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World Journal of Neuroscience 2016年第1期6卷 52-61页

作者： Richard lawrence Norman Editorial Department Journal of Unconscious Psychology and Mind Magazine O’Brien USA

Derived through the dual focus of psychology and neuroscience, disciplines such as Affective Neuroscience and Neuropsychoanalysis may offer new directions of approach to many pathologies, which demonstrate psychical and somatic etiology. Insights gained from these two trustworthy yet still peripheral scientific disciplines, are deserving of consideration and exploration. It is the purpose of this paper to offer up several such possible new avenues of exploration, as they relate to depression, Obsessive Compulsive Disorder (OCD), and Parkinson’s Disease (PD). The basic therapeutic focus in deriving these proposed new clinical approaches is twofold: 1) Deep Brain stimulation (DBs) and 2) Mnemic alteration via neuropeptide assisted therapy producing positive relative adjustment in the balance of basic sympathetic (dopaminergic) and parasympathetic affective circuitry independent of drugs or surgery. New conductance level and target strategies designed to prevent homeostatic degeneration are advanced under the concept of homeostatic conductance. New electrical stimulation targets are suggested, which restore basic rhythmic balance between pathologically affected and unaffected brain areas. In this way, we offer up new directions for research, strategies for noninvasive and nontoxic potential therapies and new targets/ approaches to DBs therapy.

关键词： Deep-Brain-stimulation Obsessive-Compulsive-Disorder Depression Parkinson’s Hippocampus

Antioxidant proteins TsA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila

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Protein & Cell 2011年第7期2卷 554-563页

作者： Michael F.Wangler lawrence T.Reiter Georgianna Zimm Jennifer Trimble-Morgan Jane Wu Ethan Bier Department of Biology University of California at San DiegoSan DiegoCA 92093USA Department of Molecular and Human Genetics Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Neurology University of Tennessee Health Science CenterMemphisTN 38163USA saddleback College 28000 Marguerite ParkwayMission ViejoCalifornia 92692USA Department of Neurology and Center for Genetic Medicine Northwestern UniversityChicagoIL 60611USA

Alzheimer’s disease(AD)pathogenesis is characterized by senile plaques in the brain and evidence of oxidative *** stress may precede plaque formation in AD;however,the link between oxidative damage and plaque formation remains *** are transmembrane proteins in which mutations lead to accelerated plaque formation and early-onset familial Alzheimer’s *** physically interact with two antioxidant enzymes thiol-specific antioxidant(TsA)and proliferation-associated gene(PAG)of the peroxiredoxin *** functional consequences of these interactions are *** the current study we expressed a presenilin transgene in Drosophila wing and sensory organ precursors of the *** caused phenotypes typical of Notch signaling loss-of-function *** found that while expression of TsA or PAG alone produced no phenotype,co-expression of TsA and PAG with presenilin led to an enhanced Notch loss-offunction *** phenotype was more severe and more penetrant than that caused by the expression of Psn *** order to determine whether these phenotypes were indeed affecting Notch signaling,this experiment was performed in a genetic background carrying an activated Notch(Abruptex)*** phenotypes were almost completely rescued by this activated Notch *** results link peroxiredoxins with the in vivo function of Presenilin,which ultimately connects two key pathogenetic mechanisms in AD,namely,antioxidant activity and plaque formation,and raises the possibility of a role for peroxiredoxin family members in Alzheimer’s pathogenesis.

关键词： Presenilin Alzheimer’s disease peroxiredoxin Notch

Attend to the “small p” stuff: state Policy Issues Affecting Cervical Cancer Efforts

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Open Journal of Obstetrics and Gynecology 2014年第8期4卷 455-461页

作者： Beth E. Meyerson Carrie A. lawrence Jennifer s. smith Indiana University school of Public Health-Bloomington Bloomington USA Rural Center for AIDs/sTD Prevention Indiana University School of Public Health-Bloomington Bloomington USA University of North Carolina-Chapel Hill Gillings School of Global Public Health Chapel Hill USA

Background: states in the United states have primary public health authority. This is the case with cervical cancer, and yet little is known about state policy issues affecting the comprehensive public health response. This study identifies and explores state policy issues affecting cervical cancer efforts in the United states. Methods: Key informant interviews were conducted with a purposeful sample of 15 professionals affiliated with cervical cancer prevention and treatment from national, state and local levels;across sectors: public, private and non-profit;and aspects of the work: screening, treatment and vaccine;program implementation, research, coalition work, and policy. Results: Identified policy issues were administrative and implementation oriented (“small p” policy issues). While participants recognized the importance of laws for vaccine or no cost screening access, the key policy issues preventing successful cervical cancer efforts involved 1) health system complexity;2) general lack of state level policy, program and funding coordination;and 3) social and organizational cultural issues affecting the adoption of national recommendations and reinforcing program inertia. Conclusions: Understanding state policy issues in cervical cancer is critical for public health success. Dramatic reduction or even elimination of cervical cancer in the United states depends upon the policy work in the “little p” policy areas such as planning and health system organization to affect change. This will require greater leadership and coordination of state efforts across myriad programs. It will require health system improvements, and also the adoption of new practice and program behaviors to capitalize on available technology to reach underserved women.

