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Discussion on evolution of Mongolian medicinal material names and countermeasures for standardization

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Chinese Herbal Medicines 2022年第3期14卷 362-366页

作者： Bao Long Aodungerile laxinamujila bai Inner Mongolia Minzu University Tongliao 028000China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Tongliao 028000China

Mongolian pharmacy is an important part of traditional medicine for the Chinese nation,with a long history and a complete theoretical *** Mongolian people have accumulated and summarized the types and usage of Mongolian medicines in the practice of fighting against diseases over a long *** medicinal resources are rich and diverse,the processing is self-contained,and the methods of medication are scientific and *** pharmacy not only has a deep historical relationship with traditional Chinese medicine but has also absorbed the essence of ancient Tibetan and Indian Ayurvedic medicine in the process of its *** can identify the historical traces of the continuous exchange,communication,and integration of various ethnic medicinal cultures from the names of Mongolian medicinal *** of the differences in languages and cultures of the various ethnic groups,the names of Mongolian medicinal materials have undergone a long historical period of *** need to be further standardized owing to complications caused by the existence of synonyms and homonyms.

关键词： medicinal resources Mongolian pharmacy names of Mongolian medicinal materials

Mongolian medicine:History,development and existing problems

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Chinese Herbal Medicines 2022年第3期14卷 345-355页

作者： Songbo Qu Jinshan Bao Wuliji Ao laxinamujila bai Almaz Borjigidai Key Laboratory of Ethnomedicine Ministry of EducationMinzu University of ChinaBeijing 100081China College of Mongolian Medicine Inner Mongolia Minzu UniversityTongliao 028000China

Mongolian medicine(MM)is an important part of Mongolian *** of MM can play a crucial role in the prevention and treatment of various diseases and can help provide better health care *** this article,we gave a brief introduction to the origin and development of MM,the theoretical system of MM,the principles of Mongolian materia medica formula,the modern research on Mongolian materia medica and the quality control of Mongolian materia *** present situation and outlook of MM were also discussed.

关键词： Mongolian medicine origin and development principles and contral theoretical system development history existing problems

Chemical constituents of Lomatogonium carinthiacum and Halenia corniculata

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Chinese Herbal Medicines 2022年第3期14卷 459-463页

作者： Aodungerile Xigurigan Tunumula Gang Bao Sudabilige Chaogebadalafu Chenlin He Qirigeer laxinamujila bai Shuzhen bai NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) School of Mongolian MedicineInner Mongolia Minzu UniversityTongliao 028000China College of Mongolian Medicine and Pharmacy Inner Mongolia MinZu UniversityTongliao 028000China College of College of Chemistry and Materials Science Inner Mongolia MinZu UniversityTongliao 028000China

Objective:To study the chemical constituents from traditional Chinese(Mongolian)medicine,Lomatogonium carinthiacum and Halenia ***:The chemical constituents were isolated and purified by silicagel column,Sephadex LH-20,ODS and high performance liquid *** structures were identified by NMR and MS analysis ***:Twelve compounds were isolated and identified as isovitexin(1),Luteolin-5-O-β-D-glucoside(2),Isosaponarin(3),Luteolin-7-O-β-D-glucoside(4,7),1,4,8-Trimethoxy-xanthone-6-O-β-D-glucoronyl-(1→6)O-β-Dglucoside(5),friginoside D(6),1-hydroxy-2,3,5-trimethoxyxanthone(8),1-hydroxy-2,3,4,5-tet ramethoxyxanthone(9),1-hydroxy-2,3,4,7-tetramethoxyxanthone(10),1-hydroxy-2,3,4,5,7-pentame thoxyxanthone(11)and usnic acid(12).Conclusion:Compounds 6 and 12 are obtained from *** and *** for the first time.

