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EXPRESSION OF FLIP IN HUMAN COLON CARCINOMAS: A NEW MECHANISM OF IMMUNE EVASION

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Chinese Journal of Cancer Research 2005年第3期17卷 193-198页

作者：邢宝才 S. Wimmenauer eh. Farthmann Department of Surgery Peking University School of Oncology Beijing Cancer Hospital Beijing Institute for Cancer Research Department of Surgery University Hospital of Freiburg

Objective： It has been proposed that Fas ligand （FasL） may play an important role in immune escape of tumors and FLIP is an important mediator of Fas/FasL pathway. In this study, the expression of FLIP was determined in human colon carcinoma cell lines and tissue to investigate the new mechanism of immune evasion of human colon carcinomas. Methods： RT-PCR and immunohistochemistry （IHC） were performed to investigate the expression of FLIP in human colon carcinoma cell lines SW480, LS174 and twenty human primary colon carcinoma specimens. Results： It was shown that SW480 cells, LS174 cells and primary colon carcinoma specimen constitutively expressed FLIP at the mRNA and protein level. The expression of FLIP was not found in the epithelial cells of normal colon mucosa. Conclusion： FLIP was expressed in human primary colon carcinoma specimens but not in the normal counterpart. It suggested that the expression of FLIP may occur during the malignant transformation from normal colon epithelial cells to colon carcinoma cells. Tumor cells might obtain the ability to resist the Fas-mediated apoptosis by expressing FLIP. The expression of FLIP might contribute to the formation of colon carcinomas.

关键词： Colon carcinoma Fas/FasL FLIP Immune evasion

废液种类变换时生化处理的微生物体系与污染物质去除

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中国造纸学报 2001年第1期16卷 91-96页

作者：高扬许玮 H.-claude lavallée 华南理工大学制浆造纸工程国家重点实验室广州510641 Université du Québec à Trois-Rivières

化学机械法制浆系统中有阔叶木和针叶木交替使用的情况。原料种类的变化导致了制浆废液污染特性和污染负荷的差异 ,对废液生化处理系统会产生冲击。本文讨论了不同制浆废液的更换过程中 ,废水活性污泥法处理的污染物质去除。

关键词：生化处理系统污染物质制浆废液污染特性污染负荷废水污泥水活性阔叶木针叶木

Clinical efficacy of rosuvastatin in lipid management in Chinese patients in Hong Kong

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Chinese Medical Journal 2009年第23期122卷 2814-2819页

作者： Vivian W.Y. Lee T.S. Chau Vice eh. Leung Kenneth K.C. Lee Brian Tomlinson School of Pharmacy Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

Background Rosuvastatin has been claimed to be more potent than other statins in its ability to lower the low-density lipoprotein （LDL） cholesterol levels. This study aimed to investigate the clinical efficacy of rosuvastatin in LDL cholesterol lowering therapy for new or switched hyperlipidaemic Chinese patients. Methods This study was a retrospective one in patients who took rosuvastatin in the outpatient clinics of Prince of Wales Hospital during the period of July 1,2004 to June 30, 2005. The prescribing pattern, the utilization pattern and the side effect profile were recorded. Attainment of lipid goals for each patient was assessed according to the National Cholesterol Education Program Adult Treatment Panel （NCEP ATP） III guidelines. Results A total of 261 Chinese patients （mean age （64.8±12） years; 55.6% male） were recruited into the study. The mean LDL-cholesterol level was （3.50±1.29） mmol/L prior to Rosuvastatin and （2.30±1.73） mmol/L after Rosuvastatin treatment （P 〈0.0001）. Rosuvastatin raised the LDL-cholesterol goal achievement rate from 28.0% to 74.3% in all patients combined （P 〈0.0001） and from 11.0% to 79.0% for statin naive patients （P 〈0.0001）. Approximately 4% of patients developed side effects including myalgia, elevated liver enzymes, and dizziness. Conclusion Rosuvastatin was effective in improving LDL-cholesterol goal attainment and lowering LDL-cholesterol and triglyceride （TG） levels in either newly started or switched patients.

