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Follow up of serial urea breath test results in patients after consumption of antibiotics for non-gastric infections

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World Journal of Gastroenterology 2002年第4期8卷 703-706页

作者： Wai-Keung Leung lawrence cheung-tsui hung Carrie Ka-Li Kwok Rupert Wing-Loong Leong Daniel Kwok-Keung Ng Joseph Jao-Yiu Sung Department of Medicine & Therapeutics Prince of Wales Hospitalthe Chinese University of Hong KongShatinHong KongChina Department of Paediatrics Kwong Wah HospitalKowloonHong KongChina

AIM: The widespread use of antibacterial therapy hasbeen suggested to be the cause for the decline in theprevalence of Helicobacter pyloriinfection. This studyexamine the serial changes of urea breath test resultsin a group of hospitalized patients who were givenantibacterial therapy for non-gastric ***: Thirty-five hospitalized patients who weregiven antibacterial therapy for clinical infections,predominantly chest and urinary infections, werestudied. Most (91%) patients were given singleantibiotic of either a penicillin or cephalosporin *** 13C-urea breath tests were performed within 24hours of initiation of antibiotics, at one-week and atsix-week post-therapy. H. pylori infection wasdiagnosed when one or more urea breath tests ***: All 35 patients completed three serial ureabreath tests and 26 (74 %) were H. pylori-positive. Ten(38 %) H. pylori-infected patients had at least onenegative breath test results during the study *** medium delta 13C values were significantly lowerat baseline (8.8) than at one-week (20.3) and six-week(24.5) post-treatment in H. pylori-positive individuals(P=0.022). Clearance of H. pyloriat six-week was onlyseen in one patient who had received anti-helicobactertherapy from another ***: Our results suggested that one-third ofH. pylori-infected individuals had transient false-negative urea breath test results during treatment withantibacterial agent. However, clearance of H. pyloriinfection by regular antibiotic consumption is rare.

关键词：抗生素 HP感染连续尿素呼吸试验耐药

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Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment

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World Journal of Gastroenterology 2003年第12期9卷 2695-2697页

作者： Henry Lik-Yuen Chan May-Ling Wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse lawrence cheung-tsui hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung Department of Medicine and Therapeutics Chinese University of Hong KongHong Kong

AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue ***: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 ***: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were *** was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug *** B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) ***: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype.

关键词：乙型肝炎乙型肝炎病毒拉米夫定 HBeAg 基因型抗病毒治疗

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Recent research situation in tin dioxide nanomaterials： synthesis, microstructures, and properties

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Frontiers of Materials Science 2013年第3期7卷 203-226页

作者： Zhi-Wen CHEN Chan-hung SHEK C. M. lawrence WU Joseph K. L. LAI Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China Department of Physics and Materials Science City University of Hong Kong Tat Chee Avenue Kowloon Tong Hong Kong China

This review article summarizes the new research in solid-state physical chemistry understanding of the microstructure characteristics of semiconductor tin oxide thin films made in the last years in our group. The work mainly focuses on the fabrication technology of semiconductor tin oxides thin films by using pulsed laser deposition （PLD） as well as the application of this technology on new micro- and nanostructured materials. It is an interdisciplinary work that integrates the areas of physics, chemistry and materials science.

关键词： tin dioxide thin film synthesis microstructure nanostructure property

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Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

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Asian Journal of Urology 2016年第4期3卷 223-228页

作者： Belinda Nghiem Xiaotun Zhang hung-Ming Lam lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard Colm Morrissey Department of Urology University of WashingtonSeattleWAUSA State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao(SAR)China Department of Pathology University of WashingtonSeattleWAUSA Divison of Human Biology Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Medicine University of WashingtonSeattleWAUSA Department of Laboratory Medicine University of WashingtonSeattleWAUSA

Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 ***(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression *** between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were ***:There was no correlation between levels of MMR protein and *** of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,***2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC *** of individual MMR proteins did not correlate with BCR or time from diagnosis to *** absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression *** finding correlated with microsatellite instability previously reported in this CRPC cohort.

