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Plasma Membrane-Associated SCAR Complex Subunits Promote Cortical F-Actin Accumulation and Normal Growth Characteristics in Arabidopsis Roots

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Molecular Plant 2008年第6期1卷 990-1006页

作者： Julia Dyachok Mon-Ray Shao Kevin Vaughn Andrew Bowling Michelle Facette Stevan Djakovic Lauren Clark laurie smith Section of Cell and Developmental Biology University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0116 USA Southern Weed Science Research Unit USDA-ARS 141 Experiment Station Road Stoneville MS 38776 USA Carnegie Institution Department of Plant Biology 260 Panama Street Stanford CA 94305 USA Present address: Division of Plant Biology The Samuel Roberts Noble Foundation 2510 Sam Noble Pkwy Ardmore OK 73401 USA Present address: Section of Neurobiology University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0116 USA

The ARP2/3 complex, a highly conserved nucleator of F-actin polymerization, and its activator, the SCAR complex, have been shown to play important roles in leaf epidermal cell morphogenesis in Arabidopsis. However, the intracellular site（s） and function（s） of SCAR and ARP2/3 complex-dependent actin polymerization in plant cells remain unclear. We demonstrate that putative SCAR complex subunits BRK1 and SCAR1 are localized to the plasma membrane at sites of cell growth and wall deposition in expanding cells of leaves and roots. BRK1 localization is SCAR-dependent, providing further evidence of an association between these proteins in vivo. Consistent with plasma membrane localization of SCAR complex subunits, cortical F-actin accumulation in root tip cells is reduced in brkl mutants. Moreover, mutations disrupting the SCAR or ARP2/3 complex reduce the growth rate of roots and their ability to penetrate semi-solid medium, suggesting reduced rigidity. Cell walls of mutant roots exhibit abnormal structure and composition at intercellular junctions where BRK1 and SCAR1 are enriched in the adjacent plasma membrane. Taken together, our results suggest that SCAR and ARP2/3 complex-dependent actin polymerization promotes processes at the plasma membrane that are important for normal growth and wall assembly.

关键词： cell expansion cell morphogenesis cytoskeleton root biology Arabidopsis.

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Side effects and acceptability measures for thermal ablation as a treatment for cervical precancer in low-income and middle-income countries:a systematic review and meta-synthesis

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Family Medicine and Community Health 2022年第2期10卷 40-51页

作者： Evelyne Marie Piret Beth A Payne laurie W smith Jessica Trawin Jackson Orem Gina Ogilvie Carolyn Nakisige British Columbia Women's Hospital and Health Centre Women’s Health Research InstituteVancouverBritish ColumbiaCanada Faculty of Medicine School of Population and Public HealthThe University of British ColumbiaVancouverBritish ColumbiaCanada Department of Reproductive Oncology Uganda Cancer InstituteKampalaUganda

Objective Understanding the side effects and acceptability of thermal ablation(TA)is necessary before large-scale application in screen-and treat programmes can be justified in low-income and middle-income countries(LMICs).Design Articles were selected for inclusion by two independent *** of bias was assessed using the Downs and Black’s *** data were extracted,and authors contacted for data when *** of interest and 95%CIs were estimated using a random effects *** analysis was performed based on place of treatment and timing of post-treatment *** was estimated using the I^(2).Eligibility criteria Studies that reported one or more side effects or patient acceptability measures after treatment of the cervix using TA in women living in LMICs who completed a cervical cancer screening *** articles were clinical trials or observational studies available in English and published before 18 December *** sources Ovid MEDLINE,EMBASE,CINAHL,CAB Global Health and WHO Global Index Medicus were searched for this systematic review and *** A total of 1590 abstracts were screened,84 full text papers reviewed and 15 papers selected for inclusion in the qualitative review,10 for meta-synthesis(N=2039).Significant heterogeneity was found in screening tests used to identify women eligible for TA and in methods to ascertain side *** most commonly reported side effect during treatment was pain(70%,95%CI 52%to 85%;I^(2)=98.01%)(8 studies;n=1454).No women discontinued treatment due to *** treatment follow-up,common side effects included vaginal discharge(72%,95%CI 18%to 100%;I^(2)=99.55%)(5 studies;n=771)and bleeding(38%,95%CI 15%to 64%;I^(2)=98.14%)(4 studies;n=856).Satisfaction with treatment was high in 99%(95%CI 98%to 100%;I^(2)=0.00%)of women(3 studies;n=679).Conclusions TA results in a number of common side effects,though acceptability remains high among women t

关键词： cervical treatment income

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High Intensity Interval Training in Healthy Males Does not Improve Markers of Insulin Sensitivity

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Journal of Sports Science 2015年第2期3卷 49-56页