关键词： Cervical Cancer state Policy Health system Improvements state Program Coordination

simulated Microbe Removal around Finger Rings Using Different Hand sanitation Methods

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International Journal of Oral science 2009年第3期1卷 136-142页

作者： Archana A. Alur Madhavi J. Rane James P. scheetz Douglas J. Lorenz lawrence Gettleman Ballard High school Louisville Kentucky USA school of Medicine University of Louisville Louisville Kentucky USA school of Dentistry University of Louisville Louisville Kentucky USA school of Public Health & Information sciences University of Louisville Louisville Kentucky USA

Aim It is our opinion that the CDC and the WHO have underestimated cross-contamination under examination gloves in dental clinics while wearing jewelry, such as finger rings. These agencies only ＂recommend＂ removing jewelry, and only washing hands for 15 seconds with soap and warm water before donning gloves. This study examined several washing procedures and finger rings using simulated microbes. Methodology A gloved robber hand manikin was made and fitted with a flesh disposable vinyl glove. Four fingers were fitted with rings or no ring, dusted with simulated microbes, and washed with a scrub brush for 5, 15, and 25 seconds under 20℃ and 40℃ water alone, or with liquid hand soap. Light levels （in lux） of fluorescent powder before and after washing were measured and delta scores calculated for changes in light levels, equivalent to effectiveness of hand washing procedures. A full-factorial, 3-factor analysis of variance （ANOVA） was used to test for differences among levels of the three study factors-time, temperature, and soap use. Tukey＇s post hoc honestly significant difference （HsD） test was applied to significant factors to examine pair-wise differences between factor levels. Results It was found that the longer the hands with rings were washed with a scrub brush under flowing water, the more simulated microbes were removed. By 25 seconds, all methods were essentially the same. simulated microbes were more difficult to remove from the palm compared to the back of the hand. The liquid hand soap used in this study was more effective with warm water than cold. When given a choice of washing with cold water up to 15 seconds, it would be preferable not to use soap to remove simulated microbes. Qualitatively, the outer surface of finger rings were more effectively cleaned than the crevice below the ring, and the ring with a stone setting appeared to accumulate and retain simulated microbes more than other rings. Conclusion The most effective treatment was washing wi

关键词： dental exam gloves finger ring jewelry crosscontamination hand hygiene microbes fluorescent powder dental health care workers

Oxidation, Chain scission and Cross-Linking studies of Polysiloxanes upon Ageings

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Open Journal of Organic Polymer Materials 2012年第2期2卷 13-22页

作者： Namrata s. Tomer Florence Delor-Jestin lawrence Frezet Jacques Lacoste Clermont Université ENSCCF-LPMM Clermont-Ferrand France Clermont Université Université Blaise Pascal LPMM UMR CNRS 6505 Clermont-Ferrand France

The comparison between physical properties and chemical structures of several polysiloxanes was studied at initial state and upon ageings. Techniques such as densimetry, gel permeation chromatography, FTIR spectroscopy, thermogravim- etric analysis coupled with IR spectroscopy and the new tool photo-DsC were used to give assessments of average mo- lecular weight, chemical evolution, cristallinity and thermal stability. Different types of ageing such as thermal ageing (60?C and 100?C), photo-ageing and acid vapour ageing were performed. After ageing we observed an evolution of chemical structures and physical properties for all samples. The main pathway of degradation is given for each sample. It results in oxidation, chain scission or cross-linking. Cross-linking levels are dependant on the type of ageing, the chemical structure and the initial rate of cristallinity. Cross-linking reactions are favoured after photo-ageing. Oxidation is higher for polysiloxane with aliphatic carbon chain.

关键词： Polysiloxane Degradation Thermal Properties Cross-Linking Cristallinity

New Insights into the Growth Mechanism and surface structure of Palladium Nanocrystals

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Nano Research 2010年第3期3卷 180-188页

作者： Byungkwon Lim Hirokazu Kobayashi Pedro H.G.Camargo lawrence F.Allard Jingyue Liu Younan Xia Department of Biomedical Engineering Washington UniversitySt.LouisMissouri 63130USA Materials science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Center for Nanoscience and Department of Chemistry and Biochemistry University of Missouri-St.LouisSt.LouisMissouri 63121USA

This paper presents a systematic study of the growth mechanism for Pd nanobars synthesized by reducing Na_(2)PdCl_(4) with L-ascorbic acid in an aqueous solution in the presence of bromide ions as a capping *** electron microscopy(TEM)and high-resolution TEM analyses revealed that the growth at early stages of the synthesis was dominated by particle coalescence,followed by shape focusing via recrystallization and further growth via atomic *** also investigated the detailed surface structure of the nanobars using aberration-corrected scanning TEM and found that the exposed{100}surfaces contained several types of defects such as an adatom island,a vacancy pit,and atomic *** thermal annealing,the nanobars evolved into a more thermodynamically favored shape with enhanced truncation at the corners.

