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On the Topological Entropy of Nonautonomous Differential Equations

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Journal of Applied Mathematics and Physics 2019年第2期7卷 418-429页

作者： le huy tien le Duc Nhien Department of Mathematics Mechanics and Informatics Vietnam National University at Hanoi Hanoi Vietnam

The purpose of this paper is to extend the concept topological entropy to nonautonomous linear systems. Next, we shall give estimation of the topological entropy for the class of bounded linear equations on Rn. Finally, we are about to investigate the invariant properties of one through the transformations such as topological conjugacy, topological equivalence and kinematically similar and then show that topological entropy of one is equal to sum of positive Lyapunov characteristic exponents.

关键词： Kinematically Similar Topological Conjugacy Linear Dynamic Equation Topological Entropy

<i>N</i>-Expansive Property for Flows

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Journal of Applied Mathematics and Physics 2019年第2期7卷 410-417页

作者： le huy tien le Duc Nhien Department of Mathematics Mechanics and Informatics Vietnam National University at Hanoi Hanoi Vietnam

In this paper, we discuss the dynamics of n-expansive homeomorphisms with the shadowing property defined on compact metric spaces in continuous case. For every n∈N, we exhibit an n-expansive homeomorphism but not (n-1)-expansive. Furthermore, that flow has the shadowing property and admits an infinite number of chain-recurrent classes.

关键词： Expansive Flow N-Expansive Shadowing

Comparative Study of Light Manipulation in Three-level Systems Via Spontaneously Generated Coherence and Relative Phase of Laser Fields

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Communications in Theoretical Physics 2019年第8期71卷 947-954页

作者： Nguyen huy Bang le Nguyen Mai Anh Nguyen tien Dung le Van Doai Vinh University 182 Le Duan Street Vinh City Vietnam Nong Lam University Ho Chi Minh City Vietnam (Received March 21 2019revised manuscript

We present a comparative study of the control of group velocity in three-level atomic systems including Λ-, Ladder-, and V-types via spontaneously generated coherence(SGC) and relative phase of laser *** the steady regime, expressions of group index are derived as an analytical function of controllable parameters related to SGC and relative *** is shown that the group velocity can be further slowed down or speeded up under SGC in which modifications of group velocity due to the SGC in Λ-and V-systems are stronger than that in *** particular, when interference strength of SGC p increases from 0.7 to 1.0, the light propagation is switched from superluminal to subluminal modes(for Λ-and Ladder-systems) or from subluminal to superluminal modes(for Vsystem).In the presence of relative phase, the group velocity changes between subluminal and superluminal modes with a period of 2π.In resonant region, the largest positive value of group index reaches at the relative phase φ=π while the largest negative value of group index reaches at φ= 0 and 2π for the Λ-and Ladder-systems, otherwise, for the V-system the largest positive group index occurs at φ= 0 and 2π, and the largest negative group index occurs at φ=π.

关键词： electromagnetically induced transparency spontaneously generated coherence group velocity

Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： Nguyen Quang Thu Nguyen Tran Nam tien Nguyen Thi Hai Yen Thuc-huy Duong Nguyen Phuoc Long huy Truong Nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

Examining unobserved factors associated with red light running in Vietnam:A latent class model analysis

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Transportation Safety and Environment 2022年第1期4卷 110-122页

作者： tien Dung Chu Tomio Miwa Tuan Anh Bui Quang Phuc Nguyen Quang huy Vu Department of Highway and Traffic Engineering University of Transport and CommunicationsNo.3 Cau Giay StreetLang Thuong WardDong Da DistrictHanoi 10001Vietnam Institute of Materials and Systems for Sustainability Nagoya UniversityFuro-choChikusa-kuNagoya cityAichi Prefecture464-8603Japan

Red-light running(RLR)is a crucial violation that causes traffic accidents and *** factors that affect RLR is very significant to reduce the potential of this *** studies have paid considerable attention to the observable factors,but not to unobservable *** study aims to examine the effects of observable and unobservable factors on *** study uses a latent class model(LCM)to assign individuals into two classes—red-light-respectful and red-light-disrespectful road users—by surveying 751 respondents who use private transportation *** study incorporates psychological determinants into the LCM to account for unobservable *** contribution of this study is the in-depth investigation into law-respectful and law-disrespectful behaviours and intentional and unintentional *** a study has not yet been conducted in the existing *** addition,a comprehensive comparison of the LCM and a traditional ordered probit model was ***,the results suggest that the LCM is superior to the model that does not consider latent *** estimation results are in alignment with previous studies on RLR:males,younger drivers/riders,less educated road users and motorcyclists are more likely to run red *** analysis of the latent variables shows that surrounding conditions—the behaviour of other violators,the absence of traffic police,and long waiting times—increase the possibility of *** on these results,we provide suggestions to policymakers and traffic engineers:the implementation of enforcement cameras and penalties for violators are critical countermeasures to minimize the potential of RLR.

