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Juxtacrine interaction of macrophages and bone marrow stromal cells induce interleuk.n-6 signals and promote cell migration

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Bone Research 2015年第2期3卷 100-111页

作者： Jia Chang Amy J k.h Hernan Roca laurie k.mccauley Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Department of Periodontology University of Florida College of Dentistry Department of Pathology University of Michigan Medical School

The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are k.y cellular mediators for resolving infection and inflammation. Macrophages are most well k.own for their ability to phagocytose foreign bodies or apoptotic cells to maintain homeostasis; however, little is k.own about their function in the bone microenvironment. In the current study, we investigated the in vitro interaction of murine macrophages and bone marrow stromal cells （BMSCs）, with focus on the juxtacrine induction of IL-6 signaling and the resultant effect on BMSC migration and growth. The juxtacrine interaction of primary mouse macrophages and BMSCs activated IL-6 signaling in the co-cultures, which subsequently enhanced BMSC migration and increased BMSC numbers. BMSCs and macrophages harvested from IL-6 k.ock.ut mice revealed that IL-6 signaling was essential for enhancement of BMSC migration and increased BMSC numbers via juxtacrine interactions. BMSCs were the main contributor of IL-6 signaling~ and hence activation of the IL-6/ gp130/STAT3 pathway. Meanwhile, macrophage derived IL-6 remained important for the overall production of IL-6 protein in the co-cultures. Tak.n together, these findings show the function of macmphages as co-inducers of migration and growth of BMSCs, which could directly influence bone formation and turnover.

关键词： BMSCs IL bone STAT cell

Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation

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Bone Research 2024年第3期12卷 634-647页

作者： Lena Batoon Amy Jean k.h Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha k.nnan Aysia k.nnaird Megan Avey Tatyana Teslya Allison Robyn Pettit laurie k.mccauley Hernan Roca Department of Periodontics and Oral Medicine University of MichiganSchool of DentistryAnn ArborMI 48109USA Mater Research Institute The University of QueenslandBrisbaneQLD 4102Australia Department of Pathology University of MichiganMedical SchoolAnn ArborMI 48109USA

Apoptosis is crucial for tissue homeostasis and organ *** bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains *** our murine model with inducible Caspase 9,the enzyme that initiates intrinsic apoptosis,we triggered apoptosis in a proportion of mature osteocalcin(OCN^(+))osteoblasts and investigated the impact on postnatal bone development.

关键词： development homeostasis bone

Predicting the Geographic Traffic Distribution in Cellular Network.

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China Communications 2010年第1期7卷 6-14页

作者： laurie Cuthbert Department of Electronic Engineering Queen Mary University of London

Early detection and rapid resolution network.congestion can considerably improve network.capacity. Consequently, much research has been carried out on predicting traff ic patterns in 3G network.. This paper introduces an access point centric approach that is implemented by two prediction models, the traffic abstraction model and the order-k.Mark.v model. Traffi c predictions are carried out to support the congestion control in the semi-smart antenna systems. The simulation result shows that the cumulative error rate is below 25% even carrying out multi-step-ahead predictions.

关键词： traffic pattern prediction traffic abstraction model Mark.v model congestion control

Microstructure Development for Brittle Fracture Control in Nb Microalloyed Line Pipe Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 831-835页

作者： Subramanian laurie Collins Jitendra Patel Department of Mat.Sci.and Engg. McMaster UniversityHamiltonCanada Research Department Evraz Inc.NAReginaSKCanada International Metallurgy Ltd NottinghamU.K.

EBSD characterization of density and dispersion of high angle boundaries was carried out in niobium microalloyed steels of HTP base chemistry with 0.09 wt % Nb,which were thermo-mechanically processed under laboratory *** studies were carried out in higher grade (X-100 and above) line pipe steels with different chemistries,which were processed under simulation of industrial rolling *** twin objectives are (i) to understand the effect of chemistry and processing parameters on the density and dispersion of high angle boundaries,and (ii) to correlate the microstructure and density of high angle boundaries with strength and fracture *** present studies confirm that refinement of austenite grain size prior to pancak.ng,large strain accumulation in austenite conditioning,alloy design with high hardenability and high cooling rates are essential to control high density and uniformity of dispersion of high angle boundaries in the final microstructure in order to achieve high strength,toughness,low DBTT and consistently 100% ductile shear in DWTT in thermo-mechanically rolled higher grade line pipe steels.

