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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona Al hammad Fatima Ali mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Amblyopia screening for first and second-grade children in Jordan

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 352-356页

作者： Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani layal mohammed hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar Department of Ophthalmology and Visual Sciences Mutah UniversityAl-Karak 11183Jordan Royal Medical Services Department of Ophthalmology Amman 11855Jordan Department of Ophthalmology and Visual Sciences Al-Sharif Eye CenterAmman 11194Jordan Jordanian Menistrery of Health IrbidAmman 11855Jordan National Woman's Health Care Center(NWHCC) Amman 11855Jordan

AIM:To share the results of a national screening program for amblyopia in school children in the north of ***:This is a prospective national screening study for *** program rolls first and second-grade children(6 to 7 years old) in the north of *** eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic *** visual acuity was tested using an ETDRS visual acuity chart without ***,children were tested with full cycloplegic refraction when the test criteria were *** amblyopia was defined as a best-corrected visual acuity difference of 2 or more *** comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best ***:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with *** their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population.

关键词： amblyopia screening Jordan community ophthalmology pediatric ophthalmology population-based study screening program

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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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New topological and non-topological unidirectional-wave solutions for the modifie d-mixe d KdV equation and bidirectional-waves solutions for the Benjamin Ono equation using recent techniques

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Journal of Ocean Engineering and Science 2022年第2期7卷 163-169页

作者： Marwan Alquran mohammed Ali hammad Jadallah Department of Mathematics and Statistics Jordan University of Science&TechnologyIrbid 22110Jordan

In this paper,new explicit unidirectional wave solutions for the modified-mixed KdV equation and bidi-rectional waves for the Benjamin Ono equation are *** extension of the rational sine-cosine and sinh-cosh methods are *** addition,an extension of the recent polynomial function method is applied as *** types of topological and non-topological soliton solutions are extracted to the proposed models and categorized by providing 2D and 3D ***,some physical properties of the new bidirectional waves solutions to the Benjamin Ono model are discussed.

关键词： Single-wave solutions Two-waves solutions Extended rational sine-cosine method Extended rational sinh-cosh method Polynomial-function method

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Correlation between Fibroscan and laboratory tests in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients for assessing liver fibrosis

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World Journal of Hepatology 2022年第4期14卷 744-753页

作者： layal Al Nanaf mohammed Hussein Kamareddine Emilie Fayad Aniqa Hussain Said Farhat Department of Radiological Science American University of Science and TechnologyFaculty of Health SciencesBeirut 1100Lebanon Department of Internal Medicine Lankenau Medical CenterPhiladelphiaPA 19131United States Department of Radiology Saint George Hospital University Medical CenterBeirut 1100Lebanon Faculty of Medicine University of New South WalesSydney 2052Australia Department of Gastroenterology Saint George Hospital University Medical CenterBeirut 1100Lebanon

BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a spectrum of disease ranging from simple steatosis to non-alcoholic steatohepatitis(NASH), through to advanced fibrosis and cirrhosis. Many patients with NAFLD remain undiagnosed and recognizing those at risk is very crucial. Although liver biopsy is the gold standard method for diagnosing and staging NAFLD, non-invasive imaging and lab modalities are also very promising in diagnosing these *** To explore some of these non-invasive modalities in this context and assess how they hold up in terms of making a diagnosis while avoiding an invasive procedure like a liver *** This study was conducted on NAFLD/NASH patients(n = 73) who underwent Fibroscan examinations at Saint George Hospital University Medical Center over 17 mo in order to assess liver fibrosis. Obtained Fibroscan results were correlated to laboratory tests and calculated aspartate transaminase(AST)/alanine transaminase(ALT) ratio, AST platelet ratio index(APRI) score and Fibrosis-4 *** A significant age difference was observed across fibrosis stages of investigated patients. The mean stiffness score was 9.48 ± 11.77 KPa. A significant negative correlation was observed between ALT, AST, Albumin, gamma-glutamyl transferase, cholesterol, LDL, HDL, triglycerides, and ALP when compared across fibrosis stages. On the other hand, a significant positive correlation was found between Bilirubin, PT INR, partial thromboplastin time, glucose, and Platelet count when compared across fibrosis stages, in addition to AST/ALT ratio, APRI, and Fib-4 *** This study showed that Ultrasound alone is not efficient in the assessment of advancement of liver disease. Furthermore, the high positive relation between AST/ALT ratio, APRI and Fib-4 scores with fibrosis stages in NAFLD patients suggests that they could be used clinically in combination with Fibroscan to predict significant fibrosis and cirrhosis and to avoid liver biopsy.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Fibroscan Cirrhosis Hepatology

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Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma： a single-center experience

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 264-270页

作者： mohammed Elshamy Naftali Presser Abdulrahman Y hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo Hepatobiliary and Transplant Surgery Digestive Disease and Surgery Institute Cleveland Clinic Cleveland OH USA Imaging Institute Cleveland Clinic Cleveland OH USA

BACKGROUND： Reports of fiver transplantation （LT） in patients with mixed hepatocellular carcinoma/cholangiocarcinoma （HCC/CC） and intrahepatic cholangiocarcinoma （ICC） are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC. METHODS： From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS： The observed recurrence rate post-LT was 31% （4/13） and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS： Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation.

