表达形式简单等特点。

关键词：钢梁抗震设计临界侧向长细比循环荷载抗震等级转动能力端部弯矩比

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知识生产和文化传播使命下的绘画展强策展趋势——基于美术馆与博物馆的对比研究

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东南文化 2020年第2期 181-185,I0011-I0012页

作者：陈同乐江苏省美术馆江苏南京210018

在知识获取途径极其多样和便捷的今天,美术馆、博物馆的知识生产和文化传播使命对策展提出明显的新要求。美术馆和综合性博物馆的绘画展在朝各自擅长的领域进发并担任不同方向公共教育责任的同时,也在一个大的社会环境中经受检验后向彼... 详细信息

在知识获取途径极其多样和便捷的今天,美术馆、博物馆的知识生产和文化传播使命对策展提出明显的新要求。美术馆和综合性博物馆的绘画展在朝各自擅长的领域进发并担任不同方向公共教育责任的同时,也在一个大的社会环境中经受检验后向彼此学习。这类绘画展在保持自己独有气质的同时,发挥美育功能,并有意识地开拓文化挖掘和文化传播功能,形成"强策展"趋势。"强策展"理念对于当今绘画展策展的意义重大,也对策展人提出更高的艺术专业素养要求。他们须同时是合格的艺术批评家、具有创新思想的创作者、艺术传播专家等。未来展览界将出现深具历史眼光和前瞻性的"展览的展览"以及专业中立、理性辩证的"展览批评"。

关键词：博物馆美术馆绘画展知识生产文化传播强策展策展人

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公路旧桥加固效果综合评价方法

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交通运输工程学报 2005年第1期5卷 28-32页

作者：武同乐徐岳河南省交通规划勘察设计院长安大学桥梁与隧道陕西省重点实验室陕西西安710064

阐述了公路旧桥加固效果后评价的基本概念和内容体系,在传统成功度评价法的基础上,提出了成功度综合评价法用以评价桥梁加固后的综合效果。该方法应用层次分析法建立桥梁加固项目成功度综合评价指标体系;采用德尔菲评分法确定评价指标集... 详细信息

阐述了公路旧桥加固效果后评价的基本概念和内容体系,在传统成功度评价法的基础上,提出了成功度综合评价法用以评价桥梁加固后的综合效果。该方法应用层次分析法建立桥梁加固项目成功度综合评价指标体系;采用德尔菲评分法确定评价指标集,并根据指标类型的不同对其进行优化处理,得到成功度综合评价矩阵;对模糊数学理论的矩阵算子进行拓广,建立了既全面考虑又兼顾重点的成功度综合评价计算模型。算例中双曲拱桥加固后项目成功度的计算结果为0 46,成功度综合评价结论为“部分成功”,与实际相符,这说明成功度综合评价方法可综合专家的模糊评价信息,能对桥梁加固效果作出合理的定性评价。

关键词：桥梁工程加固效果综合评价成功度

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