关键词： cholesterol rosuvastatin clinical efficacy

制浆废液污染特性变化对于生化处理系统的冲击与影响

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中国造纸学报 2001年第1期16卷 87-90,96页

作者：高扬许玮 H.claude lavallée 华南理工大学制浆造纸工程国家重点实验室广州510641 Université du Québecà Trois-Rivières

研究了阔叶木和针叶木两种原料交替更换使用时 ,化学机械法制浆废液污染特性变化对于生化处理系统的冲击与影响。本研究采用的活性污泥法处理系统具有高效菌类群体 ,对于针叶木和阔叶木两种原料的化机浆废液均有着良好的处理效果。当废... 详细信息

研究了阔叶木和针叶木两种原料交替更换使用时 ,化学机械法制浆废液污染特性变化对于生化处理系统的冲击与影响。本研究采用的活性污泥法处理系统具有高效菌类群体 ,对于针叶木和阔叶木两种原料的化机浆废液均有着良好的处理效果。当废液种类改变时 ,通过采取调控措施。

关键词：生化处理系统污染特性制浆废液高效菌活性污泥法处理废水处理系统处理效果阔叶木针叶木化机浆

Determination of Electron Collision Cross Sections Set for Tetramethysilane

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Plasma Science and Technology 2007年第6期9卷 756-759页

作者： Marie-claude BORDAGE Toulouse University LAPLACE UMR 5213 CNRS-UPSPaul Sabatier University118Route de Narbonne31062 Toulouse CedexFrance

A swarm analysis technique based on the solution of the Boltzmann equation is used to derive low energy electron collision cross sections for tetramethylsilane （TMS）. The calculated swarm parameters with this first available cross sections set is consistent with measured values of the swarm parameters. Calculations of transport parameters in mixtures of TMS with argon are also presented.

关键词： tetramethysilane electron cross section swarm parameters

Advantages and Drawbacks of Quantum Mechanical Static and Dynamic Approaches to Modelling Infrared Spectra

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Chinese Journal of Chemical Physics 2009年第2期22卷 123-128页

作者： claude Pouchan Philippe Carbonniere Groupe Chimie Théorique et Réactivité ECP IPREM UMR CNRS 5254 Université de Pau et des Pays de I'Adour 2 Rue Jules Ferry F-54000 Pau France

We present quantum mechanical vibrational computations beyond the harmonic approximation from effective second order perturbative and variation perturbation treatments defined as static approaches, as well as vibrational analysis from density functional theory molecular dynamics trajectories at 300 and 600 K. The four schemes are compared in terms of prediction of fundamental transitions, and simulation of the corresponding medium infrared spectrum at the same level of theory using the B3LYP/6-31＋G（d,p） description of the electronic structure. We summarize conclusions about advantages and drawbacks of these two approaches and report the main results obtained for semi-rigid and flexible molecules.

关键词： Anharmonic vibrations Vibrational configuration interaction Perturbative approach Ab initio molecular dynamic treatment

The synergy between the payloads on the ASO-S mission

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Research in Astronomy and Astrophysics 2019年第11期19卷 115-126页

作者： Jean-claude Vial Institut d’Astrophysique Spatiale University Paris-Sud

This paper addresses the improved science resulting from joint observations performed by the different instruments onboard the Advanced Space-based Solar Observatory(ASO-S)mission along with ancillary instruments on missions flying at the same *** first describes the three major instruments along with their stated *** it presents some basic science issues concerning jointly observed flares,coronal mass ejections(CMEs)and eruptive prominences(EPs).Each physical candidate(magnetic reconnection,instability,hard X-ray emission and magnetic coronal field topology)is discussed in terms of its signature and identification with ASO-S *** importance of Lyαdetection and non-LTE modeling is *** instrumental and science challenges are briefly discussed.

关键词： techniques imagery,polarimetry-Sun eruptions,flares,coronal mass ejections

More constructions of APN and differentially 4-uniform functions by concatenation

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Science China Mathematics 2013年第7期56卷 1373-1384页

作者： CARLET claude LAGA University of Paris 13CNRS (UMR 7539)France Department of Mathematics University of Paris 8 2 rue de la liberté 93526 Saint-Denis Ced-exFrance

We study further the method of concatenating the outputs of two functions for designing an APN or a differentially 4-uniform (n, n)-function for every even n. We deduce several specific constructions of APN or differentially 4-uniform (n, n)-functions from APN and differentially 4-uniform (n/2, n/2)-functions. We also give a construction of quadratic APN functions which includes as particular cases a previous construction by the author and a more recent construction by Pott and Zhou.

关键词： block cipher vectorial function substitution box almost perfect nonlinear almost bent

Biomechanics of transendothelial migration by cancer cells

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BIOCELL 2022年第11期46卷 2381-2386页

作者： claude VERDIER UniversitéGrenoble Alpes CNRSLIPhyGrenoble38000France

Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their *** addition the formation of metastases is very difficult to understand,since it involves very complex physical mechanisms such as cellular interactions and cell rheology,which are *** studies investigated transendothelial migration using sophisticated techniques such as microfluidics,traction force microscopy(TFM)or Atomic Force Microscopy(AFM),combined with physical *** we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration.

关键词： Rheology Deformation Forces Adhesion Biophysics