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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi hyun-Woo Rhee Kwang-hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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A Lookahead Read Cache： Improving Read Performance for Deduplication Backup Storage

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Journal of Computer Science & Technology 2017年第1期32卷 26-40页

作者： Dongchul Park Ziqi Fan young Jin Nam David h. C. Du Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis MN 55455 U.S.A.

Data deduplication （dedupe for short） is a special data compression technique. It has been widely adopted to save backup time as well as storage space, particularly in backup storage systems. Therefore, most dedupe research has primarily focused on improving dedupe write performance. however, backup storage dedupe read performance is also a crucial problem for storage recovery. This paper designs a new dedupe storage read cache for backup applications that improves read performance by exploiting a special characteristic： the read sequence is the same as the write sequence. Consequently, for better cache utilization, by looking ahead for future references within a moving window, it evicts victims from the cache having the smallest future access. Moreover~ to further improve read cache performance. it maintains a small log buffer to judiciously cache future access data chunks. Extensive experiments with real-world backup workloads demonstrate that the proposed read cache scheme improves read performance by up to 64.3%

关键词： deduplication dedupe read cache backup

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AdS/Deep-Learning made easy:simple examples

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Chinese Physics C 2021年第7期45卷 132-141页

作者： Mugeon Song Maverick S.h.Oh Yongjun Ahn Keun-young Kima Gwangju Institute of Science and Technology(GIST) Department of Physics and Photon ScienceGwangjuSouth Korea University of California–Merced Department of PhysicsMercedCAUSA

Deep learning has been widely and actively used in various research ***,in gauge/gravity duality,a new deep learning technique called AdS/DL(Deep Learning)has been *** goal of this paper is to explain the essence of AdS/DL in the simplest possible setups,without resorting to knowledge of gauge/gravity *** perspective will be useful for various physics problems:from the emergent spacetime as a neural network to classical mechanics *** prototypical examples,we choose simple classical mechanics *** method is slightly different from standard deep learning techniques in the sense that we not only have the right final answers but also obtain physical understanding of learning parameters.

关键词： gauge/gravity duality holographic principle machine learning

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Effects of the concentration and nature of total dissolved solids in drinking water on feed intake, nutrient digestion, energy balance,methane emission, ruminal fermentation, and blood constituents in different breeds of young goats and hair sheep

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Animal Nutrition 2024年第01期16卷 84-95页

作者： Amlan Kumar Patra Luana Paula dos Santos Ribeiro hirut Yirga Adekayode O.Sonibare Ahmed R.Askar Ali h.hussein Ryszard Puchala Arthur Louis Goetsch American Institute for Goat Research Langston University Animal and Poultry Nutrition Department Desert Research Center Agriculture Food and Natural ResourcesEastern New Mexico University

Understanding how different livestock species and breeds respond to consumption of brackish water could improve usage of this ***,Angora,Boer,and Spanish goat doelings and Dorper,Katahdin,and *** ewe lambs (6 animals per animal type[AT];initial age=296±2.1 days)consuming water with varying concentrations of minerals of a natural brackish water source (BR) and sodium chloride (NaCl;SL) were used to determine effects on water and feed intake,nutrient digestion,heat energy,methane emission,ruminal fluid conditions,and blood constituent *** were 6 simultaneous 6 (water treatments[WT])×6 (AT) Latin squares with 3-wk *** WT were fresh (FR),BR alone (100-BR),a similar total dissolved solids (TDS) concentration as 100-BR via NaCl addition to FR (100-SL),BR with concentrations of all minerals increased by approximately 50%(150-BR),a similar TDS level as 150-BR by NaCl addition to FR (150-SL),and a similar 150 TDS level achieved by addition of a 1:1 mixture of BR minerals and NaCl to 100-BR (150-BR/SL).Concentrations (mg/kg) in BR were 4928 TDS,85.9 bicarbonate,224.9 calcium,1175 chloride,60.5 magnesium,4.59 potassium,1387sodium,1962 sulfate,and 8.3 boron,and TDS in other WT were 209,5684,7508,8309,and 7319 mg/kg for FR,100-SL,150-BR,150-SL,and 150-BR/SL,*** were very few significant effects of WT or AT×WT interactions,although AT had numerous *** intake was affected by AT (P=0.02)and WT (P=0.04),with greater water intake for 150-SL than for FR,100-BR,100-SL,and *** matter intake among AT was lowest (Pheat energy differed among AT (Phane emission were similar among *** aldosterone concentration was higher (Phan for other *** conclusion,all AT seemed resilient to these WT regardless of mineral source and concentrations,with TDS less than 8300 mg/kg,which did

关键词： Goats hair sheep Nutrient utilization Ruminal fermentation Salinity Water quality

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Management of cytomegalovirus corneal endotheliitis

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Eye and Vision 2021年第1期8卷 18-30页

作者： Angela h.Y.Wong Wee Nie Kua Alvin L.young Kelvin h.Wan Department of Ophthalmology Tuen Mun HospitalHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina

Background:Cytomegalovirus(CMV)can manifest as corneal endotheliitis in immunocompetent *** diagnosis is prudent to prevent endothelial cell loss,which could ultimately lead to corneal *** DNA was first detected in an eye with corneal endotheliitis in 2006;since then,clinical evidence from numerous case reports and case series have *** text:In this narrative review,we identified several drugs,including ganciclovir,valganciclovir,and their combination in oral,intravenous,intravitreal,and topical forms in different concentrations,together with the judicious use of topical steroids,have reported variable *** has yet to be any prospective comparative study evaluating the efficacy and safety of these assorted forms of treatment;clinical evidence is based on case reports and case *** endotheliitis presenting with corneal edema can masquerade as other corneal diseases and thus poses a great challenge especially in post-keratoplasty *** awareness is needed before and after keratoplasty to start prompt prophylaxis and ***:There is no consensus on the management of CMV *** studies are much needed to elucidate the optimal treatment modality,regime,and duration in the treatment and prophylaxis of CMV endotheliitis.

