检索结果-南通市图书馆

Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-IO and TGF-β

引用

Cellular & Molecular Immunology 2017年第6期14卷 546-556页

作者： Josip Mikulic Stephanie Longet laurent Favre Jalil Benyacoub Blaise Corthesy R&D Laboratory Division of Immunology and Allergy CHUV Centre des Laboratoires d'Epalinges 1066 Epalinges Switzerl Nutrition and Health Nestle Research Center 1000 Lausanne 26 Switzerland

The importance of secretory IgA in controlling the microbiota is well known, yet how the antibody affects the perception of the commensals by the local immune system is still poorly defined. We have previously shown that the transport of secretory IgA in complex with bacteria across intestinal micmfold cells results in an association with dendritic cells in Peyer＇s patches. However, the consequences of such an interaction on dendritic cell conditioning have not been elucidated. In this study, we analyzed the impact of the commensal Lactobacillus rhamnosus, alone or associated with secretory IgA, on the responsiveness of dendritic cells freshly recovered from mouse Peyer＇s patches, mesenteric lymph nodes, and spleen. Lactobacillus rhamnosus-conditioned mucosal dendritic cells are characterized by increased expression of Toll-like receptor regulatory proteins lincluding single immunoglobulin interleukin-1 receptor-related molecule, suppressor of cytokine signaling 1, and Toll-interacting moleculel and retinaldehyde dehydrogenase 2, low surface expression of co-stimulatory markers, high anti- versus pro-inflammatory cytokine production ratios, and induction of T regulatory cells with suppressive function. Association with secretory IgA enhanced the anti-inflammatory/regulatory Lactobacillus rhamnosus-induced conditioning of mucosal dendritic cells, particularly in Peyer＇s patches. At the systemic level, activation of splenic dendritic cells exposed to Lactobacillus rhamnosus was partially dampened upon association with secretory IgA. These data suggest that secretory IgA, through coating of commensal bacteria, contributes to the conditioning of mucosal dendritic cells toward tolerogenic profiles essential for the maintenance of intestinal homeostasis.

关键词： commensal bacteria dendritic cells secretory IgA TLR regulatory proteins T regulatory cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applying chemical engineering concepts to non-thermal plasma reactors

引用

Plasma Science and Technology 2018年第6期20卷 161-171页

作者： Pedro AFFONSO NOBREGA Alain GAUNAND VANDad ROHANI Fran?ois CAUNEAU laurent FULCHERI MINES ParisTech PSL Research UniversityPERSEE-Centre for ProcessesRenewable Energy and Energy Systems MINES ParisTech PSL Research UniversityCTP-Centre for Thermodynamics of p Processes

Process scale-up remains a considerable challenge for environmental applications of non-thermal *** the impact of reactor hydrodynamics in the performance of the process is a key step to overcome this *** this work,we apply chemical engineering concepts to analyse the impact that different non-thermal plasma reactor configurations and regimes,such as laminar or plug flow,may have on the reactor *** do this in the particular context of the removal of pollutants by non-thermal plasmas,for which a simplified model is *** generalise this model to different reactor configurations and,under certain hypotheses,we show that a reactor in the laminar regime may have a behaviour significantly different from one in the plug flow regime,often assumed in the non-thermal plasma *** the other hand,we show that a packed-bed reactor behaves very similarly to one in the plug flow *** those results,the reader will find in this work a quick introduction to chemical reaction engineering concepts.

关键词： non-thermal plasma chemical engineering dielectric barrier discharge(DBD) corona discharge plug flow reactor volatile organic compounds

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Five-year outcomes with anti-vascular endothelial growth factor in neovascular age-related macular degeneration:results of the Comparison of Age-related Macular Degeneration Treatments Trials

引用

Annals of Eye Science 2017年第1期2卷 50-52页

作者： Thibaud Mathis laurent Kodjikian Department of Ophthalmology Croix-Rousse teaching HospitalHospices Civils de LyonUniversity of Lyon ILyon F-69004France CNRS UMR 5510 Mateis University of Lyon IVilleurbanne F-69621France

Age-related macular degeneration(AMD)is the leading cause of irreversible blindness in the elderly in industrialized countries(1,2).Current treatments for AMD are severely limited and only the wet form can be treated with anti-vascular endothelial growth factor(anti-VEGF).Although anti-VEGF is a palliative treatment,this drug dramatically improves the prognosis for patients with this disease(3).For example,in a population-based study in Denmark,the incidence of legal blindness from AMD was reduced by 50%after 2006(4).