关键词： Palladium nanocrystals growth coalescence surface evolution

How China's Political Leadership Elevates Progress

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Beijing Review 2021年第39期64卷 22-23页

作者： lawrence Kuhn the Kuhn Foundation in the U.s.

I have been coming to China for more than 30 years.I have traveled all across the country,visiting over 100 cities together with my long-term partner,Adam Zhu,for research and interviews,books and essays,television and documentaries.I have given much thought,over the years,as to what has brought about China's developmental *** underlying principles One,a people who work hard to improve the lives of their families and the destiny of their country.

关键词： travel partner has

Recent research situation in tin dioxide nanomaterials： synthesis, microstructures, and properties

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Frontiers of Materials science 2013年第3期7卷 203-226页

作者： Zhi-Wen CHEN Chan-Hung sHEK C. M. lawrence WU Joseph K. L. LAI shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China Department of Physics and Materials science City University of Hong Kong Tat Chee Avenue Kowloon Tong Hong Kong China

This review article summarizes the new research in solid-state physical chemistry understanding of the microstructure characteristics of semiconductor tin oxide thin films made in the last years in our group. The work mainly focuses on the fabrication technology of semiconductor tin oxides thin films by using pulsed laser deposition （PLD） as well as the application of this technology on new micro- and nanostructured materials. It is an interdisciplinary work that integrates the areas of physics, chemistry and materials science.

关键词： tin dioxide thin film synthesis microstructure nanostructure property

An annually laminated stalagmite from the eastern Qinghai-Tibetan Plateau provides evidence of climate instability during the early MIs5e in the Asian summer monsoon

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science China Earth sciences 2023年第5期66卷 1147-1164页

作者： Tao GAO Pingzhong ZHANG Hai CHENG Leilei ZHANG Xinhu LI Hongyu sHI Wei JIA Youfeng NING Hanying LI R.lawrence EDWARDs Key Laboratory of Mineral Resources in Western China(Gansu Province)and school of Earth sciences Lanzhou UniversityLanzhou730000China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an710054China Department of Earth sciences University of MinnesotaMinneapolis55455USA

The Marine Isotope stage(MIs5e)is characterized by a warmer climate than that of the pre-industrial period,and serves as an analog for the Current Warm Period(CWP).However,uncertainties persist regarding its climatic ***,we retrieved a stalagmite(WXB075)from Wanxiang Cave in the eastern Qinghai-Tibetan Plateau,and employed abs-olute^(230)Th dating and relative annual layer data to establish a high-precision chronological framework for reconstructing the history of the Asian summer monsoon(AsM)and environmental evolution during early MIs5e with multiple *** findings indicate that the annually laminated stalagmite was formed during Cooling Event 27(C27).The deposition of WXB075 experienced a hiatus(~125.58 ka BP)due to a significant cooling event in the North Atlantic,which may be linked to the unstable climate in the Northern ***,the impact of meltwater discharge in high northern latitudes results in a two-phase evolution of the AsM,i.e.,an initial weaker stage followed by a gradual increase(with exception of deposition hiatus).The climatic instability of AsM is generally characterized by a quasi-60 year cycle that affects vegetation conditions,biological productivity,and karst hydroclimate ***,the increase in meltwater and decrease in temperature in the Northern Hemisphere have led to a weakened AsM and subsequent reduction in ***,vegetation degradation above the cave has occurred along with a slowdown of karst *** vegetation conditions,organic matter content,and wet/drought of the karst hydroclimate were affected by both the large-scale monsoon circulation and local environment during extreme weakening(strengthening)of the monsoon when high-frequency climatic events of AsM occurred.A comparison ofδ^(18)O records between early MIs5e and the past 2000 years reveals that the climate during early MIs5e differed significantly from that of CWP,Medieval Warm Period(MWP),and Dark Age Co

关键词： Eastern Qinghai-Tibetan Plateau Climate instability Wanxiang Cave stalagmite Asian summer monsoon Environmental response Deposition hiatus

“Inspire Confidence,stay Relevant”

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国际人才交流 2012年第6期 60-61页

作者： lawrence Phillips 不详

(Continued from the last issue)However,I did not feel I had made the right choice and the next time I saw her I *** said to me I had done nothing wrong and said "it’s not your fault teacher,it’s my fault my English is too poor." But I still insisted that I had made a ***,I had corrected her,but at what cost? The experience obviously embarrassed her,and her peers by the third time she repeated the word incorrectly had been shaking their *** may have left the classroom being able to pronounce the word correctly but what about the damage to her confidence? I thought about it for literally hours.I feared that perhaps next time she might not want to stand up,or shout out the answer in class in case she might be humiliated *** her mind it was her own incompetence but for me it was my own ignorance.

关键词：英语课外阅读个人家庭生活