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Chinese Journal of Traumatology 2022年第5期25卷 272-276页

作者： Nils muhlenfeld Philipp Stormann Ingo marzi Felix Rosenow Adam Strzelczyk Rene D.Verboket laurent m.willems Department of Traurma Hand and Reconstructive SurgeryGoethe University FrankfurtFrankfurt Am MainGermany Epilepsy Center Frankfurt Rhine-main Department of NeurologyGoethe University FrankfurlFrankfurt Am MainGermany LOEWE Center for Personalized Translational Epilepsy Research(CePTER) Goethe-Universitat FrankfurtFrankfurt Am MainGermany Department of Neurology and Epilepsy Center Hessen Philipps-University MarburgMarburg(Lahn)Germany

Purpose: Epileptic seizures frequently result in distinct physical injuries, fractures, traumatic brain injuries and minor trauma. The aim of this study was to retrospectively determine the frequent injury patterns due to seizure episode and to analyze consecutive acute medical care. methods: This retrospective mono-center study was conducted at Frankfurt University Hospital, Frankfurt am main, Germany between January 2007 and December 2017. Epilepsy patients with seizure-related fractures admitted to the emergency department were identified via a retrospective systematic query in the hospital information system using the ICD-10 German modification codes G40.0—G40.9. Patients with an unclear diagnosis of epilepsy were excluded. Sociodemographic as well as disease specific aspects were analyzed. Descriptive and Kruskal—Wallis one-way analysis of variance were used for statistical analysis. Results: A total number of 62 epilepsy patients were included. The mean age was 58.1 years. Fractures concerned the upper extremity most frequently (43.5%,n= 20), and 70.0% (14/20) were humerus fractures. Admission to intensive care unit for acute trauma care was necessary in 29.0% patients (n = 18), and surgery in 45.2% patients (n = 28). Twenty-five patients (26.6%) showed clinical or radiological signs of traumatic brain injury. Provoking factors were identified in 20 patients (32.3%), i.e., acute withdrawal or excess of alcohol (n = 15), relevant sleep deprivation (n = 2), and intoxication or withdrawal of other illegal drugs or trivial infect (n = 1 for each) and non-compliance with anti-seizure drugs (n = 1). A decreased T-score (-1.04 ± 1.15) and Z-score (-0.84 ± 0.75) compared to healthy subjects were found. Conclusion: Fractures in upper extremities, trunk and craniocerebral trauma occur frequently as seizure-induced injuries. Alcohol excess and withdrawal are important provoking factors and should be targeted with preventive measurements to avoid seizure related injuries

关键词： Epilepsy Wounds and injuries Falls Quality of life

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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

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Journal of Animal Science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan Schokker Soumya K.Kar Els willems Alex Bossers Ruud A.Dekker Alfons J.m.Jansman Wageningen Bioveterinary Research LelystadThe Netherlands Wageningen Livestock Research Wageningen University&ResearchWageningenThe Netherlands Royal Agrifirm Group ApeldoornThe Netherlands Institute for Risk Assessment Sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality microbiota Piglets Zinc oxide

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A high-power electromagnetic source for disabling improvised explosive devices

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High Voltage 2024年第2期9卷 403-409页

作者： laurent Ariztia Njomza Ibrahimi Alexey Zhabin Antoine Silvestre de Ferron marc Rivaletto Edson martinod Valérie Bertrand Bucur Novac laurent Pécastaing Universite de Pau et des Pays de l’Adour E2S UPPASIAMEPauFrance XLIm UMR CNRS BriveLimogesFrance CISTEmE LimogesFrance Wolfson School of mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK

