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Enhancing sensitivity in atomic force microscopy for planar tip-on-chip probes

Microsystems & Nanoengineering 2022年第3期8卷 39-49页

作者： H.Tung Ciftci Michael Verhage Tamar Cromwijk laurent pham van Bert Koopmans Kees Flipse Oleg Kurmosikov Department of Applied Physics Eindhoven University of TechnologyPO Box 5135600 MB Eindhoventhe Netherlands DRF/RAMIS/SPEC-LEPO Centre CEA de Saclay91191 Gif-sr-VvetteFrance Institut Jean Lamour Lorraine University54000 NancyFrance

We present a new approach to tuning-fork-based atomic force microscopy for utilizing advanced"tip-on-chip"probes with high sensitivity and broad ***,such chip-like probes with a size reaching 2×2 mm^(2)drastically perturb the oscillation of the tuning fork,resulting in poor performance in its intrinsic force ***,restoring initial oscillatory characteristics is necessary for regaining high *** this end,we developed a new approach consisting of three basic steps:tuning-fork rebalancing,revamping holder-sensor fixation,and electrode *** rebalancing allows the tuning fork to recover the frequency and regain high Q-factor values up to 10^(4)in air and up to 4×10^(4)in ultra-high vacuum *** floating-like holder-fxation using soft wires significantly reduces energy dissipation from the mounting *** with the soft wires,reconfigured electrodes provide electrical access to the chip-like probe without intervening in the force-sensing ***,our easy-to-implement approach allows converting the atomic force microscopy tip from a passive tool to a dedicated microdevice with extended functionality.

关键词： tuning atomic utilizing

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Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 541-546页

作者： pham Thi Kim Lien Vu Trong Duoc laurent Gavotte Emmanuel Cornillot Phan Thi Nga Laurence Briant Roger Frutos Tran Nhu Duong National Institute of Hygiene and Epidemiology CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France ISEM UMR 5554 CNRS-UM2-IRD Université Montpellier 2 CC065 Place E. Bataillon34095 Montpellier Cedex 5 France CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France Intertryp UMR 17 Cirad-IRD Campus International de Baillarguet34398 Montpellier Cedex 5 France

Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.

关键词： Aedes aegypti Aedes albopictus Dengue Vector density

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Surveillance of dengue and chikungunya infection in Dong Thap,Vietnam:A 13-month study

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 36-40页

作者： pham Thi Kim Lien Laurence Briant Truong Ba Tang Bui Minh Trang laurent Gavotte Emmanuel Comillot Vu Trong Duoc Tran Nhu Duong Roger Frutos Phan Thi Nga National Institute of Hygiene and Epidemiology University of Montpellier Department of Biology Dong Thap General Hospital Cirad TA-A17/GCampus International de Raillarguet

Objective:To establish a surveillance in Dong Thap,at the border with Cambodia by assessing the presence of DHNV serotypes and CHIKV among patients hospitalized at Dong Thap general ***:Cross-sectional descriptive analysis was conducted on a cohort of 131 patients hospitalized with acute fever and symptoms compatible with dengue or *** study was conducted from January 2012 to February *** full clinical picture was established as well as serological and molecular *** analysis was sequentially performed on blood samples collected on admission and an average of seven days after *** detection of IgM antibody to DENV was performed by IgM capture ELTSA and the detection of DENV and CHIKV RNA was done by reverse-transcription multiplex ***:101 patients out of 131(77%) were confirmed with *** four dengue serotypes were detected with a predominance of DENV2 and *** chikungunya infection was detected although reported in neighboring Cambodia.A differential efficiency of serological dengue detection was *** was 29%upon admission and 53%after seven days on the same patients.30 patients out of 131(23%) were negative with both DENV and ***:Dengue is at risk of being underestimated and chikungunya is not systematically *** in detection and surveillance procedures are therefore discussed to increase efficiency of dengue detection and continue the monitoring the emergence of CHIKV in Dong Thap province and in Vietnam.

关键词： Dengue Chikungunya Arbovirus Dong ThapVietnam

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低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验

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英国医学杂志中文版 2019年第2期22卷 123-123页

作者： Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) 不详北京大学第一医院

背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。... 详细信息

背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506.

关键词：白细胞介素-2 自身免疫疾病临床疗效临床试验低剂量自身免疫性疾病免疫学免疫表型分析

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