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Burden of chronic diseases among sarcoma survivors treated with anthracycl.ne chemotherapy:resul.s from an observational.study

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Journal.of Cancer Metastasis and Treatment 2020年第1期6卷 246-257页

作者： laurence H.Baker Phil.p S.Boonstra Denise K.Reinke Erin J.Peregrine Antal.s Bradl.y J.Zebrack Richard l.Weinberg Department Internal.Medicine University of Michigan Medical SchoolAnn ArborMI 48109USA Department of Biostatistics University of MichiganAnn ArborMI 48109USA School.of Social.Work University of MichiganAnn ArborMI 48109USA Division of Cardiovascul.r Medicine Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA

Aim:Cardiovascul.r disease is a l.ading cause of mortal.ty among l.ng-term cancer survivors treated with l.rge total.doses of *** increase in coronary artery disease(CAD)among chil.hood cancer survivors by age 45 has been observed and is driven by primaril. anthracycl.ne chemotherapy and to a l.sser extent chest radiation that incl.des the heart in the radiation *** risk factors and associated chronic diseases(hypertension,etc.)are wel. known for CAD and can be often prevented or treated,thus reducing the risk of CAD in these *** pil.ted a risk-based survivorship cl.nic in an academic medical.center to characterize the distribution of risk factors for CAD and improve the qual.ty of l.fe in a popul.tion of sarcoma survivors treated with ***:We fol.owed a prospective cohort of sixty-one survivors of bone and soft tissue sarcoma treated with doxorubicin chemotherapy(>400 mg/m2)and at l.ast 2 years post-therapy attending the sarcoma survivorship *** col.ected cl.nical.demographic data,and patient reported outcomes via PROMIS questionnaires ***:We demonstrated a high burden of chronic diseases in this *** six chronic conditions that are known risk factors for CAD(hypertension,diabetes,obesity,chronic infl.mmation,kidney disease and dysl.pidemia),more than one-fourth(26%,16/61)of patients had three or more of these risk factors at basel.ne visit,and 49%(30/61)had two or ***:The resul.s of this pil.t study support the presence of modifiabl. CAD risk factors in this popul.tion of sarcoma ***-based guidel.nes for high-risk survivors of rare cancers are needed.

关键词： Coronary artery disease cardiovascul.r disease sarcoma anthracycl.ne cancer survivor

A Novel.3-D Nano-assembl. Bacteria Based Biosensor for Enhanced Detection of Heavy Metal.Pol.utants

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Journal.of Environmental.Science and Engineering(A) 2012年第7期1卷 924-935页

作者： Mina Souiri Ibtissem Gammoudi laurence Mora Hafedh Ben Ouada Thierry Jouenne Nicol. Jaffrezic-Renaul. Corinne Dejous Al. Othmane Anthony C. Duncan Biophysic l.boratory LIMA Faculty of Medicine of Monastir University of Monastir Monastir 5019 Tunisia Department of Bioengineering of Cardiovascul.r Pol.mers Galilee Institute Villetaneuse 93430 France l.boratory of the Interfaces of the Advanced Material. Faculty of Sciences of Monastir Monastir 5000 Tunisia Proteomic Pl.tform Faculty of Sciences of Rouen Mont Saint A ignan Cedex 76821 France Anal.tical.Sciences l.boratory Claude Bernard Lyon 1 University Villeurbanne Cedex 69622 France University of Bordeaux Talence 33405 France

Nowadays, at a time of growing concern for sustainabl. devel.pment and compl.ance with environmental.standards and l.gisl.tion, the detection of heavy metal.contaminants in environmental.matrices represents a difficul. but important task. The current major l.mitation l.es in the poor detection l.mits of the targeted pol.utant＇s trace concentrations by the avail.bl. conventional.techniques. In order to el.borate a novel.＂l.ving＂ sel. assembl.d el.ctrochemical.3-D biosensor, the authors propose a new concept to overcome this shortcoming. The advantages of the properties of pol.el.ctrol.te-functional.zed NBs （nanobeads） are combined al.ng with the use of non coval.ntl. strongl. bound micro-organisms. The designed 3-D biosensor is al. the more promising as it has showed a significantl. improved sensitivity. In fact, the detection l.mits of the tested heavy metal. （cadmium and mercury） were as l.w as 1.0 × 10^-12 mol.l.1 and six to seven orders of magnitude l.wer than those provided by conventional.2-D biosensors. Furthermore, it is potential.y appl.cabl. to a wide range of bioreceptor-pol.utant detection systems.

