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Rapid health estimation of in-service battery packs based on limited labels and domain adaptation

Journal of Energy Chemistry 2024年第2期89卷 345-354,I0009页

作者： Zhongwei deng le Xu Hongao Liu Xiaosong Hu Bing Wang Jingjing Zhou School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Sustainability Stanford UniversityStanfordCA 94305USA College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China China Automotive Engineering Research Institute Co.Ltd. Chongqing 401122China

For large-scale in-service electric vehicles(EVs)that undergo potential maintenance,second-hand transactions,and retirement,it is crucial to rapidly evaluate the health status of their battery packs.However,existing methods often rely on lengthy battery charging/discharging data or extensive training samples,which hinders their implementation in practical scenarios.To address this issue,a rapid health estimation method based on short-time charging data and limited labels for in-service battery packs is proposed in this paper.First,a digital twin of battery pack is established to emulate its dynamic behavior across various aging levels and inconsistency degrees.Then,increment capacity sequences(△Q)within a short voltage span are extracted from charging process to indicate battery health.Furthermore,data-driven models based on deep convolutional neural network(DCNN)are constructed to estimate battery state of health(SOH),where the synthetic data is employed to pre-train the models,and transfer learning strategies by using fine-tuning and domain adaptation are utilized to enhance the model adaptability.Finally,field data of 10 EVs exhibiting different SOHs are used to verify the proposed methods.By using the△Q with 100 m V voltage change,the SOH of battery packs can be accurately estimated with an error around 3.2%.

关键词： Lithium-ion battery Electric vehicles Health estimation Feature extraction Convolutional neural network Domain adapatation

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Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1359-1388页

作者： Qian Zhou Yu Meng Daishi Li lei Yao Jiayuan le Yihuang Liu Yuming Sun Furong Zeng Xiang Chen Guangtong deng Department of Dermatology Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Furong Laboratory 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya Hospital87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of General Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Plastic and Cosmetic Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Oncology Xiangya HospitalCentral South University87Xiangya RoadChangsha 410008Hunan ProvinceChina

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membranelocalized lipid peroxides.It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors.Intriguingly,mesenchymal and dedifferentiated cancer cells,which are usually resistant to apoptosis and traditional therapies,are exquisitely vulnerable to ferroptosis,further underscoring its potential as a treatment approach for cancers,especially for refractory cancers.However,the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor cells.Ferroptosis induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer immunity.Thus,a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical applications.In this review,we provide an overview of the recent advancements in understanding ferroptosis in cancer,covering molecular mechanisms,biological functions,regulatory pathways,and interactions with the tumor microenvironment.We also summarize the potential applications of ferroptosis induction in immunotherapy,radiotherapy,and systemic therapy,as well as ferroptosis inhibition for cancer treatment in various conditions.We finally discuss ferroptosis markers,the current challenges and future directions of ferroptosis in the treatment of cancer.

关键词： cancer mechanisms treatment

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Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain elusive.Comparing reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways.The interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in hybrids.In compartment domain(CD)boundaries,the distal interactions were more in hybrids than their parents.In the hybrids of CURLY leAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower H3K27me3.ChIP-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance interactions.In addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop regions.Our findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo Shi Cheng-Jie Lyu Zhen-Kai le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu Jin-Fa Tou deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease conditions.This study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western blot.Hypertonic pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of NEC.The mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various treatments.Macrophages,intestinal epithelial cell injuries,and IL-1β release were determined.Results Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β levels.Furthermore,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC mice.NLRP3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell injuries.Conclusions Macrophage activation may be essential for NEC development.NLRP3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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新污染物健康风险需高度重视与有效防范

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科学通报 2024年第6期69卷 645-647页

作者：邓启红于云江康乐郑州大学公共卫生学院郑州450001 生态环境部华南环境科学研究所国家环境保护环境污染健康风险评价重点实验室广州510655 中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室北京100101

自党的十八大,特别是“健康中国”国家战略实施以来,党中央以前所未有的力度抓生态文明建设,使我国生态环境保护发生历史性、转折性、全局性变化.2018年6月,中共中央国务院《关于全面加强生态环境保护坚决打好污染防治攻坚战的意见》进... 详细信息

自党的十八大,特别是“健康中国”国家战略实施以来,党中央以前所未有的力度抓生态文明建设,使我国生态环境保护发生历史性、转折性、全局性变化.2018年6月,中共中央国务院《关于全面加强生态环境保护坚决打好污染防治攻坚战的意见》进一步加紧部署了“坚决打赢蓝天保卫战、着力打好碧水保卫战、扎实推进净土保卫战”.目前,我国传统环境污染(包括雾霾)已得到明显改善,空气质量显著提升,呈现蓝天、白云、绿水、青山/净土的美好景象.

