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Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第41期12卷 6620-6626页

作者： myron J Tong lawrence m blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey The Liver Center Huntington Medical Research InstitutesPasadenaCaliforniaUnited States The Pfleger Liver InstituteDavid Geffen Schoolof Medicine at the University of California in Los AngelesCaliforniaUnited States Intermune Inc.BrisbaneCaliforniaUnited States The Hepatitis Research Center National TaiwanUniversity HospitalTaipeiTaiwanChina The Liver Center Huntington Medical Research InstitutesPasadenaCaliforniaUnited States

AIm: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular ***: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P ma. multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular ***: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma.

关键词：乙型病毒肝炎肝癌肝坏死病理

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The Protocol of Ultrasonic Backscatter measurements of musculoskeletal Properties

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Phenomics 2024年第1期4卷 72-80页

作者： Dongsheng Bi Lingwei Shi Boyi Li Ying Li Chengcheng Liu lawrence HLe Jingchun Luo Sijia Wang Dean Ta Center for Biomedical Engineering School of InformationScience and TechnologyFudan University2005 SonghuRoadYangpu DistrictShanghai 200438China Academy for Engineering and Technology Fudan UniversityShanghai 200433China Department of Radiology and Diagnostic Imaging University of AlbertaEdmonton T6G2B7Canada Human Phenome Institute Fudan UniversityShanghai 201203China Shanghai Institute of Nutrition and Health Chinese Academyof SciencesShanghai 200031China

This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic(UBBD)***-energy X-ray absorptiometry(DXA)can be adopted to measure bone mineral density(BmD)in the hip,spine,legs and the whole *** muscle and fat mass in the legs and the whole body can be also calculated by DXA body composition *** on the proposed protocol for backscatter measurements by UBBD,ultrasonic backscatter signals can be measured in vivo,deriving three backscatter parameters[apparent integral backscatter(AIB),backscatter signal peak amplitude(BSPA)and the corresponding arrival time(BSPT)].AIB may provide important diagnostic information about bone *** and BSPT may be important indicators of muscle and fat *** standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics,providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders(mSDs),such as osteoporosis and muscular atrophy.

关键词： Ultrasonic backscatter musculoskeletal disorders Bone mineral density muscle mass Fat mass

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Oxidative Stress in Collegiate Cross Country Skiers in mid- and Post-Seasons

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Journal of Biosciences and medicines 2024年第5期12卷 99-110页

作者： Scott P. Jerome Kriya L. Dunlap Ava m. Parrish matthew L. Lowman Emily m. Shipman lawrence K. Duffy Arleigh J. Reynolds Department of Chemistry & Biochemistry University of Alaska Fairbanks Fairbanks AK USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK USA Department of Biology & Wildlife University of Alaska Fairbanks Fairbanks AK USA Department of Veterinary medicine University of Alaska Fairbanks Fairbanks AK USA

Purpose: The oxidative stress (OS) hypothesis of overtraining syndrome argues that increased production of free radicals through exercise cause muscle fatigue and damage resulting in lower athletic performance. Several studies have investigated OS immediately before and after exercise bouts in a training macrocycle. Our study aimed to compare OS of endurance athletes between a competition macrocycle and the immediate post-season recovery macrocycle. In addition, we aimed to identify athletes who experienced an unexplainable drop in athletic performance during the competition season in order to compare their OS to those who experienced no drop in performance. methods: Fifteen members of the University of Alaska Fairbanks cross country ski team volunteered for this study. Blood samples were taken in early February (“mid-season”) and late April (“post-season”). Participants completed questionnaires regarding physical activity and athletic performance at the time of the blood draws. Plasma was analyzed for 4-hydroxynonenal (HNE), nitrotyrosine, nitric oxide (NOX), and superoxide dismutase (SOD). Significance was determined by Wilcoxon and mann-Whitney tests. Results: Participants displayed significantly higher (p Conclusion: Signs of oxidative stress and mitigation during the post-season recovery macrocycle were higher in athletes who reported experiencing a drop in athletic performance during the competition season macrocycle.

关键词： Oxidative Stress 4-Hydroxynonenal Superoxide Dismutase Athletic Performance Training macrocycle

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Theory for Charge Density Wave and Orbital-Flux State in Antiferromagnetic Kagome metal FeGe

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Chinese Physics Letters 2024年第4期41卷 90-104页

作者：马海洋殷嘉鑫 m.Zahid Hasan 刘健鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Quantum Science Center of Guangdong-HongKong-macao Greater Bay Area Shenzhen 518045China Laboratory for Topological Quantum matter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrincetonNew Jersey 08544USA Princeton Institute for Science and Technology of materials Princeton UniversityPrincetonNew Jersey 08544USA materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Liaoning Academy of materials Shenyang 110167China