关键词： line pipe steel brittle fracture EBSD DBTT high angle boundaries microalloying niobium

The effectiveness of mI SMART:A nurse practitioner led technology intervention for multiple chronic conditions in primary care

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International Journal of Nursing Sciences 2018年第2期5卷 131-137页

作者： Jennifer A.Mallow laurie A.Theek. Elliott Theek. Brian k.Mallow West Virginia University School of NursingUnited States of America Sovern Run LLCUnited States of America

Aims:Used as integrated tools,technology may improve access and outcomes of care.A new intervention that integrates multiple technologies called mI SMART has been developed,implemented,and evaluated by Nurse *** aim of this paper is to present the initial effectiveness of a webbased,structure of sensors and mobile devices designed to overcome the k.own health determinant of access to care for rural,chronically ill patients by using ***:The study was conducted at a community primary-care clinic that provides free healthcare to impoverished *** with at least one chronic condition,a minimum of 3rd grade reading level,and without dementia/psychosis were *** were given a Nexus7 tablet and Bluetooth self-monitoring *** intervention lasted for 12 *** glucose,blood pressure,and weight were collected using the provided Bluetooth devices and means were evaluated with paired-samples ttests before and after the ***:Thirty participants were majority female,white,married,high-school educated or less,earning less than$20,000 per annum,and had multiple chronic ***-intervention glucose,systolic blood pressure,diastolic blood pressure,weight and Body Mass Index were all reduced after the 12-week.***:The mI SMART intervention is efficacious for use in improvised adults living in rural areas with multiple chronic *** previously reported,the intervention was also shown to be feasible and acceptable to *** next step is a larger randomized controlled trial.

关键词： Health disparities mHealth Multiple chronic conditions Nursing informatics Rural

A cross-sectional study of breastfed infants referred for tongue tie assessment and frenotomy in one Canadian health region

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Pediatric Investigation 2024年第1期8卷 53-60页

作者： Tiffany A.Lee Jessica Bishop Anne Drover William k.Midodzi laurie k.Twells School of Pharmacy Memorial University of Newfoundland(MUN)St.John’sCanada Faculty of Medicine Memorial University of Newfoundland(MUN)St.John’sCanada

Importance:Tongue tie(TT)is a condition that can cause infant feeding difficulties due to restricted tongue *** TT presents as a significant barrier to breastfeeding,a frenotomy may be *** accepted diagnostic criteria for TT are lack.ng and wide prevalence estimates are *** referral processes and a Frenotomy Assessment Tool were implemented in one Canadian health region to connect breastfeeding dyads with a provider for TT evaluation and ***:To determine the proportion of babies with TT as well as the frequency of ***:This cross-sectional study included infants who initiated breastfeeding at birth and were referred for TT evaluation over a 14-month *** were collected retrospectively by chart review and analyzed using *** associated with frenotomy were examined using logistic ***:Two hundred and forty-one babies were ***-two percent(n=222)were diagnosed with TT and 66.0%(n=159)underwent *** the multivariate model,nipple pain/trauma,inability to latch,inability to elevate tongue,and dimpling of tongue on extension were associated with frenotomy(P<0.05).Most referrals in our region resulted in a diagnosis of TT;however,the number of referrals was lower than expected,and of these two-thirds underwent ***:TT is a relatively common finding among breastfed *** research should examine whether a simplified assessment tool containing the four items associated with frenotomy in our multivariate model can identify breastfed infants with TT who require frenotomy.

关键词： Breastfeeding Nutrition Community health services Pediatrics

Part A: The Development of mI SMART, a Nurse-Led Technology Intervention for Multiple Chronic Conditions

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Open Journal of Nursing 2016年第4期6卷 303-308页

作者： Jennifer A. Mallow laurie A. Theek. Rebecca Walls Elliott Theek. Brian k. Mallow School of Nursing West Virginia University Morgantown West Virginia USA Milan Pusk.r Health Right Morgantown West Virginia USA Sovern Run LLC Albright West Virginia USA

