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Advances in Computed Tomography 2013年第1期2卷 13-19页

作者： Edouard Cheneau Bruno Vahdat Noemie Resseguier laurent bernard Annamaria Molon Roch Giorgi Dimitri Panagides Service de Cardiologie Clinique BouchardMarseilleFrance Service de Sante Publique et d’Information Medicale Hopital de la TimoneMarseilleFrance

Purpose:When Coronary Computed Tomography (CCT) detects coronary obstruction, patients are regularly referred to invasive angiogram. With higher sensitivity than specificity, CCT might induce unnecessary angiograms (“false positive CCT”). We sought to determine the patients and CCT findings associated with false positive CCT. Methods: Patients were prospectively referred to CCT with a 64-slice CT scan for suspected CAD. Inclusion criteria were: 1) clinically suspected angina pectoris;or 2) suspected silent ischemia on resting EKG. Exclusion criteria were acute coronary syndrome and non sinus rhythm. Invasive coronary angiogram (ICA) was performed on the basis of CCT findings (stenosis >50%). Analysis was performed on a per patient basis. Results: Out of 702 patients, 228 had suspected significant stenosis by CCT and ICA was performed in 176 patients. Coronary stenosis >50% was not confirmed by ICA in 44 (25%). In multivariate analysis, we observed that atypical angina (OR 3.63,CI 1.43-9.66), silent ischemia (OR 5.11, CI 1.89-14.6) and number of suspected stenosed arteries by CCT (OR 1.81, CI 1.15-2.94) were independently predictive of false positive CCT (p Conclusions:Performing CCT for atypical angina or silent ischemia is associated with higher rate of unnecessary invasive coronary angiograms. We failed to identify lesions characteristics prone to be “false positive” of CCT.

关键词： Angina Coronary Disease Diagnosis CCT

Measuring the Stoichiometry of Functional PspA Complexes in Living Bacterial Cells by Single Molecule Photobleaching

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Measuring the Stoichiometry of Functional PspA Complexes in ...

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Tchern Lenn Christos N.Gkekas laurent bernard Christoph Engl Goran Jovanovic Martin Buck Centre for Bioinformatics Division of Molecular Biosciences Imperial College London

＜正＞Proteins often function as multimeric complexes in cellular processes such as signal transduction and ion *** well-established techniques exist to determine the structure and composition of protein complexes in their isolated forms in vitro,yet it is challenging to measure the stoichiometry of functional complexes in living *** we

关键词： single molecule stoichiometry photobleaching fluorescence imaging

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Transaction fees optimization in the Ethereum blockchain

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Blockchain(Research and Applications) 2022年第3期3卷 12-22页

作者： Arnaud laurent Luce Brotcorne bernard Fortz INRIA Lille Nord-Europe 40 Avenue HalleyLille59000France Universitélibre de Bruxelles Bruxelles1050Belgium

In blockchains,transaction fees are fixed by the *** probability for a transaction to be processed quickly increases with the fee *** this paper,we study the transaction fee optimization problem in the Ethereum *** problem consists of determining the minimum price a user should pay so that its transaction is processed with a given probability in a given amount of *** reach this goal,we define a new solution method based on a Monte Carlo approach to predict the probability that a transaction will be mined within a given time *** results on real data highlight the quality of the results.

关键词： Pricing Blockchain Ethereum Optimization Gasprice Ether Monte-Carlo

Discrimination of conspecifics from heterospecifics in a hybrid zone: Behavioral and chemical cues in ants

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Insect Science 2022年第1期29卷 276-288页

作者： Marion Cordonnier bernard Kaufmann laurent Simon Gilles Escarguel Nathalie Mondy Univ Lyon Universite Claude Bernard Lyon 1CNRSENTPEUMR 5023 LEHNAF-69622VilleurbanneFrance

Species and nestmate recognition in social insects occurs mostly through cuticular hydrocarbons acting as chemical cues. These compounds generate a colony-specific odor profile depending on genetic and environmental factors. Species and nestmate recognition results in specific behavioral responses, regulating the level of aggression toward other individuals during an interaction. Although species discrimination and recognition cues have been poorly studied in the context of interspecific hybridization, such systems offer an opportunity to further investigate the influence of heritable and environmental factors on recognition. We explored the strength of discrimination in a hybrid zone between two ant species—Tetramorium immigrans and T. caespitum—by comparing cuticular hydrocarbon profiles and measuring intra- and interspecific worker aggression in both areas of sympatry and areas of allopatry among species. Species cuticular hydrocarbon profiles were well-differentiated and interspecific aggression was high, revealing highly discriminating species recognition cues. Hybrids’ cuticular hydrocarbon profiles consisted of a mixture of the parental bouquets, but also exhibited hybrid-specific patterns. Behavioral assays showed that T. immigrans is as aggressive toward hybrids as toward heterospecifics. Finally, aggression between heterospecific workers was lower when interacting individuals came from areas of sympatry among species than from areas of allopatry. Taken as a whole, these findings paint a particularly complex picture of the recognition system in T. immigrans, T. caespitum, and their hybrids, and highlight that hybrid zones afford a still underexplored opportunity for investigating recognition mechanisms and discrimination between species.