We theoretically study the charge order and orbital magnetic properties of a new type of antiferromagnetic kagome metal *** on first-principles density functional theory calculations,we study the electronic structures,Fermi-surface quantum fluctuations,as well as phonon properties of the antiferromagnetic kagome metal *** is found that charge density wave emerges in such a system due to a subtle cooperation between electron-electron interactions and electron–phonon couplings,which gives rise to an unusual scenario of interaction-triggered phonon instabilities,and eventually yields a charge density wave(CDW)*** further show that,in the CDW phase,the ground-state current density distribution exhibits an intriguing star-of-David pattern,leading to flux density *** orbital fluxes(or current loops)in this system emerge as a result of the subtle interplay between magnetism,lattice geometries,charge order,and spin-orbit coupling(SOC),which can be described by a simple,yet universal,tight-binding theory including a Kane-mele-type SOC term and a magnetic exchange *** further study the origin of the peculiar step-edge states in FeGe,which sheds light on the topological properties and correlation effects in this new type of kagome antiferromagnetic material.

关键词： interaction phonon orbital

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Residential energy transition and chronic respiratory diseases

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The Innovation 2024年第3期5卷 33-43页

作者： Hongcheng Wei Qiurun Yu Danrong Chen mingzhi Zhang Quanquan Guan Bo Hang Antoine m.Snijders Adrian Covaci Yankai Xia State Key Laboratory of Reproductive medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of modern Toxicology of ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166China The Affiliated Wuxi People’s Hospital of Nanjing medical University Wuxi People’s HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214023China Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Toxicological Centre University of Antwerp2610 WilrijkBelgium

Obtaining clean energy is of prime importance for planetary health and sustainable *** aimed to assess the association between residential energy transition and the risk of chronic respiratory *** data from the Global Health Observatory and Global Burden of Diseases,Injuries,and Risk Factors Study,we delineated the spatial distribution and temporal trends of the population using clean fuels for cooking at a global *** the China Health and Retirement Longitudinal Study,we performed rigorous and well-structured multistage analyses incorporating both cross-sectional and prospective data analyses to examine the associations between solid fuel use,residential energy transition,duration of solid fuel use,and the risk of chronic respiratory *** great progress,huge disparities in access to clean energy persist *** energy transition was associated with a lower risk of chronic respiratory *** the period of 2011–2013,compared with persistent solid fuel users,both participants who switched from solid to clean fuels(adjusted risk ratio[RR]0.78,95%confidence interval[CI]0.62–0.98)and persistent clean fuel users(adjusted RR 0.71,95%CI 0.57–0.89)had significantly lower risk of chronic respiratory diseases(pm solid to clean fuels could reduce the risk of chronic respiratory *** is a valuable lesson for policy-makers and the general public to accelerate energy switching to alleviate the burden of chronic respiratory diseases and achieve health benefits,particularly in low-and middle-income countries.

关键词： cooking income globally

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Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

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Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi Asaoka Fuyuhiko Sumikawa Yoshifumi Watanabe Waqar Azeem Jadoon masaki Ohno Nobumichi Shutoh Yuki Wakamatsu lawrence m.Liao Akane Kanazawa Yuka Sato Natsumi Fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance mass mortality Oak trees Sustainable development goals

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AdsorbmL: a leap in efficiency for adsorption energy calculations using generalizable machine learning potentials

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npj Computational materials 2023年第1期9卷 565-573页

作者： Janice Lan Aini Palizhati muhammed Shuaibi Brandon m.Wood Brook Wander Abhishek Das matt Uyttendaele C.lawrence Zitnick Zachary W.Ulissi Fundamental AI Research(FAIR) Meta AIMetaMenlo ParkCAUSA Department of Chemical Engineering Carnegie Mellon UniversityPittsburghPAUSA Scott Institute for Energy Innovation Carnegie Mellon UniversityPittsburghPAUSA

Computational catalysis is playing an increasingly significant role in the design of catalysts across a wide range of applications.A common task for many computational methods is the need to accurately compute the adsorption energy for an adsorbate and a catalyst surface of ***,the identification of low-energy adsorbate-surface configurations relies on heuristic methods and researcher *** the desire to perform high-throughput screening increases,it becomes challenging to use heuristics and intuition *** this paper,we demonstrate machine learning potentials can be leveraged to identify low-energy adsorbate-surface configurations more accurately and *** algorithm provides a spectrum of trade-offs between accuracy and efficiency,with one balanced option finding the lowest energy configuration 87.36%of the time,while achieving a~2000×speedup in *** standardize benchmarking,we introduce the Open Catalyst Dense dataset containing nearly 1000 diverse surfaces and~100,000 unique configurations.

关键词： adsorption configuration energy

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Evolving Frameworks for the Foundation and Practice of Electronic Fetal monitoring

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maternal-Fetal medicine 2022年第2期4卷 141-151页

作者： mark I.Evans David W.Britt Shara m.Evans lawrence D.Devoe Fetal medicine Foundation of America New YorkNY 10065USA Comprehensive Genetics PLLCNew YorkNY 10065USA Department of Obstetrics&Gynecology Icahn School of Medicine at Mt.SinaiNew YorkNY10029USA Department of maternal Child Health Gillings School of Public Health University of North Carolina at Chapel HillChapel HillNY 27599USA Department of Obstetrics and Gynecology Medical College of GeorgiaAugusta UniversityAugustaGA 30907USA.

