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Severe COVID-19 patients exhibit an ILC2 NKG2D^(+) population in their impaired ILC compartment

Cellular & Molecular Immunology 2021年第2期18卷 484-486页

作者： Alejandra Gomez-Cadena laurie spehner Marie Kroemer Myriam Ben Khelil Kevin Bouiller Grégory Verdeil Sara Trabanelli Christophe Borg Romain Loyon Camilla Jandus Department of Pathology and Immunology University of GenevaGenevaSwitzerlandand Ludwig Institute for Cancer ResearchLausanneSwitzerland University of Bourgogne Franche-Comté INSERMEFS BFCUMR1098RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueF-25000BesançonFrance Department of Pharmacy University Hospital of BesançonF-25000BesançonFrance Department of Infectious Disease University Hospital of BesançonF-25000BesançonFrance UMR-CNRS 6249 Chrono-Environment UniversitéBourgogne Franche-ComtéF-25000BesançonFrance Department of Oncology UNIL-CHUVUniversity of Lausanne1066EpalingesSwitzerland Department of Medical Oncology University Hospital of BesançonF-25000BesançonFrance

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the current COVID-19 disease *** some patients,the symptoms are mild,and a fraction of SARS-CoV-2-infected individuals develop severe illness with a high fatality rate due to lung damage and acute respiratory distress syndrome.1 Innate lymphoid cells(ILCs)are a recently identified type of effector immune cells that rapidly sense environmental stimuli and participate in early immune responses by promptly secreting large amounts of cytokines.2 The ILC2 subpopulation was shown to mediate Type 2 responses and to recruit eosinophils during viral lung infections upon the release of alarmins(e.g.,IL-33)by damaged epithelial cells.3,4,5 ILC2s were also shown to participate in the termination of inflammatory responses and tissue repair by amphiregulin *** addition,ILC2s are critical in the early phases of allergic lung inflammation,including that induced by the protease allergen papain.6 Based on the essential function of the papain-like protease PLpro in regulating SARS-CoV-27(Fig.1a)and the severe lung damage caused by this virus,we sought to investigate the potential involvement of ILC2s in immune responses to COVID-19.

关键词： impaired patients acute

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CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

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Cellular & Molecular Immunology 2023年第4期20卷 365-378页

作者： Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar laurie spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe Borg Marie Kroemer Department of Medical Oncology Biotechnology and Immuno-Oncology PlatformUniversity Hospital of BesançonBesançonFrance INSERM EFS BFCUMR1098RIGHTUniversity of Franche-ComtéInteractions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueBesançonFrance Department of Pathology University Hospital of BesançonBesançonFrance Department of Surgery University Hospital of BesançonBesançonFrance EPIGENEXP platform University of Bourgogne Franche-ComtéBesançonFrance Department of Pharmacy University Hospital of BesançonBesançonFrance

CD226 has been reported to participate in the rescue of CD8^(+)T cell *** this study,we aimed to assess the prognostic value of CD226 in tumor-inﬁltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical *** from 43 metastases were isolated and analyzed ex vivo usingﬂow ***155 and CD3 levels in the tumor microenvironment were assessed by *** and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression ***226 expression contributes to the deﬁnition of the immune context in CRC liver metastases and primary ***226 on CD8^(+)T cells was not speciﬁcally coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver *** Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of *** expression analysis in a validation dataset conﬁrmed the prognostic value of CD226 in CRC liver metastases but not in primary *** of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 ***,CD226 expression on liver metastasis-inﬁltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.

关键词： CD226 antigen Colorectal Neoplasms Liver metastasis Lymphocytes Tumor-Inﬁltrating

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