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Th-and U-bearing minerals in the SE mediterranean margin of Spain

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Episodes 2004年第1期27卷 33-38页

作者： Jesusmartinez-frias RosarioLunar RaulBenito LaboratoriodeGeologiaPlanetaria CentrodeAstrobiologia（CSIC-INTA）CtradeTorrej6naAjalvirkm428850TorrejondeArdozMadrid（Spain）. DepartamentodeCristalografiaymineralogla FacultaddeCienciasGeol6gicasUniversidadComplutensedeMadrid28040Madrid（Spain） DepartamentodeGeologia MuseoNacionaldeCienciasNaturalesCSICJos6GutierrezAbascal228006Madrid（Spain）

This paper presents the first specific study of the Th-and U-bearing minerals, which were recently found in the SE mediterranean margin of Spain (El Hoyazo area,Almeria province). These minerals are REE phosphates (mainly monazite) which occur as amoeboidal-to-elongate inclusions,from around 10 120μm to 120μm, hosted in single garnet crystals from dacite lavas and metamorphic rocks from the El Hoyazo Volcanic Complex. Th and U contents are higher than 1 wt%, with 3.04 to 5.62wt% for Th02, and 0.7 to 1.75 wt% for UO2. Both elements are also found in xenotime (ThO2:0.24,UO2:0.27wt%). Given that the erosion of the volcanic source rocks has generated a “placer-type” deposit of monazite sands and that garnets (main carriers of monazite) are being commercialised, an environmental monitoring and management plan should be urgently executed in the area.

关键词：铀钍矿物学地中海磷酸盐

The health benefits of selenium in food animals:a review

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1623-1633页

作者： Brittany m.Pecoraro Diego F.Leal Alba frias-De-Diego matthew Browning Jack Odle Elisa Crisci College of Veterinary medicine Department of Population Health and PathobiologyNorth Carolina State UniversityRaleighNorth CarolinaUSA Laboratory of Developmental Nutrition Department of Animal ScienceNorth Carolina State UniversityRaleighNorth CarolinaUSA

Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and *** evinces a strong antioxidant,anti-inflammatory and potential antimicrobial *** biological function is primarily achieved by its presence in selenoproteins as a form of *** deficiency may result in an array of health disorders,affecting many organs and systems;to prevent this,dietary supplementation,mainly in the forms of organic(i.e.,selenomethionine and selenocysteine)inorganic(i.e.,selenate and selenite)sources is *** pigs as well as other food animals,dietary selenium supplementation has been used for improving growth performance,immune function,and meat quality.A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative *** also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral *** this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation,its antioxidant and immunomodulatory actions,and the putative antimicrobial effect ***,our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral,underscoring the need for further in vivo and in vitro studies,particularly in pigs.

关键词： Antimicrobial Antioxidant Food animals Immunomodulation Pig Selenium

Effects of "Candidatus Liberibacter solanacearum"(haplotype B)on Bactericera cockerelli fitness and vitellogenesis

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Insect Science 2020年第1期27卷 58-68页

作者： Angelica Albuquerque Tomilhero frias Freddy Ibanez Azucena mendoza William mario de Carvalho Nunes Cecilia Tamborindeguy Department of Entomology Texas A&M University412 Heep CenterCollege StationTexasUSA DEm-Depto.de Agronomia Nucleo de Pesquisa em Biotecnologia AplicadaMaringaBrazil

"Candidatus Liberibacter solanacearum"(Lso)are phloem-restricted and unculturable Gram-negative *** five haplotypes have been identified worldwide;but only haplotypes A and B are associated with the vector Bactericera cockerelli(Sulc.)in the *** studies showed that Lso-infection reduces *** reproductive output and that Lso haplotype B is more pathogenic than Lso haplotype *** understand the interaction of Lso haplotype B and ***,the fitness of Lso-free and Lso B-infected insects,and the expression of vitellogenin(5cKg7-like),a gene involved directly in the insect reproduction were *** differences in the number of eggs oviposited,and the total number of progeny nymphs and adults were found among crosses of insects with or without *** differences in sex proportions were found between Lso B-infected and Lso-free crosses:a higher proportion of Fi adult females were obtained from Lso B-infected mothers.A significant reduction of BcVgl-like was observed in crosses performed with Lso B-infected females compared to the Lso-free *** female cohorts of different age,a significant reduction of BcVgl-like expression was measured in 7-d-old Lso B-infected females(virgin and mated)compared with 7-d-old Lso-free females(virgin and mated),*** reduction of BcVgl-like transcript was associated with a lower number of developing oocytes observed in female5s reproductive ***,this study represents the first step to understand the interaction of Lso B with ***,highlighting the effect of Lso B infection on egg production,BcVgl-like expression,and oocyte development.

