检索结果-南通市图书馆

The first-line management of psychogenic non-epileptic seizures(PNES)in adults in the emergency:a practical approach

引用

Acta Epileptologica 2020年第1期2卷 48-58页

作者： Dènahin Hinnoutondji Toffa laurence poirier Dang Khoa Nguyen Neurosciences Division Centre de Recherche du Centre Hospitalier de l’Universitéde Montréal900 Rue Saint-DenisMontreal(QC)H2X 0A9Canada. Neurology Department Centre Hospitalier de l’Universitéde MontréalMontrealQuebecCanada. Faculty of Medicine McGill UniversityMontrealCanada.

Distinguishing non-epileptic events,especially psychogenic non-epileptic seizures(PNES),from epileptic seizures(ES)constitutes a diagnostic *** are frequent,especially when video-EEG recording,the gold-standard for PNES confirmation,cannot be *** issue is further complicated in cases of combined PNES with *** emergency units,a misdiagnosis can lead to extreme antiepileptic drug escalade,unnecessary resuscitation measures(intubation,catheterization,etc.),as well as needless biologic and imaging *** of the acute window,an incorrect diagnosis can lead to prolonged hospitalization or increase of unhelpful antiepileptic drug *** recognition is thus desirable to initiate adequate treatment and improve *** experience-based strategies and a thorough review of the literature,we aimed to present the main clinical clues for physicians facing PNES in non-specialized units,before management is transferred to epileptologists and *** such conditions,patient recall or witness-report provide the first orientation for the diagnosis,recognizing that collected information may be *** analysis of an event(live or based on home-video)may lead to a clinical diagnosis of PNES with a high confidence ***,a fluctuating course,crying with gestures of frustration,pelvic thrusting,eye closure during the episode,and the absence of postictal confusion and/or amnesia are highly suggestive of ***,induction and/or inhibition tests of PNES have a good diagnostic value when *** may also be a useful biomarker to distinguish PNES from epileptic seizures,especially following bilateral tonic-clonic ***,regardless the level of certainty in the diagnosis of the PNES,it is important to subsequently refer the patient for epileptological and neuropsychiatric follow-up.

关键词： Psychogenic non-epileptic seizures(PNES) Epilepsy Emergency Pseudostatus Prolactin dosage Homemade video

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jasmonic Acid Oxidase 2 Hydroxylates Jasmonic Acid and Represses Basal Defense and Resistance Responses against Botrytis cinerea Infection

引用

Molecular Plant 2017年第9期10卷 1159-1173页

作者： Ekaterina Smirnova Institut de Biologie Moléculaire des Plantes CNRS Université de Strasbourg Strasbourg France Laboratoire de Chimie Organique Synthétique Institut de Chimie Université de Strasbourg CNRS Strasbourg France

Jasmonates （JAs） orchestrate immune responses upon wound/herbivore injury or infection by necrotro- phic pathogens. Elucidation of catabolic routes has revealed new complexity in jasmonate metabolism. Two integrated pathways attenuate signaling by turning over the active hormone jasmonoyl-isoleucine （JA-Ile） through w-oxidation or deconjugation, and define an indirect route forming the derivative 12OH-JA. Here, we provide evidence for a second 12OH-JA formation pathway by direct jasmonic acid （JA） oxidation. Three jasmonic acid oxidases （JAOs） of the 2-oxoglutarate dioxygenase family catalyze spe- cific oxidation of JA to 12OH-JA, and their genes are induced by wounding or infection by the fungus Botrytis cinerea. JA02 exhibits the highest basal expression, and its deficiency in jao2 mutants strongly enhanced antifungal resistance. The resistance phenotype resulted from constitutive expression of antimi- crobial markers rather than from their higher induction in infected jao2 plants and could be reversed by ectopic expression of any of the three JAOs injao2. Elevated defense injao2 was dependent on the activity of JASMONATE RESPONSE 1 （JAR1） and CORONATINE-INSENSITIVE 1 （COI1） but was not correlated with erihanced JA-Ile accumulation. Instead, jao2 mutant lines displayed altered accumulation of several JA species in healthy and challenged plants, suggesting elevated metabolic flux through JA-Ile. Collectively, these data identify the missing enzymes hydroxylating JA and uncover an important metabolic diversion mechanism for repressing basal JA defense responses.

关键词： 2-oxoglutarate oxygenase jasmonic acid defense regulation hormone metabolism Botrytis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CD70 defines a subset of proinflammatory and CNSpathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

引用

Cellular & Molecular Immunology 2019年第7期16卷 652-665页

作者： Tessa Dhaeze laurence Tremblay Catherine Lachance Evelyn Peelen Stephanie Zandee Camille Grasmuck Lyne Bourbonnière Sandra Larouche Xavier Ayrignac Rose-Marie Rébillard Josée poirier Boaz Lahav Pierre Duquette Marc Girard Robert Moumdjian Alain Bouthillier Catherine Larochelle Alexandre Prat Department of Neuroscience Faculty of MedicineUniversitéde Montréaland Centre de Recherche du CHUM(CRCHUM)MontréalQC H2X0A9Canada Multiple Sclerosis Clinic Division of NeurologyCHUMMontréalQC H2X0A9Canada Division of Neurosurgery CHUMMontréalQC H2X0A9Canada CD70 is the unique ligand of CD27 and is expressed on immune cells only upon

***,engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of ***,the T cell-intrinsic effect and function of human CD70 remain ***,we describe that CD70 expression distinguishes proinflammatory CD4^(+)T lymphocytes that display an increased potential to migrate into the central nervous system(CNS).Upregulation of CD70 on CD4^(+)T lymphocytes is induced by TGF-β1 and TGF-β3,which promote a pathogenic *** addition,CD70 is associated with a TH1 and TH17 profile of lymphocytes and is important for T-bet and IFN-γexpression by both T helper ***,adoptive transfer of CD70−/−CD4^(+)T lymphocytes induced less severe experimental autoimmune encephalomyelitis(EAE)disease than transfer of WT CD4^(+)T ***70+CD4^(+)T lymphocytes are found in the CNS during acute autoimmune inflammation in humans and mice,highlighting CD70 as both an immune marker and an important costimulator of highly pathogenic proinflammatory TH1/TH17 lymphocytes infiltrating the CNS.

关键词： CD70+CD4^(+)T lymphocytes multiple sclerosis CD27/CD70 pathway TGF-β1 TGF-β3 soluble CD70 blood-brain barrier endothelial cells experimental autoimmune encephalitis TCR1640 transgene mouse model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：