关键词： degeneration AMD legal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Local and teleconnected temperature effects of afforestation and vegetation greening in China

引用

National Science Review 2020年第5期7卷 897-912页

作者： Yue Li Shilong Piao Anping Chen Philippe Ciais laurent Z.X.Li Sino-French Institute for Earth System Science College of Urban and Environmental Sciences Peking University Key Laboratory of Alpine Ecology and Biodiversity Institute of Tibetan Plateau Research Chinese Academy of Sciences Center for Excellence in Tibetan Earth Science Chinese Academy of Sciences Department of Biology Colorado State University Laboratoire des Sciences du Climat et de l'Environnement/Institut Pierre Simon Laplace Commissariata l Energie Atomique et aux Energies Alternatives–CNRS–Universite de Versailles Saint-QuentinUniversite Paris-Saclay Laboratoire de Met eorologie Dynamique Centre National de la Recherche ScientifiqueSorbonne UniversiteEcole Normale Superieure Ecole Polytechnique

Afforestation in China provides carbon sequestration and prevents soil erosion, but its remote impacts on climate in other regions via the coupling of forest energy fluxes with atmospheric circulation are largely unknown. Here, we prescribe inventory-based forest cover change and satellite-observed leaf area index from 1982 to 2011 in a coupled land-atmosphere model to simulate their biophysical climate effects. Both local and global surface air temperatures show a seasonal contrast in response to past vegetation cover expansion over China:a phenomenon we primarily attribute to a variation of seasonality of vegetation greening. A large cooling in spring results in concurrent decreases in geopotential height over China and zonal wind over Mongolia, causing a dipole structure in the upper troposphere over the Arctic. This accounts for～58%of simulated spring warming over the Russian Arctic and～61% of simulated spring cooling over the Canadian Artic. Our results imply that spring vegetation dynamics in China may affect climate in northern high latitudes.

关键词： afforestation vegetation greening China biophysical climate effect coupled land-atmosphere model

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Woody plant assemblage and the structure of miombo woodland along a disturbance gradient in Hurungwe, Zambezi Valley, Zimbabwe

引用

Journal of Forestry Research 2021年第5期32卷 1867-1877页

作者： Tatenda Gotore Hilton GTNdagurwa Shakkie Kativu Denis Gautier laurent Gazull Forest Research Centre P.O.Box HG595HighlandsHarareZimbabwe Department of Forest Resources and Wildlife Management Faculty of Applied ScienceNational University of Science and TechnologyP.O.Box AC 939 AscotBulawayoZimbabwe School of Animal Plant and Environmental SciencesUniversity of the WitwatersrandPrivate Bag 3Wits 2050South Africa Department of Biological Sciences Faculty of ScienceUniversity of ZimbabweP.O.Box MP167 Mount PleasantHarareZimbabwe Forêt et Sociétés Univ MontpellierCIRADTA C-105/DCampus international de Baillarguet34398 Montpellier Cedex 5France

Miombo woodlands near human settlements are under significant pressures from human activities,with negative consequences on their structure and *** studies are limited,we assessed the structure and species composition of a portion of miombo woodland along an increasing disturbance gradient from a national park,through a buffer zone to communal lands in northeast *** concentric plots of 2 and 11 m radii were established in each area to record woody species composition,diameter,height,basal area,density and volume as well as evidence of *** of site,growth stage and their interaction on vegetation diversity and structural parameters were tested using a general linear model(GLM).Principal component analysis(PCA) tested the association between species and site and ANOVA the differences in the level of disturbance across *** diversity did not differ between sites except for evenness,which increased with *** and richness were greater in seedlings and saplings than mature trees across sites,*** and mature tree diameters differed significantly between *** and density of mature trees declined with increasing disturbance while seedling densities peaked at intermediate disturbance levels(buffer zone).Tree harvesting,was more evident in the buffer zone and in the communal area relative to the national *** contrast,fire frequency was greater in the national park and in the buffer zone relative to the communal *** results of this study identify a true miombo woodland dominated by Brachystegia boehmii with a stable population,as illustrated by an inverse-J shape in diameter class distribution on all sites,and that these woodlands are generally resilient to disturbances,maintaining similar species composition and structure at various levels of ***,continued monitoring of disturbance levels and miombo woodland response is recommended to ensure sustainable utilisation of

关键词： Miombo woodlands cComposition Diversity Structure Anthropogenic disturbances

来源：

维普期刊数据库

同方期刊数据库评论

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：