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糖尿病、糖尿病前期与亚临床心肌损害发生率

中华高血压杂志 2014年第9期22卷 899-899页

作者： Selvin E lazo m Chen Y Shen L Rubin J mcEvoy JW Hoogeveen RC Sharrett AR Ballantyne Cm Coresh J 刘莉

众所周知，处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而，糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果：应用高敏心肌肌钙蛋白T （highly sensitive cardiac troponin T hs-cTnT）分析... 详细信息

众所周知，处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而，糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果：应用高敏心肌肌钙蛋白T （highly sensitive cardiac troponin T hs-cTnT）分析，测定社区动脉粥样硬化风险研究中9331例受试者两个时间点（间隔6年）的心肌肌钙蛋白T（cardiac troponin T，cTnT）水平，所有受试者为无糖尿病或处于糖尿病前期，或糖尿病不伴心血管疾病（包括心电图检测出来的无临床症状的心肌梗死）。

关键词：糖尿病前期心肌损害亚临床 troponin 心肌肌钙蛋白T 发生率动脉粥样硬化发生风险

Variational Calculus With Conformable Fractional Derivatives

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IEEE/CAA Journal of Automatica Sinica 2017年第2期4卷 340-352页

作者： matheus J.lazo Delfim F.m.Torres Instituto de matemática Estatística e Física-FURG Center for Research and Development in mathematics and Applications (CIDmA) Department of MathematicsUniversity of Aveiro

Invariant conditions for conformable fractional problems of the calculus of variations under the presence of external forces in the dynamics are studied. Depending on the type of transformations considered, different necessary conditions of invariance are obtained. As particular cases, we prove fractional versions of Noether's symmetry theorem. Invariant conditions for fractional optimal control problems, using the Hamiltonian formalism, are also investigated. As an example of potential application in Physics, we show that with conformable derivatives it is possible to formulate an Action Principle for particles under frictional forces that is far simpler than the one obtained with classical fractional derivatives.

关键词： Conformable fractional derivative fractional calculus of variations fractional optimal control invariant variational conditions Noether’s theorem

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： merc m.Kemeh Noel D.lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(AD)is the most common form of dementia-the 7th leading cause of death *** the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

Nonalcoholic fatty liver disease and type 2 diabetes: a burgeoning problem with unclear solutions

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 514-517页

作者： mariana lazo Jeanne m.Clark Division of General Internal medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Division of Gastroenterology&Hepatology Johns Hopkins University School of MedicineBaltimoreMDUSA

The association between chronic liver disease and diabetes has been known for long time,with reports in the literature as early as in 1952(1).Currently,a bidirectional association between type 2 diabetes and nonalcoholic fatty liver disease(NAFLD)has become more widely accepted,probably as a result of the common risk factors(e.g.,obesity)and pathophysiology(e.g.,insulin resistance)(2).

关键词： diabetes liver NAFLD

Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael lazo-Gomez Ricardo Tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AmPA)into the rat spinal cord *** and resveratrol were co-infused with AmPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AmPA[1 mm]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AmPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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