关键词： aggressive behavior ants cuticular hydrocarbons hybrid zone recognition cues Tetramorium

Psychological impact of chronic hepatitis C:Comparison with other stressful life events and chronic diseases

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World Journal of Gastroenterology 2006年第10期12卷 1545-1550页

作者： laurent Castera Aymery Constant Pierre-Henri bernard Victor de Ledinghen Patrice Couzigou Service d'Hépato-Gastroentérologie Centre Hospitalier Universitaire de Bordeaux Hpital Haut Lévêque 33604 Pessac France Service d'Hépato-Gastroentérologie Centre Hospitalier Universitaire de Bordeaux Hpital St-André 33000 Bordeaux France Laboratoire de Psychologie de la Santé EA 3662 Université Victor Segalen Bordeaux-2 33000 Bordeaux France Service d'Hépato-Gastroentérologie Centre Hospitalier Universitaire de Bordeaux Hpital St-André33000 BordeauxFrance Service d'Hépato-Gastroenterologie Centre Hospitalier Universitaire de Bordeaux Hpital Haut Lévêque33604 PessacFrance

AIM： To examine the psychological impact of chronic hepatitis C （CHC） diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications. METHODS： One hundred and eighty-five outpatients with compensated CHC were asked to self-grade, using a 100-mm visual analogue scale （VAS）, the degree of stress caused by the learning of CHC diagnosis and the perceived severity of their disease. Diagnosis-related stress was compared to four other stressful life events and perceived CHC severity was compared to four other common chronic diseases. RESULTS： Learning of CHC diagnosis was considered a major stressful event （mean ± SD scores： 72±25）, significantly less than death of a loved-one （89±13, P〈0.0001） and divorce （78 ± 23, P〈0.007）, but more than job dismissal （68 ± 30, P〈 0.04） and home removal （26±24, P〈 0.0001）. CHC was considered a severe disease （74± 19）, after AIDS （94±08, P〈 0.001） and cancer （91± 11, P〈 0.001）, but before diabetes （66±23, P〈0.001） and hypertension （62±20, P〈0.001）. Perceived CHC severity was not related to the actual severity of liver disease, assessed according to Metavir fibrosis score. In multivariate analysis, diagnosisrelated stress was related to perceived disease severity （P〈0.001）, trait anxiety （P〈 0.001） and infection through blood transfusion （P〈 0.001）. CONCLUSION： Our results show the considerable psychological and emotional burden that a diagnosis of CHC represents, even in the absence of significant liver disease. They should be taken into account when announcing a diagnosis of CHC in order to reduce its negative effects.

关键词： Hepatitis C Stressful life event Perceived severity Visual analogue scale

Pancreatic head cancer in patients with chronicpancreatitis

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Hepatobiliary & Pancreatic Diseases International 2014年第2期13卷 192-197页

作者： Aude Merdrignac laurent Sulpice Michel Rayar Tanguy Rohou Emmanuel Quéhen Ayman Zamreek Karim Boudjema bernard Meunier Service de Chirurgie Hépatobiliaire et Digestive H pital PontchaillouCentre Hospitalier Universitaire INSERM UMR991 FoieMétabolismes et Cancer Service d'Imagerie Médicale H pital Pontchaillou

BACKGROUND: Chronic pancreatitis (CP) is a risk factor of pancreatic adenocarcinoma (PA). The discovery of a pancreatic head lesion in CP frequently leads to a pancreaticoduo denectomy (PD) which preceded by a multidisciplinary meeting(MM). The aim of this study was to evaluate the relevance between this indication of PD and the definitive pathological ***: Between 2000 and 2010, all patients with CP who underwent PD for suspicion of PA without any histological proof were retrospectively analyzed. The operative decision has always been made at an MM. The definitive pathological finding was retrospectively confronted with the decision made at an MM, and patients were classified in two groups according to this concordance (group 1) or not (group 2). Clinical and biological parameters were analyzed, preoperative imaging were reread and confronted to pathological findings in order to identify predictive factors of malignant ***: During the study period, five of 18 (group 1) patients with CP had PD were histologically confirmed to have PA, and the other 13 (group 2) did not have PA. The median age was52.5 ±8.2 years (gender ratio 3.5). The main symptoms were pain (94.4%) and weight loss (72.2%). There was no patient’s death. Six (33.3%) patients had a major complication (ClavienDindo classification ≥3). There was no statistical difference in clinical and biological parameters between the two groups. The rereading of imaging data could not detect efficiently all patients with ***: Our results confirmed the difficulty in detecting malignant transformation in patients with CP before surgery and therefore an elevated rate of unnecessary PD was found. A uniform imaging protocol is necessary to avoid PD as a less invasive treatment could be proposed.