关键词： feminization insect-pathogen interaction oviposition psyllids reproduction vitellogenesis

老年人记忆补偿的长期稳定性和变异性:来自维多利亚纵向研究的证据(英文)

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心理学报 2009年第11期41卷 1091-1101页

作者： Roger A. Dixon Cindy m. de frias Department of Psychology University of AlbertaCanada Department of Psychology Stockholm UniversitySweden

两种记忆状况组来自于参与加拿大维多利亚纵向研究(VLS)的老年人原样本。一种是未受损伤的控制组(NIC),另一种是轻度记忆损伤组(mmD)。在基线水平和纵向水平上(即5次追踪或12年)比较了他们在日常生活中对记忆补偿技术的使用。我们使用... 详细信息

两种记忆状况组来自于参与加拿大维多利亚纵向研究(VLS)的老年人原样本。一种是未受损伤的控制组(NIC),另一种是轻度记忆损伤组(mmD)。在基线水平和纵向水平上(即5次追踪或12年)比较了他们在日常生活中对记忆补偿技术的使用。我们使用多水平模型(以年龄和教育水平为协变量)来检验基线水平的差异和长期的变化模式。基线的结果表明mmD组被试报告了近期在日常生活中使用记忆补偿策略方面有更大的增长。纵向的结果表明记忆补偿的使用在12年中具有明显的稳定性,但是与努力相关的补偿机制存在显著组间差异。教育水平这一协变量(可认为是潜在的认知储备指标)和三种记忆补偿策略随时间的不同变化相关。

关键词：记忆补偿轻度记忆损伤多水平模型维多利亚纵向研究

Solar spectral conversion based on plastic films of lanthanide-doped ionosilicas for photovoltaics:Down-shifting layers and luminescent solar concentrators

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Journal of Rare Earths 2020年第5期38卷 531-538页

作者： m.A.Cardoso S.F.H.Correia A.R.frias H.m.R.Goncalves R.F.P.Pereira S.C.Nunes m.Armand P.S.André V.de Zea Bermudez R.A.S.Ferreira Department of Physics and CICECO-Aveiro Institute of materials University of Aveiro3810-193AveiroPortugal Department of Chemistry and CQ-VR University of Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Instituto de Telecomunicacoes University of Aveiro3810-193AveiroPortugal REQUImTE Instituto Superior de Engenharia do Porto4200-072PortoPortugal Chemistry Centre and Chemistry Department University of Minho4710-057BragaPortugal CICS-Health Sciences Research Center and Chemistry Department University of Beira Interior6201-001CovilhaPortugal Electrical Energy Storage Department CIC EnergiguneParque Tecnologico de AlavaMinano01510Spain Department of Electrical and Computer Engineering Instituto de TelecomunicacoesInstituto Superior TecnicoUniversidade de Lisboa1049-001LisbonPortugal

The mismatch between the photovoltaic(PV)cells absorption and the solar irradiance on earth is one of the major limitations towards more efficient PV energy *** aspect was addressed by downshifting the solar irradiance on Earth through luminescent down-shifting layers based on lanthanidedoped surface-functionalized ionosilicas(ISs)embedded in poly(methyl methacrylate)(PmmA)coated on the surface of commercial Si-based PV *** IS-PmmA hybrid materials exhibit efficient solar radiation harvesting(spectral overlap of^9.5×10^19 photons/(s·m2))and conversion(quantum yield^52%).The direct solar radiation and the down-shifted radiation are partially guided and lost through total internal reflection to the layer edges being unavailable for PV conversion of the coated PV *** tuning the down-shifting layer thickness,it also acts as luminescent solar concentrator enabling the collection of the guided radiation by flexible PV cells applied on the borders of the down-shifting layer leading to an enhancement of the PV energy conversion from^5%(in the case of the single-use of the luminescent down-shifting layer)to^13%comparing with the bare PV *** overall electrical output of the device resulted in an absolute external quantum efficiency increase of^32%for the optimized Eu^3+-based films in the UV spectral region(compared with the bare PV device,which is among the best values reported so far).

关键词： Ionosilicas Lanthanides Photovoltaics Luminescent solar concentrators Down-shifting layers Silicon photovoltaic cells

Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses

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International Journal of Oral Science 2018年第4期10卷 263-272页

作者： Susan Yost Philip Stashenko Yoonhee Choi maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge frias-Lopez Forsyth Institute 245 First StreetCambridgeMA 02142USA Boston University Henry m.Goldman School of Dental medicine 100 East Newton StreetBostonMA 02118USA Department of Integrative Physiology and Pathobiology Tufts University School of Medicine136 Harrison AvenueBostonMA 02111USA Department of Oral Biology College of DentistryUniversity of Florida1395 Center DriveGainesvilleFL 32610-0424USA

Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients.