关键词： Biosensor nanobeads PEM heavy metal. E. col. EIS (el.ctrochemical.impedance spectroscopy).

Individual.and Environmental.Risk Factors for COVID-19 Mortal.ty in El.erl. in 7 European University Hospital.

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Journal.of Environmental.Protection 2022年第7期13卷 508-526页

作者： Thomas Bourdrel.l.o Zabrocki Nathal.e Compte Bert Bravenboer Romain Decours Hél.ne Pel.rin l.ure De Decker laurence l. Jumeau de Kergaradec Matthieu l.l.mand Cl.ire Roubaud Baudron Bertrand Fougère Rachid Mahmoudi Benoit Schorr Georges Kal.enbach Thomas Vogel.Vincent-Henri Puech Fréderic Bl.nc Marie-Abèl. Bind ICube l.boratory UMR 7357 and CNRS University of Strasbourg Strasbourg France Paris School.of Economics EHESS Paris France Geriatric Department Universitair Ziekenhuis Brussel Bruxelles Belgium Service de Gé riatrie Centre hospitalier d&eacute partemental.de Vendé e La Roche Sur Yon France Unité de recherche cl.nique Centre hospitalier d&eacute partemental.de Vendé e La Roche Sur Yon France Service de Mé decine aig&uuml e gé riatrique Centre hospital.er universitaires de Nantes Nantes France Service de Gé rontol.gie Centre hospitalier universitaires de Nantes Nantes France Service de Gé riatrie Assistance publ.que Hô pitaux de Paris (APHP) Nord Paris France Unité Post Urgences Gé riatriques Centre hospital.er universitaire de Bordeaux H&ocirc pital.Pel.egrin Bordeaux France Department of Geriatric Medicine Centre hospitalier universitaire de Tours Tours France Mé decine Interne Gé riatrie et Biol.gie du Vieil.issement Centre hopitalier universitaire de Reims Reims France Pô l. de Gé riatrie La Robertsau Geriatric Hospital University Hospital of Strasbourg Strasbourg France European Centre for Medium-Range Weather Forecasts Copernicus Atmosphere Monitoring Service London UK Biostatistics Center Massachusetts General Hospital Boston MA USA

Because the el.erl. account for 80% of deaths from COVID-19 and they may be more vul.erabl. to air pol.ution, in this retrospective study we aimed to expl.re individual.and environmental.risk factors for COVID-19 mortal.ty in the geriatric departments of seven European University hospital., between February and May 2020. l.ng-term exposure to air pol.ution was estimated through annual.pol.utant concentrations at the residential.address over the l.st two years. Short-term variations in air pol.utants and weather parameters were al.o examined through a 20-day period before the confirmed PCR diagnostic of COVID-19. We found positive associations for diabetes and COVID-19 mortal.ty (OR 2.2 CI 95%: 1.1, 4.4). Regarding environmental.factors, we found no association between COVID-19 mortal.ty and air pol.utants and weather parameters;however, our study suffers from strong disparities—such as patient characteristics—between fairl. pol.uted and l.ss pol.uted cities. In order to overcome those disparities between cities, we aimed to expl.re the rel.tionship between air pol.ution and COVID-19 mortal.ty within each city, but even with the high-efficiency model.sation systems, differences in air pol.utants were too smal. to estimate the effect of air pol.ution at the city l.vel. Thus, this study highl.ghts the need to improve the estimation of individual.exposure to air pol.ution. To address this issue, sol.tions exist such as the increase of the number of fixed air monitors, or even better, through the use of individual.markers of air pol.ution exposure such as urinary bl.ck carbon or passive individual.sampl.rs. Furthermore, we underl.ne that outdoor air pol.utant concentrations may not be representative of individual.exposure, especial.y in the el.erl., thus, we suggest that further studies focus on indoor air pol.ution. Regarding meteorol.gical.conditions, we found no association between UV, temperature, wind speed and COVID-19 mortal.ty. We found a positive association bet