关键词：生态环境保护生态文明建设污染防治健康风险转折性空气质量环境污染保卫战

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行政诉讼“职权主义”的边界及规制

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南京社会科学 2024年第6期 65-75页

作者：邓刚宏刘乐上海海事大学法学院上海201306

行政诉讼职权主义边界是一个极具理论研究价值和实践价值的重要论题,不仅关乎我国行政审判的效果,也是衡量国家法治进程和行政审判水平的重要标准,直接影响行政诉讼功能以及立法目的的实现。厘定行政诉讼职权主义的边界,需要对行政立案... 详细信息

行政诉讼职权主义边界是一个极具理论研究价值和实践价值的重要论题,不仅关乎我国行政审判的效果,也是衡量国家法治进程和行政审判水平的重要标准,直接影响行政诉讼功能以及立法目的的实现。厘定行政诉讼职权主义的边界,需要对行政立案审查权、事实探知权、裁判权边界的法理逻辑进行分析,并以此为理论指引,提出行政诉讼职权主义边界的规制路径。从完善行政诉讼制度、增强行政审判效果出发,需要构建由形式审查与实质审查相结合的立案审查机制,明确人民法院依职权调取证据的边界,明确规范人民法院依职权作出“重作行政行为”“责令采取补救措施”以及“变更行政行为”等诉外裁判制度的适用边界。

关键词：职权主义行政争议权利救济监督行政

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Selection of water source for water transfer based on algal growth potential to prevent algal blooms

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Journal of Environmental Sciences 2021年第5期33卷 246-254页

作者： Yongjun Song Jing Qi le deng Yaohui Bai Huijuan Liu Jiuhui Qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China

Water transfer is becoming a popular method for solving the problems of water quality deterioration and water level drawdown in lakes. However, the principle of choosing water sources for water transfer projects has mainly been based on the effects on water quality, which neglects the influence in the variation of phytoplankton community and the risk of algal blooms. In this study, algal growth potential(AGP) test was applied to predict changes in the phytoplankton community caused by water transfer projects. The feasibility of proposed water transfer sources(Baqing River and Jinsha River) was assessed through the changes in both water quality and phytoplankton community in Chenghai Lake, Southwest China. The results showed that the concentration of total nitrogen(TN) and total phosphorus(TP) in Chenghai Lake could be decreased to 0.52 mg/L and 0.02 mg/L respectively with the simulated water transfer source of Jinsha River. The algal cell density could be reduced by 60%, and the phytoplankton community would become relatively stable with the Jinsha River water transfer project, and the dominant species of Anabaena cylindrica evolved into Anabaenopsis arnoldii due to the species competition. However, the risk of algal blooms would be increased after the Baqing River water transfer project even with the improved water quality. Algae gained faster proliferation with the same dominant species in water transfer source. Therefore, water transfer projects should be assessed from not only the variation of water quality but also the risk of algal blooms.

关键词： Water transfer Water quality Phytoplankton community Algal blooms Algal growth potential Chenghai Lake

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改革开放以来中小学安全管理立法的梳理与思考

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豫章师范学院学报 2024年第2期39卷 96-99,116页

作者：邓乐豫章师范学院江西南昌330103

中小学安全管理事关学生的身心健康及其家庭幸福,也是最近国家、社会和家庭关注的热点。改革开放以来,我国关于中小学安全管理的立法成果较为丰硕,但是也存在立法层级不高、存在立法漏洞、实施较为困难、赔偿机制不健全等问题。制定中... 详细信息

中小学安全管理事关学生的身心健康及其家庭幸福,也是最近国家、社会和家庭关注的热点。改革开放以来,我国关于中小学安全管理的立法成果较为丰硕,但是也存在立法层级不高、存在立法漏洞、实施较为困难、赔偿机制不健全等问题。制定中小学安全管理法律是我国实现教育法治现代化、依法治教的必由之路。

关键词：改革开放中小学安全管理依法治校

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Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying deng Sicun Song Junxuan Fan Mao Luo le Yao Shaochun Dong Yukun Shi Linna Zhang Yue Wang Haipeng Xu Huiqing Xu Yingying Zhao Zhaohui Pan Zhangshuai Hou Xiaoming Li Boheng Shen Xinran Chen Shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze Wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or topology.Geoscientists have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text analysis.However,there is currently no comprehensive paleontology KG or data-driven discovery based on it.In this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction process.An ontology containing 19365 concepts has been defined up to 2023.On this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

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舆论动力学模型综述

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计算机科学 2024年第2期51卷 15-26页

作者：刘淑娴徐欢王微邓乐新疆大学信息科学与工程学院乌鲁木齐830046

社交网络为信息传播提供了媒介,导致了舆论的快速发展。控制舆论的发展方向是舆论动力学的核心问题之一。然而,舆论动力学模型主要通过研究主体意见更新的方式,来推理出舆论演化的规律。针对目前的舆论动力学模型进行了分类,分析了各自... 详细信息

社交网络为信息传播提供了媒介,导致了舆论的快速发展。控制舆论的发展方向是舆论动力学的核心问题之一。然而,舆论动力学模型主要通过研究主体意见更新的方式,来推理出舆论演化的规律。针对目前的舆论动力学模型进行了分类,分析了各自的优缺点,及其在不同领域的应用,并总结了舆论动力学的未来研究方向。该研究有助于理解舆论演化的规律,从而可以为政府等机构控制舆论导向提供较好的指导。

关键词：舆论舆论动力学舆论演化

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