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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She Simon hing-Yin Tsang Chung Mau Lo Kwan man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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人类面临的甲基汞暴露和健康影响:世界范围的关注

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AMBIO－人类环境杂志 2007年第1期36卷 3-10页

作者： Donna Mergler Henry A.Anderson laurie hing man chan Kathryn R.Mahaffey Michael Murray Mineshi Sakamoto Alan H.Stern 甲基汞的健康风险和毒物学影响专家组生物、健康、社会和环境各学科研究中心美国预防医学委员会州立环境和职业疾病流行病学威斯康星州健康和家庭服务部盖罗德尼尔森环境研究学院医学公共健康学校北大不列颠哥伦比亚大学国家野生动物联盟大湖办公室日本国家疾病学院流行病学系新泽西环境保护部科学和研究分部风险评估和毒物学的部门新泽西医药和牙科大学环境和职业医药系和公共健康学院不详

本文基于现有的文献资料,突出了当前的认识并且识别在甲基汞暴露、健康影响、危害评估方面还未解决的问题并且得出意见一致的结论。甲基汞是一种烈性毒素,通过水中的食物链在生物体内积累和富集,使世界各地各种社会经济阶层内那些常吃... 详细信息

本文基于现有的文献资料,突出了当前的认识并且识别在甲基汞暴露、健康影响、危害评估方面还未解决的问题并且得出意见一致的结论。甲基汞是一种烈性毒素,通过水中的食物链在生物体内积累和富集,使世界各地各种社会经济阶层内那些常吃食肉鱼类或者以鱼类为主食的人置于危险境地。甲基汞对神经的发育危害已经成为制定风险评估和公共健康政策的基础。尽管在暴露的新指示生物、影响甲基汞吸收和毒性的因素、毒物动力学、成年人神经病学和心脑血管的影响,来自大量海水鱼和淡水鱼以及食鱼鱼类的营养收益和危害,各方面的知识还有许多研究断层,研究小组认为要保护人类健康,必须尽一切努力来减少并消除暴露源。

关键词：世界范围健康影响人类健康甲基汞危害评估毒物动力学文献资料生物体内

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Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei chan Sha-Sha Liu Hung-Fat Tse Wing-hing Chow man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

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Revisiting the Climatology of Atmospheric Blocking in the Northern Hemisphere

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Advances in Atmospheric Sciences 2013年第2期30卷 397-410页

作者： Ho Nam CHEUNG 周文 hing Yim MOK man Chi WU Yaping SHAO City University of Hong Kong Shenzhen Research Institute Guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and Environment City University of Hong Kong Hong Kong Observatory Institute for Geophysics and Meteorology University of Cologne

In addition to the occurrence of atmospheric blocking, the climatology of the characteristics of blocking events, including duration, intensity, and extension, in four seasons over the Northern Hemisphere was analyzed for the period 1950-2009. The seasonality and spatial variations of these characteristics were studied according to their longitudinal distributions. In general, there were sharp discrepancies in the blocking characteristics between winter and summer, and these differences were more prominent over the Atlantic and Pacific Oceans. The blocking not only occurred more frequently but also underwent stronger amplification in winter; likewise, the blocking occurred less frequently and underwent weaker amplification in summer. There are very strong interrelationships among different blocking characteristics, suggesting that they are supported by similar physical factors. In addition, the relationship between blocking over different regions and East Asian circulation was examined. Ural-Siberia is a major blocking formation region in all seasons that may exert a downstream impact on East Asia. The impact is generally weak in summer, which is due to its lower intensity and smaller duration. However, the extratropical circulation over East Asia in summer can be disturbed persistently by the frequent occurrence of blocking over the Asian continent or the Western Pacific. In particular, the blocking frequency over the Western Pacific significantly increased during the study period. This climatological information provides a background for studying the impact of blocking on East Asian circulation under both present and future climate conditions.