作者： Douglas James Oberlin Jason smith Kevin Ritsche laurie Wideman Department of Kinesiology University of North Carolina Greensboro Greensboro NC 27412 USA Department of Human Performance and Sport Science Winston-Salem State University Winston-Salem NC 27110 USA

Purpose: Determine if three weeks of HIT (high-intensity interval training) improves fasting insulin sensitivity in healthy males. Methods: Participants were recreationally active ( ≥ 10 hours per week) men between 18 and 35 years of age (Ht: 180 ± 1.44 cm; Wt: 85 ± 2.95 kg; BMI: 26.1 ± 0.59 kg/m2; body fat: 19.7 ± 1.76%). HIT training occurred 3 days weekly for 3 weeks, at intensities equivalent to 7.5% of body mass. Training volume increased weekly as follows: three sprints per session (week 1), four sprints per session (week 2), and five sprints per session (week 3). Fasting blood samples were collected at baseline and after each week and tested for glucose and insulin. A repeated measures ANOVA was used to measure changes in both fasting glucose and insulin concentrations as well as HOMA(IR) (homeostatic model assessment) and QUICKI (quantitative insulin sensitivity check index). Results: Values were in the normal range throughout the study and there were no significant improvements in glucose (P = 0.346), insulin (P = 0.680), HOMA (P = 0.567), or QUICKI (P = 0.186), as a result of HIT. Conclusion: While HIT may be useful in maintaining insulin sensitivity in healthy males, 3-weeks of HIT did not further improve insulin sensitivity in this group.

关键词：运动科学体育运动体育锻炼科学方法

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Call for emergency action to limit global temperature increases,restore biodiversity and protect health

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Stroke & Vascular Neurology 2021年第3期6卷 321-323页

作者： Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard smith Nicholas J Talley Sue Turale Damián Vázquez East African Medical Journal NairobiKenya Journal of Health Population and NutritionBaltimoreMarylandUSA Danish Medical Journal CopenhagenDenmark PLOS Medicine CambridgeUK The BMJ LondonUK British Dental Journal LondonUK The Lancet LondonUK UK Health Alliance on Climate Change LondonUK Revista de Saúde Pública S鉶PauloBrazil International Journal of Nursing Studies LondonUK CMAJ OttawaOntarioCanada Pharmaceutical Journal LondonUK Dutch Journal of Medicine NijmegenThe Netherlands NEJM BostonMassachusettsUSA National Medical Journal of India New DelhiIndia Medical Journal of Australia NewcastleNew South WalesAustralia International Nursing Review GenevaSwitzerland Pan American Journal of Public Health WashingtonDCUSA

Wealthy nations must do much more,much *** United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental *** will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,*** of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5℃,halt the destruction of nature and protect health.

关键词： action collective faster

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health

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General Psychiatry 2021年第5期34卷 53-55页

作者： Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard smith Nicholas J Talley Sue Turale Damián Vázquez East African Medical Journal NairobiKenya Journal of Health Population and NutritionBaltimoreMarylandUSA Danish Medical Journal CopenhagenDenmark PLOS Medicine CambridgeUK The BMJ LondonUK British Dental Journal LondonUK The Lancet LondonUK UK Health Alliance on Climate Change LondonUK Revista de Saúde Pública São PauloBrazil International Journal of Nursing Studies LondonUK CMAJ OttawaOntarioCanada Pharmaceutical Journal LondonUK Dutch Journal of Medicine NijmegenThe Netherlands NEJM BostonMassachusettsUSA National Medical Journal of India New DelhiIndia Medical Journal of Australia NewcastleNew South WalesAustralia International Nursing Review GenevaSwitzerland Pan American Journal of Public Health WashingtonDCUSA

Wealthy nations must do much more,much *** United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental *** will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,*** of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5°C,halt the destruction of nature and protect health.

关键词： action collective faster

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health

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World Journal of Pediatric Surgery 2021年第4期4卷 60-62页

作者： Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard smith Nicholas J Talley Sue Turale Damián Vázquez East African Medical Journal NairobiKenya Journal of Health Population and NutritionBaltimoreMarylandUSA Danish Medical Journal CopenhagenDenmark PLOS Medicine CambridgeUK The BMJ LondonUK British Dental Journal LondonUK The Lancet LondonUK UK Health Alliance on Climate Change LondonUK Revista de Saúde Pública São PauloBrazil International Journal of Nursing Studies LondonUK CMAJ OttawaOntarioCanada Pharmaceutical Journal LondonUK Dutch Journal of Medicine NijmegenThe Netherlands NEJM BostonMassachusettsUSA National Medical Journal of India New DelhiIndia Medical Journal of Australia NewcastleNew South WalesAustralia International Nursing Review GenevaSwitzerland Pan American Journal of Public Health WashingtonDCUSA

关键词： action collective faster

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