关键词： Mismatch repair Castration resistant prostate cancer MLH1 MSH2 MSH6 PMS2

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Random forest machine learning models for interpretable X-ray absorption near-edge structure spectrum-property relationships

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npj Computational Materials 2020年第1期6卷 743-753页

作者： Steven B.Torrisi Matthew R.Carbone Brian A.Rohr Joseph H.Montoya Yang Ha Junko Yano Santosh K.Suram Linda hung Accelerated Materials Design and Discovery Toyota Research InstituteLos AltosCA 94022USA Department of Physics Harvard UniversityCambridgeMA 02138USA Department of Chemistry Columbia UniversityNew YorkNY 10027USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

X-ray absorption spectroscopy(XAS)produces a wealth of information about the local structure of materials,but interpretation of spectra often relies on easily accessible trends and prior assumptions about the ***,researchers have demonstrated that machine learning models can automate this process to predict the coordinating environments of absorbing atoms from their XAS ***,machine learning models are often difficult to interpret,making it challenging to determine when they are valid and whether they are consistent with physical *** this work,we present three main advances to the data-driven analysis of XAS spectra:we demonstrate the efficacy of random forests in solving two new property determination tasks(predicting Bader charge and mean nearest neighbor distance),we address how choices in data representation affect model interpretability and accuracy,and we show that multiscale featurization can elucidate the regions and trends in spectra that encode various local properties.

关键词： property structure spectrum

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Sodium-Coordinated Polymeric Phthalocyanines as Stable High-Capacity Organic Anodes for Sodium-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 22-30页

作者： Jeongyeon Lee Yoonbin Kim Soyong Park Kang Ho Shin Gun Jang Min Jun Hwang Daekyu Kim Kyung-Ah Min Ho Seok Park Byungchan Han Dennis K.P.Ng lawrence Yoon Suk Lee Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloon Hong Kong SAR China Department of Chemistry The Chinese University of Hong KongShatinNew Territories Hong Kong SAR China Convergence Research Center for Energy and Environmental Sciences Sungkyunkwan UniversitySuwon Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon Korea

Sodium-ion batteries(SIBs)have attracted considerable interest as an alternative to lithium-ion batteries owing to their similar electrochemical performance and superior long-term cycle *** materials are regarded as promising anode materials for constructing SIBs with high capacity and good ***,utilization of organic materials is rather limited by their low energy density and poor stability at high current *** overcome these limitations,we utilized a novel polymeric disodium phthalocyanines(pNaPc)as SIB anodes to provide stable coordination sites for Na ions as well as to enhance the stability at high current *** varying the linker type during a one-pot cyclization and polymerization process,two pNaPc anodes with O-(O-pNaPc)and S-linkers(S-pNaPc)were prepared,and their structural and electrochemical properties were *** O-pNaPc binds Na ions with a lower binding energy compared with S-pNaPc,which leads to more facile Na-ion coordination/dissociation when engaged as SIB *** use of O-pNaPc significantly improves the redox kinetics and cycle stability and allows the fabrication of a full cell against Na_(3)V_(2)(PO_(4))_(2)F_(3)/C cathode,which demonstrates its practical application with high energy density(288 Wh kg^(-1))and high power density(149 W kg^(-1)).