关键词： atmospheric blocking climatology seasonality East Asian circulation

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Factors Affecting Mesenchymal Stromal Cells Yield from Bone Marrow Aspiration

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Chinese Journal of Cancer Research 2011年第1期23卷 43-48页

作者： Jing Li Wilfred hing-Sang Wong Shing chan James Chor-San Chim Kenneth man-Chee Cheung Tsz-Leung Lee Wing-Yan Au Shau-Yin Ha Albert Kwok-Wei Lie Yu-Lung Lau Raymond Hin-Suen Liang Godfrey Chi-Fung chan China Oxford Centre for International Health Research Cardiovascular Institute ＆ Fuwai HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100037China Department of Paediatrics and Adolescent Medicine Department of Medicine Department of Orthopaedics ＆Traumatology the University of Hong KongHKSARChina

Objective：This study was to investigate the variables in bone marrow harvesting procedure and individual donor factors which can potentially affect the yield of mesenchymal stromal cells（MSC）.Methods：We determined the yield of MSC from bone marrow under different clinical conditions by comparing the MSC colony numbers from：（1） donors of different ages;（2） healthy donors and patients with leukemia;（3） bone marrow aspirated at different time points during marrow harvesting;（4） bone marrow harvested by different ***：During the process of harvesting,the number of MSC significantly decreased with increase number of aspiration,from 675/ml at the initial decreased to 60/ml after 100 ml bone marrow aspirated,and 50/ml after 200 ml bone marrow *** number of MSC retrieved from leukemia patients（99/ml bone marrow） was significantly lower than that of healthy donors（708/ml bone marrow）.However,there was no significant difference in growth *** was no significant age-related difference of MSC yielded from donors 55 *** there was no significant difference in MSC number between the samples from single end-holed needle and those from multiple-side-hole ***：The optimal bone marrow samples for MSC collection should be obtained earlier in the process of harvesting *** marrow from donors 55 years was equally good as MSC *** autologous MSC from leukemia patients can be utilized for in-vitro MSC expansion.

关键词： Mesenchymal stromal cell CFU-F Bone marrow aspiration Leukemia

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Escitalopram-induced hepatitis:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2468-2473页

作者： Guillaume Wabont laurie Ferret Nicolas Houdre Antoine Lepied Johana Bene Etienne Cousein Department of Pharmacy Valenciennes HospitalValenciennes 59300France Department of Emergency Medicine Valenciennes HospitalValenciennes 59300France Department of Psychiatry Valenciennes HospitalValenciennes 59300France Department of Pharmacology Lille University HospitalLille 59000France

BACKGROUND The antidepressant escitalopram is widely prescribed for the treatment of *** is generally well-tolerated,and cholestasis is not mentioned in its summary of product characteristics(Sm PC).We present a case of cholestatic and cytolysis liver injury due to escitalopram and a Vigi Base?*** SUMMARY A 68-year-old man was admitted to our emergency unit due to clinical jaundice associated with hepatitis,pruritus and dark *** tested the patient for the most common etiologies of jaundice,including hemolysis,viral hepatitis,cirrhosis,carcinoma,cholangitis,cholelithiasis and intrahepatic or extrahepatic *** etiological study was negative,and an adverse drug reaction was the sole possible *** patient was receiving treatment with *** days after its withdrawal,pruritus was *** days after withdrawal,clinical jaundice *** took a month and three weeks after withdrawal for the patient to have normalized liver function *** our knowledge,this is the first reported case of cholestasis where treatment with escitalopram was the only possible cause,with a highly probable *** addition,we determined whether escitalopram is associated with hepatotoxicity and cholestasis by performing a disproportionality *** cases of hepatobiliary disorders induced by escitalopram and reported in the World Health Organization pharmacovigilance database(Vigi Base?)were analyzed to characterize this *** found that patients treated with escitalopram had an increased risk of hepatitis[odds ratio(OR)=1.938(1.186-3.166)]and cholestasis[OR=1.866(1.279-2.724)][OR(95%confidence interval)].The median duration between the introduction of escitalopram and the occurrence of acute hepatitis and/or cholestasis was ten days+/-seven *** Although extremely rare,this case report,the review of the literature and the pharmacovigilance update confirm that escitalopram can cause drug-induced hepatotox

关键词： Escitalopram Hepatitis Cholestasis Pharmacovigilance Case report

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Metabolic syndrome and benign prostatic hyperplasia:An update

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Asian Journal of Urology 2017年第3期4卷 164-173页

