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Prognostic impact of body mass index on in-hospital bleeding complications after ST-segment elevation myocardial infarction

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World Journal of Cardiology 2020年第1期12卷 44-54页

作者： Delphine Ingremeau Sylvain Grall Florine Valliet laurent Desprets Fabrice Prunier Alain Furber Loïc Bière Department of Cardiology Angers University HospitalAngers 49933France UmR CNRS 6015-INSERm U1083 Institut MitoVascUniversity of AngersAngers 49100France Department of Cardiology Saumur HospitalSaumur 49403France Department of Cardiology Cholet HospitalCholet 49300France

BACKGROUND ST-elevation myocardial infarction(STEmI)remains a major cause of mortality despite early revascularization and optimal medical *** individual management by considering patients’specificities may help in improving post-STEmI *** To evaluate whether in-hospital bleeding complications may be involved in post STEmI prognosis among overweight *** We prospectively included 2070 patients with a STEmI between January 2005 and December 2012 in the French observational cohort,“Registre d’Infarctus maine-Anjou”.Bleeding Academic Research Consortium(BARC)in-hospital bleeding complications were *** Of 705 patients(35.3%)were presented as being of normal weight,defined as a body mass index(BmI)m^2,877(43.9%)had a BmI between 25 and 30 kg/m^2and 416(20.8%)had a BmI≥30 kg/m^***-year cardiovascular mortality was lower for BmI≥25 kg/m^2(5.3%and 7.1%)patients than for normal weight patients(10.8%)(P=0.001).We found an interaction between the effect of BARC 3 on mortality and BmI *** a BARC 3 was related to a higher 1-year mortality in general(HR:2.58,95%CI:1.44-4.64,P≤0.001),prognosis was even worse in normal weight patients(HR:2.97,95%CI:1.61-5.5,PmI≥25 kg/m^2(HR:1.94,95%CI:1.02-3.69,P=0.041).CONCLUSION Normal weight patients presented higher rates of in-hospital bleeding complications and lower survival after a *** mortality might be due to greater vulnerability to bleeding amongst normal weight patients.

关键词： myocardial infarction Body mass index Bleeding complications Obesity paradox

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Preparation of a ε-caprolactonic diterpenoid derivate by unexpected oxidative cleavage/lactonization of 2-oxoaustroeupatol

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Natural Products and Bioprospecting 2022年第1期12卷 265-269页

作者： Pablo A.Chacón-morales Juan m.Amaro-Luis Luis Beltrán Rojas Fermín Rémi Jacquet Denis Deffieux laurent Pouységu Stéphane Quideau Natural Products Laboratory Department of ChemistryFaculty of ScienceUniversity of Los AndesMérida 5101Venezuela Research Institute Faculty of Pharmacy and BioanalysisUniversity of Los AndesMérida 5101Venezuela ISm(CNRS-UmR 5255) Univ.Bordeaux351 cours de la Libération33405 Talence CedexFrance

From aerial parts of Austroeupatorium inulifolium was isolated the ent-nor-furano triol labdane austroeupatol *** compound 1 was treated with IBX showing an unexpected selectivity at the potentially oxidizable sites of the sub-strate yielding the 2-oxoaustroeupatol(2)and 2,19-dioxoaustroeupatol(3).The treatment of 2 with sodium periodate yields a heterocyclic derivative(ε-caprolactone derivate 4)formed by oxidative cleavage and unexpected intramo-lecular attack of the hydroxymethylene(C-19)oxygen to the ketonic carbon(C-2).A plausible mechanistic pathway for the obtention of compound 4 is proposed.

关键词： Oxidative cleavage Austroeupatol NaIO4 IBX Lactonization NmR

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Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

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World Journal of Gastroenterology 2006年第45期12卷 7278-7284页

作者： laurent Castéra Anne Pedeboscq marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe laurent marie-Edith Lafon maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud Francismégraud Armelle ménard Service d'Hépato-Gastroentérologie H?pital St-André Bordeaux France Service d'Hépato-Gastroentérologie H?pital Haut Lévêque Pessac France INSERm ERI 10 Laboratoire deBactériologie Université Victor Segalen Bordeaux 2 BordeauxFrance INSERm E0362Groupe de Recherche pour l'étude du Foie Université VictorSegalen Bordeaux 2 Bordeaux France Service d'Anatomie Pathologique H?pital Pellegrin Bordeaux France Service de ChirurgieDigestive H?pital St-André Bordeaux France Laboratoire de Virologie Université VictorSegalen Bordeaux 2 Bordeaux France

AIm: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. mETHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species.