Since the 1970s,electronic fetal monitoring(EFm)also known as cardiotocography(CTG)has been used extensively in labor around the world,despite its known failure to help prevent many babies from developing neonatal encephalopathy and cerebral *** of EFm’s poor performance with respect to these outcomes arises from a fundamental misunderstanding of the differences between screening and diagnostic tests,subjective classifications of fetal heart rate(FHR)patterns that lead to large inter-observer variability in its interpretation,failure to appreciate early stages of fetal compromise,and poor statistical modeling for its use as a screening *** have developed a new approach to the practice and interpretation of EFm called the fetal reserve index(FRI)which does the following:(1)breaking FHR components down into 4 components,(heart rate,variability,accelerations,and decelerations);(2)contextualizing the metrics by adding increased uterine activity;(3)adding specific maternal,fetal,and obstetric risk *** result is an eight-point scoring metric that,when directly compared with current American College of Obstetricians and Gynecologists EFm categories,even in version 1.0 with equal weighting of variables,shows that the FRI has performed much better for identifying cases at risk before damage had occurred,reducing the need for emergency deliveries,and lowering overall Cesarean delivery *** increased data,we expect further refinements in the specifics of scoring that will allow even earlier detection of compromise in labor.

关键词： Fetal monitoring Cardiotocography Fetal reserve index

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Vascularization in interconnected 3D printed Ti-6Al-4V foams with hydrogel matrix for biomedical bone replacement implants

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Science China materials 2018年第4期61卷 565-578页

作者： Victor L.Correa Kristine m.Garza lawrence E.murr Department of metallurgical Materials and Biomedical Engineering University of Texas at El Paso Department of Biological Sciences University of Texas at El Paso

Vascularization on newly implanted metal orthopedic implants has remained a challenge in the field of tissue engineering. To address this challenge, in this research,an interconnected foam structure of Ti-6 Al-4 V was microfabricated by electron beam melting(EBm) technique. The foam in question has a density of 1.77 g cm-3 with 60% porosity and a tensile strength of 18 GPa. An extracellular matrix based hydrogel was added as an aqueous matrix to the *** mimetic stress has been closely related to many wound healing biomedical applications as it increases survival and proliferation molecular signals. To that end, increased expression of hypoxia-inducible factor-1α(Hif-1α) and vascular endothelial growth factor(VEGF) in the aqueous hydrogel matrix was achieved by the addition of a hypoxia mimetic deferoxamine mesylate(DFm). In this study, the formation of an endothelial network was achieved in a hydrogel matrix in the presence of the before mentioned 3 D printed metal foam. Cellular viability, fluorescent microscopy and scanning electron microscopy imaging analysis demonstrate that pre-osteoblasts undergo proliferation and also attach efficiently to the foam when exposed to DFm. Human umbilical vascular endothelial cells(HUVECs) were grown in an extracellular matrix-like 3 D hydrogel and a hypoxia-like stress was achieved. This research demonstrates that pre-osteoblast cells undergo cell differentiation and increase the production of hydroxyapatite on exposure to the hypoxia mimetic molecule. This proposed approach encompasses an ideal prototype for a completely living implanted structure for future orthopedic implants.

关键词： Ti-6Al-4V electron beam melting angiogenesis deferoxamine mesylate hydrogel vascularization

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Frontiers of 3D Printing/Additive manufacturing: from Human Organs to Aircraft Fabrication

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Journal of materials Science & Technology 2016年第10期32卷 987-995页

作者： lawrence E.murr Department of metallurgical Materials and Biomedical Engineering The University of Texas at El Paso W.m.Keck Center for 3D Innovation The University of Texas at El Paso

It has been more than three decades since stereolithography began to emerge in various forms of additive manufacturing and 3D printing. Today these technologies are proliferating worldwide in various forms of advanced manufacturing. The largest segment of the 3D printing market today involves various polymer component fabrications, particularly complex structures not attainable by other manufacturing *** printer head systems have also been adapted to selectively print various speciated human cells and special molecules in attempts to construct human organs, beginning with skin and various tissue patches. These efforts are discussed along with metal and alloy fabrication of a variety of implant and bone replacement components by creating powder layers, which are selectively melted into complex forms（such as foams and other open-cellular structures） using laser and electron beams directed by CAD software. Efforts to create a ＂living implant＂ by bone ingrowth and eventual vascularization within these implants will be discussed briefly. Novel printer heads for direct metal droplet deposition as in other 3D printing systems are briefly described since these concepts will allow for the eventual fabrication of very large and complex products, including automotive and aerospace structures and components.

关键词： 3D printing/additive manufacturing Laser and electron beam melting Organ printing Organ and implant vascularization metal droplet printing

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