关键词： mixed hepatocellular carcinoma/ cholangiocarcinoma liver transplantation survival outcomes

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Triple synchronous primary neoplasms in the gastrointestinal tract

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Chinese Medical Journal 2021年第10期134卷 1233-1235页

作者： Fozan mohammed Sauri Eman Adnan Zakarneh mohammed Yousef Alessa Ahmad hammad Sakr Yeon Seung Chung Ho Seung Kim Nam kyu Kim Department of Surgery Colorectal DivisionYonsei University College of MedicineSeoul120-752South Korea Department of General Surgery King Faisal UniversityAlahsa 31982Saudi Arabia Colorectal Surgery Unit Department of General SurgeryMansoura Faculty of MedicineMansoura University HospitalMansoura 35511Egypt Department of Pathology Yonsei University College of MedicineSeoul 120-752South Korea

To the Editor:Most of the multiple primary malignancies are metachronous or involve more than one system,we instead describe a case with synchronous triple cancers involving one organ *** study was approved by the Institutional Review Board of Severance hospital,Yonsei University(IRB No.4-2019-0889).A 61-year old man who had no chronic illness,underwent abdominal computerized tomography(CT)scan due to vague abdominal complains and was found to have descending colon wall thickening[Figure 1A],colon cancer(cT3N+)was *** is not smoker or alcohol drunker,and has no family history of malignancies.

关键词： neoplasms colon Figure

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A Water-Saving Technique Using Embedded System

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Applied Mathematics 2013年第1期4卷 119-123页

作者： Ibrahim mohammed Bader Adel hammad Abusitta College of Engeenering & IT Al Ain University of Science and Technology Al Ain UAE

A method for water-saving is presented in this paper. The proposed method is based on an electro mechanical approach and embedded system that is described mathematically. It describes a solution for water-saving in buildings by giving the ability to ensure that treasurer of water will never be empty before the maximum time T that the owner gives to the treasurer when it is filled with water. The rate of water pumped is altered based on water consumed at tr. Where tr is a random number generated by system. Simulation results in the last section shows that the method can save the water with different maximum time decided by the owner.

关键词： Treasurer of Water Tap Saving the Water Controller Differential Equations

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The Frequency of the v-AKT Murine Thymoma Viral Oncogene Homologue 1 Gene Amplification among Sudanese Women with Ovarian Cancer: A Cross-Sectional Study

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Open Journal of Genetics 2023年第2期13卷 75-82页

作者： Rawia Eljaili Elmassry Aisha Osman mohammed Amina Ibrahim Badawy Rasha Saad Abdalhamid Huda Abdalla Eltahir Safa Abass mohammed hammad Yahia Abdou Adil Abdelrahim Yousif Zubaida Abohumeda Adam Nazik Elmalaika Husaim College of Health Sciences and Nursing Al-Rayan Colleges Al Madinah Al Munawwarah Kingdom of Saudi Arabia Faculty of Medical Laboratory Sciences Alzaiem Alazhari University Khartoum Sudan College of Applied Medical Sciences King Khalid University Abha Kingdom of Saudi Arabia Faculty of Medicine Omdurman Islamic University Khartoum Sudan

Background: Protein kinase B (AKT/PKB) family is frequently amplified in ovarian cancer (OC). To the greatest of our knowledge, there is a lack of published reports about the amplification of the genes belonging to the AKT family among Sudanese women with OC. The present study was conducted to detect the AKT1 gene amplification and its association with tumour types, grades, and ages among Sudanese women with OC, bearing in mind the ethnic variation. Methods: This institution-based study included 79 cases of women diagnosed with ovarian cancer (OC) at Omdurman Maternity Hospital in the period 2013-2018. Formalin-fixed, paraffin-embedded (FFPE) tissue sections were used to extract RNA. AKT1 gene amplification was assessed using quantitative real-time PCR. Results: The mean age (±SD) of included women was 49.29 (±13.612). The amplification of AKT1 gene was observed in 18/79 (22.8%) of OC women, with a high frequency in women with undifferentiated 1/2 (50%), clear cell 2/6 (33.3%), mucinous 3/11 (27.3%), endometrioid 3/17 (17.6%), and serous carcinomas 5/30 OC (16.7%). High frequency was seen in women with low (26.3%;n = 10/28) rather than in higher (19.5%;n = 8/33) grade carcinoma, and in older (25.8%;n = 8/23) rather than younger (18.2%;n = 2/9) women. No significant association between AKT1 gene amplification and tumour types, grades, and ages of women was observed (Fisher’s Exact test: p = 0.405, 0.593 and 0.851, respectively). Conclusion: AKT1 gene amplification arises in around one-fifth of Sudanese women with ovarian cancer (OC). It is seen more in undifferentiated, clear cell, and mucinous tumours types, and more frequently in low tumour grade and older women, but not to a statistically significant level. These outcomes sustenance previous studies suggesting that activated AKT genes have a vital role in OC progression and may offer a plan for targeted therapy and prognostic evaluation.