关键词： profiles analyses

megacryometeors:Distribution on Earth and Current Research

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AmBIO－人类环境杂志 2006年第6期35卷 314-316页

作者： Jesus martinez-frias Antonio Delgado Huertas Planetary Geology Laboratory Centro de Astrobiologia Ctra de Ajalvirkm.4 28850 Torrejón de Ardoz MadridSpain Department of Earth Sciences and Environmental Chemistry Estación Experimental del Zaidín CSIC Prof.Albareda 1 18008 GranadaSpain

研究有关陨冰（ice falls）的历史记录，我们可以发现许多非常类似的事例。实际上，还没有任何关于晴天坠落的冰的适当研究，这些现象往往未经证实就被简单地归为飞机在高空的结冰现象、飞机卫生间产生的污水（蓝冰）或飞机水箱漏水而... 详细信息

研究有关陨冰（ice falls）的历史记录，我们可以发现许多非常类似的事例。实际上，还没有任何关于晴天坠落的冰的适当研究，这些现象往往未经证实就被简单地归为飞机在高空的结冰现象、飞机卫生间产生的污水（蓝冰）或飞机水箱漏水而结成的冰。然而，有必要重新考虑以下两个问题：首先，记载这些事件的历史文献可以追溯到19世纪上半叶，在飞机发明之前已经有了大量的记载。其次，如果在科学数据库（Webof Science，GeoRef）中，仔细检索众所周知的飞机结冰过程的有关案例，所得到的结论相悖于前文中简单的解释——在飞机任何部位都无法形成长达1m、重达几百公斤的冰。

关键词：陨冰地球结冰过程科学数据库历史记录历史文献飞机卫生间

LixiLan-O研究——甘精胰岛素和利司那肽固定比例复方制剂作为2型糖尿病患者起始注射治疗的有力证据

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中国糖尿病杂志 2020年第10期28卷 799-800页

作者： Juan Pablo frias 李延兵(译) National Research Institute Los AngelesCalifornia 中山大学附属第一医院内分泌科 510080

尽管降糖药在过去20年取得长足进展,人类已认识到良好BG控制的重要性,但仍有大多数T2Dm患者BG控制不佳[1],原因包括疾病的复杂病理生理、进展性质、治疗惯性及一些抗Dm治疗方案的相对复杂性和潜在不良反应,导致依从性和持久性较差。因此... 详细信息

尽管降糖药在过去20年取得长足进展,人类已认识到良好BG控制的重要性,但仍有大多数T2Dm患者BG控制不佳[1],原因包括疾病的复杂病理生理、进展性质、治疗惯性及一些抗Dm治疗方案的相对复杂性和潜在不良反应,导致依从性和持久性较差。因此,T2Dm药物管理指南要求避免延迟强化治疗,制定以患者为中心的个体化治疗方案,包括合并症、低血糖风险、对体重的影响和患者偏好等因素及早期联合使用降糖机制互补的药物[2-3]。

关键词： T2Dm 管理指南病理生理降糖机制延迟强化甘精胰岛素复方制剂降糖药

Fe-mn nodules associated with hydrocarbon seeps： A new discovery in the Gulf of Cadiz （eastern central Atlantic）

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Episodes 2007年第3期30卷 187-196页

作者： FJ．Gonzdlez L．Somoza R．Lunar J.marffnez-frias J.A．marffnRubi T.Torres J．E．oniz V.Diaz-del-Rio marineGeologyDv GeologicalSurveyofSpain（IGME）．C／RiosRosas2328003MadridSpain．E-mail：fj-gonzalez@igme．es Departamento de Cristalografla Y mineralogia UniversidadComplutensedeMadridUCM．C／JoseAntonio-Novais2CiudadUniversitaria28040MadridSpain． Centro de AstrobiologiaCSIC／INTA．29006Torrej6ndeArdozmadrid Spain． Laboratorio de Estratigraffa Biomolecular（ETSIm／UPm）．C／RfosRosas21 28003MadridSpain． Centro Oceanografico de mailaga InstitutoEspafiol de OceanograffaIEO．Apdo．28529640Fuengirola（Mailaga）Spain

The Gulf of Cadiz is situated geologically at the Gibraltar Arc, the westernmost arc of the Alpine- Himalayan orogenic belt. Based on extensive previous studies that include swath bathymetry, multi-channel and very high-resolution seismic reflection, gravime- try, magnetism, heat flow probes, and underwater photography surveys, more than 500 polymetallic nodules were collected at water depths ranging from 850 to 1000 m, associated with hydrocarbon-derived carbonate chimneys, slabs, and crusts. Nodules show a wide range of sizes, densities, weights and mor- phologies. Nodules are composed of multiple milli- metre-thick layers of Fe and mn oxyhydroxides sur- rounding a nucleus composed of Early-middle mio- cene plastic marls, which were expulsed from underly- ing units by fluid venting. Nodules show a high mean abundance of Fe （39.03%）, moderate mn （5.84%）,

关键词：碳氢化合物渗出物加的斯海湾大西洋铁锰