关键词： Cytomegalovirus CMV Endotheliitis Keratoplasty Corneal transplant Cornea

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Some Radius Problems Related to a Certain Subclass of Analytic Functions

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Acta Mathematica Sinica,English Series 2014年第7期30卷 1133-1144页

作者： Oh Sang KWON young Jae SIM Nak Eun ChO h.M.SRIVASTAVA Department of Mathematics Kyungsung University Department of Applied Mathematics Pukyung National University Department of Mathematics and Statistics University of Victoria

For real parameters αand β such that 0≤α 〈 1 〈β, we denote by S（α,β） the class of normalized analytic functions which satisfy the following two-sided inequality：where U denotes the open unit disk. We find a sufficient condition for functions to be in the class S（α,β） and solve several radius problems related to other well-known function classes.

关键词： Analytic functions univalent functions starlike functions functions of bounded real pos-itive real part radius problems

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Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu En-Yang Wang Jinbo Pang Shirong huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk hao Jia Shu-Xian hu Chongyun Jiang hong Liu Gianaurelio Cuniberti Weijia Zhou Mark h Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

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New Insights into the Growth Mechanism and Surface Structure of Palladium Nanocrystals

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Nano Research 2010年第3期3卷 180-188页

作者： Byungkwon Lim hirokazu Kobayashi Pedro h.G.Camargo lawrence F.Allard Jingyue Liu Younan Xia Department of Biomedical Engineering Washington UniversitySt.LouisMissouri 63130USA Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Center for Nanoscience and Department of Chemistry and Biochemistry University of Missouri-St.LouisSt.LouisMissouri 63121USA

This paper presents a systematic study of the growth mechanism for Pd nanobars synthesized by reducing Na_(2)PdCl_(4) with L-ascorbic acid in an aqueous solution in the presence of bromide ions as a capping *** electron microscopy(TEM)and high-resolution TEM analyses revealed that the growth at early stages of the synthesis was dominated by particle coalescence,followed by shape focusing via recrystallization and further growth via atomic *** also investigated the detailed surface structure of the nanobars using aberration-corrected scanning TEM and found that the exposed{100}surfaces contained several types of defects such as an adatom island,a vacancy pit,and atomic *** thermal annealing,the nanobars evolved into a more thermodynamically favored shape with enhanced truncation at the corners.

关键词： Palladium nanocrystals growth coalescence surface evolution

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Through-polymer,via technology-enabled,flexible,lightweight,and integrated devices for implantable neural probes

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Microsystems & Nanoengineering 2024年第2期10卷 279-291页

作者： Cunkai Zhou Ye Tian Gen Li Yifei Ye Lusha Gao Jiazhi Li Ziwei Liu haoyang Su Yunxiao Lu Meng Li Zhitao Zhou Xiaoling Wei Lunming Qin Tiger h.Tao Liuyang Sun College of Electronics and Information Engineering Shanghai University of Electric PowerShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina School of Graduate Study University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Neuroxess Co. Ltd.(Jiangxi)NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology HengqinZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal *** advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated *** conventional approach adds considerable weight and volume to the package,especially for high channel count *** address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional *** innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without ***,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action *** findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.

关键词： alloy neural recording

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Circulating immune cell landscape in patients who had mild ischaemic stroke

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Stroke & Vascular Neurology 2022年第4期7卷 319-327,I0020-I0022页

作者： young-Eun Cho hyangkyu Lee heekyong R.Bae hyungsuk Kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal lawrence Latour Jessica Gill College of Nursing The University of IowaIowa CityIowaUSA National Institute of Nursing Research National Institutes of HealthBethesdaMarylandUSA Mo-Im Kim Nursing Research Institute College of NursingYonsei UniversitySeoulSouth Korea National Eye Institute National Institutes of HealthBethesdaMarylandUSA Predictiv Care IncSunnyvaleCaliforniaUSA School of Nursing Johns Hopkins UniversityBaltimoreMarylandUSA College of Nursing University of Tennessee Health Science CenterMemphisTennesseeUSA Suburban hospital BethesdaMarylandUSA National Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaMarylandUSA

Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically *** immune cells are potential biomarkers that can assist with diagnosis in ischaemic *** the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated *** this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased *** Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched *** PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 *** Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+*** number of NK cells was increased,which was further confirmed by flow *** analysis implied that the activity of NK cells also is enhanced in patients who had a ***14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+*** found CD14+monocyte subclusters were dramatically reduced in patients who had a *** This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic *** findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke.

关键词： patients diagnosis Circulating

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