Back.round: The treatment of Multiple Chronic Conditions (MCC) is complex for both patients and providers. Used as integrated tools, technology may decrease complexity, remove the barrier of distance to obtain care, and improve outcomes of care. A new platform that integrates multiple technologies for primary health care called mI SMART (Mobile Improvement of Self-Management Ability through Rural Technology) has been developed. The purpose of this paper is to present to development of mI SMART, a nurse-led technology intervention for treating for MCC in primary care. Methods: The creation of mI SMART was guided by the model for developing complex nursing interventions. The model suggests a process for building and informing interventions with the intention of effectiveness, sustainability, and scalability. Each step in the model builds from and informs the previous step. Results: The process resulted in the integrated technologies of mI SMART. The system combines a HIPAA compliant, web-based, structure of mHealth sensors and mobile devices to treat and monitor multiple chronic conditions within an existing free primary care clinic. The mI SMART system allows patients to track.diagnoses, medications, lab results, receive reminders for self-management, perform self-monitoring, obtain feedback.in real time, engage in education, and attend visits through video conferencing. The system displays a record database to patients and providers that will be integrated into existing Electronic Health Records. Conclusion: By using the model for developing complex nursing interventions, a multifaceted solution to clinical problems was identified. Through modeling and seek.ng expert review, we have established a sustainable and scalable integrated nurse-led intervention that may increase access and improve outcomes for patients living in rural and underserved areas. The first trial of mI SMART has been completed and evaluated for feasibility, acceptability, and effectiveness in per

关键词： Multiple Chronic Conditions mHealth Telehealth Health Disparities Nursing Informatics

Part B: The Feasibility and Acceptability of mI SMART, a Nurse-Led Technology Intervention for Multiple Chronic Conditions

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Open Journal of Nursing 2016年第4期6卷 323-332页

Back.round: An opportunity to improve care of multiple chronic conditions for those living in rural areas of the country may exist through the use of technology. Integrating technology interventions into existing rural health systems allows for increased access to healthcare services and augments self-management ability for patients. However, questions remain about acceptability and feasibility of technology use in rural populations. The purpose of this paper is to present the feasibility of mI-SMART, a HIPAA compliant, web-based, structure of mHealth sensors and mobile devices designed to overcome the k.own health determinant of access to care for rural, chronically ill patients by using technology. Methods: The study was conducted at a primary-care clinic that provided healthcare at no or low cost to low income adults. Inclusion criteria encompassed adults, with at least one chronic condition, having at least 3rd grade reading level, without having dementia/psychosis. Each participant was given a Nexus7 tablet and Bluetooth self-monitoring devices. Feasibility was evaluated in four ways and acceptability was evaluated with post-intervention questionnaires. Results: Thirty participants [mean age: 52 years (SD: 10.0, range: 29 - 74)] were majority female (70%), white (70%), married (60%), high-school educated or less (56.7%), impoverished (less than $20,000 per annum (56.7%), with multiple chronic conditions (96.7%)). During the trial, all participants were able to transmit data. No error messages were due to the mI-SMART system. Errors were user related and solved with technical support. Mean number of self-monitor transmissions was 219.7 [(SD: 197.4), range: 1 - 733]. Participants logged into the system an average of 163. 1 [(SD: 169.7), range: 2 - 568] times and viewed an average of 1092.1 [(SD: 1205.6), range: 8 - 3851] intervention components. Over eighty-six percent of participants sent data for 12 week. and 43.1% used the intervention for longer. Conclusions:

关键词： Multiple Chronic Conditions mHealth Telehealth Health Disparities Nursing Informatics

Free Care Is Not Enough: Barriers to Attending Free Clinic Visits in a Sample of Uninsured Individuals with Diabetes

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Open Journal of Nursing 2014年第13期4卷 912-919页

作者： Jennifer A. Mallow laurie A. Theek. Emily R. Barnes Tara Whetsel Brian k. Mallow School of Nursing West Virginia University Morgantown West Virginia USA Sovern Run LLC Albright West Virginia USA

Free care does not always lead to improved outcomes. Attendance at free clinic appointments is unpredictable. Understanding barriers to care could identify innovative interventions. The purpose of this study was to examine patient characteristics, biophysical outcomes, and health care utilization in uninsured persons with diabetes at a free clinic. A sample of 3139 patients with at least one chronic condition was identified and comparisons were made between two groups: those who attended all scheduled appointments and those who did not. Geographic distance to clinic and multiple chronic conditions were identified as barriers to attendance. After one year, missing more than one visit had a positive correlation with increased weight, A1C, and lipids. Additionally, patients who missed visits had higher blood pressure, depression scores, and numbers of medications. Future research should further enhance understanding of barriers to care, build k.owledge of how social and behavioral determinants contribute to negative outcomes in the context of rurality. Innovative methods to deliver more frequent and intensive interventions will not be successful if they are not accessible to patients.

关键词： Diabetes Rural Health Poor Uninsured Free Clinic Chronic Conditions Health Disparities