关键词： chronic pancreatitis adenocarcinoma pancreaticoduodenectomy

Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

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World Journal of Gastroenterology 2006年第45期12卷 7278-7284页

作者： laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri bernard Christophe laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard Service d'Hépato-Gastroentérologie H?pital St-André Bordeaux France Service d'Hépato-Gastroentérologie H?pital Haut Lévêque Pessac France INSERM ERI 10 Laboratoire deBactériologie Université Victor Segalen Bordeaux 2 BordeauxFrance INSERM E0362Groupe de Recherche pour l'étude du Foie Université VictorSegalen Bordeaux 2 Bordeaux France Service d'Anatomie Pathologique H?pital Pellegrin Bordeaux France Service de ChirurgieDigestive H?pital St-André Bordeaux France Laboratoire de Virologie Université VictorSegalen Bordeaux 2 Bordeaux France

AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species.

关键词： Hepatitis C virus Hepatitis Cirrhosis Helicobacter

A Formal Passage From a System of Boltzmann Equations for Mixtures Towards a Vlasov-Euler System of Compressible Fluids

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Acta Mathematicae Applicatae Sinica 2019年第1期35卷 158-173页

作者： laurent DESVILLETTES Fran?ois GOLSE Valeria RICCI Université Paris Diderot Sorbonne Paris Cité Institut de Mathématiques de Jussieu-Paris Rive GaucheUMR CNRS 7586 CNRS Sorbonne Universités UPMC Univ CMLS Ecole polytechnique et CNRS Université Paris-Saclay Dipartimento di Matematica e Informatica Università degli Studi di Palermo

A formal asymptotics leading from a system of Boltzmann equations for mixtures towards either Vlasov-Navier-Stokes or Vlasov-Stokes equations of incompressible fluids was established by the same authors and Etienne bernard in: A Derivation of the Vlasov-Navier-Stokes Model for Aerosol Flows from Kinetic Theory Commun. Math. Sci., 15: 1703–1741(2017) and A Derivation of the Vlasov-Stokes System for Aerosol Flows from the Kinetic Theory of Binary Gas Mixtures. KRM, 11: 43–69(2018). With the same starting point but with a different scaling, we establish here a formal asymptotics leading to the Vlasov-Euler system of compressible fluids. Explicit formulas for the coupling terms are obtained in two typical situations: for elastic hard spheres on one hand, and for collisions corresponding to the inelastic interaction with a macroscopic dust speck on the other hand.

关键词： Vlasov-Euler system Boltzmann equation Hydrodynamic limit Aerosols Sprays Gas mixture

Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?

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World Journal of Gastroenterology 2018年第20期24卷 2137-2151页

作者： Marc Hilmi laurent Bartholin Cindy Neuzillet Service d'Oncologie Médicale H?pital Henri Mondor Assistance Publique-H?pitaux de Paris Université Paris Est Créteil Université de Lyon Université Claude Bernard Lyon 1 Inserm U1052 CNRS 5286Centre Léon Bérard Centre de Recherche en Cancérologie de Lyon

Pancreatic ductal adenocarcinoma(PDAC)is one of the deadliest cancers,mostly due to its resistance to *** these,checkpoint inhibitors(CPI)are inefficient when used as monotherapy,except in the case of a rare subset of tumors harboring microsatellite instability(<2%).This inefficacy mainly resides in the low immunogenicity and non-inflamed phenotype of *** abundant stroma generates a hypoxic microenvironment and drives the recruitment of immunosuppressive cells through cancerassociated-fibroblast activation and transforming growth factorβ*** strategies have recently been developed to overcome this immunosuppressive *** therapies involving CPI aim at increasing tumor immunogenicity and promoting the recruitment and activation of effector T *** studies are therefore exploring the association of CPI with vaccines,oncolytic viruses,MEK inhibitors,cytokine inhibitors,and hypoxia-and stroma-targeting *** T-cell transfer is also under ***,translational studies on tumor tissue and blood,prior to and during treatment may lead to the identification of biomarkers with predictive value for both clinical outcome and response to immunotherapy.

关键词： Drug therapy combination Immunology Hypoxia Checkpoint inhibitor Inflammation Pancreatic cancer Tumor-infiltrating lymphocyte Transforming growth factorβ Tumor microenvironment