关键词： Hepatitis C virus Hepatitis Cirrhosis Helicobacter

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Synergistic Effect of Anthropogenic Disturbances on Offspring Demography of <i>Pentadesma butyracea</i>(Clusiaceae), a Threatened Tree Species in Benin (West-Africa)

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American Journal of Plant Sciences 2019年第8期10卷 1374-1390页

作者： m’mouyohoun Kouagou Olivier E. B. Ahouandjinou laurent Houessou Aliou Dicko Armand Kuyema Natta Laboratory of Ecology Botany and Plant Biology Parakou Republic of Benin Faculty of Agronomy University of Parakou Parakou Republic of Benin

Understanding how ecological differences and anthropogenic disturbances synergistically drive population dynamics decline is critical for optimal management strategy definition. main anthropogenic disturbances such as habitat size reduction, fire and non-timber forest harvest affect demographic processes but our understanding of their interaction effects in contrasted ecological conditions is limited. We investigated the interaction effects of fruit harvest, fire, gallery forest size and distance to streambed on density, recruitment, survival and growth of Pentadesma butyracea offspring in dry and moist ecological conditions. We randomly selected in each ecological region six P. butyracea populations. We then established in each population, 10 subplots of 100 m2 within 1 ha to assess offspring demographic performance from 2015 to 2017. Results showed that fire suppressed the positive effect of large habitat size and amplified the negative effect of increasing local aridity on offspring growth. Fire and harvest synergistically reduced growth whereas offspring growth was resilient to fire in moist ecological region. moist ecological conditions mitigated the negative effect of harvest on growth. Harvest mitigated the surprise negative effect of large habitat size on survival. However, in large gallery size, high harvest limited clonal recruitment and growth. There was a positive interaction effect between harvest and distance to streambed on survival (High harvest, Z = 2.045, p = 0.041, medium, Z = 2.060, p = 0.039) but a negative interaction effect on growth (High, t = -2.357, p 0.05). Clonal offspring grew faster than sexual offspring in high harvest populations. In moist region, offspring survived better in large gallery forest size. In 2017, survival and growth were lower in large gallery forest. In 2017, offspring growth was higher near the riverbed where the survival rate low. This study suggests that management strategies should consider the interaction effects

关键词： Fire Habitat Size Reduction multiple Stressors Pentadesma butyracea Survival-Growth Trade-Off

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Analysis of Pulmonary Arteries Growth after Initial Shunt Palliation in Neonates and Infants

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Congenital Heart Disease 2023年第5期18卷 525-537页

作者： François-Xavier Van Vyve Karlien Carbonez Geoffroy de Beco Stéphane moniotte Jean ERubay mona momeni laurent Houtekie Alain J.Poncelet Department of Cardiovascular and Thoracic Surgery Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium Department of Pediatric Cardiology Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium Department of Anesthesiology Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium Department of Pediatric Intensive Care Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium

Objective:Despite increasing enthusiasm for neonatal repair,patients with ductal-dependent circulation(pulmonary/systemic)or restrictive pulmonary blood flow still require initial *** stenting has emerged as an endovascular approach whereas modified-Blalock-Taussig and central shunt remain surgical *** this study,we analyzed the relationship between pulmonary artery growth,sites of shunt connection,or antegrade pulmonary blood flow in surgically placed *** need for secondary catheter-based interventions or pulmonary arterioplasty was also ***:A retrospective single-center study analyzing 175 patients undergoing surgery for a central or modified-Blalock-Taussig *** growth variables were right pulmonary artery/left pulmonary artery diameters/Z scores,the indexed sum area(right pulmonary artery+left pulmonary artery),and the pulmonary symmetry *** imaging modalities were used:angiography,computed tomography,and ***:At baseline,pulmonary arteries were larger in patients with antegrade pulmonary blood flow(Nakata index 137 vs.114,p=0.047)as well as in patients receiving a modified-Blalock-Taussig shunt(Nakata index 138 vs.84,pme of shunt takedown,both the right pulmonary artery and left pulmonary artery had normalized their *** Nakata index increased from 134 to 233 mm^(2)/m^(2)(pmonary artery index remained stable(0.86)over *** the inter-stage period,shunt-related pulmonary artery stenosis and juxta-ductal stenosis were diagnosed in 16(10%)and 17 patients(11%),***:Surgical shunt palliation allows normal pulmonary artery *** artery stenosis was either shunt-related(10%)or secondary to juxta-ductal stenosis(11%).Close echographic follow-up allows early diagnosis and treatment of juxta-ductal stenosis.