作者： Ho-Yin Ngai Kar-Kei Steffi Yuen Chi-man Ng Cheung-hing Cheng Sau-Kwan Peggy Chu Division of Urology Department of SurgeryQueen Elizabeth HospitalHong KongChina Division of Urology Department of SurgeryTuen Mun HospitalHong KongChina

Metabolic syndrome(MetS)is a cluster of metabolic abnormalities related to central adiposity and insulin *** importance is increasingly recognized as it associates with increased risks of metabolic and cardiovascular *** metabolic aberrations of MetS may lead to development of benign prostatic hyperplasia(BPH)and lower urinary tract symptoms(LUTS)in men.A 26.5%-55.6% prevalence of MetS in men with LUTS was reported in worldwide *** the exact biological pathway is not clear yet,insulin resistance,increased visceral adiposity,sex hormone alterations and cellular inflammatory reactions played significant roles in the related pathophysiological *** should recognize the cardiovascular and metabolic impacts of MetS in men with LUTS,early risk factors optimization and use of appropriate medical therapy may possibly alter or slower the progression of LUTS/BPH,and potentially avoid unnecessary morbidities and mortalities from cardiovascular and metabolic diseases for those men.

关键词： Inflammation Insulin resistance Lower urinary tract symptoms Metabolic syndromeX Prostatic hyperplasia

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Ex-smokers are happier than current smokers among Chinese adults in Hong Kong

Ex-smokers are happier than current smokers among Chinese ad...

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第16届全国控制吸烟暨第6届青少年控烟经验学术交流会

作者： man Ping Wang Tai hing Lam Xin Wang K Viswanath Sophia S chan School of Public Health University of Hong Kong Center for Community-Based Research Dana-Farber Cancer Institute/Department of Social and Behavioral SciencesHarvard School of Public Health School of Nursing University of Hong Kong

＜正＞Introduction Being happier is commonly reported by smokers as a reason to maintain *** have shown the bi-directional associations of smoking with depression and mood *** quitting smoking was linked to happiness ...

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Factors associated with supporting total ban on tobacco sale in 2022 in Hong Kong

Factors associated with supporting total ban on tobacco sale...

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第16届全国控制吸烟暨第6届青少年控烟经验学术交流会

作者： Tai hing Lam man Ping Wang Xin Wang K Viswanath Sophia S chan School of Public Health University of Hong Kong Center for Community-Based Research Dana-Farber Cancer Institute/Department of Social and Behavioral SciencesHarvard School of Public Health School of Nursing University of Hong Kong

＜正＞Introduction Tobacco endgame policy is increasingly advocated for ending the tobacco epidemic in the *** Kong hasstringent tobacco control measures and a very low smoking prevalence（11.1%）.We have reported tha...

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中国南方大米汞污染与居民汞暴露

中国南方大米汞污染与居民汞暴露

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第六届全国环境化学大会暨环境科学仪器与分析仪器展览会

作者：李平冯新斌袁小博 hing man chan 仇广乐朱永官孙国新 School of Health Sciences University of Northern British Columbia 中国科学院城市环境研究所中国科学院生态环境研究中心

汞(Hg)是一种全球性重金属污染物,而甲基汞(MeHg)是一种神经性毒素。国际上一般认为人体甲基汞暴露的主要途径是食用鱼肉等水产品。最近的研究表明,水稻能够富集甲基汞(Qiu et al.,2008;Zhanget al,2010a),而食用大米是贵州汞矿区人群... 详细信息

汞(Hg)是一种全球性重金属污染物,而甲基汞(MeHg)是一种神经性毒素。国际上一般认为人体甲基汞暴露的主要途径是食用鱼肉等水产品。最近的研究表明,水稻能够富集甲基汞(Qiu et al.,2008;Zhanget al,2010a),而食用大米是贵州汞矿区人群甲基汞暴露的主要途径(Feng et al.,2008;Zhang et al.,2010b)。由于我国南方居民的膳食结构以大米为主,而且中国南方土壤汞具有较高的背景值,因此研究大米的汞含量对于我国南方居民的健康有重要影响。本文选取我国南方7个省市区(广东、江西、广西、湖南、贵州、江苏和上海)市

关键词：大米汞污染居民汞暴露重金属污染物土壤污染膳食结构

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