Ultra-wideband(UWB)microwave sources driven by specialised pulsed power generators have experienced a considerable development in the last decade due to their wide domain of new applications such as defence or counter-terrorism *** authors present the main findings of a research dedicated to the development of a pulsed power-driven electromagnetic field source for disabling improvised explosive devices(IED).The pulsed power generator driving the source is a 13-stage compact marx producing voltage pulses reaching an amplitude of 0.5 mV,with a pulse repetition frequency(PRF)of up to 100 *** generator is coupled to a bipolar pulse forming line,providing bipolar pulses with a dV/dt of around 1.6 mV/*** pulsed power system feeds an array composed of 16 Koshelev-type UWB antennas through an impedance matching *** resulting electromagnetic source is capable to produce pulsed electric fields(PEFs)having a figure-of-merit(FOm)of 1 ***,practical experiments were carried out to study the effects of the PEFs on *** targets used in the present study are m2B type flashbulbs,known to have the same susceptibility as the US army m6 *** configurations of wires(shielded,twisted,etc)with different lengths were used in connecting items inside these *** tests were performed by placing the flashbulbs at different distances to determine the essential parameters(i.e.,amplitude,duration,and frequency range)of the PEFs required to trigger *** overview of the experimental campaign and the main findings are also presented followed by conclusions.

关键词： power bipolar source

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Generation,bonding and reactivity of transient zinc-substituted silylenes

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Science China Chemistry 2024年第4期67卷 1256-1262页

作者： Cheng Xu Thayalan Rajeshkumar laurent maron Xuebing Leng Yaofeng Chen State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Spin-X Institute School of Chemistry and Chemical EngineeringState Key Laboratory of Luminescent Materials and DevicesGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsSouth China University of TechnologyGuangzhou 510641China LPCNO CNRS&INSAUniversitéPaul SabatierToulous 31077France

The metal-substituted silylenes are of high interest,as the theoretical studies indicated that the silylenes with electropositive substituents have a small ΔE_(S-T)(singlet-triplet energy gap)or even the ground-state ***,such compounds are highly unstable,and only two transient alkali metal-substituted silylenes m(^(t)Bu_(3)Si)Si:(m=Li,K)were generated by photoextrusion of the alkali metal-substituted silacyclopropenes and merely studied by spectroscopic method(EPR)at low temperature(14 to 50 K).Herein,we report the generation of transient zinc-substituted silylenes from zinc silacyclopropanyl complexes under very mild and convenient *** generated transient zinc-substituted silylenes are highly reactive and undergo intermolecular cycloaddition with alkenes for the synthesis of zinc-substituted Si-heterocyclic *** there is no substrate,the zinc-substituted silylenes attack the C-C bonds of the β-diketiminato ligands and break the C-C *** studies further highlight the silylene nature of the zinc-substituted silylene and a very small ΔE_(S-T)(4.4 kcal/mol).

关键词： zinc complex silylene C-C bond cleavage cycloaddition DFT calculations

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Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry Dario A.Fioretto Lorenzo m.Procopio Stéphane monfray Frédéric Boeuf laurent Vivien Eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCI Université Paris-Saclay CNRS Centre for Nanosciences and Nanotechnology Weizmann Institute of Science STmicroelectronics SAS

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability, noise resilience, parallelization, and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave mixing. However, state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation, and efficient photon pair generation. We have developed silicon ring resonators with a footprint below 0.05 mm2providing more than 70 frequency channels separated by 21 GHz. We exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic devices. We fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state tomography. We demonstrate for the first time, we believe, a fully connected five-user quantum network in the frequency domain. These results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology, for applications in quantum computing and secure communications.

关键词： frequency domain integrated photonics quantum gates quantum networks

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拉科酰胺在癫痫持续状态中的应用--针对现有证据的系统评价

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癫痫杂志 2018年第5期4卷 446-460页

作者： Adam Strzelczyk Johann Philipp Zollner laurent m willems 肖英凤童馨慕洁 Julie Jost Esther Paule Susanne Schubert-Bast Felix Rosenow Sebastian Bauer

拉科酰胺(Lacosamide,LCm)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCm在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的... 详细信息