关键词： coordination chemistry organic anode phthalocyanine polymerization sodium ion battery

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Levels and trends of current-use pesticides(CUPs)in the arctic:An updated review,2010-2018

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Emerging Contaminants 2019年第1期5卷 70-88页

作者： Jennifer E.Balmer Adam D.Morris Hayley hung Liisa Jantunen Katrin Vorkamp Frank Riget Marlene Evans Magali Houde Derek C.G.Muir Arctic Monitoring and Assessment Programme Fram CentrePO Box 6606Langnes9296TromsøNorway Department of Biology The Citadel171 Moultrie StreetCharlestonSCUSA Environment and Climate Change Canada National Wildlife Research CenterOttawaCanada Air Quality Processes Research Section Environment and Climate Change CanadaTorontoOntarioCanada Air Quality Processes Research Section Environment and Climate Change CanadaEgbertOntarioCanada Aarhus University Department of Environmental ScienceArctic Research CentreRoskildeDenmark Aarhus University Department of BioscienceRoskildeDenmark Aquatic Ecosystem Protection Research Division Environment Canada11 Innovation BlvdSaskatoonSKS7N 3H5Canada Environment and Climate Change Canada St.Lawrence CenterMontrealQuebecCanada Environment and Climate Change Canada Canada Centre for Inland WatersBurlingtonOntarioCanada

Global regulations and many regional and national controls restrict the use of substances that exhibit the potential for environmental persistence and long-range ***,many current-use pesticides(CUPs)continue to be newly discovered in remote regions,including the *** present review serves as an update,summarizing newly available information for CUPs in the Arctic environment and biota published from 2010 to *** 2010,at least seven new CUPs have been measured in Arctic media:2-methyl-4-chlorophenoxyacetic acid(MCPA),metribuzin,pendimethalin,phosalone,quizalofop-ethyl,tefluthrin and *** the large number of pesticides in current use,the number measured in the Arctic is very limited,however,modelling studies have identified additional CUPs as potential Arctic contaminants that have yet to be investigated in the *** to their recent detection,reports of CUPs in the Arctic are limited,but *** have been reported in a wide range of abiotic Arctic matrices,including air,snow,ice,freshwater and seawater,indicating their capacity for long-range atmospheric transport,however,concentrations are generally low in comparison to legacy pesticides and other persistent organic pollutants(POPs).Recent food-web studies indicate CUPs can enter Arctic terrestrial and marine food chains,however,in contrast to POPs,the highest concentrations of many CUPs were found in lower trophic-level organisms,and the lowest concentrations detected in animals at the highest trophic levels(i.e,ringed seals,polar bear,caribou,and wolves)indicating significant trophic *** detection of CUPs in the remote Arctic ecosystem reinforces the need for continued monitoring of both known and potential Arctic pollutants to prevent impacts on human and environmental health as the global arsenal of pesticides used in agriculture continuously changes.

关键词： POPs Contaminants Air Biota Long-range transport Persistence

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Discrimination and stratification tests of cardiovascular disease risk assessment models against ultrasound detection of carotid plaques in type 2 diabetics

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Health 2013年第7期5卷 1-10页

作者： lawrence W. C. Chan Yu Sun Iris F. F. Benzie Department of Health Technology and Informatics Hong Kong Polytechnic University Hung Hom China

Atherosclerosis is the early stage of arterial disease, and underlies development of cardiovascular disease (CVD) and stroke. Although sophisticated models for assessing CVD and stroke risk have been derived based on large-scale prospective studies, their abilities in detecting the presence or absence of atherosclerotic plaque have not been investigated. This study aimed to evaluate and compare discriminatory and risk stratifying abilities of 13 CVD risk assessment models against the ultrasound detection of carotid plaques in type 2 diabetes mellitus (T2DM) patients. Forty-nine T2DM subjects were recruited with informed consent, and major anthropomorphic and biomarker data for these models were collected. The model risk scores were evaluated against the carotid plaques detected by Doppler ultrasound. Only the FHS-Lpts-CHD-10Y model, which is a variant of the Framingham model, revealed an area under the receiver operating curve (AUROC) that was significantly different from a random scoring approach (AUROC: 0.681, p was able to stratify the risk levels of carotid plaque presence (Chi-Square statistic: 5.99,

关键词： Atherosclerosis Cardiovascular Disease Doppler Ultrasound Risk Assessment

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