关键词： Congenital heart disease cyanosis palliation neonates outcome

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Uranium(Ⅲ)–Phosphorus(Ⅲ) Synergistic Activation of White Phosphorus and Arsenic

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CCS Chemistry 2022年第8期4卷 2630-2638页

作者： Wei Fang Iskander Douair Adrian Hauser Kai Li Yue Zhao Peter WRoesky Shuao Wang laurent maron Congqing Zhu State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 LPCNO CNRS&INSAUniversitéPaul SabatierToulouse 31077 Institute of Inorganic Chemistry Karlsruhe Institute of Technology(KIT)Karlsruhe 76131 State Key Laboratory of Radiation medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123

The study of small-molecule activation by f-block elements still lags far behind that of transition *** a few uranium complexes have been reported to activate dinitrogen,reports on the activation of heavier congeners,such as white phosphorus(P_(4)),by uranium species are extremely rare,and no example of uranium-mediated activation of elemental arsenic has appeared.

关键词： uranium As0 nanoparticle white phosphorus small molecule activation U(Ⅲ)–P(Ⅲ)synergy density functional theory calculations

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mCANISmES mOLCULAIRES ImPLIQUS DANS L'ALTRATION DU PHNOTYPE DES CELLULES PITHLIALES TUBULAIRES PAR LES CALPANES EXTRACELLULAIRES

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Journal of Shanghai Second medical University(Foreign Language Edition) 2008年第1期20卷 18-23页

作者：张文慧 Joёlle Perez laurent Baud Département de Physiologie Faculté de Médecine de l’Université Jiaotong INSERm U702 Université Pierre et marie Curie

Objectif Rechercher les mecanismes moleculaires par lesquels des calpaines extracellulaires affectent l＇adherence et la mobilite des cellules epitheliales HK-2 derivees du tubule proximal humain. mdthodes Western blot pour detecter le clivage des chaines α des integrines; dosage radioimraunologique pour mesurer V AmP cyclique intraceUulaire; fluorescence-activated cell sorting （FACS） pour tester l＇apoptose cellulaire. La morpholo- gie des ceUules HK-2 a ete observee et photographiee. Rdsultats （ 1 ） L ＇ exposition des ceUules HK-2 a la calpaine μ n＇a pas entratne de clivage des chaines α3 et αV des integrines; （2）V exposition des cellules HK-2 -2 la calpaine μ entrafnait une augmentation progressive de V accumulation intraceUulaire d＇ AmP cyclique（ P 〈 O. 05） qui etait associee une resistance ceUulaire a Vapoptose（ P 〈 O. 05 ） ; （3）Vaddition d＇un inhibiteur pharmacologique de la protdine kinase A （ PKA ） prevenait totalement les modifications d＇ adherence et de mobilite cellulaires induites par calpaine μ. Conclusion Les calpaines externalieses peuvent modifier V adherence et la mobilite ceUulaires via un mecanisme qui implique V accumulation d＇ AmP cyclique et 1＇ activation de la PKA. Par ces mecanismes, les calpaYnes externalisees pourraient jouer un role dans Vinduction de la reparation au cours de l＇insuffucance renale aigue.

关键词： calpaine cellule tubulaire proximale insuffisance renale aigue

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moisture-Induced Non-Equilibrium Phase Segregation in Triple Cation mixed Halide Perovskite monitored by In Situ Characterization Techniques and Solid-State NmR

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Energy & Environmental materials 2023年第2期6卷 185-194页

作者： mohammad Ali Akhavan Kazemi Nicolas Folastre Parth Raval michel Sliwa Jean marie Vianney Nsanzimana Sema Golonu Arnaud Demortiere Jean Rousset Olivier Lafon laurent Delevoye G.N.manjunatha Reddy Frédéric Sauvage Laboratoire de Réactivité et Chimie des Solides(LRCS) UMR CNRS 7314-Institut de Chimie de Picardie FR 3085Université de Picardie Jules Verne33 rue Saint LeuAmiens Cedex FR-80039France CNRS Centrale LilleUMR 8181UCCSUnitéde Catalyse et Chimie du SolideUniversité de LilleUniversitéd’ArtoisLille F-59000France UmR 8516-LASIRE-Laboratoire de Spectroscopie pour les Interactions la Réactivité et l’EnvironnementCNRSUniversitéde LilleLille F-59000France EDF R&D EDF LabBoulevard Gaspard MongePalaiseau 91120France