关键词： bioactive compounds Halenia corniculate(L.)Corneaz. Lomatogonium carinthiacum(Wulf.)Reichb. Mongolian medicine

Phytochemical and pharmacological progress on Syringa oblata,a traditional Mongolian medicine

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Chinese Herbal Medicines 2022年第3期14卷 392-402页

作者： Badalahu Tai laxinamujila bai Ruifeng Ji Muyao Yu NAla Luqi Huang Han Zheng College of Pharmacy Changchun University of Chinese MedicineChangchun 130117China Mongolian Medical College Inner Mongolia Minzu UniversityTongliao 028000China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Syringa oblata is a traditional Mongolian medicine mainly distributed in the Helan Mountains(the boundaries of Inner Mongolia and Ningxia,China)and the north of Yan Mountains(Aohan Qi,Inner Mongolia,China).It is clinically used to treat diseases caused by Heyi,such as heartache and heat pathogen in the *** studies on *** revealed the presence of iridoids,lignans,triterpenes,phenylpropanoids,phenylethanoids,and volatile *** investigations revealed a broad spectrum of bioactivities,such as antimicrobial,antioxidant,antiproliferative,and hepatoprotective *** article summarized the chemical components and pharmacological activities of ***,providing a scientific rationale for its bioactive constituents,quality control,and utilization as an important medicine.

关键词： chemical constituent heartwood Mongolian medicine pharmacological activity Syringa oblata Lindl.

Traditional Mongolian medicine:Past,present and future

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Chinese Herbal Medicines 2022年第3期14卷 343-344页

作者： laxinamujila bai Minghai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) School of Mongolian MedicineInner Mongolia Minzu UniversityTongliao 028000China

Traditional Mongolian medicine(TMM)forms an essential part of traditional Chinese medicine(TCM)with its own unique and profound theoretical system,drug resources,processing technologies,and drug usage *** has the characteristics of being“raw,simple,inexpensive,and green”.It has unique advantages and remarkable efficacy in treating common diseases,frequently-occurring diseases,and certain rare diseases.

关键词： medicine(TCM) diseases Traditional

Lomatogonium rotatum extract alleviates diabetes mellitus induced by a high-fat,high-sugar diet and streptozotocin in rats

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World Journal of Diabetes 2023年第6期14卷 846-861页

作者： Li-Li Dai Sung-Bo Cho Hui-Fang Li Li-Sha A Xiao-Ping Ji Sirigunqiqige Pan Ming-Lan Bao laxinamujila bai Gen-Na Ba Ming-Hai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsHainan Medical UniversityHaikou 571199Hainan ProvinceChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND Lomatogonium rotatum(LR)is traditionally used in Mongolian folk medicine as a hypoglycemic agent,but its evidence-based pharmacological effects and mechanisms of action have not been fully *** To emphasize the hypoglycemic action mechanism of LR in a type 2 diabetic rat model and examine potential biomarkers to obtain mechanistic understanding regarding serum metabolite *** A high-fat,high-sugar diet and streptozotocin injection-induced type 2 diabetic rat model was *** chemical composition of the LR was identified by high performance liquid *** extract administrated as oral gavage at 0.5 g/kg,2.5 g/kg,and 5 g/kg for 4 ***-diabetic effects of LR extract were evaluated based on histopathological examination as well as the measurement of blood glucose,insulin,glucagon-like peptide 1(GLP-1),and lipid *** metabolites were analyzed using an untargeted metabolomics *** According to a chemical analysis,swertiamarin,sweroside,hesperetin,coumarin,1.7-dihydroxy-3,8-dimethoxyl xanthone,and 1-hydroxy-2,3,5 trimethoxanone are the principal active ingredients in *** anti-diabetic experiment revealed that the LR treatment significantly increased plasma insulin and GLP-1 levels while effectively lowering blood glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,and oral glucose tolerance test compared to the model ***,untargeted metabolomic analysis of serum samples detected 236 metabolites,among which 86 were differentially expressed between the model and the LR *** was also found that LR considerably altered the levels of metabolites such as vitamin B6,mevalonate-5P,Dproline,L-lysine,and taurine,which are involved in the regulation of the vitamin B6 metabolic pathway,selenium amino acid metabolic pathway,pyrimidine metabolic pathway,and arginine and proline metabolic *** These findings indicated that LR may have a hypoglycemic im

关键词： Mongolian medicine Lomatogonium rotatum Type 2 diabetes Metabolomics Swertiamarin Streptozotocin

基于网络药理学及动物实验探讨瑞香狼毒治疗RA作用机制

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河北大学学报（自然科学版） 2023年第1期43卷 48-57页

作者：胡伊力格其白小红白梅荣包文双胡和珠拉拉喜那木吉拉内蒙古民族大学蒙医药学院内蒙古通辽028000 内蒙古民族大学蒙医药研发工程教育部重点实验室内蒙古通辽028000