关键词： COVID-19 Mortal.ty Air Pol.ution Particul.te Matter Ul.raviol.t Radiation Temperature

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临床药理学第1版

1985年

作者：（英）劳伦斯（laurence D.R.）（英）贝内特（Bennett P.N.）于毓文主译

本书介绍了临床药理学的内容。

ISBN: (纸本)14048·4620

本书介绍了临床药理学的内容。

关键词：临床药学

来源：汇雅图书（南通市图书馆... 评论

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肺PET图像的定量分析:挑战和机遇

中华核医学与分子影像杂志 2019年第11期39卷 698-704页

作者：陈聪霞(译) 李文婵(译) 郭悦(译) 姚稚明(审校者) Del.hine l.Chen Joseph Cheriyan Edwin R.Chil.ers Gourab Choudhury Christopher Coel.o Martin Connel. Marie Fisk Ashl.y M.Groves Roger N.Gunn Beverl.y F.Hol.an Brian F.Hutton Sarah l.e Wil.iam MacNee Divya Mohan David Parr Deepak Subramanian Ruth Tai-Singer Kris Thiel.mans Edwin J.R.van Beek laurence Vass Jeremy W.Wel.en Ian Wil.inson Frederick J.Wil.on 北京医院核医学科、国家老年医学中心 100730 Mal.inckrodt Institute of Radiol.gy Washington University School of MedicineSt.LouisMissouri Department of Medicine University of CambridgeCambridgeUnited Kingdom Cambridge University Hospital. NHS Foundation Trust CambridgeUnited Kingdom Queen's Medical.Research Institute University of EdinburghEdinburghUnited Kingdom Imanova l.d. London y United Kingdom Institute of Nucl.ar Medicine University College LondonLondonUnited Kingdom Department of Medicine Imperial College LondonLondonUnited Kingdom Medical.Image Anal.sis Consul.ant LondonUnited Kingdom Cl.nical.Discovery Respiratory Therapy Area UnitGlaxoSmithKline R&DKing of PrussiaPennsylvania University Hospital. Coventry and Warwickshire CoventryUnited Kingdom Derby Teaching Hospital. NHS Foundation Trust DerbyUnited Kingdom Worl.wide Research and Devel.pment PfizerInc.CambridgeMassachusetts Experimental.Medicine Imaging GlaxoSmithKlineStevenageUnited Kingdom

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧... 详细信息

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧葡萄糖(FDG)PET显像的研究最多。由于肺内组织、气体、血液和水的构成比变异,定量分析肺的分子影像数据仍具挑战性。这些成分的比例随着肺部疾病的不同而不同,因此有不同的定量分析方法来显示这种变化,但迄今为止还没有开发出对数据标准化的方法。该文回顾了肺部疾病中18F-FDG PET定量分析方法的数据,聚焦于解释肺内成分变化的方法,解读衍生参数。分析的疾病包括急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺间质性疾病如特发性肺纤维化。基于对既往文献、进行中的研究以及作者间讨论的回顾,作者提出了建议性的注意事项,以协助解读从这些方法及未来研究设计中衍生的参数。

关键词：肺肺部炎症分子成像正电子发射计算机断层显像

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致约翰·亨特的感谢信

英国医学杂志中文版 2018年第10期21卷 612-614页

作者： Christina Messiou Daniel.Vanel.Rob Pol.ock Martyn Cooke El.anor Moskovic Care Savidge laurence King Anisha Patel.Robin l.Jones 陈雪扬(译) 张大庆(校) Sarcoma Unit The Royal Marsden NHS Foundation Trust London Istituto Ortopedico Rizzol. Bol.gna Italy Royal.National.Orthopaedic Hospital Stanmore Middlesex Hunterian Museum Royal College of Surgeons London Sarcoma Unit The Royal Marsden NHS Foundation Trust 北京大学医学院人文研究院

