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The Cytotoxic Effect of Cecropin A and Cecropin B on the MDA-MB-231 and M14K Tumour Cell Lines

Journal of Biomedical Science and Engineering 2014年第8期7卷 504-515页

作者： Radu Anghel Daniela Jitaru laurentiu badescu Manuela Ciocoiu Magda badescu Department of Cell and Molecular Biology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Laboratory ofMolecular Biology Regional Institute of Oncology Iasi Romania

The aim of the present in vitro study was to assess the tumoricidal potential of the following natural peptides belonging to the Cecropin family, namely Cecropin A and B, on a series of tumour cell lines: MDA-MB-231 (breast adenocarcinoma) and M14K (human mesothelioma). The experimental results reveal that the cytotoxic effects of the two peptides depend on their concentration. Their efficiency is significant at 120 μM concentrations and it persists even at 60 μM concentrations. The effects were insignificant at 30 μM concentrations. On the other hand, the cytotoxic potential was not significantly dependant on the type of peptide but more on the type of tumour cell line used. The MDA MB 231 line cells were much more sensitive to the action of Cecropins A and B than the M14K line cells. The prospects brought about by this experimental research consist of the collection of in vitro experimental data on the tumoricidal potential of these natural cytotoxic peptides on tumour cells. This will enable specialists to develop future in vivo experimental models in order to test the antitumor effect of these cytotoxic peptides. The ultimate goal would be the discovery of agents with efficient antitumor properties, i.e. with maximum tumoricidal effects and minimum toxic side effects.

关键词： Breast Adenocarcinoma Cecropin A Cecropin B Human Mesothelioma Tumoricidal Potential

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Polyphenolic extract association with renin inhibitors in experimental arterial hypertension

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Journal of Biomedical Science and Engineering 2013年第4期6卷 493-497页

作者： Manuela Ciocoiu Magda badescu Oana Badulescu Dana Tutunaru laurentiu badescu Department of Biochemistry University “Dunarea de Jos” Galati Romania Department of Cellular and Molecular Biology University of Medicine and Pharmacy “Gr. T. Popa” Iasi Romania Department of Pathophysiology Faculty of Medicine University of Medicine and Pharmacy “Gr. T. Popa” Iasi Romania

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure. The polyphenols are extracted from isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa. The experiment was performed on the arterial hypertension model. In the arterial hypertensive model the cardioprotective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when polyphenols are associated with Aliskiren (renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model.

关键词： Arterial Hypertension Aliskiren Aronia melanocarpa Oxidative Stress

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Modulation Possibilities of the Tissue Wettability, Marker of the Physical Modifications Produced by Senescence versus Photo Senescence at Tegument Level

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Journal of Biomedical Science and Engineering 2014年第13期7卷 1049-1055页

作者： laurentiu badescu Carmen Elena Cotrutz Raoul Lupusoru Bogdan-Mihail Diaconescu Manuela Ciocoiu Magda badescu Department of Cell and Molecular Biology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

We used an experimental model involving white Westar rats (young and old) who were subjected to precise doses of ultraviolet radiation (UV). The experiment aims to examine the influence of epidermis potential protection factors in photo senescence versus senescence. We have studied the in vivo effect of some natural polyphones extracted from black grapes seeds and zinc aspartate and in vitro effect of AED (deuterium depleted water). The substances were administered by intragastric gavages, at two days intervals for two weeks prior to UV irradiation and during the entire period of the experiment (28 days). In the end, we determined the degree of hydrophilicity of the skin, in vitro, by measuring the contact angle value, which was inversely proportional to the hydrophilicity of the tissue (the angle formed at the contact between a liquid and a solid surface). Using this method we found a large variability depending on the hydrophilicity of the epidermis (abdomen and back), the age of the animal and UV/non UV irradiation. The maintenance of the epidermis fragments in AED (for 6 hours) increased significantly the tissue wet ability degree both in the young rats subject to UV and in the senescent ones subject to UV (photo senescence).

关键词： Skin Photoimmunology Phototherapy

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