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The role of Pbx1 in T cells

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Protein & Cell 2011年第12期2卷 946-949页

作者： Mayami Sengupta laurence morel Department of Pathology Immunology and Laboratory MedicineUniversity of FloridaGainesvilleFL 32610USA

Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult *** it is vital that the genes and the protein they encode that are involved in these processes function ***,any mutation or error that occurs along the way can result in extensive damage,which is expressed in various ways in the embryo and can result in immune pathogenesis,including immunodeficiency and autoimmune diseases,when lymphocyte development is altered.

关键词： diseases lymphocytes pathogenesis

Lupus at the molecular level

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Protein & Cell 2011年第12期2卷 941-943页

作者： Mayami Sengupta laurence morel Department ofPathology ImmunologyandLaboratoryMedicineUniversityofFloridaGainesvilleFL32610USA

Systemic lupus erythematosus(SLE)is a debilitating multi-factorial autoimmune disease(Shlomchik et al.,2001;La Cava,2009;Perry et al.,2011).It involves multiple organ systems with tissue damage driven by the activation of auto-reactive Tand B cells(Bruns et al.,2000;Langer et al.,2007).It can exist for years before being diagnosed and is known to be more common in women than in *** research efforts have uncovered a complex lupus pathogenesis,many aspects of which are not very clear(Perry et al.,2011).

关键词： al. Lupus lupus

Multi-sites in the Sle2 locus derived from lupus NZM2410 mouse inhibit chronic graft versus host reaction

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Multi-sites in the Sle2 locus derived from lupus NZM2410 mou...

Islet transplantation in multicenter networks:the GRAGIL example

The 8th International Congress on SLE

作者： laurence morel Department of Pathology Immunology and Laboratory MedicineUniversity of FloridaGainesvilleFL32601USA

＜正＞Purpose:Sle2 locus,which is on chromosome 4 from lupus NZM2410 mouse,was recently divided into several subloci. Our previous evidence demonstrated that these subloci had the ability to aggravate or alleviate the...

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来源： cnki会议评论

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介入放射学杂志 2006年第10期15卷 626-631页

作者： Thierry Berney Pierre-Yves Benhamou laurence Kessler Philippe morel the Division of Visceral and Transplantation Surgery Geneva University Hospitals24rue Micheli-du-Crest1211 Geneva 14Switzerland MDMSc the Division of Endocrinology Grenoble University Hospital CenterGrenobleFranceand the Division of EndocrinologyStrasbourg University Hospital CenterStrasbourgFrance MD the Division of Visceral and Transplantation Surgery Geneva University Hospitals24rue Micheli-du-Crest1211 Geneva 14Switzerland MD the Division of Visceral and Transplantation Surgery Geneva University Hospitals24rue Micheli-du-Crest1211 Geneva 14Switzerland MD.

Purpose of review The enthusiasm generated by the results of the Edmonton protocol of islet transplantation is inciting a great number of institutions to start such ***,the procedure of islet isolation and purification is costly,complex and technically *** order to share costs and to avoid facing the steep learning curve of the procedure,many centers interested in islet transplantation have looked into collaborating with experienced groups serving as core islet isolation *** findings The proof of principle that remote islet processing and shipment could be successfully implemented with obtainng the Portland/Minneapolis,Huddinge/Giessen and Houston/Miami ***,in order to increase both the donor pool and the number of patients gaining access to islet transplantation,multicenter networks,such as the Swiss-French GRAGIL consortium and the 4-country Nordic Network in Scandinavia have been *** GRAGIL group has been fully operational since 1999,allowing the transplantation of 27 islet preparations processed in Geneva,Switzerland into 20 recipients in France over the course of 4.5 *** issues in the design of such networks are discussed based on the example of the GRAGIL *** The feasibility and the efficiency of islet transplantation in multicenter networks have been *** strategy allows to increase the donor pool and the accessibility to islet transplantation in an extended population area.(J Intervent Radiol,2006,15: 626-631)

关键词：胰岛移植胰岛分离糖尿病病例

In the name of the rose:a roadmap for rose research in the genome era

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Horticulture Research 2019年第1期6卷 948-964页

作者： Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher Plant Breeding Wageningen University and ResearchP.O.Box 3866700 AJ WageningenThe Netherlands Faculty of Natural Sciences Institute for Plant GeneticsMolecular Plant BreedingLeibniz University of HannoverHerrenhäuser Strasse 230419 HannoverGermany ILVO Plant Sciences UnitFlanders Research Institute for AgricultureFisheries and FoodCaritasstraat 399090 MelleBelgium BVpam CNRS FRE 3727UJM-Saint-ÉtienneUniv.LyonSaint-EtienneFrance IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaV42 rue Georges Morel BP 6005749071 BeaucouzéFrance

The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting *** to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in *** cultivars are highly heterogeneous and *** vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical *** can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding *** paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be *** outline possible approaches for a number of these questions.

关键词： breeding cultivar linkage