Environmental stability is a major bottleneck of perovskite solar *** a handful of studies are investigating the effect of moisture on the structural degradation of the *** mostly rely on ex situ experiments and on completely degraded samples,which restrict the assessment on initial and final *** combining in situ X-ray diffraction under controlled 85%relative humidity,and live observations of the water-induced degradation using liquid-cell transmission electron microscopy,we reveal two competitive degradation paths leading on one hand to the decomposition of state-of-theart mixed cation/anion(Cs_(0.05)(mA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17)I_(0.83))_(3)(CsmAFA)into PbI_(2) through a dissolution/recrystallization mechanism and,on the other hand,to a non-equilibrium phase segregation leading to CsPb_(2)Br_(5) and a Cesium-poor/iodide-rich Cs_(0.05)-x(mA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17-2y)I_(0.83)+2y)_(3) *** degradation mechanism is corroborated at atomic-scale resolution through solid-state ^(1)H and ^(133)Cs NmR *** to moisture leads to a film containing important heterogeneities in terms of morphology,photoluminescence intensities,and *** results provide new insights and consensus that complex perovskite compositions,though very performant as champion devices,are comparatively metastable,a trait that limits the chances to achieve long-term stability.

关键词： liquid-cell transmission electron microscopy moisture degradation perovskite stability phase segregation solid-state NmR

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基于mPI和OpenmP混合编程的非负矩阵分解并行算法

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计算机科学 2017年第3期44卷 51-54页

作者：唐兵 laurent BOBELIN 贺海武湖南科技大学计算机科学与工程学院湘潭411201 中国科学院计算机网络信息中心北京100190

非负矩阵分解(NmF)作为一种数据降维和特征提取的有效工具,已经在文本聚类、推荐系统等多个领域得到应用,但是其计算过程比较复杂。对此,提出一种基于mPI+OpenmP的混合层次化并行NmF方法,其充分利用基于mPI的消息传递模型和基于OpenmP... 详细信息

非负矩阵分解(NmF)作为一种数据降维和特征提取的有效工具,已经在文本聚类、推荐系统等多个领域得到应用,但是其计算过程比较复杂。对此,提出一种基于mPI+OpenmP的混合层次化并行NmF方法,其充分利用基于mPI的消息传递模型和基于OpenmP的共享存储模型各自的优势,并基于多核节点集群进行测试。实验结果表明,所设计的并行NmF算法达到了较高的加速比,能有效处理高阶矩阵的非负分解,极大地提高了计算的效率。

关键词：非负矩阵分解并行算法 mPI OpenmPI 可扩展

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Stretching the spectra of Kerr frequency combs with self-adaptive boundary silicon waveguides

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Advanced Photonics 2020年第4期2卷 29-38页

作者： Jianhao Zhang Vincent Pelgrin Carlos Alonso-Ramos laurent Vivien Sailing He Eric Cassan UniversitéParis-Saclay CNRSCentre de Nanosciences et de NanotechnologiesPalaiseauFrance Zhejiang University Centre for Optical and Electromagnetic ResearchState Key Laboratory for Modern Optical InstrumentationHangzhouChina

Dispersion engineering of optical waveguides is among the most important steps in enabling the realization of Kerr optical frequency combs.A recurring problem is the limited bandwidth in which the nonlinear phase matching condition is satisfied,due to the dispersion of the *** limitation is particularly stringent in high-index-contrast technologies such as *** propose a general approach to stretch the bandwidth of Kerr frequency combs based on subwavelength engineering of single-mode waveguides with self-adaptive *** wideband flattened dispersion operation comes from the particular property of the waveguide optical mode that automatically self-adapts its spatial profile at different wavelengths to slightly different effective spatial spans determined by its effective index *** flattened dispersion relies on the squeezing of small normal-dispersion regions between two anomalous spectral zones,which enables it to achieve two Cherenkov radiation points and substantially broaden the comb,achieving a bandwidth between 2.2 and 3.4μm *** strategy opens up a design space for trimming the spectra of Kerr frequency combs using high-index-contrast platforms and can provide benefits to various nonlinear applications in which the manipulation of energy spacing and phase matching are pivotal.

关键词： nonlinear optics effective boundary subwavelength grating silicon frequency comb

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