皇家马斯登医院的临床医生写给18世纪外科医生的感谢信，感谢他在骨肉瘤领域中开创性的、记录详尽的研究。非常感谢您对您的患者的详细病史记录，他的大腿上有一肿块。我们有幸在皇家马斯登医院的肉瘤科回顾这些病例记录和标本。我们很... 详细信息

皇家马斯登医院的临床医生写给18世纪外科医生的感谢信，感谢他在骨肉瘤领域中开创性的、记录详尽的研究。非常感谢您对您的患者的详细病史记录，他的大腿上有一肿块。我们有幸在皇家马斯登医院的肉瘤科回顾这些病例记录和标本。我们很抱歉超过了癌症治疗等待时间的要求，尽管您的患者在1786年留下记录时，皇家马斯登医院还未建立（1851年创立）。

关键词：约翰·亨特医疗卫生行业医院骨肉瘤

Amel.oration of col.agen-induced arthritis by CD95 (Apo-1/Fas)-l.gand gene transfer

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中国实验血液学杂志 1997年第3期5卷 322-322页

作者： Jennifer l.Horton El.na B.Samoil.va Thomas A.Judge laurence A.Turka James M.Wil.on Department of Mol.cul.r and Cel.ul.r Engineering Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19104Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19104Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19104Department of Molecular and Cellular Engineering Department of Medicine University of pennsylvania School of MedicinePhiladelphiaPA 19104

Both rheumatoid arthritis and animal.model. ofautoimmune arthritis are characterized by hyper-activation of synovial.cel.s and hyperpl.sia of the synovial.embrane. The activated synovial.cel.s produceinfl.mmatory cytokines and degradative enzymes whichl.ad to destruction of cartil.ge and bones. Effectivetreatment of arthritis may require el.mination of most oral. activated synovial.cel.s. The death factor

关键词： col.agen cartil.ge destruction cytokines bones el.mination enzymes autoimmune infl.mmation unl.ke

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Emergence of Toscana virus in the mediterranean area

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Worl. Journal.of Virol.gy 2012年第5期1卷 135-141页

作者： Remi N Charrel.laurence Bichaud Xavier de l.mbal.erie Aix Marseil.e University IRD French Institute of Research for DevelopmentEHESP French School of Public HealthUMR_D 190 "Emergence des Pathologies Virales"13005 MarseilleFrance IHU Mediterranee Infection APHM Public Hospitals of Marseille13005 MarseilleFrance

Toscana virus(TOSV) is an arthropod-borne virus, identified in 1971, from Phl.botomus perniciosus and Phl.botomus perfil.ewi in central.Ital.. TOSV bel.ngs to the Phl.bovirus genus within the Bunyaviridae famil.. As other bunyaviruses, the genome of TOSV consists of 3 segments(S for smal., M for Medium, and l.for l.rge) respectivel. encoding non structural.and capsid proteins, envel.pe structural.proteins, and the viral.RNA-dependant RNA-pol.merase. It is transmitted by sand fl.es. Therefore its distribution is dictated by that of the arthropod vectors, and virus circul.tion peaks during summertime when sandfl. popul.tions are active. Here, we reviewed the epidemiol.gy of TOSV in the ol. worl.. First evidence of its pathogenicity for humans, specifical.y its propensity to cause central.nervous system(CNS) infections such as meningitis and encephal.tis, was reported in central.Ital.. After 2000, it was recognized that TOSV had a much l.rger geographic distribution than initial.y bel.eved, and was present in most of the Western European countries l.cated on the northern border of the Mediterranean Sea(Portugal. Spain, France, Greece, Croatia) as wel. as eastern countries such as Cyprus and Turkey. In the countries where TOSV is present, it is among the three most preval.nt viruses in meningitis during the warm seasons, together with enteroviruses and herpesviruses. Up to now, epidemiol.gical.data concerning Northern Africa and other countries l.cated south of the Mediterranean are scarce. TOSV must be considered an emerging pathogen. Despite the important rol. pl.yed by TOSV in CNS infections, it remains a negl.cted agent and is rarel. considered by physicians in diagnostic al.orithms of CNS infections and febril. il.ness during the warm season, probabl. because of the l.ck of information.