关键词： red light running(RLR) developing country latent class model(LCM) multiple indicator multiple cause(MIMIC)model latent variables(LVs) motorcycles(MCs) traffic violation

Favipiravir and its potentials in COVID-19 pandemic:An update

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 433-455页

作者： Dao Ngoc Hien Tam Ahmad T Qarawi Mai Ngoc Luu Morgan Turnage Linh Tran Gehad Mohamed Tawfik le Huu Nhat Minh Nguyen tien huy Tatsuo Iiyama Kyoshi Kita Kenji Hirayama Online Research Club School of Tropical Medicine and Global HealthNagasaki UniversityNagasaki 852-8523Japan Asia Shine Trading&Service CO.LTD. Ho Chi Minh City 700000Vietnam Essen Healthcare BronxNew York 10461 USA Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh City 700000Vietnam American University of the Caribbean CupecoySint Maarten Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Natural Sciences Duy Tan UniversityDa Nang City 550000Vietnam Department of Otorhinolaryngology Faculty of MedicineAin Shams UniversityCairoEgypt Methodist Hospital MerrillvilleIndianaUnited States School of Tropical Medicine and Global Health Nagasaki University1-12-4 SakamotoNagasaki 852-8523Japan Department of International Trials Center of Clinical SciencesNational Center for Global Health and Medicine(NCGM)TokyoJapan

The COVID-19 pandemic has caused millions of deaths and hundreds of millions of confirmed infections *** pandemic has prompted researchers to produce medications or vaccines to reduce or stop the progression and spread of this disease.A variety of previously licensed and marketed medications are being tested for the treatment and recurrence of SARS-CoV2,including favipiravir(Avigan).Favipiravir was recognized as an influenza antiviral drug in Japan in 2014,and has been known to have a potential in vitro activity against SARS-CoV-2,in addition to its broad therapeutic safety *** was recently approved and officially used in many countries *** review provides insights and up-to-date knowledge of the current role of favipiravir in the treatment of COVID-19 infection,focusing on preclinical and ongoing clinical trials,evidence of its efficacy against SARS-CoV-2 in COVID-19,side effects,anti-viral mechanism,and the pharmacokinetic properties of the drug in the treatment of *** to its teratogenic effects,favipiravir cannot be offered to expectant or pregnant *** practical efficacy of such an intervention regimen will depend on its dose,treatment duration,and cost as well as difficulties in application.

关键词： Favipiravir Avigan COVID-19 SARS-CoV-2 Antiviral Review Efficacy

Association of Allergic Symptoms with Dengue Infection and Severity:A Systematic Review and Meta-analysis

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Virologica Sinica 2020年第1期35卷 83-92页

作者： Nguyen Dang Kien Amr Ehab El-Qushayri Ali Mahmoud Ahmed Adnan Safi Sarah Abdel Mageed Samar Muhammed Mehyar Mohammad Rashidul Hashan Sedighe Karimzadeh Kenji Hirayama Nguyen tien huy Department of Obstetrics and Gynecology Thai Binh University of Medicine and PharmacyThai Binh 410000Vietnam Online Research Club(http://***/) NagasakiJapan Faculty of Medicine Minia UniversityMinia 61519Egypt Faculty of Medicine Al-Azhar UniversityCairo 11865Egypt Nishtar Medical University Multan 60000Pakistan Faculty of Medicine Tanta UniversityTanta 31511Egypt Istishari Hospital Amman 11953Jordan Infectious Disease Division Respiratory and Enteric Infections DepartmentInternational Center for Diarrheal Disease ResearchDhakaGPO Box 128Dhaka 1000Bangladesh School of Medicine Sabzevar University of Medical SciencesSabzevar ***Iran Department of Immunogenetics Institute of Tropical Medicine(NEKKEN)Leading Graduate School Programand Graduate School of Biomedical SciencesNagasaki University1-12-4 SakamotoNagasaki 852-8523Japan Evidence Based Medicine Research Group Ton Duc Thang UniversityHo Chi Minh City 70000Vietnam Faculty of Applied Sciences Ton Duc Thang UniversityHo Chi Minh City 70000Vietnam

The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P \ 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.

关键词： Dengue Allergy Severity IgE Asthma Association

Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c

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World Journal of Hepatology 2018年第9期10卷 612-621页

作者： tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-huy Han Folasade P May Joseph R Pisegna the Vatche and Tamar Manoukian Division of Digestive Diseases University of California Los AngelesDepartment of MedicineUniversity of California David Geffen School of MedicineLos AngelesCA 90095United States Division of Gastroenterology Hepatology and Parenteral NutritionDepartment of MedicineVA Greater Los Angeles Healthcare SystemLos AngelesCA 90073United States the Pfleger Liver Institute Department of SurgeryUniversity of California David Geffen School of MedicineLos AngelesCA 90095United States VA Health Services Research and Development Center for the Study of Healthcare Innovation Center for the Study of Healthcare Innovation Implementation and Policy(CSHIIP)Los AngelesCA 90073United States Jonsson Comprehensive Cancer Center Los AngelesCA 90095United States

AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA.

关键词： Hepatitis C virus Hemoglobin A1c Diabetes mellitus Direct-acting antivirals Metabolic syndrome

Monkeypox:A comprehensive review of a multifaceted virus

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Infectious Medicine

Infectious Medicine 2023年第2期2卷 74-88页

作者： Randa Elsheikh Abdelrahman M.Makram Tamilarasy Vasanthakumaran Shubham Tomar Khizer Shamim Nguyen Dong Tranh Sara S.Elsheikh Nguyen Thanh Van Nguyen tien huy Deanery of Biomedical Sciences at Edinburgh Medical School University of EdinburghEdinburgh EH105HFUnited Kingdom Online Research Club(http://***) Nagasaki 852-8523Japan School of Public Health Imperial College LondonLondon SW72BXUnited Kingdom Global Clinical Scholars Research Training Harvard Medical SchoolBostonMA 02115USA Tata Memorial Hospital Varanasi 400012India DataQ Health Karachi 75100Pakistan Department of Infection Control Binh Dinh Provincial General HospitalBinh Dinh 55000Vietnam Faculty of Medicine Zagazig UniversityZagazig 44519Egypt School of Tropical Medicine and Global Health Nagasaki UniversityNagasaki 852-8523Japan

In May 2022,the world witnessed the re-emergence of the zoonotic disease *** this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health *** the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical *** further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle *** is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and ***,some pre-exposure and postexposure prophylactic vaccines have been *** paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.

关键词： Monkeypox Orthopoxvirus Outbreak Smallpox