关键词： AKT1 Gene Amplification Ovarian Cancer Cross-Sectional Study Quantitative Real-Time PCR Sudan

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Checklist of the Birds of the Gaza Strip—Palestine

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Open Journal of Ecology 2023年第3期13卷 155-182页

作者： Abdel Fattah N. Abd Rabou Bashar S. Jarayseh Lara M. Sirdah Mandy M. Sirdah Sinaa A. Ababsa Daoud I. Al-Hali Ayman W. Dardona Ashraf A. Shafei Nedal A. Fayyad Abdallah S. Awad Wael I. Almeshal Samer S. Abuzerr Inas A. Abd Rabou Othman A. Abd Rabou mohammed A. Abd Rabou Sabah A. Abu Sharekh mohammed R. Al-Agha Maged M. Yassin Abed Al Qader I. hammad Norman A. Khalaf Walid F. Mohamed Department of Biology Faculty of Science Islamic University of Gaza Gaza Strip Palestine Environmental Education Center Beit Jala West Bank Palestine Wildlife Documenter and Photographer Gaza Strip Palestine Wildlife Documenter and Photographer Kafr Kanna Galilee Palestine Qimmah Secondary School Jerusalem (Al-Quds) Palestine Environment Quality Authority Gaza Strip Palestine Center for Desert Agriculture King Abdullah University of Science and Technology Thuwal Kingdom of Saudi Arabia Doctoral School of Environmental Sciences E&#246tv&#246s Loránd University Budapest Hungary Department of Medical Sciences University College of Science & Technology Gaza Strip Palestine Department of Nursing and Health Sciences University College of Applied Sciences Gaza Strip Palestine Department of Journalism and Media Islamic University of Gaza Gaza Strip Palestine Department of GIS University College of Applied Sciences Gaza Strip Palestine Department of School Health Ministry of Education and Higher Education Gaza Strip Palestine Department of Environment and Earth Sciences Faculty of Science Islamic University of Gaza Gaza Palestine Faculty of Medicine Islamic University of Gaza Gaza Strip Palestine Department of Geography Al-Aqsa University Gaza Strip Palestine Department of Environmental Research and Media National Research Center Palestine Department of Biological and Geological Sciences Faculty of Education Ain Shams University Roxy Cairo Egypt

Bird fauna checklists are important tools in ecology, biology, and conservation planning for scientists, stakeholders, and decision-makers. Despite its small area, the Gaza Strip (365 km2) has a relatively large variety of resident and migratory bird fauna. Therefore, the current study aimed to provide an updated checklist of all bird fauna living in or inhabiting the Gaza Strip. Direct field observations using binoculars, continuous visits to zoos, pet stores and biology museums, discussion with bird hunters, follow-up of news and social networking sites, review of scientific publications and photography were the main tools to satisfy the purpose of the study. At least 250 bird species collected from different sources occur in the Gaza Strip and are included in the checklist. This list will not be static, but is inevitably subject to additions and changes in the face of times. The current 250 bird species of the Gaza Strip represent 45.4% of the 551 species of birds living in Palestine. The bird species were found to belong to 21 orders and 61 families. The Passeriformes (passerines) represented the largest order with 96 species of birds (38.4%), followed by the Charadriiformes 54 (21.6%), the Accipitriformes 18 (7.2%), Anseriformes 17 (6.8%) and Pelecaniformes 14 (5.6%), while the other orders represented the remaining percentage (20.4%). With regard to families, the Scolopacidae represented the largest family with 22 species of birds (8.8%), followed by the Anatidae and Accipitridae 17 for each (6.8%), the Muscicapidae 16 (6.4%) and Chariidridae and Fringillidae 11 for each (4.4%), while the other families represented the remaining percentage (62.4%). According to the IUCN regional threat categories, 226 species (90.4%) were Least Concern (LC), 12 (4.8%) were Near Threatened (NT), 6 (2.4%) were Vulnerable (VU), 4 (1.6%) were Endangered (EN) and 2 (0.8%) were Critically Endangered (CR). In conclusion, the study recommends a sustainable control of bird h

关键词： Bird Fauna Checklist Bird Hunting Conservation IUCN Categories Gaza Strip

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