为探讨瑞香狼毒(Stellera chamaejasme L.)治疗类风湿性关节炎(rheumatoid arthritis,RA)的潜在机制,利用TCMSP、PubMed及TCMID数据库和文献挖掘获得瑞香狼毒主要化学成分,利用Swiss Target Prediction、Uniprot数据库获得瑞香狼毒治疗疾病靶点,运用OMIM、GeneCards及PharmGKB数据库获取RA主要作用靶点,通过对化学成分靶点与疾病基因进行交集整合,筛选瑞香狼毒治疗RA的潜在治疗靶点.使用Cytoscape 3.6.1软件构建“药物-活性成分-靶点-疾病”相互作用网络图,将潜在治疗靶点用DAVID软件分析预测相关的生物学过程,并通过动物实验对主要生物学过程进行验证.采用ELISA检测瑞香狼毒对RA模型大鼠血清炎症因子的影响,该研究共筛选出瑞香狼毒60个活性成分,5017个与RA潜在治疗靶点及380个交集靶点;动物实验结果表明,瑞香狼毒可以通过抑制炎症因子肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、白介素-1β(IL-1β)表达以发挥抗RA作用.该研究揭示了网络药理学预测并指导实验设计的合理性,证实瑞香狼毒可以通过抑制炎症因子以发挥抗RA作用,为瑞香狼毒治疗RA的机制研究提供依据.

关键词：网络药理学瑞香狼毒类风湿性关节炎肿瘤坏死因子白介素-6 白介素-1β

国家一流专业背景下“蒙药学”课程建设及改革——基于“以学生为中心”的教学模式

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教育教学论坛 2023年第37期 64-67页

作者：胡和珠拉白金亮拉喜那木吉拉内蒙古民族大学蒙医药学院内蒙古通辽028000 质量研究与评价重点实验室内蒙古通辽028000

“蒙药学”课程,是蒙医类、蒙西医结合类、蒙药学类、药物制剂类等专业的一门重要专业基础课。在国家一流专业背景下,如何更加积极、科学、有效地建设“蒙药学”课程,为国家培养高质量、高水平、高素质的蒙医药人才,显得日益重要。通过... 详细信息

“蒙药学”课程,是蒙医类、蒙西医结合类、蒙药学类、药物制剂类等专业的一门重要专业基础课。在国家一流专业背景下,如何更加积极、科学、有效地建设“蒙药学”课程,为国家培养高质量、高水平、高素质的蒙医药人才,显得日益重要。通过创新教学手段、拓展教学内容、改变教学方式,深入挖掘课程中的思政元素,并借助超星平台搭建“线上+线下”的全新教学框架,有利于吸引学生积极参与课堂,具有较强的互动性、趣味性、多元性,在提高学生知识技能的基础上,培养学生的爱国主义情怀以及敢为人先、守正创新的品质,更有利于培养学生的钻研精神、传承精神,使学生成长为复合型蒙医药人才。

关键词：蒙药学一流专业课程改革复合型蒙医药人才

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民族药石花中松萝酸在不同产地的含量比较

中国民族医药杂志 2023年第4期29卷 54-56页

作者：何陈林其日格尔白淑珍拉喜那木吉拉内蒙古民族大学蒙医药学院内蒙古通辽028000 内蒙古民族大学化学与材料学院内蒙古通辽028000

目的:采用高效液相色谱法,建立民族药石花中松萝酸的含量测定方法,明确不同产地石花中松萝酸的含量,对其进行质量评价。方法:采用Venusil MP C18柱(4.60 mm×300 mm,5μm),流动相为乙腈-0.5%乙酸水溶液(78∶22),流速为1.0 mL/min,柱温30... 详细信息

目的:采用高效液相色谱法,建立民族药石花中松萝酸的含量测定方法,明确不同产地石花中松萝酸的含量,对其进行质量评价。方法:采用Venusil MP C18柱(4.60 mm×300 mm,5μm),流动相为乙腈-0.5%乙酸水溶液(78∶22),流速为1.0 mL/min,柱温30℃,紫外检测波长254 nm,进样量10μL。结果:松萝酸浓度在0.21~4.2 mg/mL范围内与峰面积有良好的线性关系,平均回收率为99.16%,RSD=1.3%(n=6)。不同产地石花药材中松萝酸含量差异较大。结论:该方法准确、简便,对石花药材中有效成分松萝酸进行含量测定对于保证其质量和临床疗效具有重要意义。

关键词：民族药石花松萝酸含量测定