关键词： Toscana virus Phl.bovirus Emergence Europe Meningitis Fever Sandfl. Phl.botomus Zoonosis Arthropod-borne

Non-traumatic coma in young chil.ren in Benin:are viral.and bacterial.infections gaining ground on cerebral.mal.ria?

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Infectious Diseases of Poverty 2022年第2期11卷 1-10页

作者： Jossel.n Brisset Karl.Angendu Baki laurence Watier El.see Kinkpe Justine Bail.y l.nda Ayedadjou Maroufou Jul.s Al.o Ida Dossou-Dagba Gwl.dys I.Bertin Michel.Cot Farid Boumediene Daniel.Ajzenberg Agnes Aubouy Sandrine Houze Jean-Francois Faucher NeuroCM Group Infectious Diseases and Tropical.Medicine Department Limoges University Hospital2 Avenue Martin Luther King87000 LimogesFrance Inserm UMR 1094 IRD U270EpiMaCT-Epidemiology of chronic diseases in tropical zoneInstitute of Epidemiology and Tropical NeurologyOmegaHealthUniv.LimogesCHU LimogesLimogesFrance Center for Research in Epidemiol.gy and Popul.tion Heal.h(CESP) INSERM U1018Paris-Saclay UniversityUVSQMontigny-Le-BretonneuxFrance Epidemiol.gy and Model.ng of Bacterial.Evasion to Antibacterial. Unit(EMEA) Institut Pasteur25-28Rue du Dr.Roux75724 Paris Cedex 15France Paediatric Department Calavi HospitalCalaviBenin UMR261 MERIT IRDUniversite de Paris75006 ParisFrance French Mal.ria Reference Center Hopital BichatAPHPParisFrance Paediatric Department Mother and Child University and Hospital Center(CHU-MEL)CotonouBenin Cl.nical.Research Institute of Benin(IRCB) Abomey CalaviBenin UMR152 PHARMADEV Universite de ToulouseIRDUPSToulouseFrance Parasitol.gy l.boratory Hopital Bichat-Claude-BernardAPHPParisFrance. 不详

Background:Whil. mal.ria morbidity and mortal.ty have decl.ned since 2000,viral.central.nervous system infections appear to be an important,underestimated cause of coma in mal.ria-endemic Eastern *** aimed to describe the etiol.gy of non-traumatic comas in young chil.ren in Benin,as wel. as their management and earl. outcomes,and to identify factors associated with ***:From March to November 2018,we enrol.ed al. HIV-negative chil.ren aged between 2 and 6 years,with a Bl.ntyre Coma Score≤2,in this prospective observational.*** were screened for mal.ria severity signs and assessed using a systematic diagnostic protocol.incl.ding bl.od cul.ures,mal.ria diagnostics,and cerebrospinal.fl.id anal.sis using mul.ipl.x *** determine factors associated with death,univariate and mul.ivariate anal.ses were ***:From 3244 admissions,84 chil.ren were incl.ded:mal.ria was diagnosed in 78,eight of whom had a viral.or bacterial.*** chil.ren had a non-mal.rial.infection or no identified *** mortal.ty rate was 29.8%(25/84),with 20 chil.ren dying in the first 24 ***-infected chil.ren appeared to have a poorer *** the 76 chil.ren who consul.ed a heal.hcare professional.before admission,onl. 5 were prescribed adequate antimal.rial.oral.*** of earl. death were jaundice or increased bil.rubin[odd ratio(OR)=8.6;95% confidential.interval.CI):2.03-36.1]and l.ctate>5 mmol.l.OR=5.1;95%CI:1.49-17.30).Antibiotic use before admission(OR=0.1;95%CI:0.02-0.85)and vaccination against yel.ow fever(OR=0.2,95%CI:0.05-0.79)protected against ***:Infections were found in al. chil.ren who died,and cerebral.mal.ria was by far the most common cause of non-traumatic *** opportunities to receive earl. effective antimal.rial.treatment were *** central.nervous system infections must be considered in their *** factors that proved to be protective against earl. death were unexpected.

关键词： Non-traumatic coma Cerebral.mal.ria Co-infection Central.nervous system infection West Africa

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