拉科酰胺(Lacosamide,LCm)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCm在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的文献进行了系统检索,并使用标准化的评估表格从各项研究中将有关研究设计、方法框架、数据源、有效性和LCm引起的不良反应的信息进行提取并系统地报告。研究共评估了522次SE发作,其中包括486例成人和36例儿童及青少年发作,女性占51.7%。LCm的总体效力为57%。LCm对非惊厥性(57%,82/145)和全面痉挛性(61%,30/49,P=0.68)SE的效力相似,但对局灶运动性SE的总体有效率更高(92%,34/39,Pm在用药次序靠后时其疗效从100%下降到20%。治疗期间的主要不良反应是眩晕,视力异常,复视和共济失调。总体而言,LCm具有良好的耐受性,并且没有具临床意义的药物相互作用。现有数据表明LCm在SE中的使用是有前景的,有效率为57%。LCm的优势在于没有潜在的药物相互作用,并且在紧急情况需迅速增加剂量时可静脉使用。

关键词：拉科酰胺癫痫持续状态痫性发作癫痫电压门控钠通道

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BSN:Photometric Light Curve Analysis of Two Contact Binary Systems LS Del and V997 Cyg

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Research in Astronomy and Astrophysics 2024年第4期24卷 192-213页

作者： Atila Poro mehmet Tanriver Elham Sarvari Shayan Zavvarei Hossein Azarara laurent Corp Sabrina Baudart Asma Ababafi Nazanin Kahali Poor Fariba Zare Ahmet Bulut Ahmet Keskin Astronomy Department of the Raderon AI Lab. BurnabyBC.Canada Department of Astronomy and Space Science Faculty of ScienceErciyes UniversityKayseri TR-38039Turkiye Erciyes University Astronomy and Space Science Observatory Application and Research CenterKayseri TR-38039Turkiye Independent Astrophysics Researcher TehranIran Department of Physics Shahid Beheshti UniversityTehranIran Faculty of Physics Shahid Bahonar University of KermanP.O.Box 76175KermanIran Double Stars Committee SociétéAstronomique de FranceParisFrance Dez Astronomical Association Khouzestan ProvinceDezfulIran Department of Physics Amirkabir University of TechnologyTehranIran Department of Physics Faculty of SciencesCanakkale Onsekiz Mart UniversityTerzioglu KampusuTR-17020CanakkaleTurkiye Astrophysics Research Center and Observatory Canakkale Onsekiz Mart UniversityTerzioğlu KampusuTR-17020CanakkaleTürkiye

The light curve analyses and orbital period variations for two contact binary stars,LS Del and V997 Cyg,are presented in this work which was conducted in the frame of the Binary Systems of South and North project Ground-based photometric observations were performed at two observatories in *** used the Transiting Exoplanet Survey Satellite(TESS)data for extracting times of minima and light curve analysis of the targe *** O-C diagram for both systems displays a parabolic *** Del and V997 Cyg’s orbital periods are increasing at rates of dP/dt=7.20×10^(-08)days yr^(-1)and dP/dt=2.54×10^(-08)days yr^(-1),respectively Therefore,it can be concluded that mass is being transferred from the less massive star to the more massive component with a rate of dm/dt=-1.96×10^(-7)m_(⊙)yr^(-1)for the LS Del system,and dm/dt=-3.83×10^(-7)m_(⊙)yr-1for V997 *** parameters of a third possible object in the system are also *** PHysics Of Eclipsing BinariEs Python code was used to analyze the light *** light curve solutions needed a cold starspot due to the asymmetry in the LS Del system’s light curve *** mass ratio fill-out factor,and star temperature all indicate that both systems are contact binary types in this *** methods were applied to estimate the absolute parameters of the systems:one method relied on the parallax of Gaia DR3,and the other used a P-m *** positions of the systems are also depicted on the m-L,m-R q-L_(ratio),and logm_(tot)-logJ_(0)*** recommend that further observations and investigations be done on the existence of a fourth body in this system.

关键词： (stars:)binaries:eclipsing methods:observational stars:individual(LS Del and V997 Cyg)

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标准铂钴电阻温度计百次低温温循稳定性研究

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哈尔滨工业大学学报 2024年第6期56卷 133-142页

作者：宋耀楠刘思琦张海洋高波李福洪 PITRE laurent 中法低温计量科学与技术国际联合实验室(中国科学院理化技术研究所) 北京100190 中国科学院低温工程学重点实验室(中国科学院理化技术研究所) 北京100190 中国科学院大学北京100049 东北大学冶金学院沈阳110819 云南大方米特尔实业有限公司昆明650300 法国国家计量院-法国国立科学技术与管理学院巴黎F93210

标准铂钴电阻温度计是0.65~24.5561 K(氖三相点)温区重要的测温器件,特别是高稳定的标准铂钴电阻温度计有潜力作为温度标定和温度国际比对的数据载体。为筛选出高稳定的标准铂钴电阻温度计,在前期研究基础上,建立以制冷机为冷源的温度... 详细信息

标准铂钴电阻温度计是0.65~24.5561 K(氖三相点)温区重要的测温器件,特别是高稳定的标准铂钴电阻温度计有潜力作为温度标定和温度国际比对的数据载体。为筛选出高稳定的标准铂钴电阻温度计,在前期研究基础上,建立以制冷机为冷源的温度计低温考核装置,5 K控温稳定性达13μK,24.5561 K控温稳定性达27μK,优于当前同类考核装置公开报道的控温稳定性结果。基于此,在5~24.5561 K温区开展标准铂钴电阻温度计百次低温温循研究,获得5支高稳定的标准铂钴电阻温度计,其中,4支50Ω标准铂钴电阻温度计的稳定性均优于0.2 mK@24.5561 K,1支100Ω标准铂钴电阻温度计的稳定性优于0.5 mK@24.5561 K,为当前标准铂钴电阻温度计低温稳定性国际最好结果。未来本文筛选的高稳定性标准铂钴电阻温度计将用于低温温度标定和低温温度国际比对等相关应用和研究。

关键词：低温考核装置控温稳定性标准铂钴电阻温度计低温稳定性低温温循

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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas laurent O.martinez Philipe de Souto Barreto For the mAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine mitochondria

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2023: Weather and Climate Extremes Hitting the Globe with Emerging Features

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Advances in Atmospheric Sciences 2024年第6期41卷 1001-1016页

作者： Wenxia ZHANG Robin CLARK Tianjun ZHOU laurent LI Chao LI Juan RIVERA Lixia ZHANG Kexin GUI Tingyu ZHANG Lan LI Rongyun PAN Yongjun CHEN Shijie TANG Xin HUANG Shuai HU State Key Laboratory of Numerical modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China met Office Hadley Centre Exeter EX13PBUK University of Chinese Academy of Sciences Beijing 100049China Laboratoire de météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75230France max Planck Institute for meteorology Hamburg 20146Germany Instituto Argentino de Nivología Glaciología Y Ciencias Ambientales(IANIGLA)CCT CONICETMendoza CP 5500Argentina Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Asia-Pacific Typhoon Collaborative Research Center Shanghai 201306China

Globally,2023 was the warmest observed year on record since at least 1850 and,according to proxy evidence,possibly of the past 100000 *** in recent years,the record warmth has again been accompanied with yet more extreme weather and climate events throughout the ***,we provide an overview of those of 2023,with details and key background causes to help build upon our understanding of the roles of internal climate variability and anthropogenic climate *** also highlight emerging features associated with some of these extreme *** extremes are occurring earlier in the year,and increasingly simultaneously in differing parts of the world(e.g.,the concurrent hot extremes in the Northern Hemisphere in July 2023).Intense cyclones are exacerbating precipitation extremes(e.g.,the North China flooding in July and the Libya flooding in September).Droughts in some regions(e.g.,California and the Horn of Africa)have transitioned into flood *** extremes also show increasing interactions with ecosystems via wildfires(e.g.,those in Hawaii in August and in Canada from spring to autumn 2023)and sandstorms(e.g.,those in mongolia in April 2023).Finally,we also consider the challenges to research that these emerging characteristics present for the strategy and practice of adaptation.

关键词： weather and climate extremes temperature extremes extreme precipitation drought wildfires

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